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MOLECUALR BASIS OF INHERITANCE

Total questions: 80

Worksheet time: 40mins

Name
Class
Date
1.

DNA was first identified by

a)

Franklin

b)

Hershey

c)

Miescher

d)

Chargaff

2.

The diameter of a DNA double helix is

a)

10 Å

b)

20 Å

c)

34 Å

d)

3.4 Å

3.

Which is NOT a component of a nucleotide?

a)

Nitrogen base

b)

Sugar

c)

Phosphate

d)

Amino group

4.

The bond between two nucleotides is called

a)

Hydrogen bond

b)

Ionic bond

c)

Phosphodiester bond

d)

Peptide bond

5.

A-T pairs in DNA are held by

a)

1 H-bond

b)

2 H-bonds

c)

3 H-bonds

d)

4 H-bonds

6.

G–C pairs are held by

a)

1 hydrogen bond

b)

2 hydrogen bonds

c)

3 hydrogen bonds

d)

4 hydrogen bonds

7.

Who proposed the central dogma?

a)

Crick

b)

Watson

c)

Griffith

d)

Hershey

8.

The first genetic material was probably

a)

DNA

b)

Protein

c)

RNA

d)

Carbohydrates

9.

DNA polymerase polymerizes in which direction?

a)

3' → 5'

b)

5' → 3'

c)

Both directions

d)

Random

10.

The lagging strand is synthesized as

a)

Okazaki fragments

b)

Continuous strand

c)

RNA fragments

d)

DNA loops

11.

RNA polymerase in prokaryotes has

a)

One subunit

b)

Two subunits

c)

Three subunits

d)

Multiple subunits

12.

Transcription takes place in

a)

Cytoplasm (in eukaryotes)

b)

Nucleus (in eukaryotes)

c)

Mitochondria only

d)

Ribosomes

13.

Translation occurs on

a)

Nucleus

b)

Ribosomes

c)

Golgi

14.

Which is NOT a type of RNA?

a)

mRNA

b)

tRNA

c)

sRNA

d)

rRNA

15.

Three nucleotides on mRNA form a

a)

Anticodon

b)

Codon

c)

Intron

d)

Exon

16.

The anticodon is found on

a)

mRNA

b)

tRNA

c)

rRNA

d)

DNA

17.

Which is the start codon?

a)

UGA

b)

UAG

c)

AUG

d)

UAA

18.

Which of the following is NOT a stop codon?

a)

UGA

b)

UAG

c)

UAA

d)

AUG

19.

Hershey and Chase used

a)

35S and 32P

b)

14C and 32P

c)

35S and 14C

d)

32P only

20.

Griffith worked with

a)

E. coli

b)

S. pneumoniae

c)

Neurospora

d)

Tobacco plant

21.

Who proposed semi-conservative replication?

a)

Watson

b)

Meselson and Stahl

c)

Boyer

d)

Karry Mullis

22.

The enzyme that joins Okazaki fragments is

a)

DNA polymerase

b)

DNA ligase

c)

Primase

d)

Helicase

23.

Exons represent

a)

Coding sequence

b)

Non-coding sequence

c)

Repetitive DNA

d)

Satellite DNA

24.

Introns are removed during

a)

Translation

b)

Replication

c)

Splicing

d)

Transduction

25.

VNTRs are

a)

Highly repetitive DNA

b)

Coding sequences

c)

tRNA genes

d)

Ribosomal units

26.

The enzyme that unwinds DNA is

a)

Ligase

b)

Primase

c)

Helicase

d)

Gyrase

27.

Telomerase is active in

a)

Adult somatic cells

b)

Cancer cells

c)

RBCs

d)

All cells

28.

Which base is NOT present in RNA?

a)

Adenine

b)

Cytosine

c)

Thymine

29.

The smallest RNA is

a)

rRNA

b)

mRNA

c)

tRNA

d)

hnRNA

30.

The functional unit of heredity is

a)

Protein

b)

Gene

c)

Chromosome

d)

Nucleosome

31.

Chromatin consists of

a)

Protein only

b)

DNA only

c)

DNA + protein

d)

RNA + lipids

32.

Histones are rich in

a)

Acidic amino acids

b)

Basic amino acids

c)

Neutral amino acids

d)

Sulfur

33.

Which scientist discovered nuclein?

a)

Griffith

b)

Miescher

c)

Hershey

d)

Morgan

34.

Satellite DNA is used in

a)

Protein synthesis

b)

Gene expression

c)

DNA fingerprinting

d)

Mutation study

35.

DNA replication occurs in

a)

M phase

b)

G1 phase

c)

G2 phase

d)

S phase

36.

Genetic code is

a)

Overlapping

b)

Ambiguous

c)

Non-ambiguous

d)

Variable

37.

Wobble hypothesis is associated with

a)

mRNA

b)

rRNA

c)

tRNA

d)

DNA

38.

A nucleosome has

a)

4 histones

b)

6 histones

c)

8 histones

d)

10 histones

39.

