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WorksheetsModule 6 QC Green 200-298
Total questions: 98
Worksheet time: 49mins
Name
Class
Date
1.
A reaction is led to completion by:
a)
a. Formation of ash
b)
b. Formation of insoluble acid
c)
c. Production of slightly ionized molecules
d)
d. All of the above
2.
Karl Fischer electrometric titration is a method used to assay for its:
a)
a. Oxygen content
b)
b. Nitrogen content
c)
c. Carbonate content
d)
d. Water content
3.
The primary standard used to standardize Karl Fischer reagent is:
a)
a. Anhydrous sodium carbonate
b)
b. Potassium bipthalate
c)
c. Sodium tartrate
d)
d. Sodium oxalate
4.
Assay of atropine in Belladonna is an example of:
a)
a. Proximate assay
b)
b. Ultimate assay
c)
c. Both A and B
d)
d. Neither A nor B
5.
Oils with iodine value above 120 are classified as:
a)
a. Non-drying
b)
b. Semi-drying
c)
c. Drying
d)
d. None of the above
6.
If a sample is beeswax is found to have an acid number of 15.5 and a saponification value of 71.2, the ester value of the sample is:
a)
a. 86.7
b)
b. 55.7
c)
c. 90
d)
d. None of the above
7.
The temperature for ignition described as dull red heat is:
a)
a. 500 – 1000 oC
b)
b. 550 – 700 oC
c)
c. 500 – 750 oC
d)
d. 300 – 450 oC
8.
The assay of the aldehyde content of volatile oils may be done by:
a)
a. Extraction
b)
b. Bisulfite method
c)
c. Bobcock method
d)
d. Gravimetric method
9.
Quantitative determinations of alkaloids may be done by:
a)
a. Volumetric
b)
b. Gravimetric
c)
c. Spectrophotometric
d)
d. Any of the above
10.
Calculate percentage of Atropine in Belladonna powder using 10.7 g sample and adding 20 mL of 0.0225N H2SO4 and back titrated with 12.5 mL of 0.0295N NaOH. Each mL of 0.02N H2SO4 is equivalent to 5.788g of Belladona alkaloids in terms of Atropine.
a)
a. 5.60%
b)
b. 0.56%
c)
c. 0.59%
d)
d. 0.22%
11.
Calculate the normality of sulfuric acid solution using 22.15 mL of it. The volume of NaOH used in the standardization was 20.75 mL and its normality was 1.1055.
a)
a. 1.0356
b)
b. 1.3056
c)
c. 1.0035
d)
d. 1.0030
12.
Compute for the iodine value of corn oil 0.2048g dissolved in 10 mL chloroform and 25 mL iodobromide TS was added, mixed and allowed to stand for one hour. Thirty mL of KI TS and 100 mL distilled water were added and titrated with 10 mL of 0.1065 N sodium thiosulfate. The volume of sodium thiosulfate consumed in the blank was 25.7. I is equal to 126.9.
a)
a. 103.61
b)
b. 103.16
c)
c. 101.36
d)
d. 103.66
13.
This is the acceptable tablet hardness range of chewable tablets:
a)
a. 4 – 10 kg
b)
b. 2 – 3 kg
c)
c. 5 – 8 kg
d)
d. 2 – 8 kg
14.
How many samples should be tested if a batch consists of 120 bottles of paracetamol suspension when the square root method is used?
a)
a. 12
b)
b. 11
c)
c. 10
d)
d. 9
15.
In normal phase chromatography:
a)
a. Stationary phase and mobile phase are both polar
b)
b. Stationary phase is nonpolar, mobile phase is polar
c)
c. Stationary phase is polar, mobile phase is nonpolar
d)
d. Stationary phase and mobile phase are both nonpolar
16.
Fats are:
a)
a. Esters of glycerin and fatty acid
b)
b. Polypeptides
c)
c. Compounds of glycerol, fatty acid. Phosphoric acid and choline
d)
d. Steroids with one or more hydroxyl groups
e)
e. Esters of fatty acids with high molecular weight alcohol
17.
