TUTORIAL 2

Type III hypersensitivity is characterized by:

• Antibody-mediated cytotoxicity against cells
  

• Immune complex deposition activating complement
  

• T-cell-mediated cytotoxicity

Type I hypersensitivity reactions involve:

• IgG antibodies and complement

• IgE antibodies and mast cells

• Immune complex deposition

Which type of hypersensitivity is primarily T-cell mediated and delayed?

• Type II
  

• Type III
  

• Type IV

Which of the following antibodies is most commonly associated with MG?

• Anti-AChR

• Anti-dsDNA

• Anti-thyroid peroxidase

Which mechanism best describes acute cellular rejection?

• NK cells destroying graft tissue independently

• Pre-existing antibodies binding donor endothelium

• T lymphocytes recognizing foreign antigens on transplanted tissue

Which of the following is an example of Type II hypersensitivity?

• Hemolytic transfusion reaction
  

• Serum sickness
  

• Contact dermatitis

Which graft type uses tissue from the same individual?

• Allograft

• 
  Isograft
  

• Autograft

Which type of rejection is most likely to cause long-term graft failure?

• Hyperacute rejection

• Acute cellular rejection

• Chronic rejection

Which mechanism is mainly responsible for tissue damage in SLE?

• Direct cytotoxicity by T cells

• Immune complex deposition and complement activation

• NK-cell mediated killing

The typical timing of hyperacute rejection is:

• Minutes to hours after transplantation

• Days to weeks

• Months to years