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WorksheetsPathophysiology Test 1
Total questions: 81
Worksheet time: 20hrs 15mins
Blood is considered which type of tissue?
Simple Epithelial Tissue
Specialized Connective Tissue
Loose Connective Tissue
Proper Connective Tissue
Which type is the most abundant muscle tissue?
Cardiac
Smooth
Skeletal
Which description best describes smooth muscle?
striated, voluntary
nonstriated, voluntary
nonstriated, involuntary
striated, involuntary
True/False Atrophied cells have less energy sufficiency
True
False
Cervical tissue is an example of _________
Dysplasia
Metaplasia
Hyperplasia
Anaplasia
Peroxisomes perform which of the following functions (select all that apply)
Produce bile in the liver
Ubiquitination
Stabilize the antioxidative and reactive oxygen species (ROS) system
Create proteins
Which of the following are effects of long term hypoxia? (select all that apply)
Build up of lactic acid
Swelling of cells due to increased intracellular sodium
Increased intracellular potassium
Less ATP produced
T/F Cells inherit specific portions of DNA which explains how cell differentiation occurs
True
False
When one gene masks the effects of another, it is called____________
Polygenic
Epigenetic
Expressivity
Epistasis
Which of the following is a common trait between benign and malignant tumors? (select all that apply)
Well differentiated
Forms a fibrous capsule
Lost ability to regulate proliferation
Grows Locally
Metastasizes
T/F Cancer in situ is considered the earliest form of cancer and is not considered invasive
True
False
When both cell and nuclei exhibit variations in size and shape
Anaplasia
Pleomorphism
Dysplasia
Polygenic
What is the hallmark of cancer?
Genetic instability
Seeding
Divergent phenotype
Forming a capsid
Carcinomas are mainly spread by:
hematogenous
connective
lymphatic
epithelial
Sarcomas are mainly spread by:
hematogenous
epithelial
lymphatic
connective
the P53 tumor suppressor gene is important in all of the following EXCEPT:
Senses DNA damage
Promotes apoptosis
Promotes angiogenesis
Cancer cells with this gene respond to chemotherapy
Ras protooncogene is an example of:
Translocation
Point mutation
Gene amplification
Gene insertion
Her-2/neu gene is an example of:
Point mutation
Gene amplification
Translocation
Base substitution
Identify the correct order of stages in carcinogenesis
Initiation, Promotion, Progression
Initiation, Progression, Promotion
Promotion, Initiation, Progression
Progression, Promotion, Initiation
_____________ is characteristic in ovarian cancer
Cachexia
Anemia
Peritoneal effusion
Ulceration
Insulin is released by the:
Spleen
Liver
Pancreas
Gall Bladder
Karen and John are both cramming for a pathophysiology test the night before. Karen starts hyperventilating from the stress while John takes a deep breath and resumes working. This difference in coping with the stress is best described as:
Eustress
Conditioning factor
Adaptive eustress
General Adaptation Syndrome (GAS)
The release of cortisol and catecholamines occur in which stage of the General Adaptation Syndrome (GAS)?
Exhaustion
Alarm
Resistance
Promotion
T/F Allostasis is the body's way of maintaining homeostasis
True
False
None of the above
All of the above
All of the following occur when the HPA axis is activated EXCEPT:
Hypothalamus releases CRF/CRH
Posterior pituitary releases cortisol
Adrenal Cortex releases cortisol
Anterior pituitary releases ACTH
Which part of the brain responds to the emotional components of the stress response?
Hypothalamus
Thalamus
Limbic system
Reticular activating system (RAS)
The ____________ is central to the release of norepinephrine
Adrenal Cortex
Reticular activating system (RAS)
Anterior pituitary
Locus Ceruleus
During stress, the adrenal cortex releases which of the following hormones? (select all that apply)
Angiotensin
Cortisol
Aldosterone
norepinephrine
Which of the following are physiologic manifestations of stress? (select all that apply)
Pupils dilate
Erythema of the skin
Urine production decreases
Increased blood pressure
Which of the following statements are true about Vasopressin/Antidiuretic hormone? (select all that apply)
Released by the hypothalamus and posterior pituitary
Vasodilates the blood vessels
Stimulates the anterior pituitary to release ACTH
Increases water absorption by the kidneys
Mark, a Vietnam war veteran, has started to forget details about the war. What symptom of PTSD is most exhibiting?
Marked alterations in arousal and reactivity
Intrusion
Avoidance
Negative alterations in cognition and mood
In the pathophysiology of PTSD, after which step is there inhibition of the pathway?
Adrenal cortex releasing cortisol
Hypothalamus releasing CRH
Anterior pituitary releasing ACTH
adrenal cortex releasing aldosterone
Whole blood is made up of:
Plasma and proteins
Platelets and leukocytes
Erythrocytes and formed elements
Plasma and formed elements
An allergic reaction will cause an increase in this type of cell:
Neutrophil
B lymphocyte
Eosinophil
Macrophages
All the granulocytes and B cells mature in the:
Bone marrow
Spleen
Liver
Pancreas
IgE immunoglobulin mediates which leukocyte?
B cells
Basophils
Eosinophils
Mast cells
T/F Mast cells are blood cells that release heparin, histamine, and other inflammatory mediators
True
False
Monocytes and platelets are stored in the:
Pancreas
Spleen
Liver
Bone marrow
Red color of blood comes from: (select the best answer)
Heme
The binding of oxygen to hemoglobin
The binding of oxygen and iron
Oxygen deficiency
All but which of the following are true about platelets?
They are made from megakaryocytes.
They are stored in the spleen.
