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WorksheetsMCB5252 - Immunology
Total questions: 102
Worksheet time: 5hrs 6mins
Name
Class
Date
1.
Antigens are processed and presented by dendritic cells
a)
True
b)
false
2.
CD4 or CD8 are found on surface of T cells
a)
True
b)
False
3.
Cell-mediated immunity is part of the body's _________ immunity, which is part of the body's _______ line of defense.
a)
Acquired; 3rd
b)
Acquired; 1st
c)
Innate; 2nd
d)
Acquired; 2nd
e)
Innate; 1st
4.
Choose the correctly matched pair.
a)
Primary immune response to infection === long latent period
b)
Secondary immune response to infection === mainly IgM
c)
Primary immune response to infection === long lasting
d)
Secondary immune response to infection === slow acting
5.
Humoral immunity is primarily directed against extracellular pathogens
a)
True
b)
False
6.
Immune cells communincate through which s:
a)
Cytokines
b)
Antibodies
c)
Antigens
d)
Perforins
e)
Complements
7.
Immunity is created when body makes B cells and T cells specific for an antigen. This is an example of:
a)
Active immunity
b)
Passive immunity
c)
Both
d)
Neither
8.
In addition to phagocytosis, macrophages also trigger acute-phase response by releasing compound such as IL-1. IL-1 can trigger:
a)
Fever
b)
Tumoricidal activity
c)
Tissue damage
d)
None of the choices
9.
In the secondary response:
a)
the response is more rapid and large amounts of IgG are produced
b)
the response is more rapid and large amounts of IgM are produced
c)
the response is slower and large amounts of IgM are produced
d)
the response is more rapid but small amount of IgG are produced
e)
the response is slower and large amounts of IgG are produced
10.
Interferons are types of cytokines that are primarily produced in response to:
a)
viral infection
b)
protozoan infection
c)
bacterial infection
d)
fungal infection
11.
Involved in nonspecific defense composed of tightly packed live cells that continuously shed carrying germs away from the internal surfaces
a)
epithelium
b)
mucous Membrane
c)
all of these
d)
epidermis
e)
two of these
12.
Mannose receptors on the surface of macrophages allow these cells to directly bind to surface of bacteria
a)
True
b)
False
13.
Perforin is produced by __________, which results in cell ______.
a)
NK cells , lysis
b)
T cells, division
c)
B cells, maturation
d)
macrophages, division
14.
Respiratory burst is due to increase oxygen uptake by macrophages during phagocytosis
a)
True
b)
False
15.
Superantigens stimulate T cells to proliferate nonspecifically, causing the release of massive quantities of cytokines, which leads to tissue damage
a)
True
b)
False
16.
The Fc portion of an immunoglobulin can interact with complement system and macrophages
a)
True
b)
False
17.
The humoral immune system involves:
a)
the production of antibodies by B cells
b)
the production of antibodies by T cells
c)
T cells that act against foreign cells
d)
the regulation of the immune system
18.
The only class of antibody that can cross the placenta is:
a)
epithelium
b)
IgE
c)
IgM
d)
IgE
e)
IgA
19.
The secondary response:
a)
All answers are correct
b)
Consists of mainly IgG
c)
Reaches a higher titer than primary response
d)
Is the result of re-exposure to an immunogen
e)
Lasts longer than primary response
20.
True or False: NK cells are components of the second line of defense.
a)
True
b)
False
21.
What are the advantages to the immune system?
a)
all of these
b)
kills bacteria and other infectious agents
c)
kills cells infected with intra-cellular pathogens
d)
inactiviates or destroys viruses and toxins
e)
kills cancer cells
22.
What is the major function of B cells?
a)
The secretion of antibodies
b)
To stimulate T cells to produce antibodies to fight infections
c)
To solely circulate in the blood looking for antigens
d)
To act as intercellular mediators or signaling molecules
23.
Which are the main players in cell-mediated immunity?
a)
T-cells
b)
Red blood cells
c)
Complement system
d)
B-cells
e)
Antibodies
24.
Which does NOT pertain to complement system?
a)
It is produced by lymphocytes
b)
It consists of a set of serum proteins that (in a healthy person) circulate in inactive form
c)
It is activated by antibody-antigen complexes
d)
It enhances phagocytosis and lysis of microbes
25.
