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Midterm I - 405a (2020)

Total questions: 60

Worksheet time: 3600secs

Name
Class
Date
1.

Practically insoluble in water, … is a preparation from the group of terpenoids.

a)

A. sulfocamphoric acid

b)

B. sulfocamphocaine

c)

C. terpinhydrate

d)

D. camphor

e)

E. validol

2.

Hot solution of ... from the addition of a few drops of sulfuric acid conc. becomes blurred and takes on a aromatic odor.

a)

A. sulfocamfocaine

b)

B. terpine hydrate

c)

C. sulfocamphoric acid

d)

D. menthol

e)

E. camphor

3.

The rational name of menthol is … .

a)

A. 5-methylcyclohexanol-1

b)

B. p-menthanediol-1.8

c)

C. p-2-isopropyl-5-methylhexane

d)

D. 3-isopropyl-5-methylcyclohexanol-1

e)

E. L-2-isopropyl-5-methylcyclohexanol-1

4.

The description "clear, oily, colorless liquid with a menthol odor" corresponds to ... .

a)

menthol

b)

sulfocamphocaine

c)

terpinhydrate

d)

validol

e)

camphor

5.

The deoxy sugar in the molecule of cardiac glycosides is identified by the … .

a)

Erdmann’s reagent

b)

Raymond's test

c)

Marquis reagent

d)

Keller-kiliani test

e)

Baljet test

6.

The toxicity of cardiac glycosides is reduced by the introduction of … into the structure.

a)

lactone

b)

angular methyl groups

c)

carbohydrate

d)

C3-hydroxyl group

e)

C3-ketone group

7.

Bufodienolides are identified by the …

a)

Keller-kiliani test

b)

Raymond's test

c)

Baljet test

d)

with antimony chloride

e)

with xanthhydrol

8.

Common in the structure of ethinyl estradiol and pregnin is the presence of ... .

a)

ethynyl group

b)

hydroxyl groups

c)

17α-ketol group

d)

keto group

e)

aromatic cycle A

9.

The … formation reaction below is used to identify pregnin.

a)

hydrazone

b)

hydroxamic acid

c)

oxime

d)

semicarbazone

e)

phenylhydrazone

10.

The chemical structure below corresponds to the drug … .

a)

cortisone acetate

b)

prednisolone

c)

hydrocortisone acetate

d)

prednisone

e)

norcolut

11.

The rational name "pregnene-4-trion-3,11,20-diol-17α, 21-acetate" corresponds to the drug ... .

a)

cortisone

b)

prednisolone

c)

norcolut

d)

hydrocortisone

e)

prednisone

12.

Hydrocortisone acetate is distinguished from hydrocortisone by the reaction of the … .

a)

(Ferric) Hydroxamate Test

b)

with sulfuric acid conc.

c)

Liebermann-Burchard

d)

oxime formation

e)

formations of the "silver mirror"

13.

Normative documentation for the quantitative determination of steroid hormone drugs recommends the … method.

a)

spectrophotometry

b)

nitritometry

c)

nephelometry

d)

neutralization

e)

complexometry

14.

To detect the tartrate ion in adrenaline salts, a reaction based on dehydration and subsequent oxidation by heating with concentrated acid in the presence of resorcinol is used. This is accompanied by the formation of … :

a)

acetaldehyde and formic acid

b)

glyoxal and salicylic acid

c)

glyoxal and formic aldehyde

d)

acetic acid and formic aldehyde

e)

glyoxal and formic acid

15.

The ability of norepinephrine to easily oxidize is associated with the presence of … in the structure.

a)

benzene ring

b)

ethanol residue

c)

phenolic hydroxyls

d)

methyl group

e)

primary amino group

16.

Tartaric acid in the epinephrine hydrotartrate molecule is detected by reaction with … .

a)

barium chloride

b)

β-naphthol in sulfuric acid conc.

c)

ninhydrin

d)

sodium nitrite in an acidic environment

e)

Fehling's reagent

17.

When iodine solution is added to the adrenaline solution in an acidic and neutral medium, dark red … is formed.

a)

methylamine

b)

p-quinone

c)

adrenochrome

d)

2,5,6-triiodadrenaline

e)

aminoethanol

18.

