Font size
WorksheetsActual Patho Final
Total questions: 101
Worksheet time: 57mins
What disease category best describes involvement of elements from both the mind and body?
Iatrogenic
Psychological
Psychosomatic
Nosocomial
What type of necrosis is indicative of TB associated infection?
Caseous
Liquefactive
Gangrenous
Fibrinoid
Coagulative
What is considered one of the leading health behavior risk factors in the United States reported by the CDC?
Excessive exercise
Peppermint Schnapps
Tobacco Use
Constipation
What is the most common site of cancer for females in the United States?
Breast
Uterus
Ovaries
Cervix
What two cell types produce prostaglandins?
Mast cells
Macrophages
Endothelial cells
Leukocytes
What is the number one pathologic concern for uncontrolled hyperplasia?
Increased risk of edema
Increased risk of malignancy
Increased risk of necrosis
Increased risk of infarction
What are the two current leading causes of death in the United States?
Heart Disease
Diabetes
Obesity
Cancer
What is a common factor associated with aging cells?
Accumulation of mutations in DNA
Loss of telomeres
Accumulation of free radicals
Loss of function
What term best describes a transformation of one differentiated cell type to another differentiated cell type?
Hyperplasia
Metaplasia
Anaplasia
Dysplasia
What disease can be best described as a failure of the body’s immune system to recognize its own cells, forming a cellular attack?
Traumatic
Allergic
Infection
Autoimmune
What type of cellular impairment is most associated with hypoxia and ischemia?
Energy-dependent cellular functions
Oxygen-dependent cellular functions
Energy-independent cellular functions
Oxygen-independent cellular functions
What are considered common intracellular changes seen in cellular injury?
Increased DNA transcription
Increased metabolism
Nuclear alterations such as chromatin clumping
Dilation of the ER
Decreased mitochondrial activity
The complete failure of an organ to develop during embryonic growth and development due to the absence of primordial tissue?
Agenesis
Aplasia
Dysplasia
Hyperplasia
What mediator most commonly causes vasodilation in an acute inflammatory response?
Prostaglandins
Leukotrienes
Histamine
Lipoxins
What term best describes nuclear fragmentation?
Pyknosis
Karyorrhexis
Karyolysis
Cell death associated with the normal cycle of cell replacement or as a protective mechanism of defense when the body recognizes cell defects is called?
Necrosis
Autophagy
Apoptosis
Pyknosis
What is the primary white blood cell found in the tissue that is responsible for phagocytosis of pathogens?
Macrophages
Mast cells
Monocytes
Lymphocytes
What term best describes nuclear shrinkage and increased basophilia?
Pyknosis
Karyorrhexis
Karyolysis
What morphologic characteristic is most consistent with advanced tumor stage?
Hyperplasia
Metaplasia
Anaplasia
Dysplasia
What are anticipated systemic effects of cytokines?
Fever
Hypermetabolic lymphadenopathy
Metabolic abnormalities
Shock
What term best describes the condition resulting from excess transudate or exudate in the tissue or serous cavities?
Anasarca
Edema
Ecchymoses
Something bad
What is the most common site of cancer for males in the United States?
Lungs
Testicles
Liver
Prostate
What cancer has one of the highest mortality rates in the United States?
Lung and bronchial
Breast
Prostate
Skin
What antibody(immunoglobulin) is stimulated with an allergic inflammatory response?
IgE
IgA
IgM
IgG
What type of cirrhosis is most commonly associated with chronic alcoholism?
Micronodular cirrhosis
Macronodular cirrhosis
Macronodular cirrhosis (> 3cm nodules) is most commonly associated with what disease?
Alcoholism
Fungal infections such as Candidiasis
Viral diseases such as Hepatitis
A "cytokine storm" that results from a severe inflammatory response is most likely to attribute to what condition?
Shock
Exsanguination
Reperfusion
Ischemia
What is the incidence of chronic disease in the United States?
1 out of 10
3 out of 10
6 out of 10
9 out of 10
A "guardian" tumor suppressor gene serves what purpose?
It senses genomic d______, causing the cell to either repair DNA or induce a________
(a)
What hormone does Medullary Carcinoma of thyroid secrete?
Triiodothyronine
Tetraiodothyronine
Calcitonin
Dopamine
What type of diabetes results from an absolute deficiency of insulin secretion caused by beta cell destruction?
Type 1
Type 2
What is a severe, advanced form of hypothyroidism that can result in heart enlargement and non-pitting edema?
Subacute Lymphocytic Thyroiditis
Myxedema
Subacute Granulomatous Thyroiditis
Chronic lymphocytic thyroiditis
What appears to be the two constant features in enabling cancer to grow?
Uncontrolled apoptosis
Genetic instability
Cancer promoting inflammation
Radiation
What is the name for the aggressive variant of a corticotroph adenoma of the pituitary gland often diagnosed on a touch smear because of its morphology?
Crooke's Cell Adenoma
Cushing Syndrome
Somatptroph Adenoma
Prolactinoma
What is the most common cause of a thyroid goiter world wide?
