WorksheetsModule 6 QC Green 100-200
Total questions: 100
Worksheet time: 50mins
Name
Class
Date
1.
The substance being analyzed is the:
a)
a. Titrant
b)
b. Indicator
c)
c. Salt
d)
d. Analyte
2.
In infrared spectrometry, water is not used as solvent for the sample because the water will:
a)
a. Absorb IR radiation
b)
b. Dissolve the sodium chloride cell holder
c)
c. Not dissolve the sample
d)
d. A and B
3.
The law related to spectrometry wherein the power of transmitted light decreases exponentially as the thickness of the solution increases arithmetically is:
a)
a. Charle’s
b)
b. Beer’s
c)
c. Lambert’s
d)
d. Henry’s
4.
The end point in iodimetry using starch TS as indicator is:
a)
a. Blue color
b)
b. Disappearance of blue color
c)
c. Greenish blue color
d)
d. A or C
5.
The type of titration in ultimate assay of alkaloids is:
a)
a. Direct
b)
b. Residual
c)
c. Back
d)
d. B and C
6.
What would be the aldehyde content of peppermint oil if the sample used was 15mL and the insoluble portion as read in the graduated neck of the Cassia flask was 2.2mL? The percentage of aldehyde content is:
a)
a. 85.33
b)
b. 83.33
c)
c. 84.30
d)
d. 14.67
7.
A sample of Magnesia Magma weighing 12.35g was dissolved in 50mL of 1.0340N sulfuric acid and titrated until end point is reached consuming 24.6mL of 1.1255N sodium hydroxide solution. The percentage of MgO content is: At. Wt. of Mg = 24.3: O = 16
a)
a. 3.92
b)
b. 4.0
c)
c. 3.85
d)
d. 3.91
8.
The alcohol content of a volatile oil can be determined by:
a)
a. Bisulfite method
b)
b. Complexation process
c)
c. Acetylization process
d)
d. A and C
9.
The index of refraction of a volatile oil can be determined by:
a)
a. Spectrophotometer
b)
b. Pycnometer
c)
c. Refractometer
d)
d. Polarimeter
10.
Turbidimetric and nephelometric methods of assay are applied to:
a)
a. Suspensions
b)
b. Solutions
c)
c. Colored samples
d)
d. A and B
11.
The adsorbent in the thin layer chromatography may be as follows, except:
a)
a. Alumina
b)
b. Silica gel
c)
c. Calcium oxide
d)
d. Silica gel G
12.
Way to separate the constituents in gravimetric analysis:
a)
a. Neutralization process
b)
b. Physical means
c)
c. Chemical means
d)
d. B and C
13.
Way to obtain the gram equivalent of a substance (GEW) is:
a)
a. Based on the replaceable H+ ion
b)
b. Based on the valence of the cation
c)
c. A or B
d)
d. Based on atomic weight
14.
Expression of concentration in volumetric solutions, except:
a)
a. Normality
b)
b. Titer
c)
c. Molarity
d)
d. Molality
15.
The assay procedures in volumetric precipitation were introduced by the following scientists, except:
a)
a. Arrhenius
b)
b. Mohr
c)
c. Fajan
d)
d. Volhard
16.
The following are characteristics of a product with quality, except:
a)
a. Safe
b)
b. Acceptable
c)
c. Cheap price
d)
d. Effective therapeutically
17.
The terms used when equivalent amounts of each reactant have reacted are the following, except:
a)
a. End point
b)
b. Equivalence point
c)
c. Stoichiometric point
d)
d. Theoretical point
18.
Constant weight in analytical procedures of drying means that consecutive weighing after heating and cooling do not differ by:
a)
a. More than 0.25mg
b)
b. More than 0.50mg
c)
c. More than 0.255mg
d)
d. Not more than 0.75mg
19.
The concentration of an unknown sample in spectrophotometric procedures can be calculated by:
a)
a. Use of Beer’s plot
b)
b. Use of chemical factor
c)
c. Use of mathematical formula using a reference standard data
d)
d. A or C
20.
In thin layer chromatography, finding the spot of the colorless compound in the chromatogram can be done by:
a)
a. Use of sulfuric acid spray to obtain a brown color
b)
b. Use of ultraviolet radiation
c)
c. Use of carbon tetrachloride spray
d)
d. A or B
21.