Adrenaline differs from norepinephrine by the presence of … in the structure.

a)

ethanol residue

b)

primary aliphatic amino group

c)

benzene cycle

d)

phenolic hydroxyls

e)

methyl-amine group

19.

The polarimetric method for the analysis of epinephrine and norepinephrine is based on the presence of ... .

a)

regenerative properties

b)

oxidizing properties

c)

optical activity

d)

basic properties

e)

aromatic properties

20.

In the testing laboratory, the examination of the drug substance of norepinephrine hydrotartrate is carried out by the spectrophotometric method. For this, concentrated phosphoric acid, potassium iodate are added to the sample of the drug, the flask with the resulting solution is immersed in a boiling water bath, cooled and the optical density of the resulting solution is measured at a wavelength of 310 nm.

What quality parameter is determined by this method?

a)

admixture of adrenaline

b)

drug identification

c)

quantitative content

d)

impurity of noradrenolone

e)

related impurities

21.

What chemical process takes place during storage of epinephrine solution?

a)

hydrolysis

b)

pyrrolysis

c)

reduction

d)

photochemical destruction

e)

racemization

22.

In accordance with the requirements of the regulatory document, the quantitative determination of the substance of epinephrine (adrenaline) is carried out by the method of non-aqueous titration. The drug is dissolved in glacial acetic acid and titrated to an equivalent point, the indicator is crystal violet.

Which titrant should be used by the analyst pharmacist based on the acid-base properties of epinephrine?

a)

sodium methoxide solution

b)

hydrochloric acid solution

c)

perchloric acid solution

d)

sodium hydroxide solution

e)

sulfuric acid solution

23.

To identify ascorbic acid, use the following reaction of interaction with the … reagent.

a)

Marquis

b)

Tollens’

c)

Fehling’s

d)

chromotropic acid

e)

Nessler’s

24.

The following silver reduction reaction is used for … of ascorbic acid.

a)

quantification

b)

determination of oxymethylfurfural impurity

c)

definition of stability

d)

identification

e)

determination of furfural impurity

25.

The formation of purple iron ascorbate according to the reaction below is based on the presence of the … of ascorbic acid.

a)

hydroxyl group at position C2

b)

acidic properties

c)

keto group at position C1

d)

double bond at positions C2-C3

e)

asymmetric carbon atoms at positions C4, C5

26.

Under the action of strong oxidants according to the reaction below, the lactone ring of ascorbic acid is hydrolyzed to form … .

a)

furfural

b)

glucofuranose

c)

dehydroascorbic acid

d)

dextrose

e)

galactofuranose

27.

To identify ascorbic acid, use the reaction of interaction with a blue-colored solution of 2,6-dichlorophenolindophenol for the formation of … .

a)

black cheesy sediment

b)

pink Schiff bases

c)

colorless leuco-base

d)

arylmethane dye red

e)

diazo dye red

28.

The quantitative content of ascorbic acid is carried out in accordance with the chemical reaction below by the … method.

a)

alkalimetry, back titration

b)

alkalimetry, direct titration

c)

Volhard, back titration

d)

Mohr, direct titration in alkali medium

e)

Mohr, direct titration in neutral medium

29.

Ascorbic acid has asymmetric carbon atoms in …

a)

С3 and С2

b)

С4 and С5

c)

С6 and С1

d)

С2 and С1

e)

С3 and С1

30.

To identify ascorbic acid, a reaction of interaction with a blue-colored solution of 2,6-dichlorophenolindophenol is used to form … .

a)

black cheesy sediment

b)

pink Schiff bases

c)

red arylmethane dye

d)

colorless leuco-base

e)

red diazo dye

31.

The following reaction chemistry is recommended for the quantitative determination of … by cerimetry.

a)

retinol acetate

b)

cortisone acetate

c)

deoxycorticosterone acetate

d)

tocopherol acetate

e)

hydrocortisone acetate

32.

When tocopherol acetate is heated to 80 ° C with concentrated nitric acid, … , colored in a red-orange color, is formed.

a)

o-tocopherylquinone

b)

p-tocopherylquinone

c)

m-tocopherylquinone

d)

cyanine chloride

e)

aurine dye

33.