Dietary vitamin C deficiency
Dietary vitamin B deficiency
Dietary iron deficiency
Dietary iodine deficiency
Exposure to asbestos fibers presents a risk for what type of lung cancer?
Hamartoma
Mesothelioma
Rhabdomyosarcoma
Leiomyosarcoma
Which of the following are common sites for breast cancer metastasis?
Bone
Brain
Liver
Lung
Spleen
What hormone raises blood calcium levels?
Calcitonin
Parathyroid hormone
What chronic inflammatory process is most associated with enhancing tumor promoters resulting in cancer?
Cystic Fibrosis
Multiple Sclerosis
Asthma
Inflammatory Bowel Disease
Which of the following hormones is secreted by the anterior pituitary gland?
TSH
ACTH
LH and FSH
GH
Prolactin
What is the etiology of Hashimoto thyroiditis?
Multinodular toxic goiter
Autoimmune associated inflammation
Viral infection
Subacute granulomatous
What cells are most abundant in the parathyroid gland?
Chief cells
Oxyphil cells
Fat cells
What specific name is given to a nodular granulomatous lesion associated with TB?
T (a)
What does a “shift to the left” imply?
An accelerated breakdown of red blood cells in the spleen
An accelerated breakdown of white blood cells in the spleen
An accelerated release of white blood cells from the bone marrow
An accelerated release of red blood cells from the bone marrow
What is the most common hyperfunctioning pituitary adenoma?
Somatostatinoma
Prolactinoma/Lactotroph adenoma
Insulinoma
Corticotropinoma
A category 1A carcinogen is a known or presumed carcinogen based on what research?
Human research
Animal research
What is the most common cause of primary hypothyroidism?
An intrinsic abnormality in the production of TSH/Intrinsic malfunction of the thyroid
An intrinsic abnormality in the production of ACTH
An intrinsic abnormality in the production of GH
An intrinsic abnormality in the production of thyroid hormone/Intrinsic malfunction of the thyroid
What is the nomenclature for a malignant tumor of striated muscle?
Leiomyosarcoma
Rhabdomyosarcoma
Chondrosarcoma
Angiosarcoma
What islet cells of the pancreas secrete insulin?
Alpha cells
Beta cells
Delta cells
F/PP cells
What cancer is most associated with radiation exposure?
Leiomyoma
Burkitt Lymphoma
Myeloid leukemia
Chondroma
What tumor is associated with Epstein Bar virus?
Leiomyoma
Burkitt Lymphoma
Myeloid leukemia
Chondroma
What cells of the pancreas synthesize serotonin?
Alpha cells
Beta cells
Enterochromaffin cells
F/PP cells
What is the most common malignancy of the thyroid?
Medullary carcinoma
Follicular cell carcinoma
Papillary cell carcinoma
Medullary adenocarcinoma
What cell type leaves the blood stream and enters the tissue to become a macrophage during an inflammatory response?
Basophil
Monocyte
Eosinophil
Plasma cell
Which of the following situations is most responsible for the permeability of the endothelial lining of blood vessels?
Estrogen
Hemodynamic stress
Vasoactive agents
Emotional stress
Where in the heart do myocardial infarcts have the greatest risk for wall rupture and mural thrombi?
Left anterior wall
Right anterior wall
Left posterior wall
Right posterior wall
What type of myocardial infarcts in general have the greatest risk for conduction blocks and right ventricular involvement?
Left anterior transmural infarcts
Right posterior transmural infarcts
Left posterior transmural infarcts
Right anterior transmural infarcts
What is the elastic membrane called between the intima and the media?
Internal elastic lamina
External elastic lamina
What is the name of retinal hemorrhages associated with infective endocarditis?
Janeway Lesions
Roth Spots
Aschoff Bodies
Amyloid Deposits
What is the greatest risk factor of atrial fibrillation?
Stroke
MI
Bundle Branch Block
Primary electrical disorders
Temporal arteritis can lead to what clinical presentation?
Sudden and temporary blindness
Sudden and permanent blindness
Sudden and temporary deafness
Sudden and permanent deafness
What term best describes the scarring and thinning of the infarcted zones, hypertrophy, and dilation after a myocardial infarction?
Cardiac remodeling
Ventricular remodeling
Atrial remodeling
Myocardial remodeling
What factor is critical is limit endothelial clotting and allow resorption of a clot is tissue repair?
Fibrin
Tissue plasminogen activator
Endothelin
von Willebrand Factor
Which of the following is a common tumor to metastasize to the heart?
Carcinomas of the lung and breast
Mesothelioma
Lymphomas
Melanoma
Leukemias
What pathogen most commonly causes rheumatic valve disease?
Epstein-Barr viral infection
H. pylori
Group A β-hemolytic streptococcal infections
Aspergillus fungal infection
What is Cor Pulmonale?
Left sided heart failure
Right sided heart failure
Pulmonary hypertension
Pulmonary hypotension
What is the number one cause of ischemic heart disease?
Pulmonary hypertension
Systemic hypertension
Amyloidosis
Atherosclerosis
What hormone is released by the adrenal gland in response to angiotensin II to increase blood pressure?
Dopamine
Aldosterone
Epinephrine
Norepinephrine
What is the most common congenital heart defect?
