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imunology

Total questions: 108

Worksheet time: 1hrs 23mins

Name
Class
Date
1.
The first line of localized defense of the immune system is:
a)
lymphatic response
b)
infection response
c)
auto-immune response
d)
inflammatory response
2.
This gland, located anterior to the heart, but posterior to the sternum, is the lymphatic site where T cells are produced and mature:
a)
tonsils
b)
trachea
c)
thymus
d)
thalamus
3.
A type of T cell that destroys infected cells is a:
a)
cytotoxic T cell
b)
helper T cell
c)
memory T cell
d)
suppressor T cell
4.
Viruses, like bacteria, can be successfully treated with doctor prescribed antibiotics.
a)
TRUE
b)
FALSE
5.
Signs of an inflammatory reaction include redness, swelling, heat, and itch.
a)
TRUE
b)
FALSE
6.
The first line of defense against antigen is the _________ system.
a)
respiratory
b)
digestive
c)
integumentary
d)
lymphatic
7.
Innate and adaptive immunity are the same thing.
a)
TRUE
b)
FALSE
8.

In lymph nodes

a)

white blood cells mature into T cells.

b)

lymph drains back into the circulatory system.

c)

old and damaged red blood cells are destroyed.

d)

B and T cells gather and attach to foreign antigens.

9.

Cellular agents capable of causing infection of body cells include

a)

prions.

b)

toxins.

c)

DNA viruses.

d)

Gram-negative bacteria.

10.

An inflammation reaction involves the

a)

release of histamines.

b)

agglutination of bacteria.

c)

production of immunoglobulin.

d)

vaseconstriction of blood vessels.

11.

White blood cells that are involved in the third line of defence of the immune system include

a)

mast cells.

b)

eosinophils.

c)

lymphocytes.

d)

macrophages.

12.

White blood cells that are involved in the third line of defence of the immune system include

a)

mast cells.

b)

eosinophils.

c)

lymphocytes.

d)

macrophages.

13.

Cytotoxic T cells are

a)

antibodies.

b)

able to kill virus-infected cells.

c)

part of the humoral immune response.

d)

part of the second line of the immune defence.

14.

Which statement best describes the T cell antigen receptor (TCR)?

a)

Signaling through Iga and Igb proteins

b)

Binds conformational lipid/sugar epitopes

c)

Recognizes only peptide/MHC complex

d)

Active form membrane-bound IgM/IgD

15.

Which statement best describes the T cell antigen receptor (TCR)?

a)

Signaling through Iga and Igb proteins

b)

Binds conformational lipid/sugar epitopes

c)

Recognizes only peptide/MHC complex

d)

Active form membrane-bound IgM/IgD

16.

What is the degree of cellular sensitivity to ionizing radiation (from most sensitive to least sensitive?

a)

B cells > T cells > macrophage

b)

Macrophage > T cells > B cells

c)

T cells > Macrophage > B cells

17.

What produce antibodies?

a)

Helper T cells

b)

Killer T-cells

c)

B Cells

d)

Phagocytes

18.

What specific type of acquired immunity do vaccines provide:

a)

naturally acquired active immunity

b)

naturally acquired passive immunity

c)

artificially acquired active immunity

d)

artificially acquired passive immunity

19.
Which one of the following target cell's membrane and disintegrates nucleus rapidly?
a)
Phagocyte
b)
Killer T-Cell
c)
Memory B Cells
d)
Natural killer cell
20.

Sebutkan komponen respon imun adaptif

a)

Sitokin

b)

Makrofag

c)

Sel limfosit T

d)

Sel dendritik

21.

Vaksinisasi tergolong ke dalam usaha dalam membentuk kekebalan …

a)

Aktif alami

b)

Seluler

c)

Pasif alami

d)

Aktif buatan

e)

Pasif alami

22.

This type of immunity can be called nonspecific and refers to the bodies defenses that are present since birth.

a)

resistance

b)

adaptive immunity

c)

acquired immunity

d)

innate immunity

23.

