NEW! Hexokinase Physiology, Biochemistry, and Mechanism

The video tutorial explores glycolysis, focusing on the role and mechanism of hexokinase. Glycolysis occurs in the cytosol, and hexokinase is crucial for glucose metabolism, acting as a committed step in pathways like glycogen synthesis and the pentose phosphate pathway. The enzyme's mechanism involves ATP binding and phosphorylation of glucose, facilitated by electrostatic interactions. Hexokinase's closed conformation prevents ATP hydrolysis, ensuring efficient catalysis. The enzyme's function is vital for retaining glucose in cells, preventing its re-entry into the bloodstream, and committing it to metabolic pathways.

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