wayground logo

Free Printable Worksheets

Font size

S
M
L
XL
Worksheets

Ceutics - Exam 1 - Preformulation 1 - Yang

Total questions: 75

Worksheet time: 46mins

Name
Class
Date
1.

Preformulation is the investigation of physicochemical properties of drugs and excipients ______ formulation

a)

before

b)

after

c)

during

2.

Preformulation is a case of

a)

learning before doing

b)

learning as you're doing

c)

learning after doing

3.

Why is preformulation important

a)

foundation of developing robust formulations

b)

foundation of creating already made formulations

4.

What are the goals of preformulation

a)

to establish physical characteristics

b)

to establish the necessary physicochemical parameters of new drug substances

c)

to establish compatibility with common excipients

d)

to determine stability profile

e)

to establish the necessary physicochemical parameters of existing drug substances

5.

A drug is synthesized and tested or screened for pharmacological action. From here, when will the initial preformulation work begin

a)

once there is a sufficient quantity of a compound that has been synthesized to perform initial toxicity studies and analytical work

b)

once there is a minute quantity of a compound that has been synthesized to perform initial toxicity studies and analytical work

6.

What are components of the preliminary evaluation of the preformulation process

a)

compound identity

b)

formula and molecular weight

c)

chemical structure

d)

physical description

e)

toxicity levels

7.

What colors can a preformulation drug have

a)

off-white

b)

cream-yellow

c)

shiny

d)

clear

8.

What types of odors can a preformulation compound have

a)

pungent

b)

sulfurous

c)

fruity

d)

aromatic

e)

rotten

9.

What primary tastes can a preformulation compound have

a)

acidic/sour

b)

bitter

c)

sweet

d)

salty

e)

fruity

10.

Which flavor do chemical structures with H+ have

a)

acidic/sour

b)

bitter

c)

sweet

d)

salty

11.

Which flavor do chemical structures with anions & cations have

a)

acidic/sour

b)

bitter

c)

sweet

d)

salty

12.

Which flavor do chemical structures with high molecular weight salts have

a)

acidic/sour

b)

bitter

c)

sweet

d)

salty

13.

Which flavor do chemical structures with polyhydroxyl compounds, polyhalogenated compounds, and alpha amino acids have

a)

acidic/sour

b)

bitter

c)

sweet

d)

salty

14.

Which equation is this

a)

Stokes-Einstein Equation

b)

Bragg's Law

c)

Index of Refraction (R.I. or n)

d)

Drug Solubility in Ideal Solution

e)

Solubility Prediction

15.

What is the r in this equation

a)

Solvated Radius of Diffusing Solute

b)

Stoke's Radius

c)

Solvent Viscosity

d)

Diffusion Coefficient

e)

Gas Constant

16.

The bigger the Stoke's radius

a)

the smaller the diffusion coefficient; inverse relationship

b)

the larger the diffusion coefficient; complementary relationship

c)

the smaller the diffusion coefficient; complementary relationship

d)

the larger the diffusion coefficient; inverse relationship

17.

What is the D in this equation

a)

Solvated Radius of Diffusing Solute

b)

Stoke's Radius

c)

Solvent Viscosity

d)

Diffusion Coefficient

e)

Gas Constant

18.

What is the R in this equation

a)

Solvated Radius of Diffusing Solute

b)

Stoke's Radius

c)

Solvent Viscosity

d)

Diffusion Coefficient

e)

Gas Constant

19.

What is the n in this equation

a)

Solvated Radius of Diffusing Solute

b)

Stoke's Radius

c)

Solvent Viscosity

d)

Diffusion Coefficient

e)

Gas Constant

20.

Diffusion

a)

is the net movement of molecules/atoms from high concentration to low concentration

b)

is the net movement of molecules/atoms from low concentration to high concentration

c)

results in mixing/mass transport without requiring bulk motion

d)

results in mixing/mass transport with bulk motion

21.

Which drug has the higher molecular weight

a)

Caffeine (194.2 g/mol)

b)

Insulin (41,000 g/mol)

22.

What is the units for diffusion coefficient

a)

cm²/s

b)

K

c)

g/mol

d)

J/mol*K

e)

erg/mol*K

23.

