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WorksheetsBiochem
Total questions: 115
Worksheet time: 58mins
Saliva defense proteins include:
peroxidase, renin, gastromucoprotein
immunoglobulins, peroxidase
mucins, lactoferrin, lysozyme
catalase, lysozyme, transferrin
amylase, transferase, pepsin
Which protein is predominant in oral fluid composition?
Albumin
Mucin
Immunoglobulin A
Lysozyme
α-Amylase
Which transports cholesterol from organs and tissues to the liver?
albumins
VLDL
chylomicrons
LDL
HDL
Which enzymes are involved in carbohydrate hydrolysis in the oral cavity?
bacterial glycosidases
gamma-amylase
bacterial phosphatases
bacterial proteinases
maltases
What is the main buffer system of saliva called?
protein
nitrate
phosphate
bicarbonate
hemoglobin
What is the pH level characteristic of oral fluid?
7.5-8.0
7.0-7.5
6.4-7.8
6.5-7.0
6.0-6.3
Which enzyme in the oral cavity breaks down polysaccharides?
Sucrase
Peroxidase
Catalase
Maltose
α-Amylase
Which salivary enzyme has antibacterial properties?
Proteinase
Peroxidase
Lysozyme
Acid phosphatase
Alkaline phosphatase
How much saliva is secreted per day?
0.5L
1.5-2L
3.5-5L
More than 3L
2.5-3L
Name the proteinase inhibitor synthesized by salivary glands.
Acid-resistant proteinase inhibitor
α1-Antitrypsin
Superoxide dismutase
Neuraminidase
α2-Macroglobulin
Which type of immunoglobulin predominates in saliva composition, forming local immunity of the oral cavity?
Secretory Immunoglobulin A
Immunoglobulin A
Immunoglobulin G
Immunoglobulin E
Immunoglobulin M
Which salivary protein prevents precipitation of calcium-phosphate salts and keeps them in colloidal state?
Proline
Seromucoids
Globulin
Albumin
Amylase
An increase in which hormones characterizes the development of the body's stress responses?
Thyroid hormones (T3, T4)
Testosterone, estradiol
Parathyroid hormone, calcitonin
Cortisol, adrenaline
Insulin
Which ions have higher concentration in saliva in the morning hours?
Ni, Cr, and Sr
K, Ca, P, Fe
Mn, Se, Zn, Si
Al, Cu, Na, and Mg
Ca, P
When re-examining mixed saliva of a patient with periodontitis, the dentist noted an increase in free amino acids. Based on this indicator, what conclusion can be drawn?
Activation of nucleic acid degradation in periodontal tissues
Activation of free radical processes
Negative nitrogen balance
Activation of proteolytic enzymes
Deficiency of water-soluble vitamins
What is the role of hydrochloric acid in gastric juice composition?
free hydrochloric acid, bound hydrochloric acid, and acid residues
free hydrochloric acid and hydrocarbons
in cases of disturbed metabolism
free, bound hydrochloric acid and amino acids
free hydrochloric acid and acid residues
In which organ can lactate entering the blood be converted back to glucose?
in erythrocytes
in adipose tissue
in the brain
in the liver
in cardiac muscle
What is the cause of physiological jaundice in newborns?
group incompatibility of mother and fetus blood
insufficient activity of liver UDP-glucuronyltransferase
Rh conflict between mother and fetus
decreased degradation of erythrocytes in the first days of life
Rh conflict between father and mother
What does the term "Achilia" indicate the absence of?
free, bound hydrochloric acid and amino acids
free, bound hydrochloric acid and pepsin
free hydrochloric acid and hydrocarbons
free hydrochloric acid and acid residues
when indican is absent
Indicate the acid-producing cells in the gastric mucosa?
epithelium of the gastric lining
accessory cells of the gastric mucosa
chief cells of the gastric mucosa
surface epithelium
parietal cells of the gastric mucosa
What is the main role of gastrin in the body?
conversion of pepsinogen to pepsin in the stomach
dehydration of salts
stimulation of gastric juice secretion
activation of pancreatic enzymes
stimulation of pancreatic secretion
Name the hormonoid (histohormone) that stimulates bile formation in the liver?