Acid insoluble ash is the part of the total ash, which is insoluble in:
a)
a. Dilute nitric acid
b)
b. Acetic acid
c)
c. Dilute sulfuric acid
d)
d. Dilute hydrochloric acid
18.
What would be the accepted weight range of tablets weighing 130mg?
a)
a. 123.5 – 136.5 mg
b)
b. 120.25 - 139.75 mg
c)
c. 117 – 123 mg
d)
d. 120.9 – 139.1 mg
19.
Disintegration test is done at this temperature:
a)
a. 36.5 – 37.5 oC
b)
b. 36 – 37 oC
c)
c. 35 – 39 oC
d)
d. 37 oC
20.
Efficiency of HEPA filters is assessed using:
a)
a. DOP test
b)
b. Water attack test
c)
c. Carr’s index
d)
d. Bubble point test
21.
A concentration expression referring to the number of equivalents of solute per liter of solution is:
a)
a. Normality
b)
b. Molarity
c)
c. Molality
d)
d. Formality
22.
A solution of known concentration used to standardize another solution is:
a)
a. Primary standard
b)
b. Dilute solution
c)
c. Secondary standard
d)
d. B and C
23.
Water attack test is used in this type of glass container:
a)
a. Type I
b)
b. Type II
c)
c. Type III
d)
d. Type III
24.
A person who determines the presence of pyrogens and microorganisms of a pharmaceutical product is performing:
a)
a. Special method
b)
b. Identification test
c)
c. Pharmaceutical assaying
d)
d. Pharmacopoeial test
25.
The process by which the exact concentration of a solution is determined is:
a)
a. Standardization
b)
b. Neutralization
c)
c. Redox
d)
d. Acidimetry
26.
The apparatus used to keep samples free from moisture is:
a)
a. Oven
b)
b. Dessicator
c)
c. Furnace
d)
d. A and C
27.
Materials being controlled by Quality Control, except:
a)
a. Active ingredient
b)
b. Excipients
c)
c. Finished products
d)
d. Packages
28.
To assure stability of the product until expiry date, the label should indicate:
a)
a. Proper storage
b)
b. Proper dosage
c)
c. Proper color
d)
d. Proper drug administration
29.
Neutralization reactions in titrimetric methods of analysis may be:
a)
a. Precipitimetry
b)
b. Alkalimetry
c)
c. Compleximetry
d)
d. A and C
30.
The type of ligand where EDTA belongs;
a)
a. Unidentate
b)
b. Bidentate
c)
c. Hexadentate
d)
d. Tridentate
31.
To remove stains of iodine, the most effective chemical substance is:
a)
a. Calamansi juice
b)
b. Hydrogen peroxide
c)
c. Sodium thiosulfate
d)
d. Sodium hypochlorite
32.
A type of titration where the first titrant is added in excess with the sample and the second titrant reacts with the added excess is:
a)
a. Back
b)
b. Direct
c)
c. Residual
d)
d. A and C
33.
Light scattering method of analysis include/s:
a)
a. Flourometry
b)
b. Turbidimetry
c)
c. Nephelometry
d)
d. B and C
34.
Ferric alum TS is used as indicator in volumetric precipitation method if the titrant is:
a)
a. AgNO3
b)
b. BaCl2
c)
c. NH4SCN
d)
d. NH4Cl
35.
In gravimetric analysis, when the process used in extraction to obtain the original constituent, this method belongs to:
a)
a. Chemical
b)
b. Physical
c)
c. Precipitation
d)
d. Any of the above
36.
To find the milliequivalent factor of a reducing agent, divide its molecular weight by:
a)
a. No. of electrons gained
b)
b. Valence
c)
c. No. of electrons lost
d)
d. Replaceable hydrogen
37.
A spectrophotometer differs from a colorimeter because it consists of:
a)
a. Prism
b)
b. Lamp house
c)
c. Cell compartment
d)
d. Optical scale
38.
Compute for the angle of repose of the sample powder using fixed funnel method if the height and diameter obtained was 5 cm and 13 cm respectively.
a)
a. 37.57o
b)
b. 36.57o
c)
c. 35.75o
d)
d. 36o
39.