It has been established that tocopherol acetate has a signified antioxidant activity.

What fragment of the chemical structure is the pharmacological action of tocopherol acetate associated with?

a)

with a phytyl radical

b)

with phenolic hydroxyl

c)

with acetic acid residue

d)

with pyran core

e)

with a benzene cycle

34.

Cyclohexanolethylenehydrindane compounds include:

strophanthin?

retinol acetate?

ergocalciferol?

digitoxin?

adonidin?

a)
b)
c)
d)
35.

Retinol acetate is distinguished by its reaction with ... .

a)

antimony chloride

b)

vanillin

c)

furfural

d)

benzaldehyde

e)

silver nitrate

36.

Distinctive for retinol acetate is ... .

a)

hydroxamic test

b)

ninhydrin test

c)

thaleyoquin test

d)

Zincke reaction

e)

Vitali-Morin’s test

37.

The rational name "trans-9,13-dimethyl-7- (1,1,5-trimethylcyclohexen-5-yl-6) -nonatetraen-7,9,11,13-ola-15 acetate" corresponds to ... .

a)

retinol acetate

b)

remantadine

c)

midantan

d)

cortisone acetate

e)

terpinhydrate

38.

The formation of the following red-colored complex of cobalt with nitroso-R-salt is characteristic of the identification of … .

a)

clindamycin

b)

platyphylline hydrotartrate

c)

lincomycin

d)

cyanocobalamin

e)

piracetam

39.

An unknown drug was submitted for examination, the spectral analysis of which showed the presence of 2 absorption maxima in the UV region, characteristic of 5,6-benzimidazole at a wavelength of 278 nm and at a wavelength of 361 nm for a corrin system with 6 conjugated double bonds and 1 absorption maximum in visible spectrum at 548 nm, characteristic of an inorganic element.

Which medicinal product should be subject to additional tests to confirm its authenticity?

a)

Riboflavin

b)

Ergocalciferol

c)

Rifampicin

d)

Cyanocobalamin

e)

Folic acid

40.

The nucleotide that is part of cyanocobalamin consists of:

A) Deoxyribofuranose

B) Acetoribofuranose

C) Aminoribofuranose

D) Ribofuranose phosphate

E) 5,6-dimethylbenzimidazole

F) Adenine

G) Guanine

H) 1-aminopropanol-2

a)

C, G, Н

b)

В, D, Н

c)

D, E, H

d)

A, E, G

e)

D, B, Н

41.

Cyanocobalamin can be characterized as:

A) Chelated compound

B) Dibasic acid

C) Complex compound with monodentate ligands

D) Internal salt

E) Acisalt

F) Aglycon

G) Diester of phosphoric acid

H) Phosphoric acid ester

a)

B, E, G

b)

В, D, Н

c)

D, G, Н

d)

А, D, G

e)

C, B, Н

42.

The following reaction with the nitroso-R-salt is carried out for… .

a)

stabilization of dosage forms of cyanocobalamin

b)

quantification of cyanocobalamin

c)

determination of impurities of cobalt ions in pharmaceuticals

d)

identification of cobalt ions in the cyanocobalamin molecule

e)

quantification of cobalt salts in combination preparations

43.

The reaction of the formation of perilium salt for the identification of rutin and quercetin is due to the presence of … .

a)

phenolic hydroxyls at positions С5,7

b)

phenyl radical at position С2

c)

rhamnose residue in position С3

d)

residual glucose in position С3

e)

keto groups and double bonds in the γ-pyrone cycle

44.

Fehling's reaction to identify rutin is due to the presence of ... .

a)

oxygen atom in position С4

b)

phenyl radical at position С2

c)

residue of rhamnose and glucose in position С3

d)

double bond in positions 2,3

e)

phenolic hydroxyls at positions С5,7

45.

The cyanine chloride formation reaction for the identification of rutin and quercetin is due to the presence … .

a)

phenyl radical at position С2

b)

keto group and double bonds in the γ-pyrone cycle

c)

residue of rhamnose in position С3

d)

residue of glucose in position С3

e)

phenolic hydroxyls at positions С5,7

46.

