Tolerance

Which of the following is NOT a mechanism of T cell tolerance

• T cell anergy in the periphery

• Deletion of self reactive cells in the thymus

• Down regulation of TCR cells in periphery

• Generation of regulatory T cells in the thymus

Central and Peripheral tolerance of T and B cells, develop in primary lymphoid organs

• Yes

• No

To achieve tolerance in primary lymphoid organs, receptor editing occurs in :

• B cell

• T cell

T cells that could recognise self-antigens in thymus will differentiate into

• Th1 cells

• T regs

• Th17 cells

• Th2 cells

Peripheral Tolerance in B cells includes

• BCR formation

• Receptor editing

• IgM Production

• Anergy and deletion

Which of the following best describes the fundamental cause of autoimmunity?

• Excessive production of antibodies against foreign antigens

• Breakdown of immune tolerance leading to self-reactivity

• Increased activation of regulatory T cells (Tregs)

• Failure of antigen-presenting cells to recognize self-antigens

What is the primary immunological mechanism responsible for Insulin-Dependent Diabetes Mellitus (IDDM)?

• T lymphocyte-mediated destruction of pancreatic beta cells

• Production of autoantibodies against insulin receptors, preventing glucose uptake

• Deposition of immune complexes in pancreatic tissue, leading to inflammation

• Excessive activation of regulatory T cells, inhibiting insulin production