Lecture 14 B cell mediated immunity

Which of the following is required for activation of T-independent B cells?

• signaling after the engagement of the immunoglobulin with the antigen

• signaling after the engagement of CR2 with C3d on the microbe's surface

• signaling after the engagement of the antigen-stimulated B cell with TFH cells

• signaling resulting from the interaction of CD40 on the B cell with the CD40L on the pathogen's surface

Which of the following statement is false about a person deficient in CD81 that has been infected with bacteria Z.

• can still produce low affinity IgM antibodies against bacteria Z

• its secondary lymphatic tissues will present germinal centers in the B cell zone

• will not produce memory B cells

Tags

NGSS.HS-LS1-4

In a T-dependent B cell response...

• multiple B cell receptors are crosslinked by antigen

• a B cell receptor must interact with a T cell receptor

• a B cell must endocytose an antigen and display it on MHC-II

• a T cell receptor must bind to CD8 on the B cell surface

• somatic recombination occurs, but not clonal selection

In which of the following does affinity maturation and isotype switching takes place?

• T independent B cell activation

• T dependent B cell activation

Cytokines secreted by TFH guide the isotype switch that centroblasts undergo

• True

• False

What antibody isotype is first produced?

• IgM

• IgG

• IgA

• IgE

• IgD

Which of the following can negatively affect the activation of T-dependent B cells? (Select all that apply)

• inability to produce any type of C3 convertase

• CD28 deficiency on T cells

• expression of AID by centroblasts

• deficiency in the CD40L on T cells

• deficiency in MHC-I

Which of the following scenarios represents cooperation between the innate and adaptive immunity? (Select all that apply)

• peptide presentation by an antigen-stimulated B cell to a TFH cell via MHC-II

• signaling of the B co-receptor upon interaction with C3d on the pathogen

• cytokine release by TFH cells that guide centroblasts isotype switching

• peptide presentation by a dendritic cell to a naive T cell in the lymph node

During somatic hypermutation and isotype switching, centroblasts are actively expressing immunoglobulin proteins.

• True

• False

At the height of the immune response, centroblasts are favored to become __________

• plasma cells

• memory cells

Tags

NGSS.HS-LS1-4