Enterocrinin
histamine
Secretin
gastrin
villikinin
Histamine is used in diagnosing the functional state of the stomach. Which physiological property of histamine is favorable for this purpose?
constricts blood vessels
enhances gastric juice secretion
improves memory
inhibits gastric juice secretion
inhibits nerve impulse transmission
With which compound does indirect bilirubin interact to become direct bilirubin?
with uridine phosphoglucuronic acid in the intestine
with 3-phosphoadenine 5-phosphosulfate in the liver
with serum albumins
with uridine phosphoglucuronic acid in the liver
with benzoic acid in the liver
What is the main enzyme for fat absorption in adults?
gastric lipase
trypsin
pepsin
amylase
pancreatic lipase
A significant decrease in gastric juice acidity is associated with what?
irritated stomach
gastric ulcer
chronic superficial gastritis
chronic atrophic gastritis
duodenal ulcer
Where do detoxification of toxic products and degradation of amino acids occur?
in the blood
in the spleen
in the intestine
in the pancreas
in the liver
Which enzyme is used for gastritis with reduced secretory function?
pepsin
amylase
trepsin
chymotrypsin
lactase
Hydrolysis of triglycerides in the intestinal lumen is catalyzed by the participation of which enzymes?
transacylases
cholesteroleesterases
phospholipases
lipases
acetylcholinesterases
What substances are needed to activate pancreatic lipase?
coenzyme-A and bile acids
colipase and bile acids
colipase
bile acids and glycerol
bile acids
Indicate the strongest parenteral stimulant of gastric juice secretion:
pentagastrin
histamine
atropine
adrenaline
secretin
Free hydrochloric acid is determined with the participation of what?
amino acids
dimethylaminoazobenzene
methyl orange
sodium alizarin sulfonate
A patient has impaired liver function. Which biochemical blood indicator should be determined to assess liver condition?
creatine phosphokinase
ALT (Alanine aminotransferase)
LDH1
lipase
aldolase
Indicate the acid residues of gastric juice?
all strong inorganic acids
lactic acid and carbonic acids
organic acids and phosphate bound to oxygen
hydrochloric acids and alcohols
lactic, fatty, valeric, acetic and other organic acids
To prevent fatty degeneration of the liver after viral hepatitis, the patient should be prescribed lipotropic factors. Indicate one of them:
Vikasol
allopurinol
tryptophan
choline
Contrycal
What stimulates gallbladder contraction?
cholecystokinin-pancreozymin
enterocrinin
villikinin
secretin
chymodenin
Which proteolytic enzymes are synthesized in the gastric mucosa?
enterogastrone
gastrin
trypsin
gastricin
pepsinogen
In case of pancreatic secretory insufficiency, sometimes the drug "Festal" containing pancreatic enzymes is prescribed together with bile acid preparations to improve digestion. For what purpose is such an addition used?
to activate α-amylase
to activate proteolytic enzymes
to stimulate intestinal motility
to emulsify fats
to stimulate pancreatic juice secretion
Increased activity of LDH4, LDH5, alanine aminotransferase, gamma-glutamyltransferase, and carbamoyl-ornithine transferase was found in a patient's blood plasma. Which organ's pathology do the results indicate?
Pancreas
Kidney
Heart
Liver
Lungs
Lipids in blood are transported as lipoproteins. Which lipoprotein fraction transports cholesterol from peripheral tissues to the liver?
LDL
chylomicrons
IDL
HDL
VLDL
In what order do metabolism processes occur?
absorption, excretion, digestion, intermediary metabolism
excretion, digestion, absorption, intermediary metabolism
digestion, excretion, absorption, intermediary metabolism
digestion, absorption, intermediary metabolism, excretion
absorption, digestion, intermediary metabolism, excretion
Which proteolytic enzyme is synthesized in pancreatic cells?
trypsin
chymotrypsin
procarboxypeptidase A and B
elastase
prodipeptidase
Which class do enzymes involved in carbohydrate digestion belong to?
esterases
peptidases
acyltransferases
methyltransferases
glycosidases
A 36-year-old man was admitted to the hospital with complaints of acute girdle pain in the upper abdomen after drinking alcohol. Which enzyme test would confirm suspected acute pancreatitis?
amylases
creatine kinases
catalases
carbonic anhydrases
pepsin
In a patient, transport of amino acids into intestinal enterocytes is reduced. Which substance is involved in this process?