Volatile oils are complex compounds composed of:
a)
a. Phenols
b)
b. Inorganic salts
c)
c. Hydrocarbons
d)
d. A and C
40.
The name of originator who introduced the adsorption dyes as an indicator in volumetric precipitation method:
a)
a. Volhard
b)
b. Charles
c)
c. Mohr
d)
d. Fajan
41.
The acid necessary for permanganate titrations is:
a)
a. Acetic acid
b)
b. Sulfuric acid
c)
c. Hydrochloric acid
d)
d. Nitric acid
42.
Using a sampling plan by military standard 105 D, the sample size required is obtained from:
a)
a. Master table
b)
b. Ratio and proportion
c)
c. Samples needed
d)
d. A and B
43.
To control finished products in the warehouse of a company, the distribution practice is:
a)
a. First-in first-out
b)
b. Samples needed
c)
c. Ratio and proportion
d)
d. A and B
44.
The number of retention samples collected by the Quality Control Inspector from the packaging line is:
a)
a. Two times the number required for testing
b)
b. Three labeled containers
c)
c. Not less than two labeled containers
d)
d. Any of A and C
45.
A type of quality control chart based on the number of defectives found is:
a)
a. Go or no-go
b)
b. Variable
c)
c. Attribute
d)
d. A and C
46.
Sources of quality variations are as follows, except:
a)
a. Technician
b)
b. Inadequate procedure
c)
c. Equipment
d)
d. General manager
47.
Acetylation method of analysis in volatile oils is done to determine:
a)
a. Phenol
b)
b. Aldehyde
c)
c. Alcohol
d)
d. Ketone
48.
In spectrometry, when a test solution is prepared and observed identically with a reference standard, they are:
a)
a. Isometric substances
b)
b. Similar solutions
c)
c. Similar preparations
d)
d. B and C
49.
The material used to make the cell holder for infrared analysis are, except:
a)
a. Sodium bromide
b)
b. Potassium bromide
c)
c. Sodium chloride
d)
d. Potassium chloride
50.
Calculate the water content of streptomycin powder weighing 4.20g as sample. The water equivalence factor (F) of the Karl Fischer reagent was found to be 5.1 and the volume consumed was 11.50. The % of water is:
a)
a. 1.39
b)
b. 1.40
c)
c. 1.41
d)
d. 13.96
51.
The Karl Fischer reagent used for moisture content determination consists of the following except:
a)
a. Pyridine
b)
b. Acetone
c)
c. Sulfur dioxide
d)
d. Iodine
52.
This is the sum of all tests performed to determine the conformance of the product to specifications:
a)
a. Quality control
b)
b. Quality Assurance
c)
c. CGMP
d)
d. A and B
53.
Complex inorganic compounds that are used to determine the end point in titration:
a)
a. Indicators
b)
b. Standard solutions
c)
c. Precipitating agents
d)
d. None of the above
54.
The name of the originator who introduced the use of 0.1N silver nitrate as the titrant and potassium chromate TS as the indicator in volumetric precipitation of chlorides is:
a)
a. Volhard
b)
b. Mohr
c)
c. Fajan
d)
d. Beer
55.
In the assay of ascorbic acid by iodimetry, it acts as:
a)
a. Reducing agent
b)
b. Oxidizing agent
c)
c. Buffer
d)
d. Neutral agent
56.
This is the weight of the substance chemically equivalent to 1 mL of the standard solution:
a)
a. Titrant
b)
b. Equivalence point
c)
c. Titer
d)
d. End point
57.
When a strong acid is titrated against a weak base, the indicator is:
a)
a. Methyl red
b)
b. Phenolphthalein
c)
c. Methyl orange
d)
d. Crystal violet
58.
Residual titration method under EDTA titrations is applied to metal ion:
a)
a. Zinc
b)
b. Calcium
c)
c. Bismuth
d)
d. A and C
59.
The gram equivalent weight of potassium permanganate (MW = 158.03) is:
a)
a. 29.60
b)
b. 31.60
c)
c. 158.03
d)
d. 79.01
60.