The following reaction of … formation is recommended for the identification of rutin.

a)

cyanine chloride

b)

thiochrome

c)

murexid

d)

eriochrome

e)

talleyoquine

47.

The quantitative determination of nicotinic acid in accordance with the chemistry of reactions given below is carried out by the … method.

a)

direct iodometry

b)

photoelectrocolorimetry

c)

gravimetry

d)

cuprimetry

e)

reverse iodometry

48.

The chemical properties of pyridoxal phosphate are due to the presence of … :

A) Phenolic hydroxyl B) Benzene nucleus C) Aldehyde group D) Azomethine group E) Mercapto groups F) Nitrogen and phosphorus atoms G) Nitro groups H) Amino groups

a)

В, C, Е

b)

B, D, Е

c)

А, C, F

d)

С, E, Н

e)

A, C, Н

49.

The presence of … group in pyridoxal phosphate is detected by reaction of the formation of a Schiff base with phenylhydrazine.

a)

carbonyl

b)

ester

c)

azomethine

d)

aldehyde

e)

carboxyl

50.

By the method of anhydrous neutralization according to the reaction below, the quantitative content of … is determined.

a)

papaverine hydrochloride

b)

quinine hydrochloride

c)

pyridoxine hydrochloride

d)

drotaverine hydrochloride

e)

epinephrine hydrochloride

51.

The unknown drug is a white crystalline powder, readily soluble in water, slightly soluble in ethanol, and melts with decomposition. Found a specific impurity 5-hydroxymethyl-2,4-dimethylpyridin-3-ol.

Which drug should be used for specific authenticity?

a)

Papaverine hydrochloride

b)

Drotaverine hydrochloride

c)

Pyridoxine hydrochloride

d)

Ticlodipine hydrochloride

e)

Diphenyltropine hydrochloride

52.

To identify drugs, pyrimidino-thiazole derivatives the … reaction is used.

a)

murexid test

b)

thaleyoquin test

c)

thiochromic test

d)

hydroxamic sample

e)

cyanine sample

53.

The chemical formula below corresponds to the medicinal product … .

a)

benfotiamine

b)

cocarboxylase

c)

thiamine bromide

d)

phosphotiamine

e)

bromocriptine

54.

The unknown drug substance is a yellow-orange crystalline powder with a weak specific odor and bitter taste. The aqueous solution of the drug has a bright greenish-yellow color and intense green fluorescence when viewed under UV light.

Which drug should be used for additional tests of authenticity?

a)

Riboflavin

b)

Furagin

c)

Furacilin

d)

Rutin

e)

Quinosol

55.

The Malaprade reaction consists in the oxidation of the ribityl fragment of the riboflavin molecule under the action of ... .

a)

potassium bromide

b)

potassium permanganate

c)

potassium periodate

d)

ammonium persulfate

e)

potassium dichromate

56.

The optical activity of riboflavin is due to the presence of … .

a)

tertiary nitrogen atoms

b)

double bonds in positions N1-C10 and C11-N12

c)

ribose residue in position С9

d)

secondary nitrogen atom in position С3

e)

methyl groups

57.

Riboflavin mononucleotide is distinguished from other structural analogs by its reaction to the … .

a)

benzene cycle

b)

tertiary nitrogen atoms

c)

secondary nitrogen atom

d)

phosphates after mineralization

e)

ribose residue

58.

A dry purified extract of licorice root with a content of the main active substance - glycyrrhizic acid at least 80% is ... .

a)

validol

b)

glyderinin

c)

glycyram

d)

bioslastin

e)

cordiamine

59.

Glycyram belongs to derivatives of … .

a)

monocyclic diterpenoids

b)

bicyclic terpenoids

c)

pentacyclic triterpenoids

d)

bicyclic tetraterpenoids

e)

tricyclic sesquiterepnoids

60.

The quantitative determination of thyroidin is carried out by organically bound iodine by the … method.

a)

iodometry after mineralization

b)

Kjeldahl

c)

Belstein

d)

nitritometry

e)

argentometry after mineralization

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