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WorksheetsPathology
Total questions: 61
Worksheet time: 20mins
Pathway of the cell death induced by a tightly regulated suicide program
Apoptosis
Gangrenous necrosis
Fibrinoid necrosis
Caseous necrosis
Which one is not an aspect of pathology?
Etiology
Adpatation
Clinical manifestation
Pathogenesis
Type of cell injury that is characterized by functional and structural alterations in early stages or mild forms of injury:
Reversible
Irreversible
What structural changes occurs in reversible cell injury:
Plasma membrane alteration
Contraction of the ER
Mitochondrial changes
Accumulation of myelin figures
In necrosis, the cell size is enlarge, the plasma membrane is disrupted and there is no adjacent inflammation:
True
False
Cellular swelling cause:
Palor
Decreased weight of affected organ
Decreased size of the cell
Increased turgor
In __________, active proteases leak out of the cell and damage surrounding tissue.
Necrosis
Apoptosis
Reversible cell injury
Adaptation
In necrosis occurs:
Local inflammation
Enzymatic digestion of the lethally injured cells
Leakage of extracellular proteins through the damage plasma
Denaturation of cellular proteins
Some of the causes of cell injury are:
Hypoxia
Mechanical trauma
Glucose in hypotonic concentrations
Genetic abnormalities
________ is the initiating cause of the disease:
Pathogenesis
Etiology
Morphological changes
Clinical manifestations
Sequence of molecular, biochemical and cellular events that lead to the development of disease:
Pathogenesis
Etiology
Morphologic changes
Clinical manifestations
Structural alterations in cells and tissues that are characteristic of a disease:
Pathogenesis
Etiology
Morphologic changes
Clinical manifestations
Early alterations of reversible injury does not include:
Blebbing of the plasma
Generalized shrinkage of the cell
Clumping of nuclear chromatin
Detachment of ribosomes from the ER
The inability to reverse mitochondrial dysfunction and profound disturbances in membrane functions, characterize irreversibility in cell injury
False
True
Form of necrosis in which the architecture of dead tissue is preserved for at least some days.
Fat
Gangrenous
Liquefactive
Coagulative
Form of necrosis usually applied to a limb that has lost its blood supply.
Fat
Gangrenous
Liquefactive
Coagulative
Form of necrosis typically resulting from release of activated pancreatic lipases into the substance of the pancreas.
Fat
Gangrenous
Liquefactive
Coagulative
It's also known as cheeselike:
Caseous
Gangrenous
Liquefactive
Coagulative
Form of necrosis characterized by digestion of dead cells, resulting frequently in pus:
Caseous
Gangrenous
Liquefactive
Coagulative
Hypoxic death of cells within the central nervous system is often manifests as ___________ necrosis.
Caseous
Gangrenous
Liquefactive
Coagulative
Typically occurs when complexes of antigens and antibodies are deposited in the walls of arteries resulting in vascular damage.
Coagulative
Fat
Liquefactive
Fibrinoid
Apoptosis:
Can be induced during certain infections
Contribute to pathologic atrophy in parenchymal organs after duct obstruction.
Eliminates cell that are injured beyond repair eliciting a host reaction.
Eliminates cells that are needed.
Is the most characteristic feature of apoptosis:
Cell shrinkage
Formation of cytoplasmic blebs
Chromatin condensation
Formation of apoptotic bodies
In apoptosis, in the execution phase some caspases become catalytically active and unleash a cascade of other caspases.
False
True
Apoptosis results from the activation of enzymes called:
Caspases
Lipases
Trypsin
Pepsin
The__________ pathway of apoptosis results from increased permeability of the mitochondrial outer membrane with consequent release of pro-apoptotic molecules:
Extrinsic
Death Receptor
Intrinsic
Caspase
Principal pro-apoptotic members:
BAX
BAD
BAK
BCL2
The principal targets of injurious stimuli are:
Endoplasmic Reticulum
Mitochondria
DNA
Cell membranes
Increased size of cells:
Hypertrophy
Hyperplasia
Metaplasia
Atrophy
Is a result of increased cellular protein production
Hypertrophy
Hyperplasia
Metaplasia
Atrophy
Is an increase in the number of cells in an organ or tissue.