In paper chromatography, the data needed to compute for Rf value:
a)
a. Distance traveled by the solute
b)
b. Distance traveled by the solvent
c)
c. A and B
d)
d. Distance traveled by the blank
22.
The mobile phase in the gas chromatography is consists of:
a)
a. Alcohol-ethyl acetate mixture
b)
b. Alcohol-chloroform mixture
c)
c. Inert gas
d)
d. A and B
23.
In gas chromatography, the result in the chromatogram is in terms of:
a)
a. Retention on the column
b)
b. Retention of time/volume
c)
c. A and B
d)
d. Volume of sample injected in the column
24.
The components of a blank used in the assay of a substance are, except:
a)
a. Solvent
b)
b. Reagent
c)
c. Indicator
d)
d. Analyte
25.
The purpose of using a combination of indicators is:
a)
a. To attain a sharp end point
b)
b. To facilitate reaction
c)
c. To attain a complete reaction
d)
d. A and B
26.
The purity and strength of chemicals and drugs official in the USP/NF is usually expressed in terms of:
a)
a. Percentage
b)
b. g/mL
c)
c. mg/mL
d)
d. g/L
27.
The gram equivalent of Magnesium oxide (MW = 40.30) is:
a)
a. 0.0403
b)
b. 0.0215
c)
c. 21.15
d)
d. 0.4030
28.
A sample of potassium dichromate (K2Cr2O7) weighing 1.5650g was assayed iodometrically using 26.6mL of 0.1120N sodium thiosulfate. Each mL of 0.1N sodium thiosulfate is equivalent to 49.03mg of K2Cr2O7. The percentage purity of the sample is:
a)
a. 93.50
b)
b. 95.33
c)
c. 93.33
d)
d. 93.40
29.
Nephelometry is based on the measurement of light that is:
a)
a. Refelected
b)
b. Absorbed
c)
c. Transmitted
d)
d. Adsorbed by the particles of a suspension
30.
The infrared region of the spectrometer used to identify a substance has a wavelength range of:
a)
a. 200 – 380 nm
b)
b. 380 – 780 nm
c)
c. 780 – 3000 nm
d)
d. 3 – 15 mm
31.
Flame spectroscopy procedures may be divided into:
a)
a. Flame emission
b)
b. Atomic absorption
c)
c. Nuclear magnetic resonance
d)
d. A and B
32.
The instrument used to measure sodium and potassium ions quantitatively:
a)
a. Colorimeter
b)
b. Refractometer
c)
c. Spectrophotometer
d)
d. Flame photometer
33.
The following are optical methods of analysis, except:
a)
a. Colorimetry
b)
b. Nephelometry
c)
c. Chromatography
d)
d. Spectrophotometry
34.
The calcium and sodium content of the blood can be determined by:
a)
a. Flame spectrometry
b)
b. Nephelometry
c)
c. Colorimetry
d)
d. Turbidimetry
35.
Thiamine is assayed by:
a)
a. Refractometry
b)
b. Potentiometry
c)
c. Colorimetry
d)
d. Fluorimetry
36.
The term given to the functional group of an organic molecule that absorbs maximum radiation in UV or IR region is:
a)
a. Moiety
b)
b. Carbonyl
c)
c. Chromophore
d)
d. Nitrile
37.
Content uniformity test is conducted in:
a)
a. 10 tablets
b)
b. 15 tablets
c)
c. 20 tablets
d)
d. 30 tablets
38.
It is the number of complete cycles that pass a given point per second:
a)
a. Wavelength
b)
b. Spectrum
c)
c. Radiant energy
d)
d. Frequency
39.
The operating speed for paddle in a dissolution apparatus is:
a)
a. 150 rpm
b)
b. 100 rpm
c)
c. 200 rpm
d)
d. 50 rpm
40.
Beer’s plot in spectrometry is prepared to determine:
a)
a. Absorbance of the sample
b)
b. Wavelength to be used
c)
c. Blank
d)
d. Concentration of the sample
41.
The pharmaceutical excipient, which affects the disintegration of a tablet is:
a)
a. Disintegrant
b)
b. Lubricant
c)
c. Filler
d)
d. Colorant
42.
Antibiotics are assayed by:
a)
a. UV-Vis Spectrometry
b)
b. IR
c)
c. NMR
d)
d. Turbidimetry
e)
e. Fluorimetry
43.