Assay method that determines the presence of pyrogens in injectables:
a)
a. Rabbit test
b)
b. Limulus amoebocyte lysate test
c)
c. White mice test
d)
d. A and B
61.
The measurement of a weak base in nonaqueous medium of a given sample by titration with standard perchloric acid:
a)
a. Acidimetry
b)
b. Alkalimetry
c)
c. Compleximetry
d)
d. Redoc titration
62.
This is used for quantitative preparation of a standard solution:
a)
a. Pipet
b)
b. Graduated cylinder
c)
c. Volumetric flask
d)
d. Buret
63.
Which of the following is an oxidizing agent?
a)
a. Ascorbic acid
b)
b. KMNO4
c)
c. Sodium thiosulfate
d)
d. Sodium nitrite
64.
266. The concentration of official diluted alcohol is:
a)
a. 10%
b)
b. 50%
c)
c. 80%
d)
d. 70%
65.
The oxidation number of atomic iodine is:
a)
a. +1
b)
b. +2
c)
c. +4
d)
d. +3
66.
Safety and toxicity tests are conducted for:
a)
a. Plastic tubings
b)
b. Solutions in vial
c)
c. Tablets
d)
d. Oral liquids
67.
The type of ash where sulfuric acid is used to whiten the ash is:
a)
a. Acid-insoluble ash
b)
b. Sulfated ash
c)
c. Loss on ignition
d)
d. Residue on ignition
68.
A sample of 0.1350 g of As2O3 was assayed iodimetrically using 23.4 mL of 0.1055N Iodine solution. The percentage purity of the sample is: At. wt. of As = 74.92; O = 16
a)
a. 90.44
b)
b. 90.23
c)
c. 89.00
d)
d. 90.54
69.
The residue after incineration of a drug was 0.1185 g from a sample of 7.0 g. The percentage of ash is:
a)
a. 1.56
b)
b. 2.56
c)
c. 2.0
d)
d. 1.55
70.
Calculate the amount of caffeine extracted from coffee beans using 1.0215g of the sample. The volume of 0.0252N H2SO4 added to the extract was 25.4 mL, the excess titrated by 21.75 mL of 0.02115N NaOH. Each mL of 0.02 N H2SO4 is equivalent to 3.8858 mg of caffeine (C9H10O2). The percentage of caffeine is:
a)
a. 3.40
b)
b. 3.50
c)
c. 3.42
d)
d. 3.60
71.
If a 0.4600g of potassium iodide (KI) yielded a 0.715g of silver iodide precipitate by gravimetric assay, what would be the percentage purity of KI? At. wt.: Ag = 107.87; K = 39.1; I = 126/9
a)
a. 110.90
b)
b. 110.89
c)
c. 45.08
d)
d. 109.90
72.
Compute for the Rf value of a substance if the substance traveled by the solvent is 12.5 cm and the distance traveled by the sample is 7.5 cm:
a)
a. 0.70
b)
b. 0.60
c)
c. 1.67
d)
d. 1.66
73.
Compute for the percentage loss on ignition of magnesium sulfate hydrated using 3.20 g sample yielding a residue of 2.15g. The loss is:
a)
a. 33.81%
b)
b. 32.98%
c)
c. 32.81
d)
d. 32.75%
74.
If a 0.3800 g sample of sodium sulfate yielded 0.55 g of barium sulfate precipitate by gravimetric assay, what would be the percentage purity of sodium sulfate? At. wt.: Ba = 173.3; S = 32.06; Na = 23; O = 16
a)
a. 88.11
b)
b. 99.94
c)
c. 99.15
d)
d. 88.51
75.
Analysis of substances that fluoresce falls under:
a)
a. Fluorometry
b)
b. Requires UV light
c)
c. Absorbance reading is obtained
d)
d. A and B
76.
An instrument in spectrometry using the filter as radiant energy device:
a)
a. Filter photometer
b)
b. Infrared spectrometer
c)
c. UV – Vis spectrometer
d)
d. Flame photometer
77.
