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WorksheetsPharmacology Week 3 Part 1
Total questions: 50
Worksheet time: 25mins
A 24-year-old has a fluctuant, tender abscess on the thigh with no systemic symptoms. What is the most appropriate first-line management?
Oral cephalexin
Incision and drainage
IV vancomycin
Oral penicillin VK
The primary pathogen for purulent SSTIs such as furuncles and abscesses is most commonly:
Streptococcus pyogenes
Staphylococcus aureus
Candida species
Eikenella corrodens
A patient has a carbuncle with fever and tachycardia. After I&D, which outpatient oral regimen best fits moderate purulent SSTI coverage?
Oral penicillin VK
Oral TMP-SMX
Oral amoxicillin only
Topical mupirocin
A patient with a purulent SSTI fails I&D plus oral antibiotics and now appears ill. Which agent is most appropriate for severe infection or failure of oral therapy?
IV vancomycin
Oral dicloxacillin
Oral cephalexin
Topical retapamulin
Typical duration of antibiotic therapy for purulent SSTIs when antibiotics are used is:
1 day
3 months
5–7 days
21 days minimum
A patient presents with raised borders and clearly demarcated margins on the leg, consistent with erysipelas. The most common pathogen is:
Staphylococcus aureus
Streptococcus pyogenes
Pseudomonas aeruginosa
Cutibacterium acnes
Mild non-purulent cellulitis without systemic signs should be treated with:
Oral penicillin VK
Oral TMP-SMX
IV piperacillin-tazobactam
Topical mupirocin
Which is an appropriate oral option for mild non-purulent infection?
Oral cephalexin
Oral terbinafine
IV cefazolin
IV vancomycin
A patient has moderate non-purulent cellulitis with systemic signs and needs IV therapy. Which set lists IV options specifically included in the slides?
IV penicillin, IV ceftriaxone, IV cefazolin, or IV clindamycin
IV TMP-SMX, IV doxycycline, IV mupirocin, IV retapamulin
IV terbinafine, IV azelaic acid, IV ivermectin, IV metronidazole
IV erythromycin, IV isoniazid, IV gold, IV iodides
Severe non-purulent infection management includes which paired approach?
Topical retinoid plus benzoyl peroxide
Emergent surgical inspection/debridement plus IV vancomycin + piperacillin-tazobactam
Oral doxycycline plus oral terbinafine
Oral penicillin VK plus topical mupirocin
Which finding best distinguishes impetigo treatment as "mild, localized" rather than requiring oral antibiotics?
Multiple lesions across a large area
Localized disease suitable for topical therapy
Beta-lactam allergy
MRSA confirmed
First-line topical options for mild, localized impetigo include:
Mupirocin and retapamulin
Valacyclovir and famciclovir
Terbinafine and piperacillin-tazobactam
Dapsone and clascoterone
Extensive impetigo or multiple lesions should be treated with:
Oral cephalexin
IV acyclovir
Topical azelaic acid
Oral isotretinoin
Which oral antibiotic is listed as an option for extensive impetigo?
Oral dicloxacillin
Oral valacyclovir
Oral brimonidine
Oral oxymetazoline
Impetigo common pathogens include which pair?
Streptococcus pyogenes and Staphylococcus aureus
Eikenella corrodens and Candida species
Clostridium perfringens and Cutibacterium acnes
Pseudomonas aeruginosa and Trifarotene
In impetigo, if MRSA is suspected or the patient has a beta-lactam allergy, which is an appropriate option?
Clindamycin
Penicillin VK
Cephalexin
Retapamulin only
For varicella-zoster virus SSTI, which oral antiviral is preferred as first-line?
Valacyclovir
Terbinafine
Amoxicillin-clavulanate
Metronidazole
Which dosing matches the recommended oral antiviral regimens for zoster treatment duration in the slides?
Acyclovir 400 mg once daily for 3 days
Valacyclovir 500 mg once daily for 14 days
Acyclovir 800 mg five times daily for 7 days
Valacyclovir 250 mg twice daily for 5 days
Which dosing matches the recommended valacyclovir regimen for zoster?
1000 mg three times daily for 7 days
800 mg five times daily for 7 days
50 mg once daily for 20 weeks
500 mg daily for 1–2 weeks
A patient with suspected disseminated zoster needs which therapy per the slides?
IV acyclovir
Oral terbinafine
Topical mupirocin
Oral cephalexin
Which complication specifically requires IV acyclovir per the slides?
Mild localized rash
Ophthalmic involvement
Mild comedonal acne
Tinea pedis
Which is also listed as a severe complication requiring IV acyclovir?
Ramsay-Hunt syndrome
Tinea corporis
Papulopustular rosacea
Folliculitis without systemic signs
OTC-appropriate superficial fungal infections include:
Tinea capitis and tinea unguium
Tinea pedis, tinea corporis, and tinea cruris
Necrotizing fasciitis and erysipelas
Papulopustular and ocular rosacea
Which infection is prescription-only and typically warrants systemic therapy rather than OTC topical management?