glutathione
alanine
amylase
anserine
ornithine
How are carbohydrates arranged according to their absorption rate in the intestine?
galactose > pentose > fructose > glucose
pentose > galactose > glucose > fructose
galactose > fructose > pentose > glucose
galactose > glucose > fructose > pentose
fructose > pentose > galactose > glucose
Pancreatic digestive enzymes are secreted in inactive form. What factor must be present in the intestine to prevent conversion of proenzymes to active form?
dipeptidases
chymotrypsin
amylases
succinate
Enterokinases
The main reserve of glucose in the human body and higher animals is a specific polysaccharide, stored mainly in the liver and muscles. Which polysaccharide is it?
inulin
cellulose
starch
agar-agar
glycogen
Toxic compounds are formed in the large intestine under the influence of microorganisms. One such compound is cadaverine. Indicate how this compound is formed.
by decarboxylation of lysine
by deamination of arginine
by reamination of lysine
by transdeamination of aspartate
by reamination of arginine
Lipoprotein classes have specific functions in transporting water-insoluble or poorly soluble fats, cholesterol, and its esters. Which one transports fats from the intestine to tissues?
LDL
VLDL
chylomicrons
pre-beta-lipoproteins
HDL
During intense muscle work, lactic acid accumulates in muscles as a result of anaerobic oxidation of glucose. What is its further fate?
used for glucose synthesis in the muscle
circulates in the blood, gradually used by all cells
enters the kidneys and is excreted in urine
transported via blood to the liver for glucose synthesis
used for synthesis of ketone bodies
A patient with liver cirrhosis has deteriorating vision. Which of the following is the most likely cause?
impaired absorption of vitamin A in the intestine
impaired conversion of trans-retinal to cis-retinal
impaired rhodopsin synthesis
insufficient vitamin A in the diet
excessive intake of vitamin A with food
Dietary fibers, which are components of plant cell walls, play an important role in preventing gastrointestinal diseases. What is the main polysaccharide in plant cell walls?
glycogen
starch
cellulose
chondroitin sulfate
inulin
Biochemical examination of a patient with gastric complaints revealed decreased secretory function of the stomach accompanied by anemia. Indicate which vitamin has an anti-anemic effect?
retinol
thiamine
cobalamin
nicotinic acid
tocopherol
Pancreatic juice contains many enzymes, some secreted in inactive form. Which enzymes are these?
amylase, lipase
nuclease, pepsin
nuclease, peptidase.
sucrase, amylase
trypsinogen, chymotrypsinogen
In children, gastric juice pH is in the range of 4.0-5.0. Name the gastric juice enzyme active under these conditions?
rennin
trypsin
pepsin
elastase
chymotrypsin
Saliva defense proteins include:
mucins, lactoferrin, lysozyme
peroxidase, pepsin, gastromucoprotein
amylase, transferrin, pepsin
catalase, lysozyme, transferrin
immunoglobulins, peroxidase, amylase
Indicate the chemical composition of saliva?
water - 99%, dry residue - 1%
water - 90%, dry residue - 10%
water - 79%, dry residue - 21%
water - 89%, dry residue - 11%
water - 80%, dry residue - 6%
What defense functions does saliva have?
Degradation of proteins
degradation of polysaccharides
degradation of lipids
cleansing and moistening of the oral cavity
participation in tooth enamel formation
Indicate the amount of saliva secreted per day?
2.0 - 2.5L
2.5 - 3L
1.5 - 2L
more than 3L
0.5L
Indicate the main buffer system of saliva?
phosphate
hemoglobin
protein
bicarbonate
nitrate
In smokers' saliva, what substances are increased?
calcium
phosphates
lactate
thiocyanates
bicarbonates
What process occurs when thiocyanates are present in saliva?
Participate in enamel mineralization
participate in prostaglandin formation
participate in vascular tone regulation
In increased amounts become carcinogenic factors; develop antibacterial defense
What role does the enzyme peptidylpeptidohydrolase play?
