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GLYCOLYSIS AND TCA

Total questions: 45

Worksheet time: 29mins

Name
Class
Date
1.
How many ATP's and NADH does glycolysis produce?
a)
3 ATP and 2 NADH
b)
1 ATP and 1 NADH
c)
2 ATP and 2 NADH
d)
2 ATP and 4 NADH
2.
What will happen if the O2 supply is limited?
a)
Aerobic Glycolysis
b)
Citric Acid Cycle
c)
Anaerobic Cycle
d)
Pyruvate
3.
This reaction of the Citric Acid Cycle converts GDP to GTP and it also frees coenzyme A. What part of the Citric Acid Cycle conversion is this?
a)
Succinate to Succinyl CoA
b)
Succinyl CoA to Succilate
c)
Succilate to Succinyl CoD
d)
Succinyl CoA to Succinate
4.
How many Carbon does oxaloacetate have?
a)
2
b)
4
c)
5
d)
6
5.
What happens during enolase?
a)
Eliminates H2O
b)
Creates H2O
c)
Converts ATP to ADP
d)
Converts ADP to ATP
6.
Which of these enzymes is reversible?
a)
Hexokinase
b)
Phosphofructokinase
c)
Pyruvate kinase
d)
Enolase
7.
How many carbons does oxaloacetate have?
a)
A. 6
b)
B. 2
c)
C. 4
d)
D. 3
8.
Glycolysis occurs in what organelle?
a)
Cytoplasm
b)
nucleus
c)
mitochondria
d)
peroxisome
9.
in which organelle does the krebs cycle takes place?
a)
cytoplasm
b)
nucleus
c)
mitochondria
d)
peroxisome
10.
Where does the "addition of a water molecule rearranges bonds in the substrate" happen in the citric acid cycle?
a)
Succincyl coA -----> Succinate
b)
Citrate -----> Isocirate
c)
Fumarate -----> Malate
d)
Malate -----> Oxaloacetate
11.
Where does Glycolysis occurs?
a)
Ribosomes
b)
Lysosomes
c)
Cytoplasm
d)
Endoplasmic Reticulum
12.
Pyruvate has three (3) fates. Which of the following is NOT a pyruvate fate?
a)
Oxaloacetate
b)
Acetyl CoA
c)
Citrate
d)
Ethanol
13.
In Kreb's cycle, succinate and FADH2 come together to form fumarate. What type of chemical reaction is responsible for this step in the cycle?
a)
Decarboxylation
b)
Isomerization
c)
Dehydration
d)
Oxidation
14.
What protein is used for glucose turning into glucose-6-phosphate?
a)
hexokinase
b)
phosphoglucose isomerose
c)
phosphofructokinase
d)
aldolase
15.
Happens in the presence of oxygen and 2 NADH formed when pyruvate is produced.
a)
Aerobic
b)
Anaerobic
c)
Glycogenesis
d)
Glucokinase
16.
Happens is the curriculum acid cycle where removal of one water molecule and addition of another happens.
a)
Fumurate- Malate
b)
Succinyl CoA- Succinate
c)
Citrate- Isocitrate
d)
Malate- Oxaloacetate
17.
Where does Glycolysis occurs?
a)
Ribosome
b)
Lysosome
c)
Cytoplasm
d)
Endoplasmic Reticulum
18.
In this phase, the starting molecule of glucose gets rearranged, and two phosphate groups are attached to it. The phosphate groups make the modified sugar—now called fructose-1,6-bisphosphate—unstable, allowing it to split in half and form two phosphate-bearing three-carbon sugars.
a)
Harvest Phase
b)
Investment Phase
c)
Energy-releasing Phase
d)
Splitting Phase
19.
What molecule is added to Fumarate to produce the next substance in the TCA cycle?
a)
ATP
b)
NADH
c)
Carbon
d)
H‚ÇÇO
20.
In the glycolysis, Which is not a process of phosphorylation (ATP to ADP)?
a)
Glucose to Glucose-6-Phosphate
b)
1,3-Biphosphate to 3-Phosphoglycerate
c)
Fructose-6-Phosphate to Fructose -1,6-Biphosphate
d)
None of the Above
21.
What was the enzyme needed for Fructose 1,6- bisphosphate to be separated into DHAP and G3P
a)
Enolase
b)
Aldolase
c)
Hexokinase
d)
Dehydrogenase
22.
Which one is NOT part in the Citric Acid Cycle
a)
Citrate
b)
Saratate
c)
Fumarate
d)
Malate
23.
Where in the Kreb's cycle does the removal and addition of H20 takes place?
a)
oxaloacetate-citrate
b)
citrate-isocitrate
c)
dihydroxyacetone - glyceraldehyde 3-phosphate
d)
3-phosphoglycerate - 2-phosphoglycerate
24.
Where does the Citric acid cycle takes place?
a)
Golgi apparatus
b)
Rough endoplasmic reticulum
c)
Mitochondria
d)
Cytoplasm
25.
Where does Kreb Cycle takes place?
a)
matrix of mitochondria
b)
cytoplasm
c)
Golgi apparatus
d)
Ribosomes
26.
What happens if NAH/ NADH decreases, what happens to lactate dehydrogenase?
a)
TCA Cycle
b)
Lactate to Pyruvate
c)
NADH to NAH
d)
Glucose to Pyruvate
27.
What are the two enzymes in glycolysis that catalyze the following reactions: (in order) <br />- fructose 6-phosphate to fructose 1,6-bisphosphate <br />- glucose 6-phosphate to fructose 6-phosphate
a)
hexokinase/glucokinase and phosphoglucoisomerase
b)
phosphofructokinase and phosphohexoisomerase
c)
hexokinase and glucokinase
d)
phosphohexoisomerase and phosophofructokinase
28.
Exceeds Oxidative capacity means?
a)
High Carbohydrates used
b)
Low Carbohydrates used
c)
Low Oxygen used
d)
High Oxygen used
29.
Krebs Cycle produce how many ATP per cycle?
a)
2
b)
3
c)
1
d)
5
30.
What molecule was needed in order for lactic acid/lactate to transform back into pyruvate?
a)
CO2 (Carbon Dioxide)
b)
H2O (Water)
c)
NADH
d)
O2 (Oxygen)
31.
What are the biomolecules?
a)
Galactose, Fates of Pyruvate, Glycolysis, Amino Acid
b)
Epimers, Diasteriomers, Enantiomers
c)
Carbohydrates, Lipids, Nucleic Acids, Protein
d)
Gulose, Arabinose, Xylulose, Psicose
32.
________ are translocated from the cytosol into the mitochondrion by a carrier protein in the mitochondrial membrane.
a)
Biomolecules
b)
Pyruvate molecules
c)
Acetyl CoA
d)
Tricarboxylic acid
33.
What substance is found at the beginning and end of the Krebs cycle?
a)
malate
b)
pyruvate
c)
oxaloacetate
d)
Acetyl-CoA
34.
The reaction of glucose-6-phosphate with the help of which ENZYME is called<br />
a)
phosphoglucose somerose
b)
hexokinase
c)
phospofructokinase
d)
aldolase
35.
this is used in liver and adipose tissue for triglyceride synthesis?
a)
tricarboxylic acid
b)
dihydroxyacetone phosphate
c)
Pyruvate kinase
d)
Glucokinase
36.
Before the pyruvate that has been generated by glycolysis can be oxidized, it must be transported into a mitochondrion. This is accomplished by: ______
a)
Succinyl-CoA
b)
Coenzyme A
c)
Nicotinamide Adenine dinucleotide
d)
Lactic dehydrogensa
37.
What enzyme that rapidly inter-converts the molecules dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P)?
a)
Hexokinase
b)
Phosphohexokinase isomerase
c)
Triosephosphate isomerase
d)
Glyceraldehyde-3-phosphate
38.
It is the primary energy currency of cells and it used to fuel the activities in the entire organism.
a)
NADH
b)
FADH2
c)
ADP
d)
ATP
39.
What is the general term used for the anaerobic degradation of glucose to obtain energy?
a)
Fermentation
b)
Anabolism
c)
Oxidation
d)
Metabolism
40.