Which immune-complex coats microbes by serum components in preparation for recognition and ingestion by phagocytic cells?
a)
Opsonization
b)
Complement fixation
c)
Neutralization
d)
Agglutination
26.
Which is NOT a characteristic of B cells?
a)
They are a major part of cell-mediated immunity
b)
They are agranulocytes
c)
They are derived from lymphoid progenitor cells
d)
They are antigen presenting cells (APC)
e)
They display immunoglobulin on their surface
27.
Which is/are true about macrophages?
a)
All of these
b)
They are named according to the tissue in which they reside
c)
They have Fc and TLR receptors
d)
They reside in specific tissues
28.
Which is/are true of passive immunity?
a)
All of these are true of passive immunity
b)
An example of naturally acquired passive immunity is when a pregnant woman passes along her antibodies to the fetus.
c)
Unlike active immunity, passive immunity does NOT have cells which continually produce antibodies.
d)
Passive immunity generally does NOT last as long as active immunity
e)
Passive immunity generally provides immediate protection
29.
Which most accurately describes how cytokines assist helper T cells?
a)
Help spread the message and magnify the immune response
b)
they do NOT assist helper T cells
c)
inhibiting secretion of specific antiviral antibodies
d)
preventing B-cell proliferation
30.
White blood cells play a major role in the innate and specific responses.
a)
True
b)
False
31.
Autoimmunity includes?
a)
natural consequence of aging
b)
All of these
c)
presence of serum antibodies against self-antigens
d)
induced by infectious organisms and drugs
e)
often benign
32.
B-cells originate in the _________ and are activated in the _________.
a)
Thymus; lymph nodes
b)
Bone marrow; lymph nodes
c)
Lymph nodes; thymus
d)
Thymus; bone marrow
e)
Bone marrow; thymus
33.
Cell-mediated immunity involves:
a)
Natural killer cells
b)
Two of these
c)
Cytotoxic T cell
d)
Eosinophills
e)
B cells
34.
Dendritic cells are professional phagocytic cells
a)
True
b)
False
35.
How antibody may be effective against bacterial infection?
a)
opsonization
b)
all choices are correct
c)
block the attachment
d)
promote complement action
e)
neutralize the toxins
36.
Major histocompatibility complex molecules are surface proteins that identify self from non-self. Therefore Class I MHC molecules are found on ____________ cells.
a)
All anucleated
b)
All nucleated
c)
All human
d)
All blood
37.
mmune globulin therapy is an example of what type of immunity?
a)
Passive natural immunity
b)
Passive artificial immunity
c)
Active artificial immunity
d)
Active natural immunity
38.
Natural killer cells most prominent role is in:
a)
intracellular pathogens
b)
more than one of these is correct
c)
cell-mediated immunity
d)
extracellular pathogens
39.
Newborns' immunity due to the transfer of antibodies from the placenta is an example of innate immunity
a)
True
b)
False
40.
NK cells and Tc cells accomplish what in the body?
a)
Produce antibodies to fight infections
b)
kill malignant cells and cells infected with pathogens
c)
De-granulate to induce inflammation
d)
Present antigens to be destroyed by macrophages
41.
The amount of antibody titer produced during the primary response is:
a)
equal to that of the secondary response
b)
less than that of the secondary response
c)
twice as high as that of the secondary response
d)
somewhat greater than that of the secondary response
42.
The first line of nonspecific defense includes which
a)
digestive
b)
all of these
c)
two of these
d)
respiratory
e)
urogenital track
43.
The receptors for Fc portion of antibodies could be found on:
a)
dendritic cells
b)
Macrophages
c)
Helper T cells
d)
IgM
e)
Plasma cells
44.
What is a difference between memory B cells and plasma cells?
a)
Memory B cells are long-lived; plasma cells are short-live
b)
More than one answer is correct.
c)
Memory B cells are short-lived; plasma cells are long-live
d)
Memory B cells do produce antibodies; plasma cells do NOT produce antibodies.
e)
Memory B cells do NOT produce antibodies; plasma cells do produce antibodies.
45.
When an individual is exposed to a pathogen, their body goes through a primary immune response and starts producing antibodies. What type of immunity is this?
a)
Hypersensitive immunity
b)
Active immunity
c)
Passive immunity
d)
Acute immunity
e)
Non-specific immunity
46.