Thermal analysis is a branch of _____ where the properties of materials are studied as they change with temperature

a)

materials science

b)

physical science

c)

thermal science

24.

What is the principle of thermal analysis: change in (1) as a function of (2)

a)

1 - thermal energy; 2 - temperature

b)

1 - temperature; 2 - thermal energy

c)

1 - degrees; 2 - temperature

d)

1 - temperature; 2 - degrees

25.

Thermal analysis utilizes

a)

Differential Scanning Calorimetry (DSC)

b)

Thermogravimetric Analysis (TGA)

c)

Thermomechanical Analysis (TMA)

d)

Melting Point Depression

e)

Polymorphism

26.

What are components of Differential Scanning Calorimetry (DSC)

a)

a thermoanalytical technique

b)

measures the difference in the amount of heat required to increase the temperature of a sample and reference is measured as a function of temperature

c)

measures the difference in the amount of heat required to decrease the temperature of a sample and reference is measured as a function of temperature

d)

a thermogravimetric analysis

27.

What are the types of DSC

a)

Power compensated

b)

Heat flux

c)

Melting point depression

d)

Crystallization

28.

What type of compound can be used during differential scanning calorimetry

a)

compounds that can form crystals

b)

any compound

c)

compounds that are unable to freeze

d)

compounds that are unstable

29.

What represents heat flow during differential scanning calorimetry

a)

dQ/dt

b)

dt/dQ

c)

Tg

d)

Delta H

30.

Crystallization is

a)

exothermic

b)

endothermic

c)

does not use heat

31.

During differential scanning calorimetry, the process of melting a crystal is a(n)

a)

exothermic process

b)

endothermic process

c)

does not use heat

32.

Tg takes place

a)

in the middle of the transition phase

b)

at the beginning of the transition phase

c)

at the end of the transition phase

d)

during Tcrystallization

33.

Thermogravimetric analysis (TGA) is commonly used to determine selected characteristics of materials that exhibit

a)

either mass loss or gain due to decomposition

b)

oxidation

c)

loss of volatiles (such as moisture)

d)

temperature crystals liquify at

34.

What second-order phase transitions can Thermogravimetric Analysis can provide

a)

vaporization

b)

sublimination

c)

aborption

d)

adsorption

e)

desorption

35.

Thermomechanical analysis (TMA) is a measurement of a change of a (1) or a (2) property of the sample against temperature

a)

1 - dimension; 2 - mechanical

b)

1 - mechanical; 2 - dimension

c)

1 - temperature; 2 - physical

d)

1 - phase; 2 - physical

36.

Thermodilatrometry is the measurement of a change of a dimension of the sample with a ____ acting on the sample while it is subjected to a temperature regime

a)

negligible force

b)

strong force

c)

weak force

d)

outside variable

37.

What is the equation for the linear expansion coefficient used in thermomechanical analysis

a)

elongation % / degrees C

b)

degrees C / elongation %

c)

(2 * elongation %) / degrees C

d)

degrees C / (2 * elongation %)

38.

On a thermomechanical analysis graph, where is the Tg point

a)

intersection point of the tangential lines

b)

the first point in the graph

c)

the last point in the graph

d)

the point exactly halfway up the graph

39.

Melting point is affected by and used to determine

a)

the purity of the compound

b)

the strength of the compound

c)

the potency of the compound

40.

The purer the compound, the _____ the melting point range

a)

narrower

b)

higher

c)

shorter

d)

wider

41.

The purer the compound, the _____ the melting point

a)

narrower

b)

higher

c)

shorter

d)

wider

42.

What happens during melting point depression when impurities are present

a)

takes less energy to disrupt the crystal lattice

b)

melting point will be lower

c)

melting point range will be broader

d)

melting point will be higher

e)

melting point range will be narrower

43.

When determining a compound's identity using melting point depression, the unknown is mixed with a little bit of known product. What are correct statements concerning the results

a)

If MP is the same, the compound is pure and the unknown is the known compound

b)

If MP is lower and broader, the compound is either mixed or different

c)

If MP is the same, the compound is impure and the unknown is the known compound

d)

If MP is lower and broader, the compound is pure or mixed

44.