Atrial septal defect
Mitral valve defect
Foramen ovale fails to close
Ventricular septal defect
Transmural infarcts are most common in what clinical setting?
Intermittent vaso spasm
Prolonged total occlusion of an artery
What is the name for infected thrombotic growths on cardiac heart valves?
Cauliflower valves
Papillated Valves
Vegetations
Gross
Where is the most common site to have an MI?
The anterior wall and anterior septum of the left ventricle
The anterior wall and anterior septum of the right ventricle
Where does a saddle embolus occur?
At the bifurcation of the right and left p (a) arteries
What size aneurysm has a 25% chance of rupturing?
Aneurysms 1 cm or greater in size
Aneurysms 2 cm or greater in size
Aneurysms 4 cm or greater in size
Aneurysms 6 cm or greater in size
What vessel would most consistently be occluded in a left lateral wall MI?
Left circumflex artery
Posterior descending artery
Left Anterior Descending artery
Right coronary artery
How are lipid proteins transported in the blood?
The lipid proteins are bound to specific a (a) that form lipoprotein complexes
What are the morphologic features of cholangiocarcinoma?
Lymphovascular invasion
Perineural invasion
Accumulation of bile pigments
Mucin producing adenocarcinomas
What is the outcome of secondary hemostasis?
Deposit of fibrin and formation of platelet plug
Migration of monocytes into the tissue
Dilation of the blood vessel
Release of histamine to fight infection
What term best describes diminished blood flow through the portal venous system that results from obstruction or liver failure?
Pulmonary hypertension
Portal hypertension
Systemic hypertension
Secondary hypertension
What is the most common site to find heterotropic pancreatic tissue?
Small intestine
Large intestine
Esophagus
Stomach
What is the most common cause of biliary obstruction in children?
Biliary atresia
Biliary agenesis
Choledocholithiasis
Cholelithiasis
What is the most common cause of acute pancreatitis?
Biliary atresia
Biliary agenesis
Choledocholithiasis
Cholelithiasis
Which types of viral hepatitis conditions have the highest risk for developing hepatocellular carcinoma?
Hepatitis A (HAV)
Hepatitis B (HBV)
Hepatitis C (HCV)
Hepatitis D (HDV)
Hepatitis E (HEV)
What are considered risk factors in the conversion of a hepatocellular adenoma to hepatocellular carcinoma?
Oral contraceptives
Flinstones chewables
Antihistamines
Anabolic steroids
Which hormones are produced by the endocrine cells of the pancreas?
Serotonin
Insulin
Glucagon
Dopamine
Somatostatin
What is a major type of immune mediated vasculitis?
Viral
Bacterial
Autoimmune
What enzyme is most commonly elevated in the blood in pancreatitis?
Lactase
Amylase
Sucrase
Aromatase
Which of the following is the most common cause of intrahepatic portal vein obstruction worldwide?
Choledocholithiasis
Gastritis
Schistosomiasis
Pancreatitis
What are the most important underlying factors in hepatocarcinogenesis?
Bacterial infection
Viral infection
Autoimmune disorders
Toxic injury
What part of the liver contains large capillaries between plates of hepatocytes that contribute to the central vein, hepatic veins, inferior vena cava?
Lobules
Lobes
Cavities
Sinusoids
What term best describes an accumulation of fat and bilirubin with the hepatic system?
Cholestasis
Choledocholithiasis
Biliary atresia
Cholangitis
What type of autoimmune cholangiopathy presents as a progressive, inflammatory, often granulomatous destruction of small and medium sized intrahepatic bile ducts?
Primary biliary cholangitis
Secondary biliary cholangitis
Primary biliary choladenopathy
Secondary biliary choladenopathy
What is the most common benign neoplasm of the liver?
Hepatocellular carcinoma
Hepatocellular adenoma
Hemangioma
Rhabdomyoma
What is the most common cause of chronic pancreatitis?
Long term opioid use
Long term alcohol abuse
Long term antihistamine use
Long term antibiotic use
What is the most common congenital anomaly of the pancreas?
Pancreas d (a)
A hexagonal division of the liver with a central terminal hepatic vein and peripheral portal tracts best describe what conceptual component of the liver?
Lobe
Lobule
Hepatone
Hepatal trigone
Excess alcohol consumption is known to be a higher risk for what cancers?
Liver
Breast
Oropharyngeal
Lung
What coronary artery is most likely to be occluded in a left posterior wall myocardial infarction?
Left circumflex artery
Posterior descending artery
Left Anterior Descending artery
Right coronary artery
What are contributing factors to atrial fibrillation?
Hypertension
Coronary artery disease
Pulmonary congestion
Cardiomyopathy
Cardiac surgery
What is the name for the cytoplasmic hyaline inclusions of hepatocytes, once thought to be specific for alcoholic hepatitis?
Mallory bodies
Roth spots
Janeway lesions
Balbioni bodies
What are conditions considered to be the root cause of primary liver disease?
Non alcoholic fatty liver disease (NAFLD)
Hepatitis
Alcoholic fatty liver disease (AFLD)
Portal hypertension
Hepatocellular carcinoma (HCC)
