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pedigree analysis

Total questions: 101

Worksheet time: 1hrs 12mins

Name
Class
Date
1.
The genotype of the affected son and daughter at the bottom of this pedigree...
a)
could be homozygous dominant
b)
could  be homozygous recessive
c)
could be heterozygous
d)
Can't tell
2.
What is the genotype of the great-grandfather? (Individual 2)
a)
A_
b)
aa
c)
Aa
d)
AA
3.
What is the mode of inheritance shown here?
a)
Sex Linked Recessive
b)
Autosomal Dominant
c)
Autosomal Recessive
d)
Sex Linked Dominant
4.
What is the mode of inheritance shown here?
a)
Autosomal Recessive
b)
Autosomal Dominant
c)
Sex Linked Recessive
d)
Sex Linked Dominant
5.
Cystic fibrosis is an autosomal recessive trait.  What must be the genotypes of Carla's parents?
a)
CC and cc
b)
Cc and Cc
c)
Cc and cc
d)
CC and CC
6.
The pedigree shown indicates the expression pattern of VHL in a specific family. Genetic counselors told the affected female that she and her non-carrier husband had a 50% chance of producing children with VHL.  Based on this information, which of the following best describes the inheritance pattern for this disorder?
a)
X-linked recessive
b)
Incomplete dominance
c)
Autosomal dominance
d)
Autosomal recessive
7.
What type of heredity is shown in the pedigree?
a)
Sex-Linked Dominant
b)
Sex-Linked Recessive
c)
Autosomal (normal) Dominant
d)
Autosomal (normal) Recessive 
8.
What type of heredity is shown in the pedigree?
a)
Sex-Linked Dominant
b)
Sex-Linked Recessive
c)
Autosomal Dominant
d)
Autosomal Recessive 
9.
What type of heredity is shown in the pedigree?
a)
Sex-Linked Dominant
b)
Sex-Linked Recessive
c)
Autosomal Dominant
d)
Autosomal Recessive 
10.
What type of heredity is shown in the pedigree?
a)
Sex-Linked Dominant
b)
Sex-Linked Recessive
c)
Autosomal Dominant
d)
Autosomal Recessive 
11.
Is the following genotype homozygous or heterozygous?
TT
a)
homozygous
b)
heterozygous 
12.
Is the following genotype homozygous or heterozygous?
Gg
a)
homozygous
b)
heterozygous 
13.

Would the following genotype exhibit the dominant or recessive trait?

Hh

a)

Dominant

b)

Recessive

14.
The image shows:
a)
Not affected Female
b)
Not affected Male
c)
Affected Male
d)
Affected Female
15.
The image shows:
a)
Not Affected Male
b)
Not Affected Female
c)
Affected Male
d)
Affected Female
16.
If this pedigree shows an autosomal recessive disorder, what MUST the genotype of individual II-3 be?
a)
HH
b)
Hh
c)
hh
d)
None of the above
17.
There are no carriers for Huntington's Disease- you either have it or you don't. Is Huntington's disease caused by a dominant or recessive trait?
a)
Dominant
b)
Recessive
18.
How many generations are shown in this pedigree?
a)
1
b)
2
c)
3
d)
4
19.
What do half colored symbols represent?
a)
The individual is a carrier (heterozygous).
b)
The individual expresses the trait.
c)
The individual has both recessive alleles.
d)
The individual has both dominant alleles.
20.

How many alleles does a person carry for a trait?

a)

1

b)

2

c)

3

d)

4

21.

How many alleles does a child get from each parent for a trait?

a)

1

b)

2

c)

3

d)

4

22.

This pedigree represents the inheritance of hemophilia in this family. How many of the males have the hemophilia trait?

a)

8

b)

5

c)

2

d)

3

23.
What is the genotype of the mother?
a)
BB
b)
bb
c)
Bb
d)
BB or Bb
24.

Assuming a trait is AUTOSOMAL DOMINANT, what genotypes could make a person AFFECTED?

a)

AA

b)

Aa

c)

aa

d)

XAY

e)

XaY

25.
What do we use pedigrees for?
a)
To look at families
b)
To make determinations about the offspring
c)
To track traits in families
d)
Nothing
26.

Assuming a trait is AUTOSOMAL DOMINANT, what genotype would make a person UNAFFECTED?

a)

AA

b)

Aa

c)

aa

d)

XAY

e)

XaY

27.