This type of immunity is acquired during one's lifetime. It is induced by antigens that invade the body.

a)

innate immunity

b)

adaptive immunity

c)

nonspecific immunity

d)

normal microbiota

24.
Which line of defense includes the skin, sweat, mucous membranes, and normal microbiota?
a)
First
b)
Second
c)
Third
25.
This refers to the type of immunity developed from exposure to a pathogen:
a)
active acquired immunity
b)
passive acquired immunity
c)
innate immunity
d)
attenuated immunity
26.

The receptors on T cells and B cells bind to

a)

antibodies.

b)

antigens

c)

natural killer cells.

d)

immunoglobulins.

27.

Which of the following is not a characteristic of the adaptive immune system?

a)

Large diversity of lymphocytes & receptors

b)

Tolerance to self

c)

Proliferation after activation

d)

Immunological memory

e)

Non-specific response

28.

Which of the following is NOT a sign of inflammation?

a)

Pain

b)

Swelling

c)

Heat

d)

Redness

e)

Cool

29.

Which of the following categorized as third line defense?

a)

Antibody

b)

Lysozymes

c)

Mucosa membrane

d)

Hydochloric acid

30.

Choose the component that belongs to adaptive immunity.

a)

Monocyte

b)

Neutrophil

c)

Lymphocyte

d)

Eosinophil

31.

Which of the following characteristic is referring to innate immunity?

a)

Highly specific

b)

Produce immunological memory

c)

Found only in jawed vertebrates

d)

Act very fast during the first infection.

32.

The thymus is a site of differential of .

a)

T cells

b)

B cells

c)

plasma cells

d)

red blood cells

33.

All of the following are true with respect to IgM antibodies EXCEPT

a)

they occur on the surface of lymphocytes

b)

they mediate allergic reaction

c)

they are glycoproteins

d)

they predominate in the primary response to antigen

34.

The immunoglobulin class that can cross the placenta is .

a)

IgA

b)

IgD

c)

IgG

d)

IgE

35.

“Second most abundant immunoglobulin in human serum. Also can be found in the nasal mucous saliva, breast milk and tears” The statement above refer to

a)

IgG

b)

IgD

c)

IgM

d)

IgA

36.

“Most of the immunoglobulin in human, approximately about 80%” .Choose the best answer applies to the statement above.

a)

The statement refer to IgG

b)

The statement refer to IgE

c)

The statement refer to IgD

d)

The statement refer to IgA

37.

All of the following are true with respect to IgE molecules, EXCEPT

a)

They are the principal immunoglobulin class involved in allergic reactions.

b)

They can effect the release of histamine and other chemical mediators.

c)

They will cross the placenta and fix complement.

d)

They are involved in mediating anti-parasitic immune responses.

38.

Which of the following immunoglobulins is present normally in plasma at the lowest concentration?

a)

IgG

b)

IgD

c)

IgA

d)

IgM

39.

All of the following conditions are required for the precipitation of the antigen / antibody complexes EXCEPT

a)

antigen must be multivalent

b)

antigen must be soluble

c)

antigen must have at least two binding sites

d)

antigen must have at least five binding sites

40.

Choose the BEST statement regarding complement.

a)

A system comprised of numerous proteins that have main role in host defense.

b)

Substance that enhance our immune system

c)

Protein that secreted by B cells

41.

A child stung by a bee experiences respiratory distress within minutes. This reaction mediated by

a)

IgE antibody

b)

IgG angtibody

c)

Sensitized T cells

d)

