Hypersensitivity

Which of the following is an example of a Type I hypersensitivity reaction?

• Tuberculin test

• Asthma

• Rheumatoid arthritis

• Arthus reaction

What immunoglobulin (Ig) is primarily involved in Type I hypersensitivity reactions?

• IgA

• IgG

• IgM

• IgE

Which hypersensitivity reaction involves immune complex deposition?

• Type I

• Type II

• Type III

• Type IV

Which of the following is a clinical example of Type II hypersensitivity?

• Myasthenia gravis

• Allergic rhinitis

• Arthus reaction

• Contact dermatitis

Which hypersensitivity reaction involves T-cell-mediated cytotoxicity?

• Type I

• Type II

• Type III

• Type IV

What mediates tissue damage in Type III hypersensitivity?

• Antibody-dependent cell cytotoxicity

• Granuloma formation

• Deposition of immune complexes and complement activation

• Histamine release

In Type II hypersensitivity, antibodies target:

• Soluble antigens

• Self-tissue-bound antigens

• MHC molecules

• Free-floating IgE

Which of the following causes systemic anaphylaxis?

• Mast cell degranulation due to IgE cross-linking

• Local deposition of immune complexes

• Granuloma formation

• Antibody-dependent cytotoxicity

Type IV hypersensitivity differs from other types of hypersensitivity because it:

• Involves T lymphocytes instead of antibodies

• Requires IgG antibodies

• Occurs within minutes of exposure

• Involves mast cell degranulation

Myasthenia gravis involves autoantibodies targeting:

• Thyroid receptors

• Acetylcholine receptors

• DNA in the nucleus

• IgE on mast cells