What is a eutectic mixture

a)

one mixture of two compounds has a lower melting point than any other ratio of mixture

b)

one mixture of two compounds has a higher melting point than any other ratio of mixture

c)

one mixture of two compounds has the same melting point as other ratios of mixture

45.

The melting point of a eutectic mixture is

a)

the melting point

b)

the eutectic point

c)

solid A + melting point

d)

solid B + melting point

46.

Polymorphism in materials science is the ability of

a)

a solid material to exist in more than one form or crystal structure

b)

a solid material to exist in one form or crystal structure

c)

a liquid material to exist in more than one form or crystal structure

d)

a liquid material to exist in one form or crystal structure

47.

Differences (1) in the (2) or (3) state

a)

1 - disappear; 2 - liquid; 3 - gas

b)

1 - appear; 2 - liquid; 3 - gas

c)

1 - disappear; 2 - liquid; 3 - solid

d)

1 - appear; 2 - liquid; 3 - solid

48.

Some polymorphs are

a)

metastable and convert to a more stable form

b)

stable and convert to a more metastable form

c)

unstable and unable to maintain a form

49.

Polymorphism is relatively common in

a)

63% barbiturates

b)

67% steroids

c)

40% sulfonamides

d)

50% antihypertensive

50.

Who is the "father of polymorphism"

a)

Walter C. McCrone

b)

Edgar J. Hoover

c)

J. Haleblian

d)

Abbott Park

51.

What are some formulation problems that can occur

a)

polymorphs with certain crystal habits may be difficult to inject in suspension form or to formulate as tablets

b)

transformation between polymorphic forms during storage changes the crystal size in suspensions

c)

crystal growth in creams as a result of phase transformation can cause the cream to become gritty

d)

changes in polymorphic forms of vehicles such as theobroma oil (used for suppositories) could cause products with different and unacceptable melting characteristics

52.

What are characteristics of crystalline solids

a)

have fixed internal structure

b)

have less solubility

c)

less tendency to change its form

d)

tend to revert to more stable form during storage

e)

have greater solubility

53.

What are characteristics of amorphous solids

a)

do not have any fixed internal structure

b)

have less solubility

c)

less tendency to change its form

d)

tend to revert to more stable form during storage

e)

have greater solubility

54.

Which type of drug is more preferred

a)

crystalline solid

b)

amorphous solid

55.

What is an enantiotroph and what is an example of it

a)

when one form is stable over certain pressure and temp range while other polymorph is stable over different pressure and temp range

b)

sulfur

c)

only one polymorph is stable at all temp below the melting pt with all other polymorph being unstable

d)

glyceryl stearate

e)

chloramphenicol palmitate

56.

What is a monotroph and what is an example of it

a)

when one form is stable over certain pressure and temp range while other polymorph is stable over different pressure and temp range

b)

sulfur

c)

only one polymorph is stable at all temp below the melting pt with all other polymorph being unstable

d)

glyceryl stearate

e)

chloramphenicol palmitate

57.

What are some characteristics of an enantiotropic pair

a)

reversible phase transition, endothermic process

b)

lower melting form is thermodynamically stable below the transition temp and higher melting form is stable above the transition temp

c)

higher melting pt has lower heat of fusion

d)

irreversible phase transition, exothermic process

e)

higher melting form is always thermodynamically stable

58.

What are some characteristics of a monotropic pair

a)

reversible phase transition, endothermic process

b)

lower melting form is thermodynamically stable below the transition temp and higher melting form is stable above the transition temp

c)

higher melting pt has higher heat of fusion

d)

irreversible phase transition, exothermic process

e)

higher melting form is always thermodynamically stable

59.

What factors affect polymorphism

a)

temp and humidity

b)

photostability

c)

effect of solvent

d)

effect of grinding

e)

effect of tablet compression

60.

What parameters must be checked by a preformulator when doing a polymorphism study

a)

# of polymorphs, presence of glassy state

b)

stabilization of metastable form, temp of stability range

c)

solubility of polymorph, method of prep

d)

effects of microization, excipients incompatibility

e)

ability to become gritty if needed

61.