Hypertrophy
Hyperplasia
Metaplasia
Atrophy
____________ can only take place in cells capable of dividing.
Hypertrophy
Atrophy
Hyperplasia
Metaplasia
______________ is the result of growth factor-driven proliferation of mature cells.
Hyperplasia
Hypertrophy
Metaplasia
Atrophy
Reduction of size of an organ or tissue due to a decrease in cell size and number.
Hypertrophy
Hyperplasia
Atrophy
Metaplasia
Some of the common causes of atrophy are:
Decreased workload
Loss of innervation
Increased blood supply
Inadequate nutrition
Atrophy results from:
Decreased protein synthesis and increased protein degradation in cells.
Increased protein synthesis and increased protein degradation in cells.
Increased protein synthesis and decreased protein degradation in cells.
Decreased protein synthesis and decreased protein degradation in cells.
The degradation of cellular proteins occurs mainly by the ubiquitin-proteasome pathway:
True
False
Metaplasia is an irreversible change in which one differentiated cell type is replaced by another cell type.
True
False
The most common epithelial metaplasia is:
Cuboidal to squamous
Columnar to squamous
Columnar to cuboidal
Squamous to columnar
An example of metaplasia is:
Bernett esophagus
Barret esophagus
Barret lung
Bernett lung
The figure B is an example of:
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
The image is an example of:
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
The image is an example of __________ necrosis.
Liquefactive
Coagulative
Gangrenous
Caseous
What kind of cell injury shows the image B
Irreversible
Reversible
What form of necrosis is in the image?
Liquefactive
Coagulative
Fat
Gangrenous
What form of necrosis is in the image?
Liquefactive
Coagulative
Fat
Gangrenous
What form of necrosis is in the image?
Liquefactive
Coagulative
Fat
Gangrenous
The right image is an example of:
Normal endometrium
Endometrial hypertrophy
Endometrial hyperplasia
Endometrial atrophy
What causes cell injury?
The cell become compromised by mutations
Exposed to continuous injurious agents or stress
Deprived of essential nutrients
Adaptive responses are not exceeded
Hormonal hyperplasia and compensatory hyperplasia are examples of pathologic hyperplasia.
False
True
An example of physiologic atrophy is the postpartum uterus.
True
False
In this type of adaptive response are fewer mitochondria and filaments, and reduced amount of rough endoplasmic reticulum.
Metaplasia
Hyperplasia
Atrophy
Hypertrophy
The hallmarks of reversible injury in light microscope are:
Celular swelling
Celular shrinkage
Fatty change
Inflammation
Dead cells may be replaced by large, whorled phospholipid masses called myelin figures.
False
True
Necrotic cells shows increased:
Basophilia
Eosinophilia
Neutrophilia
Leukocytosis
Necrosis associated with ischemia or hypoxia in every organ except in the brain.
Caseous
Coagulative
Liquefactive
Fat
Type of necrosis that occurs in the brain because of its lack of any substantial supporting stroma.
Liquefactive
Coagulative
Fribinoid
Gangrenous
Cells undergo apoptosis because they are deprived of necessary survival signals, such as growth factors.
True
False
Process in which a cell eats its own contents:
Pyroptosis
Necroptosis
Autophagy
Atrophy
A 16-year-old girl is brought to the pediatrician by her mother. The girl has been trying to lose weight to fit in with her peers at school. The mother has hypothyroidism and discovered that her daughter has been taking her levothyroxine pills for the past two months to increase her metabolism. The girl has no history of thyroid disease or chronic medical conditions, and she takes no medications. Which of the following is most likely occurring in this girl’s thyroid gland?
Hyperplasia
Metaplasia
Atrophy
Hypertrophy
A 67-year-old woman with a long history of hypertension and a remote myocardial infarction presented to the emergency department with a two-hour history of left-sided weakness. She reported that she had a “fluttering” sensation in her chest and that her cardiologist had recommended treatment for atrial fibrillation which she had refused. While in the emergency department, she developed left-sided hemiparesis. She was admitted to the hospital for observation; however, her condition worsened and she went into a coma. She died 17 days after admission.
Coagulative necrosis
Caseous necrosis
Fat necrosis
Liquefactive necrosis