The sugar in DNA is

a)

Ribose

b)

Deoxyribose

c)

Fructose

d)

Glucose

40.

The basic repeating unit of DNA packaging is

a)

Histone

b)

Chromosome

c)

Nucleosome

d)

Solenoid

41.

DNA replication is ______ in nature.

a)

Semi-conservative

b)

Conservative

c)

Dispersive

d)

Random

42.

The three-dimensional model of DNA was proposed by ______.

a)

Watson and Crick

b)

Hershey and Chase

c)

Franklin and Wilkins

d)

Meselson and Stahl

43.

The sugar present in RNA is ______.

a)

Ribose

b)

Deoxyribose

c)

Glucose

d)

Fructose

44.

The start codon is ______.

a)

AUG

b)

UAA

c)

UAG

d)

UGA

45.

Okazaki fragments are joined by ______.

a)

DNA ligase

b)

DNA polymerase I

c)

Primase

d)

Topoisomerase

46.

The transforming principle was discovered by ______.

a)

Avery

b)

Hershey

c)

Griffith

d)

Watson

47.

Histones are rich in ______ and ______ amino acids.

a)

Lysine and arginine

b)

Aspartate and glutamate

c)

Serine and threonine

d)

Glycine and alanine

48.

RNA polymerase binds to ______ region.

a)

Promoter

b)

Operator

c)

Enhancer

d)

Terminator

49.

Telomerase is a type of ______ polymerase.

a)

DNA-dependent DNA polymerase

b)

Reverse transcriptase

c)

RNA polymerase II

d)

DNA ligase

50.

mRNA carries genetic information from DNA to ______.

a)

Ribosome

b)

Nucleus

c)

Golgi apparatus

d)

Lysosome

51.

The nitrogen base absent in RNA is ______.

a)

Thymine

b)

Uracil

c)

Adenine

d)

Guanine

52.

The building blocks of DNA are called ______.

a)

Nucleotides

b)

Amino acids

c)

Monosaccharides

d)

Fatty acids

53.

Satellite DNA is also called ______.

a)

Repetitive DNA

b)

Coding DNA

c)

Mitochondrial DNA

d)

Unique sequence DNA

54.

Translation occurs in ______ of eukaryotic cells.

a)

Cytoplasm

b)

Nucleus

c)

Mitochondrial matrix

d)

Endoplasmic reticulum lumen

55.

The enzyme that unwinds DNA is ______.

a)

Helicase

b)

Ligase

c)

Primase

d)

Polymerase

56.

GTG is a ______ codon.

a)

Methionine

b)

Valine

c)

Tryptophan

d)

Proline

57.

Genetic code is ______ (universal / overlapping).

a)

Universal

b)

Overlapping

58.

rRNA synthesis occurs in ______.

a)

Nucleolus

b)

Cytoplasm

c)

Golgi apparatus

d)

Plasma membrane

59.

A nucleosome contains ______ bp of DNA.

a)

about 200200 bp

b)

about 146146 bp

c)

about 100100 bp

d)

about 10001000 bp

60.

The monomeric unit of protein is ______.

a)

Nucleotide

b)

Monosaccharide

c)

Amino acid

d)

Fatty acid

61.

DNA contains uracil. Select True or False.

a)

True

b)

False

62.

RNA polymerase needs a primer to initiate synthesis. Select True or False.

a)

True

b)

False

63.

Exons are coding sequences. Select True or False.

a)

True

b)

False

64.

Introns remain in mature mRNA. Select True or False.

a)

True

b)

False

65.

Okazaki fragments occur on the leading strand. Select True or False.

a)

True

b)

False

66.

Genetic code is degenerate. Select True or False.

a)

True

b)

False

67.

Telomerase is inactive in most somatic cells. Select True or False.

a)

True

b)

False

68.

DNA replication occurs during S phase. Select True or False.

a)

True

b)

False

69.

Hershey and Chase used bacteria Streptococcus pneumoniae. Select True or False.

a)

True

b)

False

70.

mRNA carries amino acids. Select True or False.

a)

True

b)

False

71.

tRNA is also called adaptor molecule. Select True or False.

a)

True

b)

False

72.

Ribosomes are made of RNA and protein. Select True or False.

a)

True

b)

False

73.

The codon UAA is a stop codon. Select True or False.

a)

True

b)

False

74.

RNA is always double-stranded. Select True or False.

a)

True

b)

False

75.

In eukaryotes, replication occurs at multiple origins. Select True or False.

a)

True

b)

False

76.

Splicing occurs in the cytoplasm. Select True or False.

a)

True

b)

False

77.

G-C content affects DNA stability. Select True or False.

a)

True

b)

False

78.

DNA polymerase can synthesize 3′ → 5′. Select True or False.

a)

True

b)

False

79.

VNTRs are useful in DNA fingerprinting. Select True or False.

a)

True

b)

False

80.

Chromatin is made of DNA and carbohydrate. Select True or False.

a)

True

b)

False

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