Complement

42.
It provides a rapid, early response and is considered to be the first line of cellular immune defence
a)
Adaptative
b)
Skin
c)
Innate
d)
Memory
43.
Home of multipotent stem cells that give rise to red blood cells
a)
MALT
b)
Thymus
c)
Bone marrow
d)
Spleen
44.
The are NOT granulocytes
a)
neutrophils
b)
mast cells
c)
eosinophils
d)
 basophils
45.
The primary function of mast cells is to
a)
produce immunoglobulins
b)
phagocyte microbial cells
c)
initiate haematopoiesis
d)
releasing pro-inflammatory mediators
46.
Antibodies that bind to the surface of infected cells are recognized by receptors on NK cells:
a)
MCH II recognition
b)
FcR interaction
c)
ADCC
d)
Apoptosis
47.
T helper cells possess a________ co-receptor
a)
CD 1
b)
CD 8
c)
CD 44
d)
CD 4
48.
The lymphocytes that are responsible for the apoptosis of infected cells
a)
T CD 4 cells
b)
Cytotoxic cells
c)
NK cells
d)
B cells
49.
One function is the filtration and accumulation of particulate antigens and microorganisms.
a)
Spleen
b)
Lymph nodes
c)
Bone marrow
d)
Thymus
50.
Specialized stromal cells also exist within germinal centres called
a)
APCC
b)
NK
c)
FDCs
d)
Spleen
51.
  A substance or part of a substance (living or nonliving) that the immune system recognizes as foreign and activates the immune system and reacts with immune cells or their products, such as antibodies.
a)
pathogen 
b)
allergen 
c)
antigen 
d)
antibody
52.

If our body encountered an antigen for the first time, what would occur?

a)

B cells would be unable to make antibodies until antigens are presented through macrophage MHCs

b)

Antibodies would not exist until dendritic cells brought pathogens to the lymph nodes

c)

Immunity would be at its highest because antibodies for this specific antigen have not yet been depleted

d)

In order to make up for the deficit in B cell antibody production, helper and cytotoxic T cell production would increase

53.

A secondary immune response will be faster when...

a)

The individual has encountered the pathogen already

b)

The individual's macrophages are on high alert

c)

The individual has encountered the pathogen and has memory B cells circulating

d)

Antibodies are produced by T cells

54.

How do T cells differ from B cells?

a)

T cells fight pathogens by killing pathogens directly, while B cells fight pathogens by making antibodies.

b)

T cells only make memory cells, and B cells only make antigens

c)

T cells fight pathogens by making antibodies, while B cells fight pathogens by killing pathogens directly.

d)

T cells can only fight off pathogens the body has encountered once, and B cells can fight off any pathogen the body comes across.

55.
White blood cells are an important part of the human immune response. Two types of white blood cells, neutrophils and macrophages, act as phagocytes. Phagocytes perform which of the following functions in the human body? 
a)
They produce antibodies.
b)
They bind to antigens and develop into plasma cells.
c)
They form a barrier against pathogens.
d)
They engulf and destroy bacteria.
56.

B Cells can create long term cells that will remember antigens on foreign substances

a)

Memory Cells

b)

Plasma Cells

c)

T cells

d)

Helper T cells

57.

Cell-mediated immunity is a type of acquired immunity. This is the immunity one develops throughout life. Which of the following types of cells are mostly involved in cell-mediated immunity?

a)

T cells

b)

B cells

c)

erythrocytes

d)

neutrophils

58.

What do killer T-cells do?

a)

Kill all of the helper T-cells.

b)

Create antibodies to be produced into the blood stream.

c)

Destroy cells that have been infected.

59.

Histamines directly cause:

a)

Helper T cells to mark pathogens for destruction

b)

Cytotoxic T cells to become activated

c)

B and T cells to create memory cells

d)

Blood vessels to dilate and leak fluid and WBC's

60.

Substansi yang dapat menginduksi respon imun

a)

Imunogen

b)

Antigen

c)

Epitop

d)

Hapten

61.

Tempat berikatannya reseptor

a)

Imunogen

b)

Antigen

c)

Epitop

d)

Hapten

62.

Jenis imunogen yang menimbulkan respon pembentukan antibodi

a)

Protein

b)

Polisakarida

c)

Lipid

d)

Asam Nukleat

63.

Antigen yang berasal dari virus dan bakteri dikelompokkan ke dalam

a)

Eksogen

b)

Endogen

c)

Autologi

d)

Allogenic

64.

Hanya memiliki satu jenis determinan, tetapi terdapat dua atau lebih pada satu molekul

a)

Unideterminan, multivalent

b)

Unideterminan, univalent

c)

Multideterminan, univalent

d)

Multideterminan, multivalent

65.

MHC kelas I

a)

mengikat peptida dalam vesikel intrasel

b)

Berada di semua sel berinti

c)

Berikatan dengan koreseptor CD4

d)

Berada di permukaan sel APC

66.