An enzyme called erythropoietin stimulates their production
They originate from the bone marrow.
Normal ranges for hemoglobin and hematocrit for a male, respectively, are:
50%-60%, 16-17.5 g/dL
37%-47%, 14-16.5 g/dL
40%-50%, 14-16.5 g/dL
30%-40%, 12-15 g/dL
A female patient's hemoglobin levels were 30% and their hematocrit was 17 g/dL. Their ranges were:
Within range
Under range, over range
Both were under range
Over range, under range
Neoplastic disease of the pluripotent cells of bone marrow is characteristic of:
Secondary polycythemia
Primary polycythemia
Relative polycythemia
None of the above
An increase in erythropoietin is characteristic of:
Primary polycythemia
Secondary polycythemia
Tertiary polycythemia
Relative polycythemia
What symptom is central to the anemia cascade?
Acute blood loss
hemolysis of RBCs
Increased EPO
Tissue hypoxia
T/F Platelets have a longer life span than RBCs
True
False
Blink once if you need help
What disease is common in a mother and neonate of differing Rh factors in their blood?
Thalassemia
Sickle Cell Anemia
Hemolytic disease
Jaundice
When RBCs get destroyed in anemia, they bind to: (select all that apply)
Thrombin
Fibrinogen
Albumin
Haptoglobin
Excessive use of motrin causes which disease?
Iron deficient anemia
Hemolytic anemia
Hemoglobinemia
Thalassemia
Which type of deficiency is caused by pernicious anemia?
Folic Acid
B12
B6
I swear if you make me memorize one more anemia.......
Pancytopenia is characteristic of which anemia?
Iron Deficient anemia
Aplastic anemia
Megaloblastic anemia
Pernicious anemia
Mitochondria regulates __________ apoptosis
Primary
Extrinsic
Intrinsic
Secondary
Identify the correct order in hemostasis
Vessel spasm, coagulation, platelet plug, clot retraction, clot dissolution
Vessel spasm, clot retraction, clot dissolution, platelet plug, coagulation
Vessel spasm, platelet plug, coagulation, clot retraction, clot dissolution
Platelet plug, vessel spasm, coagulation, clot dissolution, clot retraction
Two important coagulation factors in hemostasis are:
B12, Calcium (factor IV)
Folic acid, B12
von Willebrand factor, B12
von Willebrand factor, Calcium (Factor IV)
T/F It is important for the intrinsic and extrinsic factors of the coagulation cascade to be balanced
True
False
The most important function of the endothelium is _____________
Anticoagulation
Coagulation
Fibrinolysis
Hemostasis
Which of the following factors is important in anticoagulant endothelium function? (select all that apply)
Calcium IV
Protein C & Protein S
Tissue Factor Pathway Inhibitor (TFPI)
von Willbrand factor
Thrombomodulin
A female who is a carrier for the hemophilia A trait (Aa) has a baby boy with a male who is dominant for hemophilia A (Aa). What is the likelihood their male child will be a recessive for the trait?
100%
75%
50%
25%
Patients are given what to treat hemophilia?
Proteins
Anticoagulation factors
Clotting factors
Whole blood
T/F DIC is the primary mechanism and independent entity that can occur in the body
True
False
T/F Mast and macrophages sit in the extracellular fluid and are able to get to an infection quickly
True
False
In acute inflammation which of the following is responsible for vasodilation? (select all that apply)
Leukotrienes
Histamine
Nitric Oxide
Bradykinins
Which of the following symptoms occurs during the vasodilation stage of acute inflammation? (select all that apply)
Pain
Heat
Swelling
Erythema
Which exudate is the first sign of an acute inflammatory response?
Serosanginous
Serous
Purulent
Pseudomembranous
What is the best indicator of inflammation?
Complete Blood Count (CBC)
Hematocrit
Sedimentation Rate
C-reactive proteins count
What is a protein made by the liver that is a good indication of inflammation?
Protein C
Protein S
Factor XII
C-reactive proteins
Which part of the body houses B and T cells?
Bone marrow
Liver
Lymphatic system
Spleen
T/F Natural Killer cells are a part of the adaptive immune response
True
False
Vaccines are an example of a __________ immune response and booster shots are an example of a ___________ immune response
Secondary, Primary
Primary, Secondary
Inflammatory, adaptive
Primary, adaptive
Which helper T cell stimulates inflammation and is important in the adaptive immune response?
TH1
TH2
TH17
TH19
Which Helper T cell stimulates phagocytes?
TH1
TH2
TH17
TH19
T/F Active immunity is achieved much quicker than passive immunity
True
False
Of which of the following are myeloid phagocytic cells in the immune response? (select all that apply)
Agranulocytes
Neutrophils
Dendritic cells
Monocytes
T/F B cells are considered effector cells in the immune response
True
False
_________are the primary messengers of the immune response
C-reactive proteins
TNFs
Interleukins
Cytokines
Secreted proteins that are secreted in response to a specific antigen are ________________
Cytokines
Immunoglobulins
Haptens
Opsonins
Penicillin is an example of_____________
Immunoglobulin
Cytokine
Hapten
Antibody
The attack of donor tissue cells onto the host cell is an example of ___________
Autoimmunity
Allergic reaction
Alloimmunity
Anaphylaxis
Rh and ABO blood incompatibility between a donor and host is indicative of what type of hypersensitivity?
Type I
Type II
Type III
Type IV
The reaction that snake venom has on your blood when you are bitten is an example of which hypersensitivity reaction?
Type I
Type II
Type III
Type IV
T/F Cell mediated hypsersensitivity involves the creation of antibodies
True
False
