WorksheetsMed Chem - Bioenergetics
Total questions: 69
Worksheet time: 38mins
Which of the following characterizes anabolic processes?
breaking down large molecules into smaller components
an endergonic process (energy utilizing)
oxidative
convergent to Acetyl-CoA
Which of the following processes is reductive?
Anabolism
Catabolism
Which of the following processes is oxidative?
Anabolism
Catabolism
Which of the following describes the synthesis of large molecules from smaller precursors (amino acids, sugars, nitrogenous bases, etc.)?
Anabolism
Catabolism
Metabolism
Cannibalism
Which of the following describes the process of breaking down large, complex molecules (proteins, DNA, etc.) into smaller ones?
Anabolism
Catabolism
Metabolism
Cannibalism
Which of the following characterizes catabolic processes?
oxidative
building up large molecules from smaller precursor molecules
divergent from Acetyl-CoA
endergonic (energy utilizing)
Which of the following describes various intermediates created during metabolic processes?
Acetyl-CoA
Enzymes
Free Radicals
Metabolites
Reactions that form or break C-C bonds often involve:
Alcohols
Carbonyl groups
Nitrogen
Thiols
The most common reactions in biochemistry include:
C-C bond breakage or formation
Isomerizations
Group Transfers
Oxidation/Reduction
Free Radical Reactions
Which is the mechanism for biochemical isomerization?
Covalent catalysis
Acid-Base catalysis
Metal ion catalysis
What is another term for group transfer?
Claisen Condensation
Glycolysis
Nucleophilic Substitution
Heterolytic Cleavage
Isomerization of Glucose 6-Phosphate is performed by which enzyme:
Hexokinase
Phosphohexose isomerase
1,3 Bisphosphoglycerate
Dr. Ilies
Isomerization of glucose 6-phosphate forms:
Fructose 6-phosphate
1,3-Bisphosphoglycerate
A tetrahedral intermediate
ATP
Which of the following is an important leaving group in many biochemical reactions?
Hydroxyl group
X
Inorganic Phosphate
Mg2+
When delta G is negative, Keq is:
positive
negative
0
1
When delta G is zero, Keq is:
positive
negative
0
1
When delta G is positive, Keq is:
positive
negative
0
1
"Normal conditions" in biochemistry are (check all that apply):
ph = 7
[H2O] = 55.5 M
[Mg2+] = 1mM
Cells change the concentration of reagents to influence delta G
True
False
A linear increase in delta G will cause a linear change in Keq
True
False
1,3-Bisphosphoglycerate is (a) ; inorganic phosphate is the leaving group; 3-Phosphoglyceric acid is produced.
The free energy change for ATP hydrolysis is _____ and _____
small, positive
small, negative
large, positive
large, negative
Phosphocreatine is found in:
muscles
skin
bones
CSF
ATP provides energy for reaction by:
group transfer
hydrolysis
osmosis
elimination
Which ion shields negative charges in ATP and ADP?
Mg2+
Ca2+
K+
PO43-
Why does ATP "like" to lose its terminal phosphate?
the phosphate groups near each other experience charge repulsion
phosphate is stabilized by resonance in its ionized form
products are more easily solvated and therefore more stable
ionization
the products of ATP hydrolysis are more stable than ATP
Which type of enzyme is responsible for transfer of phosphate groups from one molecule to another?