Region in an electromagnetic spectrum:
a)
a. Visible
b)
b. Infrared
c)
c. Ultraviolet
d)
d. All of the above
78.
Cause of quality variation due to men:
a)
a. Fatigue due to overwork
b)
b. Requires high salary
c)
c. Resourceful at work
d)
d. B and C
79.
Acetylene and aldehyde group present in a compound that absorbs radiant energy are called:
a)
a. Chromophore
b)
b. Inactive
c)
c. Inert
d)
d. B and C
80.
The reading that must be obtained in a spectrophotometer:
a)
a. Concentration error
b)
b. Absorbance
c)
c. Retention
d)
d. Angular rotation
81.
The acid used in sulfated ash determination of a crude drug is:
a)
a. Diluted HCl
b)
b. Nitric acid
c)
c. Sulfuric acid
d)
d. Any of the above
82.
Silica from the soil that is left after treatment of the ash with diluted HCl is the:
a)
a. Acid-insoluble ash
b)
b. Sulfated ash
c)
c. Residue on ignition
d)
d. Loss on ignition
83.
The end point in the water content determination using Karl Fischer reagent is determined by:
a)
a. Use of chemical indicator
b)
b. Use of potentiometer or volumeter
c)
c. Use of spectrometer
d)
d. A or B
84.
In microbial assay, the instrumental method used to prepare the inoculum is:
a)
a. Turbidimetry
b)
b. Nephelometry
c)
c. Chromatography
d)
d. A and B
85.
A polarimeter is used whether a substance is:
a)
a. Dextrorotatory
b)
b. Levorotatory
c)
c. Optically active
d)
d. All of the above
86.
A similar preparation in spectrometry refers to:
a)
a. Reference standard and sample identically made
b)
b. Reference standard greater than sample
c)
c. Sample greater than reference standard
d)
d. All of the above
87.
Stoichiometric point in titration means that:
a)
a. Equivalent amounts of the titrant and analyte have reacted.
b)
b. Normality or molarity of the reactants are the same.
c)
c. End point in titration has been reached
d)
d. A and C
88.
In-process control tablets include the following, except:
a)
a. Weight
b)
b. Hardness and thickness
c)
c. Disintegration
d)
d. Bioavailability
89.
Content uniformity test is to be performed for all products whose active ingredient is:
a)
a. 50 mg or less
b)
b. 130 – 134 mg
c)
c. 130 mg or less
d)
d. 324 mg or more
90.
A date limiting the time during which a preparation may be expected to have retained its labeled potency:
a)
a. Shelf life
b)
b. Audit time
c)
c. Expiry date
d)
d. Any of the above
91.
To identify the place where materials have to be stored in a material warehouse, a _____ is pasted on the container of the material.
a)
a. Sticker
b)
b. Label
c)
c. Ribbon
d)
d. None of the above
92.
Caps, bottles, labels and shipping containers are considered as:
a)
a. Active components
b)
b. Drug products
c)
c. Packaging materials
d)
d. None of the above
93.
A ____ is a specific amount produced according to a single manufacturing order during a single period of production.
a)
a. Batch
b)
b. Lot
c)
c. Component
d)
d. None of the above
94.
One batch can be broken into several:
a)
a. Ingredients
b)
b. Lots
c)
c. Components
d)
d. None of the above
95.
The recommended maximum limit for overage of vitamins is:
a)
a. 30%
b)
b. 10%
c)
c. 90%
d)
d. None of the above
96.
______ is the comparing of attributes and dimensions of a product against a standard to find out if the product is within the prescribed limit.
a)
a. Sampling
b)
b. Inspection
c)
c. Analysis
d)
d. Action
97.
A ______ is a definite working rule regarding N, n and c.
a)
a. Sampling plan
b)
b. QC analysis
c)
c. Risk
d)
d. Chart
98.
300. Accelerated stability testing is, except:
a)
a. Performed at higher temperatures to intensify degradation through time
b)
b. Done to determine the shelf life of the product in a short period of time
c)
c. Enough proof of shelf life and need not be further validated
d)
d. The initial method used to determine a product’s shelf life
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