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WorksheetsJMC QUIZ BOWL Biochemistry
Total questions: 50
Worksheet time: 25mins
Which Enzyme proofreads and removes RNA Primase?
DNA polymerase 1
DNA Polymerase 2
DNA Polymerase 3
RNA Polymerase
Which of the following functions to prevent premature reannealing of the dsDNA?
DNA Ligase
Single-strand binding proteins
Topoisomerases
DNA primase
A nucleotide is composed of which of the following?
A sugar, nitrogenous base and a protein.
A sugar, phosphate, and nitrogenous base
A sugar, proteins, and phosphate
A sugar, phosphate and carbons
Which enzyme fixes the Okazaki fragments in the lagging strand?
Ligase
Helicase
Primase
Polymerase
Abnormal regions of DNA, either from copying errors or DNA damage, are replaced by either of the following mechanisms, except for
Mismatch repair
Two-base alteration
Nucleotide excision repair
Double-strand break repair
When does the DNA synthesis occurs in the Cell cycle?
Gap 1 phase
Gap 2 phase
G 0
S phase
The secretion of bilirubin from hepatocytes to canaliculi is an energy-dependent process. The transporter protein involved in this protein is
MRP2 Protein
Active transport coupled with Na-K ATPase
Bilirubin transporting protein
Chylomicron
Hyperbilirubinemia caused by mutation of the protein involved in the secretion of conjugated bilirubin into the bile is seen in
Toxic hyperbilirubinemia
Dubin-Johnson Syndrome
Crigler Najjar syndrome
Rotor Syndrome
Urobilinogen is oxidized to form colored product and these give the characteristic color of urine and feces. In which type of jaundice, the stool color is clay-colored because of lack of urobilin?
Hemolytic jaundice
Viral hepatitis
Obstructive jaundice
Alcoholic cirrhosis
Dubin Johnson syndrome is the inherited metabolic disorder of bilirubin metabolism due to a defective protein
Heme oxygenase
UDP-Glucuronosyl transferase
MRP2 protein
Beta-glucuronidase
What amino acids participate in creatinine biosynthesis?
Methionine, Asparagine, Glutamine
Glycine, Methionine, Arginine
Glutamine, Glycine, Methionine
Arginine, Asparagine, Aspartate
Which of the following is incorrectly paired with the type of Collagen and its distribution? (p1450)
Collagen Type 3: Dermal-epidermal junction
Collagen Type 2: Endothelium and other tissues
Collagen Type 2: Cartilage and vitreous humor
Collagen Type 6: Muscle and most connective tissues
What Glycosaminoglycans are located or can be found in the Skin?
Chondroitin sulfate, Heparan sulfate and Dermatan sulfate
Heparin, Heparan sulfate, Keratan sulfate 1 and 2 and Hyaluronic acid
Heparan sulfate and Hyaluronic acid
Dermatan sulfate and Keratan sulfate 1 and 2
An 18-month old boy presents with delayed dentation, short stature, difficulty and painful walking and bowing of the legs. The history reveals that he has been breast-fed, but that he has not been receiving daily Vitamin D supplementation. A defect in which of the following can explain his findings?
Bone formation by osteoblasts
Bone resorption by osteoclasts
Calcification of the bone matrix
Composition of bone collagen
What glycoproteins function to regulate folding of proteins that are exported from the cell?
Calnexin and Calreticulin
Lectins and Selectins
Transferrin and Ceruloplasmin
Collagens and Mucins
Which of the following functions to lubricate and form a protective physical barrier on epithelial surfaces? (p1343)
Calnexins
Mucins
Collagens
Transferrin
Which Glycogen Storage Disease has an absence of Branching Enzyme?
Von Gierke’s disease
Pompe’s disease
Andersen’s disease
Her’s disease
A 3-month old infant was cranky and irritable, became quite lethargic between feedings, and began to develop a potbelly. A physical exam demonstrated an enlarged liver, white blood work taken between feedings demonstrated elevated lactate and uric acid levels, as well as hypoglycemia. This child most likely has a mutation in which one of the following enzymes?
Liver glycogen phosphorylase
Glycogen synthase
Glucose 6-phosphatase
Muscle glycogen phosphorylase
A 3-month old infant was cranky and irritable, became quite lethargic between feedings, and began to develop a potbelly. A physical exam demonstrated an enlarged liver, white blood work taken between feedings demonstrated elevated lactate and uric acid levels, as well as hypoglycemia. What is the glycogen storage disease of this case?
von Gierke’s disease
McArdle’s disease
Pompe’s disease
Her’s disease
In glycogen synthesis, what is the first enzyme involved when it happens in the Liver?
Phosphoglucomutase
UDP-Glucose pyrophosphorylase
Hexokinase
Glucokinase
What protein attaches to the UDP-Glucose in order for the glycogen synthase to act and form a glycoside?
Tyrosine
Alanine
Glycogenin
Uridine
What is the rate limiting enzyme in Glycogen degradation?
