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Worksheets

Med Chem - Bioenergetics

Total questions: 69

Worksheet time: 38mins

Name
Class
Date
1.

Which of the following characterizes anabolic processes?

a)

breaking down large molecules into smaller components

b)

an endergonic process (energy utilizing)

c)

oxidative

d)

convergent to Acetyl-CoA

2.

Which of the following processes is reductive?

a)

Anabolism

b)

Catabolism

3.

Which of the following processes is oxidative?

a)

Anabolism

b)

Catabolism

4.

Which of the following describes the synthesis of large molecules from smaller precursors (amino acids, sugars, nitrogenous bases, etc.)?

a)

Anabolism

b)

Catabolism

c)

Metabolism

d)

Cannibalism

5.

Which of the following describes the process of breaking down large, complex molecules (proteins, DNA, etc.) into smaller ones?

a)

Anabolism

b)

Catabolism

c)

Metabolism

d)

Cannibalism

6.

Which of the following characterizes catabolic processes?

a)

oxidative

b)

building up large molecules from smaller precursor molecules

c)

divergent from Acetyl-CoA

d)

endergonic (energy utilizing)

7.

Which of the following describes various intermediates created during metabolic processes?

a)

Acetyl-CoA

b)

Enzymes

c)

Free Radicals

d)

Metabolites

8.

Reactions that form or break C-C bonds often involve:

a)

Alcohols

b)

Carbonyl groups

c)

Nitrogen

d)

Thiols

9.

The most common reactions in biochemistry include:

a)

C-C bond breakage or formation

b)

Isomerizations

c)

Group Transfers

d)

Oxidation/Reduction

e)

Free Radical Reactions

10.

Which is the mechanism for biochemical isomerization?

a)

Covalent catalysis

b)

Acid-Base catalysis

c)

Metal ion catalysis

11.

What is another term for group transfer?

a)

Claisen Condensation

b)

Glycolysis

c)

Nucleophilic Substitution

d)

Heterolytic Cleavage

12.

Isomerization of Glucose 6-Phosphate is performed by which enzyme:

a)

Hexokinase

b)

Phosphohexose isomerase

c)

1,3 Bisphosphoglycerate

d)

Dr. Ilies

13.

Isomerization of glucose 6-phosphate forms:

a)

Fructose 6-phosphate

b)

1,3-Bisphosphoglycerate

c)

A tetrahedral intermediate

d)

ATP

14.

Which of the following is an important leaving group in many biochemical reactions?

a)

Hydroxyl group

b)

X

c)

Inorganic Phosphate

d)

Mg2+

15.

When delta G is negative, Keq is:

a)

positive

b)

negative

c)

0

d)

1

16.

When delta G is zero, Keq is:

a)

positive

b)

negative

c)

0

d)

1

17.

When delta G is positive, Keq is:

a)

positive

b)

negative

c)

0

d)

1

18.

"Normal conditions" in biochemistry are (check all that apply):

a)

ph = 7

b)

[H2O] = 55.5 M

c)

[Mg2+] = 1mM

19.

Cells change the concentration of reagents to influence delta G

a)

True

b)

False

20.

A linear increase in delta G will cause a linear change in Keq

a)

True

b)

False

21.

1,3-Bisphosphoglycerate is (a)   ; inorganic phosphate is the leaving group; 3-Phosphoglyceric acid is produced.

22.

The free energy change for ATP hydrolysis is _____ and _____

a)

small, positive

b)

small, negative

c)

large, positive

d)

large, negative

23.

Phosphocreatine is found in:

a)

muscles

b)

skin

c)

bones

d)

CSF

24.

ATP provides energy for reaction by:

a)

group transfer

b)

hydrolysis

c)

osmosis

d)

elimination

25.

Which ion shields negative charges in ATP and ADP?

a)

Mg2+

b)

Ca2+

c)

K+

d)

PO43-

26.

Why does ATP "like" to lose its terminal phosphate?

a)

the phosphate groups near each other experience charge repulsion

b)

phosphate is stabilized by resonance in its ionized form

c)

products are more easily solvated and therefore more stable

d)

ionization

e)

the products of ATP hydrolysis are more stable than ATP

27.

Which type of enzyme is responsible for transfer of phosphate groups from one molecule to another?

a)

kinases

b)

oxidoreductases

c)

isomerases

d)

ligases

28.

ATP is versatile because it can donate phosphoryl, pyrophosphate, or adenylyl groups

a)

True

b)

False

29.

The energy for DNA or RNA polymerization comes from:

a)

breaking of phosphoanhydride bonds of nucleotide triphosphates (NTP)

b)

phosphohexose isomerase

c)

ATP

d)

NADH

30.

Creatine kinase is an enzyme that can:

a)

Phosphorylate NDP to produce NTP

b)

Hydrolyze Acetyl-CoA

c)

Produce ATP from ADP and phosphocreatine in muscles

d)

Hydrolyze phosphoenol pyruvate

31.

ATP4- + H2O ---> ADP3- + Pi2- + H+

a)

ΔG = -30.5 kJ/mol

b)

ΔG = -61.9 kJ/mol

c)

ΔG = -49.3 kJ/mol

d)

ΔG = -32.2 kJ/mol

32.

Phosphoenol pyruvate (PEP) + H2O ---> pyruvate + Pi2-

a)

ΔG = -30.5 kJ/mol

b)

ΔG = -69.1 kJ/mol

c)

ΔG = -49.3 kJ/mol

d)

ΔG = -43 kJ/mol

33.

1,3 Bisphosphoglycerate + H2O ---> 3-Phosphoglycerate + Pi2- + H+

a)

ΔG = -61.9 kJ/mol

b)

ΔG = -49.3 kJ/mol

c)

ΔG = -43 kJ/mol

d)

ΔG = -32.2 kJ/mol

34.