A recessive pedigree is recognized by the trait...

a)

only showing in females.

b)

showing in every generation.

c)

skipping at least one generation.

d)

being found on the X chromosome.

28.

Pedigrees are used to

a)

determine genotypes based on phenotypes.

b)

trace the family history of a chromosomal disorder.

c)

Predict the probable occurrence of a genetic disorder in offspring.

d)

all of the above.

e)

only answers b and c.

29.

The trait being studied in this pedigree has an autosomal dominant pattern of inheritance. What are the possible genotypes for individual #1?

a)

Either AA or Aa

b)

AA only

c)

Aa only

d)

aa only

30.

The trait being studied in this pedigree has an autosomal dominant pattern of inheritance. What are the possible genotypes for individual #3?

a)

Either Aa or AA

b)

AA only

c)

Aa only

d)

aa only

31.

This pedigree shows an autosomal recessive pattern of inheritance. Will and Abigail had 3 children. What can possibly be Lyla's genotype?

a)

Either AA or Aa

b)

Either Aa or aa

c)

aa only

d)

Aa only

32.

This pedigree shows an autosomal recessive pattern of inheritance. Will and Abigail had 3 children. What can possibly be Carlos's genotype?

a)

Either AA or Aa

b)

Either Aa or aa

c)

aa only

d)

Aa only

33.

This pedigree shows an autosomal recessive pattern of inheritance. Suppose Carlos has a 4th child with Megan, what is the probability that their next child will have the trait?

a)

25%

b)

75%

c)

50%

d)

100%

34.

This pedigree shows an autosomal dominant pattern of inheritance. Daniel and Zoe have 3 children. What is Zoe's genotype?

a)

Either AA or Aa

b)

aa only

c)

AA only

d)

Aa only

35.

This pedigree shows an autosomal dominant pattern of inheritance. Daniel and Zoe have 3 children. What of the following choices is possible for Omar's genotype?

a)

Either AA or Aa

b)

aa only

c)

Either Aa or aa

d)

Aa only

36.

This pedigree shows an X-linked dominant pattern of inheritance. What is Apollo's genotype?

a)

XAY

b)

XaY

c)

XAXA

d)

XaXa

37.

An incomplete pedigree is shown for a rare genetic condition. This genetic condition has an autosomal recessive pattern of inheritance.

What symbol should be placed in the red circle in Generation II?

a)
b)
c)
d)
38.

An incomplete pedigree is shown for a rare genetic condition. This genetic condition has an autosomal recessive pattern of inheritance.

What symbol should be placed in the box in Generation III?

a)
b)
c)
d)
39.

An incomplete pedigree is shown for a rare genetic condition. This genetic condition has an X-linked recessive pattern of inheritance.

What symbol should be placed in the box for individual 4?

a)
b)
c)
d)
40.

This pedigree shows an X-linked dominant pattern of inheritance. What is Martha's genotype?

a)

XAY

b)

XAXa

c)

XAXA

d)

XaXa

41.

This pedigree shows an X-linked dominant pattern of inheritance. What is Jack's genotype?

a)

XAY

b)

XAXa

c)

XAXA

d)

XaXa

42.

This pedigree shows an X-linked recessive pattern of inheritance. What is Derek's genotype?

a)

XAY

b)

XaY

c)

XAXA

d)

XaXa

43.

This pedigree shows an X-linked recessive pattern of inheritance. What is Davis's genotype?

a)

XAY

b)

XaY

c)

XAXA

d)

XaXa

44.

This pedigree shows an X-linked recessive pattern of inheritance. What is Diana's genotype?

a)

XAXA only

b)

XAXa only

c)

XAXA or XAXa only

d)

XaXa or XAXa only

45.

Who is the daughter of individual I-1 and I-2?

a)

II-1

b)

II-7

c)

II-8

46.

How many males are in the second generation?

a)

3

b)

4

c)

5

d)

6

47.

How many generations are in this pedigree?

a)

15

b)

10

c)

9

d)

4

48.

Who is the grandfather or individual IV-5?

a)

I-1

b)

II-5

c)

III-7

49.

How many females are in generation III?

a)

2

b)

4

c)

6

d)

9

50.