kinases
oxidoreductases
isomerases
ligases
ATP is versatile because it can donate phosphoryl, pyrophosphate, or adenylyl groups
True
False
The energy for DNA or RNA polymerization comes from:
breaking of phosphoanhydride bonds of nucleotide triphosphates (NTP)
phosphohexose isomerase
ATP
NADH
Creatine kinase is an enzyme that can:
Phosphorylate NDP to produce NTP
Hydrolyze Acetyl-CoA
Produce ATP from ADP and phosphocreatine in muscles
Hydrolyze phosphoenol pyruvate
ATP4- + H2O ---> ADP3- + Pi2- + H+
ΔG = -30.5 kJ/mol
ΔG = -61.9 kJ/mol
ΔG = -49.3 kJ/mol
ΔG = -32.2 kJ/mol
Phosphoenol pyruvate (PEP) + H2O ---> pyruvate + Pi2-
ΔG = -30.5 kJ/mol
ΔG = -69.1 kJ/mol
ΔG = -49.3 kJ/mol
ΔG = -43 kJ/mol
1,3 Bisphosphoglycerate + H2O ---> 3-Phosphoglycerate + Pi2- + H+
ΔG = -61.9 kJ/mol
ΔG = -49.3 kJ/mol
ΔG = -43 kJ/mol
ΔG = -32.2 kJ/mol
Phosphocreatine + H2O ---> creatine + Pi2-
ΔG = -30.5 kJ/mol
ΔG = -61.9 kJ/mol
ΔG = -43 kJ/mol
ΔG = -49.3 kJ/mol
Acetyl-CoA + H2O ---> Acetate+ CoASH + H+
ΔG = -30.5 kJ/mol
ΔG = -61.9 kJ/mol
ΔG = -43 kJ/mol
ΔG = -32.2 kJ/mol
Low energy compounds donate phosphate groups to higher energy compounds
True
False
Reduction is:
Gain of electrons
Loss of electrons
Addition of H
Addition of O
Oxidation is:
Gain of electrons
Loss of electrons
Addition of H
Addition of O
Hydrogenation = reduction
True
False
Hydrogenation = Oxidation
True
False
Dehydrogenation = reduction
True
False
Dehydrogenation = oxidation
True
False
A common scheme of oxidation in biochemical pathways is dehydrogenation --> hydration --> dehydrogenation
True
False
Oxidation and reduction are independent of each other
True
False
E'° denotes:
activation energy
affinity of an enzyme for its substrate
free energy exchange
standard reduction potential
A more positive E'° indicates:
A stronger oxidizing agent
A stronger reducing agent
Greater tendency to accept electrons
Greater tendency to lose electrons
A more negative E'º indicates:
A stronger oxidizing agent
A stronger reducing agent
Greater tendency to gain electrons
Greater tendency to lose electrons
The unit of E'° is measured in:
Joules
calories
volts
kilocalories
When ΔG is < 0, ΔE must be:
> 0
< 0
1
100
Pellagra (rough skin) causes dermatitis, dementia, and diarrhea. It is a condition caused by:
excess vitamin D
lack of niacin
lack of riboflavin
excess glucose
When ATP is very low in muscle cells, ATP can be generated from Phosphocreatine and ADP
True
False
Which of the following reactions are transphosphorylations?
ATP + NDP ---> ADP + NTP
2ADP ---> ATP + AMP
ADP + PCr (Phosphocreatine) ---> ATP + Cr
Glucose 6-phosphate --> Fructose 6-phosphate
We can use any higher energy phosphogen than the one that we want to make because the ΔG for that reaction will be negative
True
False
Which of these is the highest energy phosphogen?
Phosphoenol pyruvate (PEP)
ATP
Phosphocreatine
1,3-Bisphosphoglycerate
Phosphoenol pyruvate (PEP) is _________ compared to 1,3-Bisphosphoglycerate
higher energy
lower energy
ATP is ________ compared to Phosphocreatine
higher energy
lower energy
1,3-Bisphosphoglycerate is ________ compared to ATP
higher energy
lower energy
Which of the following is most oxidized?
Acetaldehyde
Acetic Acid
Carbon Dioxide
Ethanol
Which of the following is most reduced?
Ethane
Ethanol
Acetic acid
Carbon dioxide
Which type of enzyme catalyzes redox reactions?
Kinases
Dehydrogenases
Isomerases
Ligases
NAD+ and FAD are:
enzymes
pointless
specialized cofactors that accept protons and electrons during redox reactions
Electrons can be transferred in which of the following forms?
as hydride ions (:H-)
as hydrogen atoms (H·)
directly e-
H+ + 2e-
H+ + e-
Which type of enzyme uses NAD+ and FAD cofactors?
Dehydrogenases
Ligases
Isomerases
Kinases
NADH + H+ + FMN ---> NAD+ + FMNH2
NADH is oxidized
NADH is reduced
FMN is oxidized
FMN is reduced
NADH + H+ + FMN ---> NAD+ + FMNH2
For NAD+/NADH, E° = -0.32
For FMN/FMNH2, E° = -0.22
ΔG is:
positive
negative
0
1
Oxygen's standard reduction potential (Eº) is _______ making it a _______
highly positive, strong reducer
highly positive, strong oxidizer
highly negative, strong reducer
highly negative, strong oxidizer
Nicotinamide is biosynthesized from
NADH
riboflavin
biotin
niacin
Ariboflavinosis is characterized by angular cheilitis, itchy eyes, light sensitivity, dermatitis, and anemia. It is caused by:
Lack of riboflavin
Lack of niacin
Lack of protein
Excess glucose
Riboflavin is found in nuts, cereal, milk, eggs, lean meat, and green leafy vegetables. It is also known as:
Vitamin B12
Vitamin B6
Vitamin B2
Vitamin B1
