Quiz 2

Which of the following is an advantage of isolated organ preparation?

• Requires large drug quantities

• Avoids interference from absorption and metabolism

• Always mimics in vivo conditions accurately

• Does not require oxygenation

Why are isolated organ preparations preferred for expensive drugs?

• They allow small quantities to be tested effectively

• They require high doses to show response

• They minimize pH changes

• They reduce oxygen consumption

Which physiological system is mainly studied using isolated guinea pig ileum?

• Respiratory

• Intestinal smooth muscle

• Cardiovascular

• Endocrine

Which of the following receptors are present in the guinea pig ileum?

• Only nicotinic and beta receptors

• Muscarinic, nicotinic, 5-HT, and histamine receptors

• Only adrenergic receptors

• Dopaminergic and GABA receptors

What is the typical response of the guinea pig ileum to stimulation of muscarinic or histamine receptors?

• Relaxation of the smooth muscle

• Contraction of the smooth muscle

• No effect

• Increased secretion only

If a compound causes stimulation of the guinea pig ileum that is blocked by atropine, the compound is likely:

• Ganglion stimulant

• Parasympathomimetic

• Direct smooth muscle relaxant

• Antihistaminic

If a compound causes stimulation of the guinea pig ileum that is blocked by mepyramine, the compound may be:

• Histamine-like agent

• Serotonin-like agent

• Parasympathomimetic

• Local anesthetic

Which of the following describes parasympatholytic activity?

• Parasympathomimetic activity

• Parasympatholytic activity

• Ganglion-stimulating activity

• Antiserotonin activity

A compound that inhibits histamine-induced contraction of the guinea pig ileum is classified as:

• Cholinesterase inhibitor

• Antihistaminic

• Direct smooth muscle stimulant

• Parasympathomimetic

If a tested drug inhibits both nicotine- and acetylcholine-induced contraction in the guinea pig ileum, it is most likely:

• Ganglion blocker or local anesthetic

• Monoamine oxidase inhibitor

• Histamine-like agent

• Sympathomimetic