TEST2myeloproliferativeneoplasms

Label the Leukoerythroblastosis.

a

b

c

d

Myeloblast

NRBC

Large platelet

Dacryocyte (tear drop)

General MPN features

Increase in ​ (a)   red cells, white cells and/or platelets

​ (b)   increased in both PB and BM

One cell line usually ​ (c)   prominently affected

Chronic conditions with a significant risk of evolving into an ​ (d)   leukemia

• mature
• Cells
• most
• acute
• chronic
• least
• immature

Match the following

• accelerated

• 
• hypogranular

• 
• Plethora

• 
• acute blastic

• 
• reticulin strain

• 

Label the Fluorescence in situ hybridization (FISH).

a

b

c

fusion

normal

abnormal

Which one of these is a group of hematologic disorders characterized by pan hypercellularity of BM, which leads to over proliferation of one or more myeloid cell lines?

• Cryptosporidiosis

• Chagas Disease (American trypanosomiasis)

• Myeloproliferative neoplasms (MPN)

• Chronic Myelogenous Leukemia (CML)

AKA ​ (a)   disorders (MPD)

Caused by a ​ (b)   mutation in PSC

​ (c)   , ​ (d)   and maturation normal

• Myeloproliferative
• somatic
• Commitment
• differentiation

General features of myeloproliferative neoplasms

​ (a)   onset: months to years

BM hypercellular at onset → ​ (b)  

Blood cell ​ (c)   in BM gradually declines

Fibrosis ​ (d)   → extramedullary hematopoiesis

• Gradual
• fibrosis
• production
• overtakes BM
• Immediate
• depletion
• overtakes RBCs

Which of these is NOT one of the four related disorders with different features of MPNs?

• CML-Chronic Myelogenous Leukemia

• PV-Polycythemia vera

• ET-Essential Thrombocythemia

• Chikungunya

• PMF-Primary Myelofibrosis

MPNs that are considered non-acute leukemic disorders, have <20% blasts during chronic phase.

• True

• False, >20%

Match the following clinical and lab findings with their characteristics.

• bizarre PLT morphology; Thrombosis

• Hepatosplenomegaly

• "abdominal fullness"

  weight loss

• Polycythemia

• increased # of red cells

• Anemia

• Leukoerythroblastosis

• Thrombocytosis

• pallor, weakness, general malaise

• Bone marrow fibrosis