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JMC QUIZ BOWL Biochemistry

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

Which Enzyme proofreads and removes RNA Primase?

a)

DNA polymerase 1

b)

DNA Polymerase 2

c)

DNA Polymerase 3

d)

RNA Polymerase

2.

Which of the following functions to prevent premature reannealing of the dsDNA?

a)

DNA Ligase

b)

Single-strand binding proteins

c)

Topoisomerases

d)

DNA primase

3.

A nucleotide is composed of which of the following?

a)

A sugar, nitrogenous base and a protein.

b)

A sugar, phosphate, and nitrogenous base

c)

A sugar, proteins, and phosphate

d)

A sugar, phosphate and carbons

4.

Which enzyme fixes the Okazaki fragments in the lagging strand?

a)

Ligase

b)

Helicase

c)

Primase

d)

Polymerase

5.

Abnormal regions of DNA, either from copying errors or DNA damage, are replaced by either of the following mechanisms, except for

a)

Mismatch repair

b)

Two-base alteration

c)

Nucleotide excision repair

d)

Double-strand break repair

6.

When does the DNA synthesis occurs in the Cell cycle?

a)

Gap 1 phase

b)

Gap 2 phase

c)

G 0

d)

S phase

7.

The secretion of bilirubin from hepatocytes to canaliculi is an energy-dependent process. The transporter protein involved in this protein is

a)

MRP2 Protein

b)

Active transport coupled with Na-K ATPase

c)

Bilirubin transporting protein

d)

Chylomicron

8.

Hyperbilirubinemia caused by mutation of the protein involved in the secretion of conjugated bilirubin into the bile is seen in

a)

Toxic hyperbilirubinemia

b)

Dubin-Johnson Syndrome

c)

Crigler Najjar syndrome

d)

Rotor Syndrome

9.

Urobilinogen is oxidized to form colored product and these give the characteristic color of urine and feces. In which type of jaundice, the stool color is clay-colored because of lack of urobilin?

a)

Hemolytic jaundice

b)

Viral hepatitis

c)

Obstructive jaundice

d)

Alcoholic cirrhosis

10.

Dubin Johnson syndrome is the inherited metabolic disorder of bilirubin metabolism due to a defective protein

a)

Heme oxygenase

b)

UDP-Glucuronosyl transferase

c)

MRP2 protein

d)

Beta-glucuronidase

11.

What amino acids participate in creatinine biosynthesis?

a)

Methionine, Asparagine, Glutamine

b)

Glycine, Methionine, Arginine

c)

Glutamine, Glycine, Methionine

d)

Arginine, Asparagine, Aspartate

12.

Which of the following is incorrectly paired with the type of Collagen and its distribution? (p1450)

a)

Collagen Type 3: Dermal-epidermal junction

b)

Collagen Type 2: Endothelium and other tissues

c)

Collagen Type 2: Cartilage and vitreous humor

d)

Collagen Type 6: Muscle and most connective tissues

13.

What Glycosaminoglycans are located or can be found in the Skin?

a)

Chondroitin sulfate, Heparan sulfate and Dermatan sulfate

b)

Heparin, Heparan sulfate, Keratan sulfate 1 and 2 and Hyaluronic acid

c)

Heparan sulfate and Hyaluronic acid

d)

Dermatan sulfate and Keratan sulfate 1 and 2

14.

An 18-month old boy presents with delayed dentation, short stature, difficulty and painful walking and bowing of the legs. The history reveals that he has been breast-fed, but that he has not been receiving daily Vitamin D supplementation. A defect in which of the following can explain his findings?

a)

Bone formation by osteoblasts

b)

Bone resorption by osteoclasts

c)

Calcification of the bone matrix

d)

Composition of bone collagen

15.

What glycoproteins function to regulate folding of proteins that are exported from the cell?

a)

Calnexin and Calreticulin

b)

Lectins and Selectins

c)

Transferrin and Ceruloplasmin

d)

Collagens and Mucins

16.

