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Pathology

Total questions: 61

Worksheet time: 20mins

Name
Class
Date
1.

Pathway of the cell death induced by a tightly regulated suicide program

a)

Apoptosis

b)

Gangrenous necrosis

c)

Fibrinoid necrosis

d)

Caseous necrosis

2.

Which one is not an aspect of pathology?

a)

Etiology

b)

Adpatation

c)

Clinical manifestation

d)

Pathogenesis

3.

Type of cell injury that is characterized by functional and structural alterations in early stages or mild forms of injury:

a)

Reversible

b)

Irreversible

4.

What structural changes occurs in reversible cell injury:

a)

Plasma membrane alteration

b)

Contraction of the ER

c)

Mitochondrial changes

d)

Accumulation of myelin figures

5.

In necrosis, the cell size is enlarge, the plasma membrane is disrupted and there is no adjacent inflammation:

a)

True

b)

False

6.

Cellular swelling cause:

a)

Palor

b)

Decreased weight of affected organ

c)

Decreased size of the cell

d)

Increased turgor

7.

In __________, active proteases leak out of the cell and damage surrounding tissue.

a)

Necrosis

b)

Apoptosis

c)

Reversible cell injury

d)

Adaptation

8.

In necrosis occurs:

a)

Local inflammation

b)

Enzymatic digestion of the lethally injured cells

c)

Leakage of extracellular proteins through the damage plasma

d)

Denaturation of cellular proteins

9.

Some of the causes of cell injury are:

a)

Hypoxia

b)

Mechanical trauma

c)

Glucose in hypotonic concentrations

d)

Genetic abnormalities

10.

________ is the initiating cause of the disease:

a)

Pathogenesis

b)

Etiology

c)

Morphological changes

d)

Clinical manifestations

11.

Sequence of molecular, biochemical and cellular events that lead to the development of disease:

a)

Pathogenesis

b)

Etiology

c)

Morphologic changes

d)

Clinical manifestations

12.

Structural alterations in cells and tissues that are characteristic of a disease:

a)

Pathogenesis

b)

Etiology

c)

Morphologic changes

d)

Clinical manifestations

13.

Early alterations of reversible injury does not include:

a)

Blebbing of the plasma

b)

Generalized shrinkage of the cell

c)

Clumping of nuclear chromatin

d)

Detachment of ribosomes from the ER

14.

The inability to reverse mitochondrial dysfunction and profound disturbances in membrane functions, characterize irreversibility in cell injury

a)

False

b)

True

15.

Form of necrosis in which the architecture of dead tissue is preserved for at least some days.

a)

Fat

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

16.

Form of necrosis usually applied to a limb that has lost its blood supply.

a)

Fat

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

17.

Form of necrosis typically resulting from release of activated pancreatic lipases into the substance of the pancreas.

a)

Fat

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

18.

It's also known as cheeselike:

a)

Caseous

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

19.

Form of necrosis characterized by digestion of dead cells, resulting frequently in pus:

a)

Caseous

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

20.

Hypoxic death of cells within the central nervous system is often manifests as ___________ necrosis.

a)

Caseous

b)

Gangrenous

c)

Liquefactive

d)

Coagulative

21.

Typically occurs when complexes of antigens and antibodies are deposited in the walls of arteries resulting in vascular damage.

a)

Coagulative

b)

Fat

c)

Liquefactive

d)

Fibrinoid

22.

Apoptosis:

a)

Can be induced during certain infections

b)

Contribute to pathologic atrophy in parenchymal organs after duct obstruction.

c)

Eliminates cell that are injured beyond repair eliciting a host reaction.

d)

Eliminates cells that are needed.

23.

Is the most characteristic feature of apoptosis:

a)

Cell shrinkage

b)

Formation of cytoplasmic blebs

c)

Chromatin condensation

d)

Formation of apoptotic bodies

24.

In apoptosis, in the execution phase some caspases become catalytically active and unleash a cascade of other caspases.

a)

False

b)

True

25.

Apoptosis results from the activation of enzymes called:

a)

Caspases

b)

Lipases

c)

Trypsin

d)

Pepsin

26.

The__________ pathway of apoptosis results from increased permeability of the mitochondrial outer membrane with consequent release of pro-apoptotic molecules:

a)

Extrinsic

b)

Death Receptor

c)

Intrinsic

d)

Caspase

27.

Principal pro-apoptotic members:

a)

BAX

b)

BAD

c)

BAK

d)

BCL2

28.

The principal targets of injurious stimuli are:

a)

Endoplasmic Reticulum

b)

Mitochondria

c)

DNA

d)

Cell membranes

29.

Increased size of cells:

a)

Hypertrophy

b)

Hyperplasia

c)

Metaplasia

d)

Atrophy

30.

Is a result of increased cellular protein production

a)

Hypertrophy

b)

Hyperplasia

c)

Metaplasia

d)

Atrophy

31.

Is an increase in the number of cells in an organ or tissue.

a)

Hypertrophy

b)

Hyperplasia

c)

Metaplasia

d)

Atrophy

32.

____________ can only take place in cells capable of dividing.

a)

Hypertrophy

b)

Atrophy

c)

Hyperplasia

d)

Metaplasia

33.

