Consider the acetaminophen suppository product shown below. If the product is formulated using Cocoa Butter base, and acetaminophen is classified as a BCS Class I drug. Your expectation of the acetaminophen release from the suppository would be?

Water-Soluble and Water-Miscible Suppository Bases Include? Select All That Apply.

Cocoa Butter, NF suppository base exhibits marked polymorphism or existence in several crystalline forms? The most stable form(s) is(are)?

Cocoa Butter, NF suppository base should be melted at which of the following conditions?

A suppository base should? Select All That Apply.

Consider the rectal absorption of Sodium salicylate. Which of following forms will be predominate in the rectal environment?

The advantages of rectal administration include, Select All That Apply?

Which of the following materials should not be stored or dispensed in a polystyrene prescription vial?

At what Tween 80 concentration, the release rate of the active ingredient in the formulation is expected to be retarded?

You are asked to compound and prepare the following prescription, assume that the Rx is also asking to include other powders to the formulation (excess powder). What would be your base of choice in this case? Note: Hydrocortisone is very slightly soluble in water. Prescription: Hydrocortisone 25 mg, M. & Ft. Suppositories #10, Insert 1 supp q6h prn

Based on these data, which size distribution area would give the highest Acetaminophen blood level?

Consider the formulation below for the emulsion-type suppository metoprolol tartrate. Based on the formula compositions, the transfer of the drug molecule present in a dissolved state in the inner phase will be?

Shown below is acetaminophen suppositories product for infants, knowing that the solubility of acetaminophen is 15 mg/mL. What do you expect the base in this product would be?

When tried for rectal administration, Tamoxifen showed decreased bioavailability compared with oral administration at the same dose, as shown in the figure below. The reason(s) behind such observation is(are)? Select All That Apply.

How many 300 mg Aspirin suppositories can be prepared from 31 g cocoa butter base. Density factor of Aspirin is 1.3 Weight of blank suppository base is 2 g

All of the following materials can be used as a lubricant for the suppository mold, Except?

Reem is planning on using the product shown below to compound 180 mg strength per suppository (in an oleaginous base) based on an Rx she just received from the neighboring clinic. Based on the information provided, what would be the appropriate BUD assignment for the to-be-compounded suppositories? If the compounding dates is Nov 21, 2024

An aerosol formulation consists of two component parts: • The product concentrate. • The propellant. For many years, the liquefied gas propellants most used in aerosol products were the .............................................

You are in a situation that is your friend is taking Intal Inhaler to manage his asthma. Intal Inhaler contains the active ingredient cromolyn sodium with particle size of 2-6 μm. Your friend is asking you about the possible location such particles can reach to in his lung? What would be your answer?

Pharmaceutical aerosols are? Select All That Apply

The aerosol diagram shown below is an example for? Note: the propellant used in the example below is a liquified gas not a compressed gas.

Types of Aerosols Include? (Select All That Apply)

In the representative figure of aerosols below, What forces the contents of the aerosol out through the opening of the valve? Select All That Apply

The function of povidone K25 in Symbicort formulation is?

All of the following inhalation pharmaceutical products contain a propellant, Except?

Which of the following products are examples for Short-acting β-2 agonists (SABAs)? Select All That Apply.

What are the major differences between the cold filling and pressure filling of pharmaceutical aerosols? Select All That Apply.

What is the most commonly used filling operation for pharmaceutical aerosols?

Shown below is a diagram for aerosol valve assembly. The parts names annotated by letters are, respectively?

What are the most widely used metal containers for aerosols?

How often, on average, is LY using her ProAir HFA inhaler based on the refill history? She is refilling every 56 days.

Most metered-dose inhalers need to be shaken well immediately before use. Which metered-dose inhaler does not have to be shaken before use?

TJ uses Spiriva Respimat 2.5 mcg/inhalation. He inhales 5 mcg once daily. If each cartridge contains 60 metered actuations, how long will each cartridge last?

A patient has been prescribed Advair Diskus for asthma. What does this product contain?

A 42-year-old female patient has been diagnosed with asthma. She only likes taking medication that comes in a pill for easy administration. Which of the following routes is preferred for drug therapy when treating asthma?

What are the medications in Symbicort?

Pulmicort Respules are used primarily in this population group:

Which of the following medications is a dry powder inhaler?

W is well-controlled on his asthma medications which include Flovent HFA 220 mcg 2 inhalations BID,
salmeterol 1 inhalation BID, and Proventil HFA 1-2 inhalations Q4-6H PRN symptoms. He is picking up his
refills and asks if anything can help with his sore throat. When inspected, the pharmacist recognizes the
throat is sore due to thrush. What are some counseling points the pharmacist can provide that will help reduce JW's risk of thrush in the future?

A patient states that he uses his albuterol inhaler 4 days per week (about 6 puffs on each of those days). While completing a medication reconciliation at the clinic, the pharmacist notices that his albuterol inhaler is the Ventolin HFA brand that contains 60 inhalations per canister. Based on his current usage, how many weeks will his inhaler last?

