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Non-neoplastic bone diseases

Total questions: 30

Worksheet time: 17mins

Name
Class
Date
1.

The technical term for "bones softened by Vitamin D deficiency"

a)

osteomalacia

b)

osteoporosis

c)

osteoscoliosis

d)

urarthritis

2.

The simplest type of fracture; bone is partly bent, but not completely separated:

a)

Greenstick

b)

Stress fracture

c)

Comminuted

d)

Simple

3.

The bone is snapped in two but doesn't break the skin

a)

Simple fracture

b)

Compound fracture

c)

Greenstick

d)

Comminuted

4.

Woven bone is normally seen in adults during:

a)

Normal growth

b)

Aging

c)

Fracture repair

d)

Osteoporosis

5.

Achondroplasia is caused by mutation in which gene?

a)

COL1A1

b)

COL2A1

c)

FGFR3

d)

PTH gene

6.

Achondroplasia mainly affects which process?

a)

Intramembranous ossification

b)

Endochondral ossification

c)

Bone remodeling

d)

Mineralization

7.

A typical clinical feature of achondroplasia is:

a)

Fragile bones

b)

Short limbs with normal trunk

c)

Blue sclera

d)

Hearing loss

8.

Osteogenesis imperfecta is caused by defective synthesis of:

a)

Vitamin D

b)

Calcium

c)

Type I collagen

d)

Phosphate

9.

Blue sclera is a feature of:

a)

Achondroplasia

b)

Osteopetrosis

c)

Osteogenesis imperfecta

d)

Paget disease

10.

Osteopetrosis is due to failure of which cell?

a)

Osteoblast

b)

Osteocyte

c)

Osteoclast

d)

Chondrocyte

11.

Bones in osteopetrosis are best described as:

a)

Soft and flexible

b)

Normal and strong

c)

Hard but brittle

d)

Thin and porous

12.

Paget disease of bone usually affects which age group?

a)

Children

b)

Adolescents

c)

Adults < 40 years

d)

Adults > 55 years

13.

A characteristic histological feature of Paget disease is:

a)

Mosaic pattern of bone

b)

Thin cortex

c)

Crowded osteocytes

d)

Caseous necrosis

14.

Which enzyme level is typically elevated in active Paget disease?

a)

ALT

b)

ALP

c)

Creatinine

d)

CK

15.

Osteoporosis is characterized by:

a)

Defective mineralization

b)

Normal bone mass

c)

Reduced bone mass with normal mineralization

d)

Excess osteoid

16.

The most common fracture site in osteoporosis is:

a)

Skull

b)

Vertebrae

c)

Clavicle

d)

Tibia

17.

Osteomalacia is primarily caused by deficiency of:

a)

Vitamin D

b)

Calcium

c)

Phosphate

d)

Magnesium

18.

A histological feature of osteomalacia is:

a)

Thick cortex

b)

Widened osteoid seams

c)

Mosaic bone

d)

Sequestrum

19.

Rickets differs from osteomalacia because it occurs in:

a)

Elderly

b)

Adults

c)

Children

d)

Pregnant women

20.

Excess parathyroid hormone causes:

a)

Decreased bone resorption

b)

Increased osteoclast activity

c)

Increased mineralization

d)

Bone sclerosis

21.

Brown tumors are seen in:

a)

Hyperparathyroidism

b)

Osteoporosis

c)

Osteomalacia

d)

Paget disease

22.

Renal osteodystrophy is caused by:

a)

Vitamin A deficiency

b)

Chronic renal failure

c)

Liver disease

d)

Excess calcium intake

23.

The first stage of fracture healing is:

a)

Soft callus formation

b)

Hard callus formation

c)

Hematoma formation

d)

Remodeling

24.

The most common causative organism of pyogenic osteomyelitis is:

a)

E. coli

b)

Streptococcus pyogenes

c)

Mycobacterium tuberculosis

d)

Staphylococcus aureus

25.

Dead bone separated from living bone in osteomyelitis is called:

a)

Involucrum

b)

Sequestrum

c)

Callus

d)

Granuloma

26.

What is the most likely diagnosis?

a)

Achondroplasia

b)

Rickets

c)

Osteopetrosis

d)

Osteogenesis imperfecta

27.

The most likely underlying diagnosis is:

a)

Osteomalacia

b)

Osteoporosis

c)

Paget disease

d)

Osteopetrosis

28.

A 69-year-old man has long-standing back and leg pain. He has difficulty hearing and reduced hip movement. His hat size has increased. X-rays show dense, sclerotic bones, and his serum alkaline phosphatase is elevated. What is the most likely diagnosis?

a)

Vitamin D deficiency

b)

Paget disease of bone

c)

Renal failure with renal osteodystrophy

d)

Osteoporosis

29.

A 4-year-old child presents with bowed legs and widened costochondral junctions. Blood tests show low vitamin D and low serum calcium. Which of the following best explains these findings?

a)

Impaired mineralization of osteoid.

b)

Defective osteoid production.

c)

Excessive bone resorption.

d)

Overproduction of woven bone.

30.

An elderly postmenopausal woman has back pain, height loss, vertebral compression fractures, and thin trabeculae with normal mineralization. What is the diagnosis?

a)

Osteodystrophy.

b)

Osteomalacia.

c)

Osteopetrosis.

d)

Osteoporosis