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Basic knowledge of iron metabolism

Total questions: 20

Worksheet time: 10mins

Name
Class
Date
1.

Iron is classified as which type of element in the body?

a)

major element

b)

heavy metal

c)

essential element

d)

electrolyte

2.

The metabolic function of iron depends mainly on its ability to:

a)

Change valence state

b)

Form covalent bonds

c)

Act as an enzyme

d)

Bind oxygen irreversibly

3.

The major source of iron in the human body is:

a)

Diet

b)

Recycling from macrophages

c)

Drinking water

d)

Supplements

4.

Approximately what percentage of total body iron is found in haemoglobin?

a)

10%

b)

18%
C. 50%

c)

68%

d)

50%

5.

Ferritin and haemosiderin are primarily found in which compartment?

a)

Plasma compartment

b)

Functional compartment

c)

Transport compartment

d)

Storage compartment

6.

Transferrin is responsible for iron transport mainly in the:

a)

Cytoplasm

b)

Plasma

c)

Liver

d)

Bone marrow

7.

The total iron content of a normal adult human body is approximately:

a)

2–4 g

b)

6–8 g

c)

0.5–1 g

d)

1–2 g

8.

Which form of dietary iron is more readily absorbed?

a)

Ferric iron

b)

Haem iron

c)

Iron phytates

d)

Inorganic iron salts

9.

Iron absorption mainly occurs in the:

a)

Ileum

b)

Stomach

c)

Duodenum

d)

jejunum

10.

Which factor enhances iron absorption?

a)

Tannins

b)

Ascorbic acid

c)

Phytates

d)

Tetracycline

11.

Two molecules of Fe³⁺ bind to apotransferrin to form:

a)

Ferritin

b)

Ferroportin

c)

Haemosiderin

d)

Transferrin

12.

Which stain is used to demonstrate iron in bone marrow?

a)

Prussian blue stain

b)

Wright stain

c)

Giemsa stain

d)

Ziehl–Neelsen stain

13.

A cause of iron overload includes all EXCEPT:

a)

Hereditary haemochromatosis

b)

Multiple transfusions

c)

Prolonged medicinal iron use

d)

Iron deficiency anaemia

14.

Which laboratory test best reflects iron stores in the body?

a)

TIBC

b)

Serum ferritin

c)

Transferrin saturation

d)

Serum iron

15.

Hepcidin reduces iron levels by inhibiting:

a)

Ferritin production

b)

Erythropoietin

c)

Ferroportin

d)

Transferrin synthesis

16.

Hepcidin is produced mainly by the:

a)

Kidney

b)

Bone marrow

c)

Spleen

d)

Liver

17.

The largest proportion of recycled iron in the body comes from:

a)

Red blood cells

b)

Diet

c)

Liver stores

d)

Myoglobin

18.

Desferrioxamine is classified as a/an:

a)

Anticoagulant

b)

Iron supplement

c)

Enzyme inhibitor

d)

Iron chelator

19.

A normal haemoglobin level may still indicate anaemia in patients with:

a)

Iron deficiency

b)

Pregnancy

c)

Malaria

d)

COPD

20.

The major physiological basis of symptoms in anaemia is:

a)

Blood loss

b)

Increased plasma volume

c)

Tissue hypoxia

d)

Reduced iron absorption