What are the active ingredients in Breo Ellipta?

What are the active ingredients in Combivent?

Inpatient Orders:
Hold home medications during hospitalization
Ipratropium bromide 0.75 mg and albuterol 3.75 mg via nebulization Q4H

The pharmacy dispenses ipratropium bromide 0.5 mg and albuterol 2.5 mg per 3 mL. How many milliliters should be given to the patient to obtain the total daily dose of ipratropium bromide ordered?

What type of medication was DK taking at home for COPD?

How often should the plastic actuator for Atrovent HFA be cleaned?

A patient is picking up a new prescription for an ipratropium metered-dose inhaler and asks the pharmacist how to use it. Which of the following instructions should the pharmacist provide on the appropriate use of this medication?

Which inhaler has a window that turns from green to red to indicate a dose was given?

Which of the following medications contains a long-acting beta-2 agonist?

Which of the following classes of medications are considered bronchodilators? (Select ALL that apply.)

A patient is currently taking 3 calcium carbonate tablets daily. Each tablet contains 1,250 mg of calcium carbonate (salt weight, not elemental). She wants to switch to the calcium citrate formulation. How many 600 mg citrate tablets (salt weight) will she need each day to provide an equivalent elemental calcium dose?

Calculate the anion gap for a patient with the following lab values: From the labs:
 Na = 138 mEq/L
 Cl = 103 mEq/L
 HCO₃ = 19 mEq/L

A clinician prescribes 600 mL of a 1:500 acetic acid bladder irrigation for a patient. How many milliliters of a 2% stock solution of acetic acid are required to prepare this irrigation?

A prescription reads: Prepare a benzocaine HCl 4% w/v solution; use benzocaine powder and qs with purified water to 75 mL. How many grams of benzocaine are required to compound this prescription?

D5 ½ NS (5% dextrose in 0.45% NaCl) at 125 mL/hr

What is the osmolarity (mOsm/L) of the D5 ½ NS intravenous fluids ordered for DL? (MW of dextrose = 198; MW of Na = 23; MW of Cl = 35.5)

The pharmacy has D50W and D10W in stock.

How many milliliters of D50W are needed to prepare the ordered 2,000 mL of D25W?

Six months later, KW returns with worsening abdominal pain, weight loss, and diarrhea. She is diagnosed with cytomegalovirus (CMV) colitis. Her serum creatinine is unchanged at 1.6 mg/dL, and her weight is still 120 lbs. You are asked to recommend an appropriate valganciclovir dose for treatment of CMV colitis. Which dose of valganciclovir is appropriate for KW?

According to the hospital’s extended-interval aminoglycoside protocol based on the Hartford Nomogram, what initial dose of gentamicin should be ordered for JW?

A 45-year-old male is recovering in the surgical intensive care unit after major abdominal surgery. The team plans to start parenteral nutrition (PN). He weighs 180 pounds, is 5'10" tall, and has normal renal function. Using the Harris–Benedict equation provided below, calculate his Basal Energy Expenditure (BEE).

A patient has the following white blood cell differential from a recent CBC: • WBC = 6.2 × 10³ cells/mm³ • Segs (segmented neutrophils) = 55% • Bands (band neutrophils) = 5% Calculate the absolute neutrophil count (ANC).

Prednisolone sodium phosphate 0.5% (E value = 0.23)
• Sodium chloride QS to make an isotonic solution
• Sterile water QS AD 15 mL

How many milligrams of sodium chloride are needed to make the ophthalmic solution isotonic?

• Calcium (total) = 8.1 mg/dL (8.5–10.5)
• Albumin = 3.0 g/dL (3.5–5)

Using the standard correction for calcium in the setting of hypoalbuminemia, calculate LM’s corrected calcium. (Answer must be numeric; no units or commas; round the final answer to the nearest TENTH.)

How many milligrams of potassium chloride (MW = 74.5) are represented by 0.35 mmol?

A 10-year-old girl is brought to the Emergency Department after a stressful event at school. She is crying, breathing rapidly, and saying she feels dizzy and “can’t catch her breath.” An arterial blood gas (ABG) is obtained: Parameter Value Reference Range pH 7.52 7.35 – 7.45 pCO2 (mmHg) 28 35 – 45 pO2 (mmHg) 98 80 – 100 What is the primary acid-base disturbance?

A surgery patient is receiving the following parenteral nutrition (PN) regimen: • 1,000 mL of D25W (25% dextrose in water) • 500 mL of 15% amino acid solution • 250 mL of 20% Intralipid • 60 mL of electrolytes/minerals What percentage of the non-protein calories is provided by dextrose?

Nutrition Goal: 2,050 total calories per day from all sources

Dextrose 280 grams
• Amino acids 75 grams

20% Intralipid- To be infused separately over 10 hours daily

At what rate (mL/hr) should the 20% Intralipid be infused to meet the stated total daily calorie goal?

Adult rectal suppositories weigh about __ g when coco butter (theobroma oil) is employed as the base.