Which does NOT properly describe the secondary response?
a)
B cells undergo an anamnestic response
b)
Mainly IgM
c)
A shorter lag and a more rapid log phase
d)
Occurs after a secondary exposure to the same antigen
47.
Which is NOT a nonspecific defense mechanism
a)
inflammation
b)
antibody
c)
fever
d)
skin
48.
Which is NOT an APC
a)
Macrophages
b)
T cells
c)
All of these are APCs
d)
Dendritic cells
e)
B cells
49.
Which leukocyte is NOT phagocytic?
a)
macrophages
b)
lymphocytes
c)
monocytes
d)
neutrophils
50.
Botulinum antitoxin produced in a horse and given to a human suffering from botulism food poisoning is an example of
a)
Naturally acquired passive immunity
b)
Artificially acquired active immunity
c)
Artificially acquired passive immunity
d)
Naturally acquired active immunity
51.
Cell-mediated immunity provides protection through cellular systems. It provides protection by all EXCEPT:
a)
Getting rid of virus-infected cells
b)
Getting rid of altered self cells
c)
Activating the complement system
d)
Destroying cancerous cells
e)
Killing the intracellular bacteria
52.
How Mycobacterium may resist body defense system?
a)
Survives inside macrophages by neutralizing the hydrolytic enzymes
b)
Develops resistance to lysozyme
c)
Survives inside the macrophages by blocking its fusion with lysosome
d)
Resists phagocytosis by possessing capsule
53.
Immunity acquired by transplacental transfer is called:
a)
artificially acquired passive immunity
b)
naturally acquired active immunity
c)
naturally acquired passive immunity
d)
artificially acquired active immunity
54.
Innate immunity is:
a)
The body's defense mediated by release of antibodies
b)
ANOTher name for humoral immunity
c)
The body's defenses against all kinds of pathogens
d)
Characterized by specificity and memory
55.
Interferon, complements, lysozyme, and membrane attach complex are all examples of
a)
Immune system components produced by white blood cells
b)
Cytokines
c)
nonspecific antimicrobial response factors
d)
Immune system enzymes
e)
Specific antimicrobial response factors
56.
Macrophages are professional phagocytic cells. In addition to ingesting and killing infections agents they are also involved in:
a)
Activating T cells
b)
Producing cytokines
c)
All of these
d)
Killing tumor cells
e)
Inducing inflammatory response
57.
MHC II molecules are found on which cells?
a)
all of these
b)
monocytes
c)
two of these
d)
macrophages
e)
dendrites
58.
The variable region or antigen-binding region is located on:
a)
Fab portion of light chain
b)
Neither light nor the heavy chain
c)
On the Fab portion of both heavy and light chains
d)
Fc region of of both light and heavy chains
e)
Fab portion of heavy chain
59.
What category of immunity best contains NK cells and T cells?
a)
Innate Immunity
b)
These two types of cells are NOT in the same category of immunity.
c)
Acquired/Adaptive immunity
d)
Humoral Immunity
60.
What does the activation of a complement result in?
a)
Strays away phagocytes from the area
b)
destroys membrane
c)
Lyse foreign cells, formation of membrane attack complex
d)
Assists in the formation of DNA
e)
Limits phagocytes in doing their job
61.
Which binds to and destroys the extracellular bacteria
a)
Antigens
b)
Antibodies
c)
Complements
d)
Interferon
e)
Acylovir
62.
Which is NOT a secondary lymphoid organ?
a)
All of these are true.
b)
Spleen
c)
Thymus
d)
Tonsils
63.
Which is true of cell mediated immunity?
a)
It activates B cells in response to extracellular pathogens
b)
It involves the production of antibodies and the formation of memory cells
c)
It activates cytotoxic T and NK cells in response to intracellular pathogens
d)
It involves the production of antibodies within cells to expel intracellular pathogens
e)
It involves the requires the recruitment of cytokines which combat extracellular pathogens
64.
Which is true of opsonins?
a)
Regulate cytokines and recruit other immune cells
b)
Prevent cell lysis by a pathogen
c)
Coat microbial cells to signal for phagocytic recognition
d)
All of these are true of opsonins
e)
Bind to antigens as a way to attract antibodies to the site of infection
65.