USP limit for tablet content uniformity:
a)
a. 90 – 110%
b)
b. 90 – 100%
c)
c. 95 – 105%
d)
d. 85 – 115%
44.
The heart of HPLC and GC:
a)
a. Pumps
b)
b. Injection valve
c)
c. Column
d)
d. Detectors
e)
e. Integrator
45.
Gas chromatography is used in the separation of:
a)
a. Volatile liquids
b)
b. Amino acid
c)
c. Carbohydrates
d)
d. Lipids
e)
e. Carboxylic acid
46.
In TLC, the separation takes place on a planar surface by:
a)
a. Dufferential migration
b)
b. Electrostatic force
c)
c. Relative solubility
d)
d. Capillary action
e)
Any of the above
47.
The separation of the components of an organic dye mixture is accomplished by using:
a)
a. PC
b)
b. TLC
c)
c. HPLC
d)
d. GC
e)
e. Any of the above
48.
This is the primary cause of product instability and involves the addition of oxygen or the removal of hydrogen:
a)
a. Incompatibility
b)
b. Oxidation-Reduction
c)
c. Hydrolysis
d)
d. Racemization
e)
e. Decarboxylation
49.
This is the method of analysis based on the measurement of current resulting from the electrolysis of an electroactive species at a given electrode potential under controlled condition:
a)
a. Potentiometry
b)
b. Polarimetry
c)
c. Polarography
d)
d. Refractometry
e)
e. pH measurement
50.
The most preferred medium in dissolution testing is:
a)
a. Alcohol
b)
b. Acetone
c)
c. Ether
d)
d. Water
e)
e. Benzene
51.
The following are the basic principles behind chromatographic separation, except:
a)
a. Partition
b)
b. Adsorption
c)
c. Absorption
d)
d. Ion-exchange
52.
The stationary phase used in gas chromatography is:
a)
a. Gas
b)
b. Liquid
c)
c. Substrate
d)
d. Cellulose
e)
e. Chromatogram
53.
The most widely used chromatographic method in drug analysis is:
a)
a. GC
b)
b. LLC
c)
c. HPLC
d)
d. SLC
e)
e. TLC
54.
In gas chromatography, the result of the assay is expressed in:
a)
a. Retention on the column
b)
b. Rf value
c)
c. Volume of gas used
d)
d. Adsorbent
e)
e. A and C
55.
In column chromatography, the resulting patterns with several bands is called:
a)
a. Chromatogram
b)
b. Eluate
c)
c. Spectrum
d)
d. Band
e)
e. A and C
56.
Color of phenolphthalein in vinegar:
a)
a. Pink
b)
b. Yellow
c)
c. Colorless
d)
d. Orange
57.
The primary standard used in the standardization of potassium permanganate is:
a)
a. Hydrogen peroxide
b)
b. Sulfuric acid
c)
c. Potassium dichromate
d)
d. Sodium oxalate
58.
An organic compound that changes from one color to another at a certain pH is called:
a)
a. Test solution
b)
b. Standard solution
c)
c. Buffer
d)
d. Indicator
59.
To find the gram equivalent weight of Phosphoric acid, divide its molecular weight by:
a)
a. 1
b)
b. 0
c)
c. 2
d)
d. 3
60.
A combining molecule containing one or more groups that donate electrons will form ____ with a metal.
a)
a. Complex
b)
b. Chelate
c)
c. Sequestering agent
d)
d. Masking agent
61.
A chelate must always contain a/an:
a)
a. Multivalent metal
b)
b. Ethylenediamine group
c)
c. Amine group
d)
d. Triple bond
62.
The assay of Menadione Sodium Sulfate (Vit. K) uses this method of analysis:
a)
a. Gravimetric method
b)
b. Acid base titration
c)
c. Precipitation method
d)
d. Redox titration
63.
In the standardization of HCl using pure anhydrous sodium carbonate as primary standard and methyl orange as indicator, 1.0mL HCl was found to be equivalent to 0.05g of sodium carbonate (MW = 106). The normality of HCl is:
a)
a. 1.0 N
b)
b. 0.94 N
c)
c. 0.4716 N
d)
d. None of the above
64.
