PK Therapeutic Ranges Part 2

Gentamicin peak (traditional dosing)

• 5-10 mcg/mL

• 15-20 mcg/mL

• 20-30 mcg/mL

• 50-100 mcg/mL

Answer explanation

5-10 mcg/mL

Amikacin peak (traditional dosing)

• 5-10 mcg/mL

• 15-20 mcg/mL

• 20-30 mcg/mL

• 50-100 mcg/mL

Answer explanation

20-30 mcg/mL

(some use 25-35 mcg/mL)

Vancomycin trough (traditional dosing; serious infections: bacteremia, endocarditis, meningitis, osteomyelitis, pneumonia)

• < 1 mcg/mL

• < 2 mcg/mL

• < 5 mcg/mL

• 10-15 mcg/mL

• 15-20 mcg/mL

Answer explanation

15-20 mcg/mL

Amikacin peak (Extended Interval Dosing)

• 56-64 mg/L

• 5-10 mg/L

• 16-24 mg/L

• 25-35 mg/L

Gentamicin trough (traditional dosing)

• < 1 mcg/mL

• < 2 mcg/mL

• < 5 mcg/mL

• 10-15 mcg/mL

• 15-20 mcg/mL

Answer explanation

< 2 mcg/mL

Tobramycin trough (traditional dosing)

• < 1 mcg/mL

• < 2 mcg/mL

• < 5 mcg/mL

• 10-15 mcg/mL

• 15-20 mcg/mL

Answer explanation

< 2 mcg/mL

Amikacin trough (traditional dosing)

• < 1 mcg/mL

• < 2 mcg/mL

• < 5 mcg/mL

• 10-15 mcg/mL

• 15-20 mcg/mL

Answer explanation

< 5 mcg/mL

Amikacin trough (Extended Interval Dosing)

• < 1 mg/L

• < 4 mg/L

• < 10 mg/L

• < 20 mg/L

Vancomycin trough (traditional dosing; other non-serious infections)

• < 1 mcg/mL

• < 2 mcg/mL

• < 5 mcg/mL

• 10-15 mcg/mL

• 15-20 mcg/mL

Answer explanation

10-15 mcg/mL

Tobramycin peak (traditional dosing)

• 5-10 mcg/mL

• 15-20 mcg/mL

• 20-30 mcg/mL

• 50-100 mcg/mL

Answer explanation

5-10 mcg/mL