Glycogen synthase
Debranching enzyme
Glycogen phosphorylase
Glucose 6-phosphatase
Insulin controls all of the following processes:
Glycolysis, Glycogenolysis, Gluconeogenesis
Glycogenesis, Glycogenolysis, GLuconeogenesis
Gluconeogenesis and Glycogenolysis only
Glycolysis, Glycogenesis, Gluconeogenesis
Insulin is an inducer in each of the following Enzymes, except
Glucokinase
Phosphofructokinase
Pyruvate kinase
Pyruvate carboxylase
Which of the following hormones are responsive to a decrease in blood glucose?
Insulin and Glucagon
Insulin and epinephrine
Glucagon and Epinephrine
Glucagon only
What is/are the major glucose transporters in the brain?
GLUT 1 and GLUT 2
GLUT 2 and GLUT 4
GLUT 3 and GLUT 1
GLUT 5
Effect of glucagon-cAMP cascade in the liver includes stimulation of the following, except
Gluconeogenesis
Glycogenolysis
Glycolysis
Gluconeogenesis and Glycogenolysis
What is the major precursor of glucose in ruminants?
Alanine
Succinate
Propionate
Oxaloacetate
What is/are usually considered as the “first” messenger/s?
3’, 5’-cAMP and epinephrine
Calcium
Hormones
5’, 3’-cAMP
What enzyme catalyzes the transfer of the terminal phosphoryl group of ATP to the hydroxyl group of various residues?
Protein phosphatases
Protein kinases
Sirtuins
Histone deacetylases
The relationship between Keq, Km and Vmax is known as
Haldane equation
Michaelis Menten equation
Numerical solution approach
Gibbs-Helmholtz equation
Acute Heavy metal poisoning can be treated by
Administration of diuretics
Ingestion of chelating agents
Hemodialysis
All of the choices
What equation describes the behavior of Enzymes that exhibit cooperative binding substrate?
Gibs equation
Ka/Km
Michaelis-Menten Equation
Hill equation
The molecule which acts directly on an enzyme to lower its catalytic rate is
repressor
inhibitor
modulator
regulator
A 40-year-old tobacco farmer is seen in the ER with bradycardia, profuse sweating, vomiting, increased salivation and blurred vision. He was spraying his field with malathion when the hose ruptured and he was covered with the malathion. Which of the following types of inhibition of enzymes does this poisoning represents?
Competitive
Noncompetitive
Irreversible
Reversible
In human metal absorption, what metal is absorbed in to the body as its Vitamin B12 complex?
Copper
Iron
Molybdeum
Cobalt
In formation of porphobilinogen, what heavy metal inhibits the conversion of 2 molecules of δ-aminolevulinate?
Lead, Arsenic and Mercury
Lead
Gallium
Mercury
A 5 year old named Gab was brought by child protective services for medical care. He has been neglected, is small for his age, and has a swollen abdomen and edematous extremities. Gab has
Marasmus
Iron deficiency anema
Kwashiorkor
Scurvy
What is the major component of keratin?
Cysteine
Glutamine
Methionine
Cystine
What amino acid is used in the diagnosis of folic acid deficiency?
Asparagine
Tyrosine
Histamine
Tryptophan
In amino acid degradation, the following are the major products, except
NADPH
Pyruvate
Acetyl Co-A
Acetoacetate
The following are amino acids that are converted to pyruvate, except
Cysteine
Alanine
Glycine
Methionine
The only amino acid with no known metabolic defect.
Cysteine
Alanine
Glycine
Methionine
In the formation of intermediates of TCA cycle, amino acid degradation reaction requires which vitamin?
Vitamin A
Vitamin B6
Vitamin B 12
Biotin
Which metabolic pathway or process is common to both aerobic and anaerobic oxidation of sugar?
Kreb’s cycle
Chemiosmosis in mitochondrion
Glycolysis
Oxidation of NAD+ by the ETC
During strenuous exercise, the NADH formed in the glyceraldehyde 3-phosphate dehydrogenase reaction in skeletal muscle must be reoxidized to NAD+ if glycolysis is to continue. The most important reaction involved in the reoxidation of NADH is:
dihydroxyacetone phosphate → glycerol 3-phosphate
glucose 6-phosphate → fructose 6-phosphate
isocitrate → α-ketoglutarate
pyruvate → lactate
Which of these cofactors participates directly in most of the oxidation-reduction reactions in the fermentation of glucose to lactate?
ADP
ATP
FAD/FADH2
NAD+/NADH
In comparison with the resting state, actively contracting human muscle tissue has a:
higher concentration of ATP
higher rate of lactate formation.
lower consumption of glucose.
lower rate of consumption of oxygen.
High concentration of glucose 6-phosphate is inhibitory to __________
Hexokinase
Pyruvate kinase
Glucokinase
Phosphofructokinase-1
Whenever the cell’s ATP supply is depleted, which of the following enzyme’s activity is increased?
Hexokinase
Pyruvate kinase
Glucokinase
Phosphofructokinase-1
