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WorksheetsPHARMA_003_ANTIMICROBIAL PART 1
Total questions: 20
Worksheet time: 7mins
Name
Class
Date
1.
It is preferred to decrease risk of antibiotic toxicity and resistance.
a)
Monotherapy
b)
Empiric Therapy
c)
Broad-spectrum therapy
2.
Low molecular weight cannot cross the blood brain barrier.
a)
true
b)
false
3.
Responsible for peptidoglycan synthesis. When it binds with penicillin, it is unable to catalyse cross-linking reaction.
a)
Macrolide esterase
b)
Acetyltransferase
c)
Transpeptidase
d)
None of the Above
4.
Drug of choice for syphilis
a)
Nafcillin
b)
Pen G
c)
Carbenicillin
d)
Piperacillin
5.
Second generation cephalosporin except:
a)
Cefactor
b)
Cefuroxime
c)
Cefadroxil
d)
Cefoxitin
6.
Produced by Streptomyces clavuligerus
a)
Clavulanic acid
b)
Sulbactam
c)
Tazobactam
d)
Entrapanem
7.
Excretion of sulbactam:
a)
Bile
b)
Sweat
c)
Urine
d)
Stool
8.
Nafcillin, Dicloxacillin and oxacillin are examples of
a)
Acid-stable penicillin
b)
Natural penicillin
c)
Penicillinase-resistant
9.
Acting only to single or limited group of bacteria
a)
Extended spectrum
b)
Narrow spectrum
c)
Broad-spectrum
d)
Light spectrum
10.
It is the lowest antibiotic concentration to inhibit the bacterial growth
a)
Maximum Inhibitory Concentration
b)
Minimum Inhibitory Concentration
c)
Minimal Inhibitory Concentration
11.
Toxicity is absolute rather than relative
a)
true
b)
false
12.
Antibiotic therapy given subsequent to the receipt of blood culture and antibiotic susceptibility test.
a)
Monotherapy
b)
Empiric Therapy
c)
Definitive Therapy
d)
Target Therapy
13.
Determinants of rational dosing except:
a)
Time-dependent killing
b)
Pre-antibiotic effect
c)
Concentration-dependent killing
d)
None of the Above
14.
Penicillin is effective against microorganisms that synthesize peptidoglycan
a)
true
b)
false
15.
The most active B-lactam antibiotic against Pen-sensitive and resistant S. pneumoniae
a)
Cefuroxime
b)
Piperacillin
c)
Amoxicillin
d)
Cefalexin
16.
All beta-lactam antibiotics are very synergistic with aminoglycosides
a)
true
b)
false
17.
First generation cephalosporin except:
a)
Cepharidine
b)
Cephazolin
c)
Cefaclor
d)
All are first generation
18.
An example of B-synthetic antibiotic that differ in structure of penicillins in that the sulfur atom of thiazolidine ring has been externalized and replaced by a carbon atom.
a)
Monobactam
b)
Sulbactam
c)
Meropenem
d)
Aztreonam
19.
Mechanism of action of Co-amoxiclav
a)
Cell wall inhibitor
b)
Beta-lactamase inhibitor
c)
Inhibit DNA synthesis
d)
Unknown
20.
Cephalosporin with the greatest effect on Gram (-) microorganisms
a)
1st Generation
b)
2nd Generation
c)
3rd Generation
d)
4th Generation
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