Which is true?
a)
More than one of these.
b)
T cells mature in bone marrow.
c)
Examples of lymphocytes include B cells, T cells, and NK cells.
d)
B cells mature in the thymus
e)
None of these.
66.
Which, if any, are both phagocytic and antigen presenting cells (APC)?
a)
Dendritic Cells
b)
Macrophages
c)
Both of these
d)
None of these
67.
All have a role in cell-mediated immunity except:
a)
Helper T cells
b)
NK cells
c)
cytotoxic T cells
d)
All DO have role in CMI
68.
Bacteria can survive phagocytosis by:
a)
Inhibiting phagosome-lysosome fusion
b)
Escaping from the phagosome
c)
Surviving inside the phagosome
d)
All of these
69.
Cross liking between bacterial cell antigens is part of:
a)
neutralization
b)
opsonization
c)
precipitation
d)
agglutination
e)
complement fixation
70.
Immunity following recovery from chickenpox is an example of:
a)
artificially acquired active immunity
b)
naturally acquired passive immunity
c)
artificially acquired passive immunity
d)
naturally acquired active immunity
71.
In addition to Macrophages and Dendritic cells, what other cells are phagocytic cells?
a)
Eosinophils and Basophils
b)
Basophils and Mast cells
c)
Neutrophils and Eosinophils
d)
Monocytes and Neutrophils
72.
T cells and Natural Killer cells target which ?
a)
infected cells
b)
altered cells
c)
cancer cells
d)
all of these
73.
The cellular organelle present in some WBC's responsible for digestion of ingested infectious agents is the
a)
Golgi apparatus
b)
Endoplasmic reticulum
c)
Phagosome
d)
Lysosome
e)
Lysozyme
74.
The complemnt pathway that is activated by an antigen-antibody complex is the
a)
Lectin pathway
b)
Alternate pathway
c)
C3 pathway
d)
Classical pathway
75.
What is Opsonization?
a)
None of these
b)
The process in which host phagocytic cells lyse the membranes of microorganisms.
c)
The process used by microorganisms to prevent phagocytic cells from recognizing antibodies.
d)
The process in which microbes are coated by serum components for recognition by phagocytes
e)
The process used by microorganisms to avoid being coated by serum components of the host.
76.
Which cell classes involve in elimination of virus-infected T cell.
a)
T cells are NOT involved in elimination of infected host (self) cells
b)
Helper T cell
c)
Suppressor T cell
d)
Cytotoxic T cell
e)
Delayed Type Hypersensitivity T cells
77.
Which concerning the functions of complement proteins is false?
a)
may unite the nonspecific and specific arms of the immune system to destroy invading pathogens
b)
lyse foreign cells
c)
formation of membrane attack complex
d)
opsonization which refers to attracting phagocytes to the area
78.
Which is a mis-match
a)
An active infection of a pathogen that you survive--Active acquired natural immunity
b)
Innate immunity--Immunity that you are born with
c)
Drinking of live attenuated polio virus--Active acquired artificial immunity
d)
Artificial passive immunity--An injection of bacteria components
e)
All of these statements match
79.
Which is NOT part of the 1st line of defense?
a)
Mucocilliary blanket
b)
Mucous membranes
c)
Skin
d)
Fever
e)
Naturally-occurring flora
80.
Which is NOT part of the immune system
a)
Lymphocytes
b)
White blood cells
c)
Spleen
d)
Red blood cells
e)
Lymph nodes
81.
Which is NOT part of the skin's role in immunity?
a)
Microbial antagonism
b)
Lysozyme
c)
Acts as a physical barrier
d)
Macrophages
e)
Normal flora
82.
Which is part of the body's first line of defense?
a)
Neutrophils
b)
B-cells
c)
NK cells
d)
Alveolar macrophages
e)
T-cells
83.
Which is true concerning antigen presentation?
a)
Dendritic cells, macrophages, and B cells are all APC's that have MCH Class II molecules
b)
APC's play a very important role in the cell-mediated immunity.
c)
APC's work to stimulate T-helper cells to cause cloning of the cell and proliferation.
d)
All of these are true
84.