Phosphocreatine + H2O ---> creatine + Pi2-

a)

ΔG = -30.5 kJ/mol

b)

ΔG = -61.9 kJ/mol

c)

ΔG = -43 kJ/mol

d)

ΔG = -49.3 kJ/mol

35.

Acetyl-CoA + H2O ---> Acetate+ CoASH + H+

a)

ΔG = -30.5 kJ/mol

b)

ΔG = -61.9 kJ/mol

c)

ΔG = -43 kJ/mol

d)

ΔG = -32.2 kJ/mol

36.

Low energy compounds donate phosphate groups to higher energy compounds

a)

True

b)

False

37.

Reduction is:

a)

Gain of electrons

b)

Loss of electrons

c)

Addition of H

d)

Addition of O

38.

Oxidation is:

a)

Gain of electrons

b)

Loss of electrons

c)

Addition of H

d)

Addition of O

39.

Hydrogenation = reduction

a)

True

b)

False

40.

Hydrogenation = Oxidation

a)

True

b)

False

41.

Dehydrogenation = reduction

a)

True

b)

False

42.

Dehydrogenation = oxidation

a)

True

b)

False

43.

A common scheme of oxidation in biochemical pathways is dehydrogenation --> hydration --> dehydrogenation

a)

True

b)

False

44.

Oxidation and reduction are independent of each other

a)

True

b)

False

45.

E'° denotes:

a)

activation energy

b)

affinity of an enzyme for its substrate

c)

free energy exchange

d)

standard reduction potential

46.

A more positive E'° indicates:

a)

A stronger oxidizing agent

b)

A stronger reducing agent

c)

Greater tendency to accept electrons

d)

Greater tendency to lose electrons

47.

A more negative E'º indicates:

a)

A stronger oxidizing agent

b)

A stronger reducing agent

c)

Greater tendency to gain electrons

d)

Greater tendency to lose electrons

48.

The unit of E'° is measured in:

a)

Joules

b)

calories

c)

volts

d)

kilocalories

49.

When ΔG is < 0, ΔE must be:

a)

> 0

b)

< 0

c)

1

d)

100

50.

Pellagra (rough skin) causes dermatitis, dementia, and diarrhea. It is a condition caused by:

a)

excess vitamin D

b)

lack of niacin

c)

lack of riboflavin

d)

excess glucose

51.

When ATP is very low in muscle cells, ATP can be generated from Phosphocreatine and ADP

a)

True

b)

False

52.

Which of the following reactions are transphosphorylations?

a)

ATP + NDP ---> ADP + NTP

b)

2ADP ---> ATP + AMP

c)

ADP + PCr (Phosphocreatine) ---> ATP + Cr

d)

Glucose 6-phosphate --> Fructose 6-phosphate

53.

We can use any higher energy phosphogen than the one that we want to make because the ΔG for that reaction will be negative

a)

True

b)

False

54.

Which of these is the highest energy phosphogen?

a)

Phosphoenol pyruvate (PEP)

b)

ATP

c)

Phosphocreatine

d)

1,3-Bisphosphoglycerate

55.

Phosphoenol pyruvate (PEP) is _________ compared to 1,3-Bisphosphoglycerate

a)

higher energy

b)

lower energy

56.

ATP is ________ compared to Phosphocreatine

a)

higher energy

b)

lower energy

57.

1,3-Bisphosphoglycerate is ________ compared to ATP

a)

higher energy

b)

lower energy

58.

Which of the following is most oxidized?

a)

Acetaldehyde

b)

Acetic Acid

c)

Carbon Dioxide

d)

Ethanol

59.

Which of the following is most reduced?

a)

Ethane

b)

Ethanol

c)

Acetic acid

d)

Carbon dioxide

60.

Which type of enzyme catalyzes redox reactions?

a)

Kinases

b)

Dehydrogenases

c)

Isomerases

d)

Ligases

61.

NAD+ and FAD are:

a)

enzymes

b)

pointless

c)

specialized cofactors that accept protons and electrons during redox reactions

62.

Electrons can be transferred in which of the following forms?

a)

as hydride ions (:H-)

b)

as hydrogen atoms (H·)

c)

directly e-

d)

H+ + 2e-

e)

H+ + e-

63.

Which type of enzyme uses NAD+ and FAD cofactors?

a)

Dehydrogenases

b)

Ligases

c)

Isomerases

d)

Kinases

64.

NADH + H+ + FMN ---> NAD+ + FMNH2

a)

NADH is oxidized

b)

NADH is reduced

c)

FMN is oxidized

d)

FMN is reduced

65.

NADH + H+ + FMN ---> NAD+ + FMNH2


For NAD+/NADH, E° = -0.32

For FMN/FMNH2, E° = -0.22


ΔG is:

a)

positive

b)

negative

c)

0

d)

1

66.

Oxygen's standard reduction potential (Eº) is _______ making it a _______

a)

highly positive, strong reducer

b)

highly positive, strong oxidizer

c)

highly negative, strong reducer

d)

highly negative, strong oxidizer

67.

Nicotinamide is biosynthesized from

a)

NADH

b)

riboflavin

c)

biotin

d)

niacin

68.

Ariboflavinosis is characterized by angular cheilitis, itchy eyes, light sensitivity, dermatitis, and anemia. It is caused by:

a)

Lack of riboflavin

b)

Lack of niacin

c)

Lack of protein

d)

Excess glucose

69.

Riboflavin is found in nuts, cereal, milk, eggs, lean meat, and green leafy vegetables. It is also known as:

a)

Vitamin B12

b)

Vitamin B6

c)

Vitamin B2

d)

Vitamin B1