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WorksheetsSecond Sessional MCQ Practice Pharmacology
Total questions: 21
Worksheet time: 11mins
Resistance to isoniazid due to low-level resistance is most commonly associated with mutation in:
katG gene
rpoB gene
inhA gene
embB gene
Rifampicin is most effective against which population of Mycobacterium tuberculosis?
Rapidly dividing extracellular bacilli
Dormant intracellular bacilli only
Slowly or intermittently dividing bacilli
Acid-fast bacilli in macrophages only
Pyrazinamide is particularly active in acidic environments because it:
Inhibits arabinosyl transferase
Gets converted to pyrazinoic acid and accumulates intracellularly
Binds β-subunit of RNA polymerase
Inhibits InhA enzyme
Which antitubercular drug causes optic neuritis with loss of red-green color discrimination?
Streptomycin
Ethambutol
Isoniazid
Rifampicin
Metronidazole is selectively toxic to anaerobes because:
It inhibits DNA gyrase
It binds directly to DNA
It undergoes reductive activation via PFOR pathway
Aerobes actively expel the drug
Drug of choice for asymptomatic cyst passers of amoebiasis is:
Metronidazole
Tinidazole
Diloxanide furoate
Emetine
Emetine is restricted to reserve use mainly due to:
Poor efficacy
Hepatotoxicity
Cardiotoxicity
Nephrotoxicity
Which antiamoebic drug is effective in hepatic amoebiasis but ineffective in intestinal amoebiasis?
Diloxanide furoate
Chloroquine
Paromomycin
Iodoquinol
Subacute myelo-optic neuropathy (SMON) is associated with prolonged use of:
Metronidazole
Emetine
Iodoquinol
Nitazoxanide
Amphotericin B causes cell death primarily by:
Inhibiting ergosterol synthesis
Blocking β-glucan synthesis
Forming pores in fungal cell membrane
Inhibiting mitotic spindle
Echinocandins act by inhibiting:
Ergosterol synthesis
Fungal DNA synthesis
β(1-3) glucan synthesis
Microtubule formation
Griseofulvin is ineffective in systemic mycoses because:
Poor oral absorption
Fungistatic action
Limited activity to dermatophytes
Rapid hepatic metabolism
Piperacillin differs from carbenicillin by being:
More acid stable
Less active against Pseudomonas
More potent antipseudomonal agent
Resistant to ESBL
Which β-lactamase inhibitor is given only parenterally?
Clavulanic acid
Sulbactam
Tazobactam
Both B and C
Mebendazole causes death of helminths mainly by:
Neuromuscular blockade
Inhibiting microtubule synthesis
GABA agonism
Increasing calcium permeability
Drug of choice for onchocerciasis is:
DEC
Albendazole
Ivermectin
Niclosamide
Piperazine causes paralysis of worms by acting as:
Acetylcholine agonist
GABA agonist
Cholinesterase inhibitor
Calcium channel blocker
Niclosamide is contraindicated in Taenia solium due to risk of:
Hepatotoxicity
Neurocysticercosis
Bone marrow suppression
Hypersensitivity
Most important dose-dependent toxicity of dapsone is:
Hepatitis
Agranulocytosis
Hemolysis
Peripheral neuropathy
Clofazimine is particularly useful in lepra reactions because of its:
Bactericidal action
Anti-inflammatory property
Rapid bactericidal effect
CNS penetration
Most potent bactericidal drug against Mycobacterium leprae is:
Dapsone
Clofazimine
Rifampicin
Minocycline