Participates in antibacterial defense of teeth
participates in vascular tone regulation
participates in prostaglandin formation
Participates in peptide hydrolysis
assists in conversion of kininogen to kinin
Which enzymes are involved in carbohydrate hydrolysis in the oral cavity?
gamma-amylase
bacterial proteinases
bacterial glycosidases
bacterial phosphatases
maltase
Which class do digestive juice enzymes belong to?
hydrolases
lyases
oxidoreductases
isomerases
Which of the following biochemical reactions do kinases catalyze?
phosphorylation
carboxylation
dehydrogenation
amidation
deamination
Which of the following biochemical reactions do lyases catalyze?
transfer of atom or group of atoms
non-hydrolytic breakdown of substances
oxidation-reduction reaction
hydrolytic breakdown of substances
isomerization reaction
Which of the following biochemical reactions do transferases catalyze?
isomerization reaction
non-hydrolytic breakdown of substances
oxidation-reduction reaction
transfer of atom or group of atoms
hydrolytic breakdown of substances
Which of the following biochemical reactions do oxidoreductases catalyze?
hydrolytic breakdown of substances
oxidation-reduction reaction
isomerization reaction
non-hydrolytic breakdown of substances
transfer of atom or group of atoms
Indicate the water content in gastric juice under normal conditions?
85.5-85.9% water
99.4-99.5% water
75.6-75.8% water
80.4-84.5% water
89.4-89.9% water
Indicate the normal pH of gastric juice?
1.5 - 2.0
10.4 - 12.8
8.8 - 9.0
3.0 - 5.0
5.5 - 6.8
What role does mucin in gastric juice play?
To protect vitamin B12 from degradation
for vitamin B12 absorption
Protection from HCl effects
to activate gastric enzymes
for protein digestion
In which pathological condition does lactate accumulate in large amounts in the stomach?
in gastric cancer
in gastric ulcer
in gastric polyp
in pancreatitis
in hyperacid gastritis
What role does hydrochloric acid in gastric juice composition play?
stimulates cathepsins
degrades food proteins
activates sucrase
participates in carbohydrate fermentation
activates pepsinogen
When examining gastric juice, total acidity was 90 titratable units, free acidity was 70 titratable units. What is this condition called?
hyperchlorhydria
hyperchloremia
achlorhydria
hypochlorhydria
achylia
Examination of gastric juice showed total acidity of 25 titratable units, free HCl - 5 titratable units. What is this condition called?
hypochloremia
hyperchlorhydria
achylia
achlorhydria
hypochlorhydria
When a tube was inserted in a patient, the gastric juice was yellow. Absence of hydrochloric acid indicated impaired pylorus function. What pathological substance causes the color change of gastric juice?
blood
lactate
volatile fatty acids
glucose
bile
Patient's gastric juice analysis results: total acidity – 28 mmol/L, free hydrochloric acid – 1.5 mmol/L, gastromucoprotein level decreased. Which vitamin deficiency is observed?
riboflavin
folic acid
cobalamin
pantothenic acid
nicotinamide
Histamine is used in diagnosing the functional state of the stomach. Which physiological property of histamine is considered for this purpose?
enhances gastric juice secretion
inhibits gastric juice secretion
inhibits nerve impulse transmission
improves memory
constricts blood vessels
What role does gastromucoprotein in gastric juice play?
for vitamin B12 absorption
Protection from HCl effects
Protecting the mucous layer of gastric juice from self-digestion
For protein digestion
To activate gastric enzymes
The absorption mechanism for galactose and glucose is:
Primary active transport
Pinocytosis
Secondary active transport
Facilitated diffusion
Simple diffusion
Indicate the process during hypoglycemia?
Decrease in blood glucose level
Increase in blood glucose level
Decrease in glycogen formation in the liver
Increase in urine glucose amount
Maintaining constant blood glucose level
Which process increases in the liver during alimentary hyperglycemia?
Hydrolysis
Glycogenolysis
Glycolysis
Glycogenesis
Gluconeogenesis
What role do ketone bodies play during prolonged fasting?
Source of bile acids
Source of lipids
Source of glucose
Source of glycogen
Energy source
What is the importance of bile acids in the body?
Inhibitors of pancreatic lipase
Activator of lipoprotein lipase
Part of lipoproteins
Part of chylomicrons
Activators of pancreatic lipase
Which gland secretes alkaline mucus that is released in the initial part of the small intestine?
Brunner’s glands
Pancreas
Liver
Salivary glands
Which substance activates trypsin?