How many children did individuals II-1 and II-2 have?

a)

3

b)

4

c)

5

d)

6

51.

How many children did individuals I-1 and I-2 have?

a)

3

b)

5

c)

7

d)

9

52.

Sickle cell anemia is the recessive disease being studied here. Who has the disease?

a)

I-1 and II-2

b)

II-2 and II-4

c)

III-1, III-2, and III-3

53.

This is a recessive disease pedigree. What is the genotype of the female in generation II?

a)

Rr

b)

RR

c)

rr

d)

R?

54.

This is a recessive disease pedigree. What is the genotype of the male in generation I?

a)

Rr

b)

RR

c)

R?

d)

rr

55.

This is the recessive disease pedigree. What is the genotype of the oldest male in generation II? (oldest is on the left)

a)

Rr

b)

RR

c)

rr

d)

R?

56.

This pedigree shows affected people with the recessive trait. What is the genotype of someone with a shaded in shape?

a)

AA

b)

Aa

c)

A?

d)

aa

57.

This pedigree shows affected people with the recessive trait. What is the genotype of individual I-2?

a)

AA

b)

Aa

c)

A?

d)

aa

58.

This pedigree shows affected people with the recessive trait. What is the genotype of individual IV-3?

a)

AA

b)

Aa

c)

A?

d)

aa

59.

If individual IV-5 has children with someone with the disorder, what are the chances of having a child with the disorder.

a)

25%

b)

50%

c)

75%

d)

100%

60.

Which trait is dominant?

a)

Brown hair

b)

Blonde hair

61.

What genotype does the F1 daughter with brown hair have?

a)

BB

b)

Bb

c)

bb

62.

If the P generation had another child, what are the chances that it will have blonde hair?

a)

0%

b)

25%

c)

50%

d)

75%

e)

100%

63.

Cystic Fibrosis is a recessive trait. Which genotype(s) will not have cystic fibrosis? Pick two.

a)

CC

b)

Cc

c)

cc

64.

Cystic Fibrosis is a recessive trait. Which phenotype will show from a heterozygous genotype (Cc)?

a)

CC

b)

Cc

c)

cc

d)

Normal (unaffected or carrier)

e)

Cystic Fibrosis (affected)

65.

Cystic Fibrosis is a recessive trait. What is the genotype of Bill?

a)

CC

b)

Cc

c)

cc

66.

Cystic Fibrosis is a recessive trait. What is the phenotype of Karen?

a)

Cystic fibrosis (affected)

b)

Normal (unaffected or carrier)

67.

Cystic Fibrosis is a recessive trait. What is the genotype of Sally?

a)

CC

b)

Cc

c)

cc

d)

Cystic Fibrosis

e)

Normal

68.

Cystic Fibrosis is a recessive trait. If Barbie and Ken have another child, what are the chances that it will not have cystic fibrosis? (Hint: make a punnett square)

a)

0%

b)

25%

c)

50%

d)

75%

e)

100%

69.

Cystic fibrosis is a recessive trait. If Karen and Dan have another child, what are the chances that it will have cystic fibrosis? (Make a punnett square!)

a)

0%

b)

25%

c)

50%

d)

75%

e)

100%

70.

The shaded individuals have the recessive phenotype. Which cross represents individuals III 1 and III 2?

a)

TT x TT

b)

TT x Tt

c)

Tt x Tt

d)

Tt x tt

e)

tt x tt

71.

Individuals II 1 and II 2 have some children with dominant phenotypes and some with recessive phenotypes. Which cross represents the genotypes of individuals II 1 and II 2?

a)

TT x TT

b)

TT x Tt

c)

Tt x Tt

d)

Tt x tt

e)

tt x tt

72.

The pedigree chart below shows the blood types of three members of a family. What could be the blood types of individuals 1 and 2?

a)

1= A 2= AB

b)

1=AB 2=A

c)

1=O 2=AB

d)

1=B 2=A

73.
The blood groups of a mother and 4 children are indicated on the pedigree chart below.  What are the possible blood groups of the father?
a)
Group A only
b)
Group A or B only
c)
Group AB only
d)
Group A, B or AB only
74.
What evidence is given in the pedigree chart below to establish that the condition is caused by a dominant allele?
a)
Two unaffected parents have unaffected children
b)
Two affected parents have affected children
c)
An affected parent and an unaffected parent have affected children
d)
Two affected parents have an unaffected child
75.