______________ is the result of growth factor-driven proliferation of mature cells.

a)

Hyperplasia

b)

Hypertrophy

c)

Metaplasia

d)

Atrophy

34.

Reduction of size of an organ or tissue due to a decrease in cell size and number.

a)

Hypertrophy

b)

Hyperplasia

c)

Atrophy

d)

Metaplasia

35.

Some of the common causes of atrophy are:

a)

Decreased workload

b)

Loss of innervation

c)

Increased blood supply

d)

Inadequate nutrition

36.

Atrophy results from:

a)

Decreased protein synthesis and increased protein degradation in cells.

b)

Increased protein synthesis and increased protein degradation in cells.

c)

Increased protein synthesis and decreased protein degradation in cells.

d)

Decreased protein synthesis and decreased protein degradation in cells.

37.

The degradation of cellular proteins occurs mainly by the ubiquitin-proteasome pathway:

a)

True

b)

False

38.

Metaplasia is an irreversible change in which one differentiated cell type is replaced by another cell type.

a)

True

b)

False

39.

The most common epithelial metaplasia is:

a)

Cuboidal to squamous

b)

Columnar to squamous

c)

Columnar to cuboidal

d)

Squamous to columnar

40.

An example of metaplasia is:

a)

Bernett esophagus

b)

Barret esophagus

c)

Barret lung

d)

Bernett lung

41.

The figure B is an example of:

a)

Atrophy

b)

Hypertrophy

c)

Hyperplasia

d)

Metaplasia

42.

The image is an example of:

a)

Atrophy

b)

Hypertrophy

c)

Hyperplasia

d)

Metaplasia

43.

The image is an example of __________ necrosis.

a)

Liquefactive

b)

Coagulative

c)

Gangrenous

d)

Caseous

44.

What kind of cell injury shows the image B

a)

Irreversible

b)

Reversible

45.

What form of necrosis is in the image?

a)

Liquefactive

b)

Coagulative

c)

Fat

d)

Gangrenous

46.

What form of necrosis is in the image?

a)

Liquefactive

b)

Coagulative

c)

Fat

d)

Gangrenous

47.

What form of necrosis is in the image?

a)

Liquefactive

b)

Coagulative

c)

Fat

d)

Gangrenous

48.

The right image is an example of:

a)

Normal endometrium

b)

Endometrial hypertrophy

c)

Endometrial hyperplasia

d)

Endometrial atrophy

49.

What causes cell injury?

a)

The cell become compromised by mutations

b)

Exposed to continuous injurious agents or stress

c)

Deprived of essential nutrients

d)

Adaptive responses are not exceeded

50.

Hormonal hyperplasia and compensatory hyperplasia are examples of pathologic hyperplasia.

a)

False

b)

True

51.

An example of physiologic atrophy is the postpartum uterus.

a)

True

b)

False

52.

In this type of adaptive response are fewer mitochondria and filaments, and reduced amount of rough endoplasmic reticulum.

a)

Metaplasia

b)

Hyperplasia

c)

Atrophy

d)

Hypertrophy

53.

The hallmarks of reversible injury in light microscope are:

a)

Celular swelling

b)

Celular shrinkage

c)

Fatty change

d)

Inflammation

54.

Dead cells may be replaced by large, whorled phospholipid masses called myelin figures.

a)

False

b)

True

55.

Necrotic cells shows increased:

a)

Basophilia

b)

Eosinophilia

c)

Neutrophilia

d)

Leukocytosis

56.

Necrosis associated with ischemia or hypoxia in every organ except in the brain.

a)

Caseous

b)

Coagulative

c)

Liquefactive

d)

Fat

57.

Type of necrosis that occurs in the brain because of its lack of any substantial supporting stroma.

a)

Liquefactive

b)

Coagulative

c)

Fribinoid

d)

Gangrenous

58.

Cells undergo apoptosis because they are deprived of necessary survival signals, such as growth factors.

a)

True

b)

False

59.

Process in which a cell eats its own contents:

a)

Pyroptosis

b)

Necroptosis

c)

Autophagy

d)

Atrophy

60.

A 16-year-old girl is brought to the pediatrician by her mother. The girl has been trying to lose weight to fit in with her peers at school. The mother has hypothyroidism and discovered that her daughter has been taking her levothyroxine pills for the past two months to increase her metabolism. The girl has no history of thyroid disease or chronic medical conditions, and she takes no medications. Which of the following is most likely occurring in this girl’s thyroid gland?

a)

Hyperplasia

b)

Metaplasia

c)

Atrophy

d)

Hypertrophy

61.

A 67-year-old woman with a long history of hypertension and a remote myocardial infarction presented to the emergency department with a two-hour history of left-sided weakness. She reported that she had a “fluttering” sensation in her chest and that her cardiologist had recommended treatment for atrial fibrillation which she had refused. While in the emergency department, she developed left-sided hemiparesis. She was admitted to the hospital for observation; however, her condition worsened and she went into a coma. She died 17 days after admission.

a)

Coagulative necrosis

b)

Caseous necrosis

c)

Fat necrosis

d)

Liquefactive necrosis