Pepsin
Enterokinase (enteropeptidase)
Chymotrypsin
Lipase
What is the main function of glucose-6-phosphatase in the liver?
Glycogen synthesis
Conversion of glucose-6-phosphate to free glucose
Fatty acid synthesis
Amino acid transamination
Which monosaccharides are formed during the complete breakdown of lactose?
Glucose and galactose
Glucose and fructose
Glucose only
Galactose only
Which hormone decreases the acidity of gastric juice?
Gastrin
Secretin
Cholecystokinin
Insulin
Which enzyme limits the rate of cholesterol biosynthesis?
Lipase
HMG-CoA reductase
Amylase
Trypsin
What is the main enzyme involved in the formation of glucose from pyruvate?
Pyruvate kinase
Pyruvate carboxylase
Hexokinase
Glucokinase
By which mechanism is glucose transported in the small intestine?
Simple diffusion
Active transport via SGLT1
Facilitated diffusion via GLUT2 only
Endocytosis
In which organelle of the enterocyte does the re-synthesis of fatty acids into triglycerides occur?
Nucleus
Mitochondria
Smooth endoplasmic reticulum
Lysosome
Into which products does pancreatic amylase break down starch?
Glucose only
Maltose and maltotriose
Fructose
Lactose
Which coenzyme is used for transamination reactions of amino acids in the liver?
NAD⁺
FAD
Pyridoxal phosphate Vitamin B6
Coenzyme A
How are chylomicrons released into the lymph from within the enterocyte?
Simple diffusion
Exocytosis into lacteals
Active transport into portal vein
Pinocytosis into blood capillaries
What is the significance of bile acids in digestion?
Digest proteins
Emulsify fats for absorption
Hydrolyze carbohydrates
Increase gastric acid secretion
Which additional substance is necessary for the re-formation of triglycerides after the products of dietary triglyceride hydrolysis enter the micelle and reach the intestinal epithelium?
Glycerol
Fatty acids
Monoglycerides
Coenzyme A
What is the main lipid contained in a chylomicron?
Phospholipids
Cholesterol
Triglycerides
Free fatty acids
In which form are pancreatic proteases secreted?
Active form
Zymogen (inactive precursor)
Denatured proteins
Free amino acids
What is the direct intermediate product in the formation of ketone bodies in the liver?
Acetoacetate
Acetyl-CoA
Beta-hydroxybutyrate
HMG-CoA
What is the optimal pH value of pepsin in the stomach?
1–2
2–3
4–5
6–7
What are the main metabolic characteristics of bile acids?
Amphiphilic, synthesized from cholesterol
Hydrophilic only, synthesized from triglycerides
Hydrophobic only, synthesized from fatty acids
Protein-bound only
Which amino acid residue is specific for the conversion of trypsinogen to trypsin?
Lysine
Arginine
Tyrosine
Phenylalanine
Which bond does pancreatic lipase hydrolyze?
Peptide bond
Ester bond in triglycerides
Glycosidic bond
Phosphodiester bond
To which class does the enzyme trypsin belong?
Lipase
Protease
Amylase
Nuclease
How does lactose differ from maltose?
Lactose is a disaccharide of glucose and galactose; maltose is glucose and glucose
Lactose is glucose and glucose; maltose is glucose and fructose
Lactose contains fructose; maltose contains galactose
Lactose is monosaccharide; maltose is disaccharide
The pepsinogen molecule secreted by gastric glands is inactive due to what reason?
Low pH in stomach
Protective peptide sequence (zymogen)
Presence of bile
High concentration of enzymes
What is the main end product formed during the complete oxidation of fats?
Glucose
Ketone bodies
Carbon dioxide and water
Lactate
Which structural feature determines the amphiphilic nature of bile acids?
Presence of hydroxyl and methyl groups on steroid nucleus
Peptide chains
Carboxylic groups only
Phosphate groups
When the liver increases its choline content, part of it is converted into what?
Betaine
Acetylcholine
Phosphatidylcholine
Carnitine
Which reaction converts bilirubin into a water-soluble form?
Oxidation by peroxidase
Conjugation with glucuronic acid
Reduction by NADH
Sulfation
What is the final product of purine catabolism in the liver?
Urea
Ammonia
Uric acid
Creatinine
