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WorksheetsTemplar Virtual EMERGE 4 - RM/SM Quiz
Total questions: 14
Worksheet time: 11mins
Describe the advantage of Rapid Sequencing over Conventional Sequencing in initiating GDMT for HFrEF?
Rapid sequencing focuses on sequential initiation of one drug at a time, allowing slow titration over 6 months or more.
Rapid sequencing introduces all four foundational drugs early, achieving therapeutic coverage within 4 weeks, with dose titration thereafter.
Rapid sequencing recommends starting with ACE inhibitors before β-blockers and SGLT2 inhibitors.
Rapid sequencing omits mineralocorticoid receptor antagonists in the initial phase.
Which neurohormonal pathway plays the most critical role in the progression of chronic heart failure? (More than 1 Answer Correct)
Dopaminergic system
Renin–Angiotensin–Aldosterone System over activation
Sympathetic overdrive
Cholinergic pathway
The benefit of SGLT2 inhibitors in HF is mainly attributed to:
Improved myocardial metabolism
Osmotic diuresis
Reduced preload/afterload
All of the Above
In chronic heart failure, ventricular remodeling happens primarily because of:
Hypertrophy and fibrosis due to neurohormonal activation
Improved myocardial compliance
Reduced preload
Coronary vasodilation
According to the ESC 2023 guidelines, which of the following drug classes has the strongest recommendation (Class Ia) for improving outcomes in patients with HFpEF & HFmrEF?
ARNI (Sacubitril/Valsartan)
MRA (Spironolactone)
SGLT2 inhibitor (Dapagliflozin or Empagliflozin)
GLP-1 receptor agonist
Acute Heart Failure (AHF) is defined as:
A slow improvement in heart function over time
Gradual or rapid change in heart failure signs and symptoms requiring urgent hospitalization
Chronic worsening of hypertension
Any asymptomatic cardiac structural change
Metabolic dysfunction-associated steatotic liver disease (MASLD) is primarily defined as:
Steatotic liver disease caused by high alcohol intake
Steatotic liver disease in the presence of one or more cardiometabolic risk factors and absence of harmful alcohol intake
Any liver disease with elevated liver enzymes
Fatty liver disease only in obese patients
Which of the following statements correctly describes MASH?
MASH is isolated liver steatosis without inflammation
MASH is metabolic dysfunction-associated steatohepatitis with hepatocellular ballooning and lobular inflammation
MASH does not progress to fibrosis or liver cancer
MASH is unrelated to metabolic dysfunction
In the DEAN trial, what was the percentage of patients in the dapagliflozin group who experienced fibrosis improvement without worsening of MASH?
15%
20%
45%
60%
In the DEAN trial, what was the percentage of patients in the dapagliflozin group who achieved MASH resolution without worsening of fibrosis?
8%
15%
23%
30%
As per the Endorse HF sub-study, how much improvement in Ejection Fraction (EF) was seen with dapagliflozin after 1 month?
0%
2%
5%
10%
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