WorksheetsPharmacology Mock Exam 3
Total questions: 50
Worksheet time: 2hrs 40mins
Which statement best explains why local anesthetics are less effective in inflamed dental tissue?
The tissue has increased blood flow that washes the anesthetic away.
The acidic environment decreases the non-ionized (base) form needed to penetrate nerves.
The anesthetic becomes more lipid soluble in low pH conditions.
Voltage-gated potassium channels become resistant to blockade.
A patient receives lidocaine with epinephrine. What is the primary purpose of adding epinephrine?
Increase systemic absorption
Decrease potency
Prolong duration and reduce bleeding
Prevent allergic reactions
Which local anesthetic is most associated with methemoglobinemia?
Lidocaine
Prilocaine
Articaine
Benzocaine
A dental patient becomes pale, sweaty, and faints during an injection. What is the most likely cause?
Local anesthetic toxicity
Psychogenic vasovagal syncope
Allergic reaction
Epinephrine overdose
Which local anesthetic has the longest duration of action?
Lidocaine
Bupivacaine
Articaine
Mepivacaine
Which anesthetic agent is most appropriate for rapid induction and rapid recovery in a pediatric patient?
Nitrous oxide
Isoflurane
Sevoflurane
Desflurane
Which intravenous anesthetic provides dissociative anesthesia and increases BP and HR?
Propofol
Ketamine
Etomidate
Thiopental
Which general anesthetic stage is characterized by irregular respirations and involuntary movements?
Stage I
Stage II
Stage III
Stage IV
Which inhalation agent has the fastest onset due to the lowest blood/gas partition coefficient?
Isoflurane
Nitrous oxide
Desflurane
Sevoflurane
A patient receiving general anesthesia with sevoflurane suddenly develops muscle rigidity, tachycardia, and hyperthermia. What is the immediate intervention?
Stop anesthesia and give naloxone
Administer dantrolene
Administer flumazenil
Give 100% N2O
A 37-year-old patient with uncontrolled hyperthyroidism presents for extraction. You plan to give lidocaine 2% with 1:100,000 epinephrine. What should you do?
Proceed as normal
Increase epinephrine concentration for hemostasis
Avoid epinephrine and use mepivacaine plain
Switch to articaine with 1:200,000 epinephrine
A child receives codeine after dental surgery and experiences severe respiratory depression. What explains this?
Allergy to codeine
Poor metabolizer phenotype
Ultra-rapid CYP2D6 metabolism
Liver toxicity
Which opioid is considered the gold standard for severe pain but is rarely used in dentistry due to low oral bioavailability?
Morphine
Hydrocodone
Oxycodone
Codeine
Which opioid combination requires caution due to hepatotoxicity risk?
Oxycodone + acetaminophen
Oxycodone alone
Tramadol alone
Hydrocodone alone
Why should codeine be avoided in children?
Risk of allergic reactions
Incomplete absorption
CYP2D6 ultra-rapid metabolism leading to morphine toxicity
Poor analgesic efficacy
What is the maximum recommended duration for opioid treatment after a dental extraction?
7–10 days
5–7 days
2–3 days
10–14 days
Which drug is the first-line treatment for opioid overdose?
Methadone
Naloxone
Buprenorphine
Naltrexone
A patient taking SSRIs develops tremors, sweating, and agitation after receiving tramadol. What is the likely diagnosis?
Opioid withdrawal
Serotonin syndrome
Malignant hyperthermia
Tramadol allergy
A dental patient on benzodiazepines should NOT receive which medication due to the risk of fatal respiratory depression?
Ketamine
Hydrocodone
Tramadol
Naloxone
Which opioid drug is a partial μ-agonist with a ceiling effect on respiratory depression?
Methadone
Buprenorphine
Tramadol
Naloxone
A 28-year-old recovering opioid addict needs third-molar surgery. He refuses opioids. What is the best postoperative regimen?
Oxycodone + ibuprofen
NSAID + acetaminophen combination therapy
Codeine + acetaminophen
Tramadol
A patient undergoing moderate IV sedation receives fentanyl and midazolam. Ten minutes later, his SpO2 drops to 86% and his respirations to 6/min. What is the priority action?
Give flumazenil
Give naloxone
Open airway + 100% oxygen, then determine if reversal is needed
Administer epinephrine
Which mediator is identified as the key driver of inflammation and the primary target of NSAIDs?
Histamine
Prostaglandins
Nitric oxide
Kinins
Why were selective COX-2 inhibitors originally developed?
To reduce renal toxicity
To prevent cardiovascular events
To avoid GI distress and ulcers
To improve platelet inhibition
Why should aspirin be avoided in children with viral infections?
Risk of nephrotoxicity
Increased bleeding time
Risk of Reye’s syndrome
Risk of bronchoconstriction
Which adverse effect of aspirin is linked to its COX-1 inhibition in the stomach?
Hypertension
Visual disturbances
Gastric ulcers and bleeding
Reduced fever response
Which NSAID is noted for a very long half-life (50–60 hours)?