Give the genotype for person II-1, for this autosomal recessive trait.

a)

Homozygous Dominant

b)

Heterozygous

c)

Homozygous Recessive

d)

we cannot be 100% sure of the genotype

76.

If hemophilia is a sex-linked recessive trait, what genotype would individual III-3 have?

a)

XhX

b)

XhXh

c)

XhYh

d)

XhY

77.

A chart that displays family relationships indicating traits or disorders

a)

Punnett square

b)

Pedigree

c)

Karyotype chart

78.

In a pedigree chart, men are represented by

a)

Circles

b)

Diamonds

c)

Squares

79.

In a pedigree chart, women are represented by

a)

Circles

b)

Diamonds

c)

Squares

80.

In a pedigree, individuals that are carriers are represented as shapes that are

a)

Not shaded

b)

Fully shaded

c)

Half shaded

81.

In a pedigree, individuals that are unaffected are represented as shapes that are

a)

Not shaded

b)

Fully shaded

c)

Half shaded

82.

In a pedigree, individuals that are affected are represented as shapes that are

a)

Not shaded

b)

Fully shaded

c)

Half shaded

83.

When working to find genotypes of individuals in a pedigree, you may need to use a

a)

Punnett square

b)

Dihybrid cross

c)

Karyotype chart

84.

A codes for 6 fingers, a codes for 5. An individual with the genotype AA would have

a)

6 fingers and not be a carrier

b)

6 fingers and be a carrier

c)

5 fingers

85.

A codes for 6 fingers, a codes for 5. An individual with the genotype Aa would have

a)

6 fingers and be a carrier

b)

5 fingers

c)

6 fingers and not be a carrier

86.

A codes for 6 fingers, a codes for 5. An individual with the genotype aa would have

a)

6 fingers and be a carrier

b)

5 fingers

c)

6 fingers and not be a carrier

87.

Each generation in a pedigree is marked with

a)

Arabic numerals

b)

Names of individuals

c)

Roman numerals

88.

Pedigrees may be difficult to construct or interpret because

a)

People may hesitate to supply information because the symptoms embarrass them

b)

Adoption/children born out of wedlock/serial relationships/blended families are difficult to construct

c)

Many people cannot trace their families back far enough to reveal of mode of inheritance

d)

All of the above

89.

In a pedigree, which shape represents a male?

a)

circle

b)

square

90.

On this pedigree, the allele for curly hair is dominant. The couple labeled 2 both have curly hair, but have a daughter who does not have curly hair. Therefore, we can tell from the chart that for the couple labeled 2 -

a)

the male is heterozygous and the female is heterozygous.

b)

the male is homozygous recessive and the female is homozygous dominant.

91.
This trait is recessive.  What is the genotype for person II-1?
a)
GG
b)
Gg
c)
gg
d)
can't be determined
92.
What is the genotype of the mother?
a)
BB
b)
bb
c)
Bb
d)
BB or Bb
93.

What does A indicate?

a)

A male that has the trait.

b)

A female that has the trait.

c)

A female that does not have the trait.

d)

A male that does not have the trait.

94.

What does B indicate?

a)

line that indicates someone likes each other

b)

line that indicates a marriage

c)

line that indicates a relationship of parents and children

d)

A male that does not have the trait.

95.

How many generations are represented in the pedigree?

a)

2

b)

3

c)

4

d)

5

96.

In the diagram, individual III-3 indicates

a)

a female with no freckles

b)

a male with no freckles

c)

a male with freckles

d)

a female with freckles

97.

In the diagram, individual II-1 indicates

a)

a female with no freckles

b)

a male with no freckles

c)

a male with freckles

d)

a female with freckles

98.

What is the Genotype of individual I-1?

a)

FF

b)

Ff

c)

ff

d)

Can't know for sure

99.

What is the Genotype of individual II-6?

a)

FF

b)

Ff

c)

ff

d)

Can't know for sure

100.

What is the Genotype of individual III-2?

a)

FF

b)

Ff

c)

ff

d)

Can't know for sure

101.

The following pedigree chart shows _______ females and ______ males that have the trait.

a)

7, 3

b)

4, 4

c)

3, 2

d)

3, 3

e)

57, 93.5

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