MHC kelas II

a)

mengikat peptida dari protein di sitoplasma

b)

dikenali koreseptor CD8

c)

terdapat pada sel APC

d)

berfungsi ketika terjadi infeksi virus

67.

Sel APC yang secara konstitutif mengekspresikan MHC II

a)

Sel B

b)

Sel T

c)

Makrofaga

d)

Sel Dendritik

68.

Sel APC non-professional

a)

Sel T

b)

Sel dendritik

c)

Sel beta pankreas

d)

Sel B

69.

Organ limfoid primer yang berfungsi dalam pembentukan antibodi

a)

Thymus

b)

Bone marrow

c)

Limfa

d)

Kelenjar limfa

70.

Reseptor yang mengenali komponen umum dinding sel bakteri

a)

TLR

b)

C-reactive protein

c)

Mannose binding lectine

d)

Komplemen

71.

Pada respon imun adaptif terhadap bakteri ekstraseluler, antigen yang dipresentasikan oleh APC ke sel T CD4+ akan mengaktifkan makrofag sehingga terjadi.....untuk mengeliminasi bakteri.

a)

Fagositosis

b)

Opsonisasi

c)

Maturasi NK

d)

Aktivasi sel Th

72.

Bagian antigen yang dapat menginduksi pembentukan antibodi dan dapat diikat secara spesifik oleh bagian dari antibodi atau reseptor pada limfosit t (tcr) disebut dengan...

a)

imunogen

b)

hapten

c)

epitop

d)

MHC

73.

dapat menjadi imunogen melalui ikatan dengan molekul besar (molekul pembawa) disebut dengan….

a)

imunogen

b)

hapten

c)

epitop

d)

MHC

74.

MHC

a)

Minor Histocompatibility Complex

b)

Major Histocompatibility Complex

c)

Major Histocompatibility carrier

d)

Minor Histocompatibility Carrier

75.

MHC

a)

Minor Histocompatibility Complex

b)

Major Histocompatibility Complex

c)

Major Histocompatibility carrier

d)

Minor Histocompatibility Carrier

76.

sel B mengenal epitop pada molekul utuh

a)

benar

b)

salah

77.

sel T mengenal epitop pada fragmen antigen saja, tidak secara utuh

a)

benar

b)

salah

78.

contoh dari sel T

a)

CD14

b)

CD8

c)

CD26

d)

CD5

79.

MHC-II diekspresikan terutama pada permukaan sel khusus seperti pada

a)

nukleus

b)

dendrit

80.

Terdiri dari dua polipeptida, rantai berat α polimorfik dan rantai ringan non polimorfik yang disebut β2 mikroglobulin

adalah ciri dari

a)

MHC 1

b)

MHC 2

c)

MHC 3

d)

MHC 4

81.

...…. berfungsi mempresentasikan antigen intraseluler kepada sel T CD8

a)

MHC 1

b)

MHC 2

c)

MHC 3

d)

MHC 4

82.

...…. berfungsi mempresentasikan antigen intraseluler kepada sel T CD8

a)

MHC 1

b)

MHC 2

c)

MHC 3

d)

MHC 4

83.

........... adalah memiliki fungsi mengaktifkan sel T CD4 yang merupakan sentral respon imun

a)

MHC 1

b)

MHC 2

c)

MHC 3

d)

MHC 4

84.

proses respon terhadap antigen yang dibantu oleh MHC 1 disebut dengan

a)

Respon endogen

b)

respon eksogen

85.

dapat menjadi imunogen melalui ikatan dengan molekul besar (molekul pembawa) disebut dengan….

a)

imunogen

b)

hapten

c)

epitop

d)

MHC

86.

What does the "MMR" vaccine stand for?

a)

Measles, meningitis, rubella

b)

Measles, mumps, rubella

c)

Meningitis, mumps, rubella

d)

Measles, mumps, rabies

87.

Struktur antibodi yang bertanggung jawab pada aktivitas biologi

a)

Variable light chain

b)

Variable heavy chain

c)

Constant light chain

d)

Constant light & heavy chain

88.