Ibuprofen
Oxaprozin
Sulindac
Indomethacin
Which adverse effect is associated with acetaminophen overdose?
GI erosion
Respiratory depression
Hepatic necrosis
Increased bleeding time
Which drug is the frontline therapy for closing a patent ductus arteriosus (PDA) in premature infants?
Ibuprofen
Indomethacin
Naproxen
Diclofenac
Why is acetaminophen considered safer than NSAIDs for patients with GI disease?
It is a strong COX-1 inhibitor
It does not cause GI erosion or hyperacidity
It increases prostacyclin
It enhances platelet aggregation
A 52-year-old patient with rheumatoid arthritis presents with severe dental pain following extraction. His medical history includes peptic ulcer disease and a previous upper GI bleed. Which is the safest analgesic option for him?
Ibuprofen 800 mg every 6 hours
Ketorolac IM
Acetaminophen 650 mg every 6 hours
Naproxen twice daily
A 30-year-old patient with a history of uncontrolled asthma reports severe facial pain from an abscess. He states aspirin causes difficulty breathing. Which drug should be avoided?
Naproxen
Acetaminophen
Ibuprofen
Celecoxib
A patient complains of ringing in the ears, nausea, sweating, and hyperventilation after taking large doses of aspirin for dental pain. What is the likely diagnosis?
Acute opioid toxicity
Salicylism
Reye’s syndrome
Anaphylaxis
A 58-year-old patient with hypertension and a prior myocardial infarction needs pain control after periodontal surgery. Which NSAID should be avoided due to increased cardiovascular risk?
Celecoxib
Naproxen
Ibuprofen
Diclofenac
Which scale is commonly used to assess dental anxiety in patients?
Hamilton Anxiety Scale
Modified Dental Anxiety Scale (MDAS)
Zung Anxiety Inventory
Beck Anxiety Inventory
Which benzodiazepine is preferred for fast-onset oral sedation in adults?
Diazepam
Lorazepam
Midazolam
Triazolam
Which drug reverses a benzodiazepine overdose?
Naloxone
Flumazenil
Atropine
Epinephrine
Which drug class is MOST associated with xerostomia and high caries risk?
Cocaine
Opioids
Hallucinogens
Inhalants
Nitrous oxide sedation should be avoided in patients with which condition?
Diabetes
COPD
Hypertension
Hypothyroidism
What is the triad of opioid overdose?
Coma, seizures, mydriasis
Tachycardia, sweating, fever
Coma, miosis, respiratory depression
Hallucinations, hypertension, agitation
A 26-year-old patient arrives extremely anxious for a root canal. You plan nitrous oxide sedation, but her medical history reveals COPD. What is the best option?
Proceed normally; nitrous is safe
Use 100% N2O instead of mixed gases
Avoid N2O and consider oral benzodiazepine
Add epinephrine to improve oxygenation
A 45-year-old patient on fluoxetine (SSRI) requests sedation for an extraction. Which is the safest sedation plan?
Fentanyl + midazolam IV
Triazolam 0.25 mg
Nitrous oxide–oxygen sedation
Meperidine with midazolam
A 32-year-old patient admits to using cocaine 12 hours ago. You plan a filling requiring local anesthesia with epinephrine. What should you do?
Proceed as normal
Increase epinephrine to overcome tolerance
Avoid epinephrine due to hypertensive crisis risk
Use only nitrous oxide
A 68-year-old patient with stable angina (ASA III) needs extraction. What is the safest sedation strategy?
Deep IV sedation
High-dose triazolam
Low-dose midazolam with monitoring
General anesthesia in the office
A 20-year-old dental patient presents with severe caries, bruxism, and extreme xerostomia. He is agitated and sweating. Which substance is MOST likely?
Opioids
Methamphetamine
Alcohol
LSD
You administer triazolam for oral sedation. After 20 minutes, the patient shows slurred speech and decreased responsiveness. What do you do first?
Give naloxone
Administer epinephrine
Administer flumazenil
Start chest compressions immediately
A 15-year-old patient vapes THC daily and presents with moderate periodontal disease. What mechanism BEST explains this?
THC increases enamel solubility
THC increases IL-6 and immunosuppression
THC causes vasoconstriction of the gingival vessels
THC destroys the cemento-enamel junction
A 72-year-old patient with dementia becomes confused and combative after receiving lorazepam for sedation. What went wrong?
Lorazepam has too fast an onset
Elderly metabolize lorazepam too quickly
Lorazepam has a prolonged duration, causing delirium
Benzodiazepines are contraindicated in all elderly patients
A patient on chronic Adderall presents for composite restorations. You plan to use lidocaine with epinephrine. What should you do?
Proceed normally
Avoid epinephrine, as it may cause a hypertensive crisis
Increase epinephrine to counteract stimulant effects
Delay treatment for 72 hours
A 45-year-old man with chronic kidney disease (CKD) stage 4 presents with severe dental pain. Which analgesic is most appropriate to minimize further renal damage?
High-dose ibuprofen
Naproxen
Aspirin
Acetaminophen (dose-adjusted if needed)