Which is true?
a)
Inflammation is associated with dilation of capillaries to allow for increased blood flow to the region affected for a better immune response.
b)
Inflammation is an innate response that is beneficial for the human body to promote healing if it occurs in an acute form.
c)
Chronic inflammation can be dangerous as it can cause permanent tissue damage.
d)
All of these are true.
85.
Which may NOT be found in lymph system?
a)
antigens
b)
antibodies
c)
complement proteins
d)
red blood cells
e)
white blood cells
86.
Which produces hydrolytic enzymes such as lysozyme?
a)
B cells
b)
T cells
c)
Red blood cells
d)
Macrophages
e)
Complement system
87.
A patient's serum is analyzed and found to have an abnormally lower titer of cells with CD8 markers. The physician will tell this patient that he has insufficient number of:
a)
B cells
b)
neutrophiles
c)
helper T cells
d)
macrophages
e)
cytotoxic T cells
88.
Adaptive immunity can assist the host in the following ways (s):
a)
Formation of antibodies
b)
Activation of complement system
c)
Activation of macrophages which destroys pathogens
d)
Killing of infected host cells by cytotoxic T helper cells
e)
All of the above
89.
An increase in eosinophils in a blood count could indicate what?
a)
A viral infection
b)
A bacterial disease
c)
An infection caused by foreign matter
d)
All of these
e)
A parasitic worm infection
90.
Complexes that are found on almost all types of nucleated cells
a)
Two of these
b)
CD11B
c)
CD4
d)
MHCII
e)
MHC I
91.
Epitopes or antigenic determinants are located on
a)
Membrane attach complex
b)
MHC proteins
c)
Antibody
d)
B cells
e)
Antigen
92.
Macrophages are mature ______________ and play a role in ____________________.
a)
Dendritic cells; phagocytosis
b)
Dendritic cells; antigen presentation (APC)
c)
All of these are true.
d)
Monocytes; inflammatory response
e)
Monocytes; antigen presentation (APC)
93.
The complement system directly involves in the defensive responses of an organism by all s EXCEPT:
a)
Lysis of antibody coated bacteria
b)
Lysis of bacteria by directly attaching to the surface of bacteria
c)
Aid with phagocytosis by opsonization
d)
Promote phagocytosis by chemotaxis
e)
Removing extra-cellular bacteria
94.
Traps microbes to prevent transportation to the lungs
a)
Epithelium
b)
mucous membrane
c)
alveolar phagocytes
d)
two of these
e)
mucocillary escalators (blanket)
95.
What is a lysosome?
a)
Organelle found in phagocytic cells used to recognize pathogens
b)
Organelle found in B-cells used to digest pathogens
c)
Organelle found in phagocytic cells used to bind to pathogens
d)
Organelle found in memory cells used to digest pathogens
e)
Organelle found in phagocytic cells used to digest pathogens
96.
Which are found in lymph system?
a)
Complement Proteins
b)
Cytokine
c)
Lymphocytes
d)
Leukocyte
e)
All of these are found in lymph system
97.
Which are functions of the complement proteins?
a)
puncture cell membranes causing cell lysis
b)
unite non-specific and specific arms of the immune system to destroy and remove invading pathogens
c)
chemotactic signals that recruit phagocytes to their activation site
d)
opsinization
e)
all of these
98.
Which DOES NOT apply to macrophages?
a)
They can recognize pathogens and bind to them directly and without help of other immune system components
b)
Their action is enhanced by complement fixation
c)
They are APC and present antigens to Helper T cells
d)
Their action is enhanced by presence of opsonin on bacteria surface
e)
All of these apply to macrophages
99.
Which is a MISMATCH?
a)
Mucous membranes=first line of defense
b)
Fever=second line of defense
c)
Lymphocytes=third line of defense
d)
Phagocytosis=second line of defense
e)
Inflammation=first line of defense
100.
Which releases histamine?<br />
a)
Bashophiles
b)
Neutrophils
c)
Mast Cells
d)
NK Cells
e)
T cells
101.
Which is/are (a) phagocytic cell(s)?<br />
a)
Neutrophils
b)
Plasm cells
c)
Macrophages
d)
Monocytes
102.
The primary lymphoid organs are:
a)
Lymph Node
b)
Bone Marrow
c)
Thymus
d)
Spleen
e)
All of these
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