An accurately measured sample of hydrogen peroxide 2.00g was dissolved in a mixture of 20mL water and 20mLband 20mL diluted sulfuric acid and was then titrated with 0.100N potassium permanganate consuming 30.0mL to reach the end point. Compute for the percentage of peroxide (MW = 34)
a)
a. 2.55%
b)
b. 5.1%
c)
c. 2.5%
d)
d. None of the above
65.
USP requires not less than 2.5g and not more than 3.5g of hydrogen peroxide /100 parts. Does the sample conforms to the standard requirement?
a)
a. Yes
b)
b. No
c)
c. Maybe
d)
d. Cannot be determined
66.
One twentieth molar solution of sulfuric acid is:
a)
a. 0.05 M
b)
b. 0.1 M
c)
c. 0.005 M
d)
d. 0.5 M
67.
Precipitation method using potassium chromate test solution as indicator and silver nitrate standard solution:
a)
a. Volhard
b)
b. Fajan
c)
c. Mohr
d)
d. None of the above
68.
The titrant most commonly used for direct compleximetry titration is:
a)
a. Zinc sulfate
b)
b. EDTA
c)
c. AgNO3
d)
d. HclO4
69.
The titer value of 1.0mL of 0.1N ceric sulfate for arsenic trioxide (MW = 197.94)
a)
a. 9.496 mg
b)
b. 197.84 mg
c)
c. 9.892 mg
d)
d. 14.838 mg
70.
The masking agent used in the assay of Mg with EDTA in the presence of Al is:
a)
a. Triethanolamine
b)
b. Thioglycol
c)
c. Potassium cyanide
d)
d. Ammonium fluoride
71.
In the assay of ZnO (MW = 81.38), each mL of 1N of H2SO4 is equivalent to ____ of ZnO.
a)
a. 81.38 mg
b)
b. 40.69 mg
c)
c. 27.13 mg
d)
d. 20.34 mg
72.
The substance used to form a film over the precipitated silver chloride particles in Volhard’s method is:
a)
a. Nitric acid
b)
b. Sodium chloride
c)
c. Triethanolamine
d)
d. Nitrobenzene
73.
Assay of Sodium Nitrite is an example of:
a)
a. Neutralization
b)
b. Precipitation
c)
c. Complexation
d)
d. Redox method
74.
Assay of NaCl in table salt by precipitation as AgCl, filtration, drying and weighing the residue is classified as:
a)
a. Direct precipitimetry
b)
b. Volhard’s method
c)
c. Gravimetry
d)
d. Residual precipitimetry
75.
Ceric sulfate is a/an:
a)
a. Precipitating agent
b)
b. Oxidizing agent
c)
c. Reducing agent
d)
d. Complexing agent
76.
The valence number of Mn in KMNO4 is:
a)
a. +2
b)
b. +1
c)
c. +5
d)
d. +7
77.
The apparatus used to wash down drops of standard solution clinging to the tip of the buret is:
a)
a. Bobcock bottle
b)
b. Cassia flask
c)
c. Acetylization flask
d)
d. Wash bottle
78.
An sample of sodium sulfate weighing 1.800g yielded 0.900g of barium sulfate (MW = 233.25). Calculate the percentage of sulfur ( AW = 32.06) in the sample.
a)
a. 12.18%
b)
b. 6.870%
c)
c. 27.48%
d)
d. 30.44%
79.
How many grams of drug are required to make 500 mL of 25.0% solution?
a)
a. 30.0 g
b)
b. 50.0 g
c)
c. 125 g
d)
d. 130 g
80.
The following are methods of determining the end point in precipitimetry, except:
a)
a. Use of adsorption indicators
b)
b. Cessation of precipitation
c)
c. Formation of turbidity
d)
Appearance of turbidity
81.
The reagent that loses the electron/s in a redox reaction is the:
a)
a. Substance that decreases in oxidation number
b)
b. Oxidizing agent
c)
c. Reducing agent
d)
d. Substance reduced
82.
A substance that has a high degree of purity and is used in direct standardization purposes:
a)
a. Technical grade
b)
b. CP grade
c)
c. Any of the answers
d)
Primary standard
83.
The type of assay employed in determining the % ZnO in a sample of Zinc White Powder using EDTA as titrant is:
a)
a. Volhard’s method
b)
b. Direct precipitimetry
c)
c. Direct compleximetry
d)
d. Residual Compleximetry
84.