Which of the following functions to lubricate and form a protective physical barrier on epithelial surfaces? (p1343)

a)

Calnexins

b)

Mucins

c)

Collagens

d)

Transferrin

17.

Which Glycogen Storage Disease has an absence of Branching Enzyme?

a)

Von Gierke’s disease

b)

Pompe’s disease

c)

Andersen’s disease

d)

Her’s disease

18.

A 3-month old infant was cranky and irritable, became quite lethargic between feedings, and began to develop a potbelly. A physical exam demonstrated an enlarged liver, white blood work taken between feedings demonstrated elevated lactate and uric acid levels, as well as hypoglycemia. This child most likely has a mutation in which one of the following enzymes?

a)

Liver glycogen phosphorylase

b)

Glycogen synthase

c)

Glucose 6-phosphatase

d)

Muscle glycogen phosphorylase

19.

A 3-month old infant was cranky and irritable, became quite lethargic between feedings, and began to develop a potbelly. A physical exam demonstrated an enlarged liver, white blood work taken between feedings demonstrated elevated lactate and uric acid levels, as well as hypoglycemia. What is the glycogen storage disease of this case?

a)

von Gierke’s disease

b)

McArdle’s disease

c)

Pompe’s disease

d)

Her’s disease

20.

In glycogen synthesis, what is the first enzyme involved when it happens in the Liver?

a)

Phosphoglucomutase

b)

UDP-Glucose pyrophosphorylase

c)

Hexokinase

d)

Glucokinase

21.

What protein attaches to the UDP-Glucose in order for the glycogen synthase to act and form a glycoside?

a)

Tyrosine

b)

Alanine

c)

Glycogenin

d)

Uridine

22.

What is the rate limiting enzyme in Glycogen degradation?

a)

Glycogen synthase

b)

Debranching enzyme

c)

Glycogen phosphorylase

d)

Glucose 6-phosphatase

23.

Insulin controls all of the following processes:

a)

Glycolysis, Glycogenolysis, Gluconeogenesis

b)

Glycogenesis, Glycogenolysis, GLuconeogenesis

c)

Gluconeogenesis and Glycogenolysis only

d)

Glycolysis, Glycogenesis, Gluconeogenesis

24.

Insulin is an inducer in each of the following Enzymes, except

a)

Glucokinase

b)

Phosphofructokinase

c)

Pyruvate kinase

d)

Pyruvate carboxylase

25.

Which of the following hormones are responsive to a decrease in blood glucose?

a)

Insulin and Glucagon

b)

Insulin and epinephrine

c)

Glucagon and Epinephrine

d)

Glucagon only

26.

What is/are the major glucose transporters in the brain?

a)

GLUT 1 and GLUT 2

b)

GLUT 2 and GLUT 4

c)

GLUT 3 and GLUT 1

d)

GLUT 5

27.

Effect of glucagon-cAMP cascade in the liver includes stimulation of the following, except

a)

Gluconeogenesis

b)

Glycogenolysis

c)

Glycolysis

d)

Gluconeogenesis and Glycogenolysis

28.

What is the major precursor of glucose in ruminants?

a)

Alanine

b)

Succinate

c)

Propionate

d)

Oxaloacetate

29.

What is/are usually considered as the “first” messenger/s?

a)

3’, 5’-cAMP and epinephrine

b)

Calcium

c)

Hormones

d)

5’, 3’-cAMP

30.

What enzyme catalyzes the transfer of the terminal phosphoryl group of ATP to the hydroxyl group of various residues?

a)

Protein phosphatases

b)

Protein kinases

c)

Sirtuins

d)

Histone deacetylases

31.

The relationship between Keq, Km and Vmax is known as

a)

Haldane equation

b)

Michaelis Menten equation

c)

Numerical solution approach

d)

Gibbs-Helmholtz equation

32.

Acute Heavy metal poisoning can be treated by

a)

Administration of diuretics

b)

Ingestion of chelating agents

c)

Hemodialysis

d)

All of the choices

33.