Tinea pedis
Tinea cruris
Tinea capitis
Tinea corporis
Which fungal infection is also prescription-only per the slides?
Tinea unguium
Tinea corporis
Tinea cruris
Tinea pedis
Systemic therapy is specifically warranted for tinea capitis using:
Oral terbinafine
Oral valacyclovir
Oral penicillin VK
Topical retapamulin
Oral terbinafine monitoring should include:
Serum troponin and BNP
LFTs and renal function
Daily pregnancy tests for all patients
Pulmonary function testing
Oral terbinafine should be avoided when CrCl is:
Greater than 120 mL/min
Less than 50 mL/min
Exactly 100 mL/min
Any value if asymptomatic
Mild diabetic foot infections are typically:
Always polymicrobial
Monomicrobial
Always viral
Always caused by Candida species
Mild diabetic foot infections should be treated with:
Narrow-spectrum oral therapy for 1–2 weeks
No therapy needed
Only topical retinoids
IV acyclovir for 7 days
Moderate to severe diabetic foot infections are often:
Monomicrobial
Polymicrobial
Always due to S. pyogenes alone
Always due to Cutibacterium acnes
Moderate to severe DFI coverage should include which set?
Only Streptococcus pyogenes
Staphylococcus aureus, streptococci, gram-negative organisms, and anaerobes
Only Candida species
Only Clostridium species
Severe DFIs often require:
Hospitalization and IV broad-spectrum antibiotics
OTC topical antifungals only
Topical mupirocin only
No debridement evaluation
Which organism is associated with under-chlorinated pools and hot tubs in SSTIs?
Pseudomonas aeruginosa
Pasteurella multocida
Eikenella corrodens
Streptococcus pyogenes
Cat bite wounds are associated with which pathogen, and what is the first-line treatment listed?
Eikenella corrodens, doxycycline
Pasteurella multocida, amoxicillin-clavulanate
Streptococcus pyogenes, penicillin VK
Staphylococcus aureus, topical mupirocin
Human bite wounds are associated with which pathogen, and what is the first-line treatment listed?
Eikenella corrodens, amoxicillin-clavulanate
Pasteurella multocida, penicillin VK
Pseudomonas aeruginosa, terbinafine
Clostridium species, retapamulin
In necrotizing fasciitis management, clindamycin’s key role is:
Disrupting fungal cell membrane
Suppressing streptococcal cytokine and toxin production
Increasing sebum production
Vasoconstriction for facial erythema
Clindamycin’s mechanism relevant to necrotizing fasciitis is that it is a:
DNA polymerase inhibitor
Protein synthesis inhibitor
Keratolytic agent
Androgen receptor activator
A key clinical point about clindamycin in necrotizing fasciitis per the slides is that it is:
Effective regardless of bacterial growth phase
Only effective in stationary phase
Only effective when combined with benzoyl peroxide
Contraindicated in all infections
Clindamycin is noted as critical in necrotizing infections involving:
Streptococcus pyogenes and Clostridium species
Cutibacterium acnes and Candida species
Only Pseudomonas aeruginosa
Only Eikenella corrodens
Acyclovir and valacyclovir share which mechanism of action?
Inhibit viral DNA polymerase and cause DNA chain termination
Inhibit bacterial protein synthesis
Vasoconstrict superficial vessels
Block androgen receptors
A key clinical consideration for acyclovir therapy is:
Restrict fluids to reduce edema
Maintain hydration to prevent crystal-induced renal injury
Avoid all sun exposure due to photosensitivity from tetracyclines
Avoid LFT monitoring because it is not needed
Mild acne first-line options include:
Benzoyl peroxide and topical retinoid
IV vancomycin and piperacillin-tazobactam
Oral isotretinoin for all patients
Brimonidine and oxymetazoline
Moderate acne first-line combinations include which set?
Benzoyl peroxide + topical antibiotic
Oral acyclovir + topical retinoid
Oral terbinafine + benzoyl peroxide
Topical mupirocin + topical retapamulin
Another moderate acne first-line combination is:
Retinoid + benzoyl peroxide
Retinoid + IV ceftriaxone
Benzoyl peroxide + IV acyclovir
Ivermectin + valacyclovir
Which option is also listed as a moderate acne first-line combination?
Retinoid + benzoyl peroxide + topical antibiotic
Oral penicillin VK + topical antibiotic
Oral clindamycin + oral terbinafine
Oxymetazoline + tretinoin
Severe acne therapy options listed include:
Oral antibiotic + topical combination therapy
Topical retapamulin alone
IV acyclovir alone
Oral amoxicillin-clavulanate alone
Another severe acne therapy option listed is:
Oral isotretinoin
Oral terbinafine
Oral penicillin VK
Brimonidine gel
Clascoterone (Winlevi) is best described as:
Topical androgen receptor inhibitor
Oral antiviral that inhibits viral DNA polymerase
Systemic antifungal requiring iPLEDGE
Vasoconstrictor that reduces pustules
Clascoterone’s place in therapy per the slides is:
Used only for rosacea triggers
Used when initial topical therapies fail
First-line for necrotizing fasciitis
Preferred over I&D for abscesses