The reaction catalyzed by phosphofructokinase-1:

a)

Is activated by high concentrations of ATP and citrate.

b)

Uses fructose 1-phosphate as substrate.

c)

Is the rate-limiting reaction of the glycolytic pathway

d)

Is inhibited by fructose 2,6-bisphosphate.

41.

A 43-year-old man presented with symptoms of weakness, fatigue, shortness of breath, and dizziness. His hemoglobin level was less than 7 g/dl (normal for a male being greater than 13.5 g/dl). Red blood cells isolated from the patient showed abnormally low level of lactate production. A deficiency of which one of the following enzymes would be the most likely cause of this patient’s anemia?

a)

Phosphoglucose isomerase

b)

Phosphofructokinase

c)

Pyruvate kinase

d)

Lactate dehydrogenase

42.

Which of the following statements about the reactions of glycolysis is correct?

a)

In glycolysis glucose-6-phosphate is split into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate

b)

In glycolysis fructose-1:6-bisphosphate is split into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate

c)

In glycolysis fructose-6-phosphate is split into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate

d)

In glycolysis glucose-6-phosphate is isomerized to fructose-1:6-bisphosphate

43.

Which of the following statements about the oxidative decarboxylation of pyruvate is correct?

a)

The oxidative decarboxylation of pyruvate forms Acetyl-CoA which is fed into the citric acid cycle

b)

The oxidative decarboxylation of pyruvate formed in aerobic glycolysis occurs in the cytosol

c)

The oxidative decarboxylation of pyruvate is catalyzed by the enzyme pyruvate decarboxylase

d)

The oxidative decarboxylation of pyruvate is reversible since there is a large decrease of free energy in the reaction

44.

Some bacteria are strict aerobes and others are strict anaerobes. Some bacteria, however, are facultative anaerobes and can live with or without oxygen. If given the choice of using oxygen or not, which should a facultative anaerobe perform?

a)

Use oxygen since aerobic metabolism provides more ATP per molecule of carbohydrate broken down than anaerobic metabolism

b)

Not use oxygen since it is a facultative anaerobe, it doesn't tolerate oxygen well

c)

Use oxygen because aerobic metabolism is easier

d)

It doesn't matter; both processes will produce the same results

45.

During strenuous exercise, the NADH formed in the glyceraldehyde-3-phosphate dehydrogenase reaction in skeletal muscle must be re-oxidized to NAD+ if glycolysis is to continue. The most important reaction involved in the re-oxidation of NADH is:

a)

Dihydroxyacetone phosphate to glycerol-3-phosphate

b)

Glucose-6-phosphate to fructose-6-phosphate

c)

Pyruvate to lactate

d)

Fructose-1,6-bisphosphate to Dihydroxyacetone phosphate

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