Imunoglobulinyang terdapat di intravaskuler sebagai respon imun awal

a)

IgM

b)

IgA

c)

IgG

d)

IgE

89.

Antibodi adalah ....

a)

Substansi yang dikenali oleh sistem imun

b)

Molekul yang menginduksi respon imun ketika membentuk kompleks dengan MHC

c)

Protein imunoglobulin yang disekresikan oleh sel B yang teraktivasi antigen

d)

Protein imunoglobulin yang disekresikan oleh sel T yang teraktivasi antigen

90.

Imunoglobulinyang terdapat di intravaskuler sebagai respon imun awal

a)

IgM

b)

IgA

c)

IgG

d)

IgE

91.

IgE

a)

Dapat melewati plasenta

b)

Degranulasi mastosit

c)

Pertahanan permukaan bersama cairan sekretori

d)

Terdapat di permukaan limfosit

92.

Menstimulasi Dan mengaktivasi fagositosis

a)

Neutralisasi

b)

Opsonisasi

c)

Inflamasi

d)

Aktivasi komplemen

93.

Neutralisasi

a)

Antibodi berikatan di permukaan patogen untuk mengaktifkan komplemen

b)

Antibodi mencegahpatogen atau toksin berikatan dengan sel target

c)

Antibodi mengaktifkan fagositosis oleh makrofaga

d)

Antibodi memanggil sel imun Lai ke situs infeksi

94.

Jalur komplemen karena adanya ikatan antigen-antibodi

a)

Jalur klasik

b)

Jalur MB-Lektin

c)

Jalur alternatif

d)

Jalur non-spesifik

95.

Protein komplemen pada jalur mannose-lectin

a)

components

b)

factors

c)

collectins

d)

complemen

96.

Komponen yang mempercepat proses fagositosis

a)

C3a

b)

C3b

c)

C5a

d)

C5b

97.

Penyusun C3 convertase

a)

C2b, C4b

b)

C2a, C4a

c)

C2b, C4a

d)

C2a, C4b

98.

C6-C9 berperan dalam efek biologis sistem komplemen

a)

Kemotaksis dan Opsonisasi

b)

Respon Inflamasi

c)

Membran attack complex

d)

Fagositosis

99.

Which type of cell is a messenger between the innate and adaptive immune system?

a)

Dendritic cells

b)

Eosinophils

c)

Helper T Cells

d)

CD4+ cells

100.

Which type of cell is NOT DIRECTLY affected by Helper T cells?

a)

Cytotoxic T cell

b)

Memory helper T cell

c)

Memory B cell

d)

B cell

101.

Which type of cell is directly activated by a non-host presenting antigen?

a)

B cell

b)

Cytotoxic T cell

c)

Plasma cell

d)

Active cytotoxic T cell

102.

How do plasma cells help protect the body against pathogens?

a)

Activated B cells attach to pathogens and and undergo phagocytosis

b)

Activated T cells release antibodies that undergo phagocytosis with pathogens

c)

Activated B cells release antibodies that serve as markers on pathogens

d)

Epitopes on activated T cells are released and attached to the antibodies on antigens

103.

Purpose of a the Th cell (helper T cell)

a)

helps with differentiation (plasma or memory) based off the antigen that is presented by the b cells

b)

decideds what consequence shoudl occur based off the antigen

c)

presents the antigen to the b cell, so the b cell knows what anitbodies need to be made

d)

allows for phagocytosis to occur in b cells and other phagocytes

104.

What is the purpose of Interleukin (IL)

a)

helps with differentiation (plasma or memory)

b)

identifies the antigen

c)

presents the antigen

d)

allows for phagocytosis

105.

what are two APC's

a)

B cells and T cells

b)

macrophages and B cells

c)

macrophages and neutrophils

d)

neutrophils and b cells

106.

H

a)

t cell receptor

b)

antigen/residual fragment

c)

CD4

d)

MHC 2

107.

Chemicals released by the Helper (Th) cell is called

a)

MHC 2

b)

Interleukin

c)

antigen

d)

t cell receptors

108.

The orange molecule in this image is a(n) _______

a)

Antibody

b)

Antigen/epitope

c)

antibiotic

d)

Blood cell

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