What are some technology in polymorphism

a)

optical crystallography, dilatrometry

b)

hot stage microscopy, thermal methods

c)

x-ray diffraction, FTIR technique

d)

dilatometry, microcalorimetry

62.

What is the best way to study polymorphism

a)

optical crystallography

b)

hot stage microscopy, thermal methods

c)

x-ray diffraction

d)

dilatrometry

e)

FTIR technique

63.

What does optical crystallography study

a)

the degree of stability of metastable form

b)

transition temp, melting point

c)

rate of transition under various thermal and physical conditions

d)

whether to pursue polymorphism as a route to an improved dosage form

64.

The index of refraction is a _____ # that describes how light propagates through that material

a)

dimensionless

b)

large

c)

small

d)

nonexistent

65.

What equation is this

a)

Stoke-Einstein Equation

b)

Bragg's Equation

c)

Index of Refraction

d)

Snell's Law of Refraction

66.

What equation is this

a)

Stoke-Einstein Equation

b)

Bragg's Equation

c)

Index of Refraction

d)

Snell's Law of Refraction

67.

For the index in the equation, what is the value of air

a)

n = 1

b)

n > 1

c)

n < 1

d)

n = 0

68.

For the index in the equation, what is the value if it is not air being measured

a)

n = 1

b)

n > 1

c)

n < 1

d)

n = 0

69.

What is this equation and what does it measure

a)

Bragg's Law

b)

Index of Refraction

c)

refractive index

d)

x-ray diffraction

70.

What is FTIR

a)

Fourier Transform Infrared Spectroscopy

b)

Fourier Transform Inverted Spectroscopy

c)

a technique which is used to obtain an infrared spectrum of absorption, emission, photoconductivity or Raman scattering of a solid, liquid, or gas

d)

a technique which is used to obtain an inverted spectrum of absorption, emission, photoconductivity or Raman scattering of a solid, liquid, or gas

71.

In FTIR, what is the only type of sample that can be used in the purpose of polymorph identification

a)

solid

b)

liquid

c)

gas

72.

What are the advantages of using FTIR in polymorph identification

a)

rapid

b)

qualitative

c)

quantitative

d)

accurate

e)

cheap

73.

What are the advantages of using thermal methods in polymorph identification

a)

thermodynamic parameter can be evaluated

b)

heat of transition from one polymorph to the other can be measured

c)

melting point can be determined

d)

heat of fusion from one polymorph to the other can be measured

e)

costs are lowered by not using highly expensive equipment

74.

What is a disadvantage of using DSC and MP determination for polymorph identification

a)

substances undergoing investigation heated through phase transition can decompose

b)

substances undergoing investigation heated through phase transition will not decompose

75.

What is pseudopolymorphism and how do you test for it

a)

solvent molecules get incorporated into the crystal lattice of solids solvates which exist in a different crystal form called pseudopolymorphs

b)

solute molecules get incorporated into the crystal lattice of solids solutes which exist in a different crystal form called pseudopolymorphs

c)

pseudopolymophs bubble when added to solution

d)

pseudopolymophs do not bubble when added to solution

Similar Resources on Wayground

Most Challenging AP Chem

71 questions

Most Challenging AP Chem

quiz

Worksheet

•

11th Grade - University

IB Chemistry HL Review

75 questions

IB Chemistry HL Review

quiz

Worksheet

•

10th Grade - University

Overview Chem 1 : before final - M.4/3 (2025)

70 questions

Overview Chem 1 : before final - M.4/3 (2025)

quiz

Worksheet

•

10th Grade - University

MCQ-Organic-I

75 questions

MCQ-Organic-I

quiz

Worksheet

•

University

Chemistry Exam Review

80 questions

Chemistry Exam Review

quiz

Worksheet

•

10th Grade - University

Periodic Table Review

80 questions

Periodic Table Review

quiz

Worksheet

•

KG - University

Cellular Respiration

75 questions

Cellular Respiration

quiz

Worksheet

•

10th Grade - University

Biochemistry Retake - Periodic Table

76 questions

Biochemistry Retake - Periodic Table

quiz

Worksheet

•

University