The experimental way of determining when equivalent amounts of reactants have reacted together is:
a)
a. Titration
b)
b. Stoichiometric point
c)
c. Standardization
d)
d. Equivalence point
85.
Calculate the calcium carbonate content of a sample of chalk weighing 0.2545g and consuming 16.7 mL of 0.1150 M EDTA. At. Wt. Of Ca = 40.08
a)
a. 75.52%
b)
b. 75.50%
c)
c. 37.76%
d)
d. 37.78%
86.
Twenty tablets of ascorbic acid weighed 4.2500g and a powdered sample of 0.3075g was titrated consuming 21.5mL of 0.1085N Iodine solution. Each mL of 0.1N Iodine is equivalent to 8.80mg of ascorbic acid. What is the amount of ascorbic acid per dose of two tablets?
a)
a. 283.72 mg
b)
b. 141.86 mg
c)
c. 283.22 mg
d)
d. A and C
87.
The official USP gravimetric methods are:<br /><br />I. Assay involving direct ignition<br />II. Assay involving sublimation<br />III. Assay involving extraction<br />IV. Assay involving precipitation followed by ignition
a)
a. 1, 3 and 4
b)
b. 2, 3 and 4
c)
c. 1, 2 and 4
d)
d. 1, 2 and 3
88.
Hexane is the best solvent for extracting:
a)
a. Resins
b)
b. Fats
c)
c. Volatile oils
d)
d. Acids
89.
Alkaloidal test solutions include:
a)
a. Valser’s TS
b)
b. Warner’s TS
c)
c. Mayer’s TS
d)
d. Any of the above
90.
How many mL of water is expected from a 20 g Digitalis sample containing 1.5% moisture?
a)
a. 0.3 mL
b)
b. 30 mL
c)
c. 3 mL
d)
d. None of the above
91.
Moisture content in grams:
a)
a. 1.146
b)
b. 1.144
c)
c. 1.164
d)
d. 1.166
92.
Percent moisture:
a)
a. 12.64%
b)
b. 12.46%
c)
c. 12.45%
d)
d. 12.54%
93.
Total ash content in grams:
a)
a. 0.545
b)
b. 0.555
c)
c. 0.554
d)
d. 0.445
94.
Percent total ash:
a)
a. 6.20%
b)
b. 6.02%
c)
c. 6.22%
d)
d. 6.92%
95.
Find the acid value of a sample weighing 1.230 g that consumes 30.0 mL pf 0.110 N NaOH to bring about the end point using KOH in the titration:
a)
a. 150.54 mg/g
b)
b. 157.72 mg/g
c)
c. 109.18 mg/g
d)
d. 124.41 mg/g
96.
During an in-process control testing, the following data were obtained from loss on drying test:<br />Wt. of sample before drying 1.146 g<br />Wt. of tare & sample after drying 25.653 g<br />Wt. of tare 24.632 g<br /><br />What is the weight of moisture lost?
a)
a. 1.021 g
b)
b. 0.125 g
c)
c. 1.125 g
d)
d. 0.021 g
97.
Calculate the water content of an antibiotic powder using 350mg sample. The water equivalence factor (F) of the Karl Fischer reagent is 4.6 and the volume of the reagent used was 9.2 mL. The % of water content is:
a)
a. 12.09%
b)
b. 1.21%
c)
c. 12.11%
d)
d. A and B
98.
Determination of iodine value of oils depends on:
a)
a. Substitution with iodine for the hydrogen in the fatty acid
b)
b. Addition of iodine at the double bond of the fatty acid
c)
c. Oxidation of the fatty acid by iodide
d)
d. All of the above
99.
The soluble constituents of crude drug in a certain solvent:
a)
a. Extractive
b)
b. Ash
c)
c. Crude fiber
d)
d. Phytosterol
100.
In-process specification requires that the percent loss on drying should not exceed 0.65% of the sample weight. Based on the given data below, what is the total amount of moisture?<br /><br />Tare wt. 26.839 g<br />Gross wt. 36.506 g<br />Gross wt. after drying 36.495 g<br />
a)
a. 0.237 g
b)
b. 0.060 g
c)
c. 9.607 g
d)
d. 0.011 g
100 %