What equation describes the behavior of Enzymes that exhibit cooperative binding substrate?

a)

Gibs equation

b)

Ka/Km

c)

Michaelis-Menten Equation

d)

Hill equation

34.

The molecule which acts directly on an enzyme to lower its catalytic rate is

a)

repressor

b)

inhibitor

c)

modulator

d)

regulator

35.

A 40-year-old tobacco farmer is seen in the ER with bradycardia, profuse sweating, vomiting, increased salivation and blurred vision. He was spraying his field with malathion when the hose ruptured and he was covered with the malathion. Which of the following types of inhibition of enzymes does this poisoning represents?

a)

Competitive

b)

Noncompetitive

c)

Irreversible

d)

Reversible

36.

In human metal absorption, what metal is absorbed in to the body as its Vitamin B12 complex?

a)

Copper

b)

Iron

c)

Molybdeum

d)

Cobalt

37.

In formation of porphobilinogen, what heavy metal inhibits the conversion of 2 molecules of δ-aminolevulinate?

a)

Lead, Arsenic and Mercury

b)

Lead

c)

Gallium

d)

Mercury

38.

A 5 year old named Gab was brought by child protective services for medical care. He has been neglected, is small for his age, and has a swollen abdomen and edematous extremities. Gab has

a)

Marasmus

b)

Iron deficiency anema

c)

Kwashiorkor

d)

Scurvy

39.

What is the major component of keratin?

a)

Cysteine

b)

Glutamine

c)

Methionine

d)

Cystine

40.

What amino acid is used in the diagnosis of folic acid deficiency?

a)

Asparagine

b)

Tyrosine

c)

Histamine

d)

Tryptophan

41.

In amino acid degradation, the following are the major products, except

a)

NADPH

b)

Pyruvate

c)

Acetyl Co-A

d)

Acetoacetate

42.

The following are amino acids that are converted to pyruvate, except

a)

Cysteine

b)

Alanine

c)

Glycine

d)

Methionine

43.

The only amino acid with no known metabolic defect.

a)

Cysteine

b)

Alanine

c)

Glycine

d)

Methionine

44.

In the formation of intermediates of TCA cycle, amino acid degradation reaction requires which vitamin?

a)

Vitamin A

b)

Vitamin B6

c)

Vitamin B 12

d)

Biotin

45.

Which metabolic pathway or process is common to both aerobic and anaerobic oxidation of sugar?

a)

Kreb’s cycle

b)

Chemiosmosis in mitochondrion

c)

Glycolysis

d)

Oxidation of NAD+ by the ETC

46.

During strenuous exercise, the NADH formed in the glyceraldehyde 3-phosphate dehydrogenase reaction in skeletal muscle must be reoxidized to NAD+ if glycolysis is to continue. The most important reaction involved in the reoxidation of NADH is:

a)

dihydroxyacetone phosphate → glycerol 3-phosphate

b)

glucose 6-phosphate → fructose 6-phosphate

c)

isocitrate → α-ketoglutarate

d)

pyruvate → lactate

47.

Which of these cofactors participates directly in most of the oxidation-reduction reactions in the fermentation of glucose to lactate?

a)

ADP

b)

ATP

c)

FAD/FADH2

d)

NAD+/NADH

48.

In comparison with the resting state, actively contracting human muscle tissue has a:

a)

higher concentration of ATP

b)

higher rate of lactate formation.

c)

lower consumption of glucose.

d)

lower rate of consumption of oxygen.

49.

High concentration of glucose 6-phosphate is inhibitory to __________

a)

Hexokinase

b)

Pyruvate kinase

c)

Glucokinase

d)

Phosphofructokinase-1

50.

Whenever the cell’s ATP supply is depleted, which of the following enzyme’s activity is increased?

a)

Hexokinase

b)

Pyruvate kinase

c)

Glucokinase

d)

Phosphofructokinase-1