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Ceutics Exam 2 - States of Matter Mirza

Total questions: 61

Worksheet time: 37mins

Name
Class
Date
1.

What are the optimal set of properties for a new drug molecule

a)

Potency

b)

ADME

c)

Selectivity

d)

Materials properties

2.

What are characteristics that are tested during preformulation studies (in vitro drug profiling)

a)

solid-form screening

b)

solubility

c)

pKa, pH-solubility profile

d)

partition and distribution coefficients

e)

dissolution, stability

3.

What are the physical states of drugs/matter

a)

solids

b)

liquids

c)

gases

d)

synthetic materials

4.

What is this

a)

solid

b)

liquid

c)

gas

5.

What is this

a)

solid

b)

liquid

c)

gas

6.

What is this

a)

solid

b)

liquid

c)

gas

7.

What are the key properties of the states of matter

a)

shape

b)

volume

c)

compressibility

d)

viscosity

8.

The magnitude of energies associated with the formation of _____ bonds is typically around ~330 kJ/mol

a)

non-covalent

b)

hydrogen

c)

electrostatic

d)

Van der Waals

9.

Going from solids to gases, what does the kinetic energy do

a)

increase

b)

decrease

10.

Potential energy can be transferred into kinetic (thermal) energy (KE)

a)

True

b)

False

11.

What types of energy can the states of matter have

a)

potential energy

b)

kinetic energy

c)

electrical energy

d)

resting energy

12.

What is kinetic energy proportional to

a)

temperature

b)

potential energy

c)

solid

d)

liquid

e)

gas

13.

Going from solids to gases, what does the temperature do

a)

increase

b)

decrease

14.

Going from solids to gases, what does the pressure do

a)

increase

b)

decrease

15.

According to Boyle's Gas Law,

a)

pressure is inversely proportional to volume (PV = constant)

b)

pressure is inversely proportional to temperature (PT = constant)

c)

volume is inversely proportional to temperature (VT = constant)

d)

temperature is inversely proportional to kinetic energy (TKE = constant)

16.

In this phase diagram of a closed system in equilibrium, what is point A

a)

triple point

b)

critical point

c)

critical pressure

d)

critical temperature

e)

gas phase

17.

In this phase diagram of a closed system in equilibrium, what is point B

a)

triple point

b)

critical point

c)

critical pressure

d)

critical temperature

e)

gas phase

18.

In this phase diagram of a closed system in equilibrium, what is point F

a)

triple point

b)

critical point

c)

critical pressure

d)

critical temperature

e)

gas phase

19.

In this phase diagram of a closed system in equilibrium, what is point G

a)

triple point

b)

critical point

c)

critical pressure

d)

critical temperature

e)

gas phase

20.

In this phase diagram of a closed system in equilibrium, what is line C

a)

melting

b)

sublimation

c)

evaporation

d)

solid phase

e)

gas phase

21.

In this phase diagram of a closed system in equilibrium, what is line D

a)

melting

b)

sublimation

c)

evaporation

d)

solid phase

e)

gas phase

22.

In this phase diagram of a closed system in equilibrium, what is line E

a)

melting

b)

sublimation

c)

evaporation

d)

solid phase

e)

gas phase

23.

In this phase diagram of a closed system in equilibrium, what is phase 1

a)

melting

b)

sublimation

c)

liquid phase

d)

solid phase

e)

gas phase

24.

In this phase diagram of a closed system in equilibrium, what is phase 2

a)

melting

b)

sublimation

c)

liquid phase

d)

solid phase

e)

gas phase

25.

In this phase diagram of a closed system in equilibrium, what is phase 3

a)

melting

b)

sublimation

c)

liquid phase

d)

solid phase

e)

gas phase

26.

What are some pharmaceutical/medical gases

a)

nitrous oxide (N2O, laughing gas)

b)

nitric oxide (NO)

c)

O2

d)

CO2

e)

H2O

27.

What are some characteristics of pharmaceutical aerosols

a)

contains a liquefied gas as dispersion medium or as a propellant

b)

it is based on the reversible phase transition (G→L→G)

c)

typically supplied as liqueified gases

28.

What are the categories of solids

a)

crystalline

b)

amorphous

c)

polymeric

d)

liquid

29.

What are the different types of crystalline solids

a)

polymorphs

b)

hydrates/solvates

c)

salts/cocrystals

d)

amorphous

e)

amorphous dispersions

30.

What are the different types of amorphous solids

a)

polymorphs

b)

hydrates/solvates

c)

salts/cocrystals

d)

amorphous

e)

amorphous dispersions

31.

What is the difference among the solid forms

a)

crystalline solids are packed in a regular order or repeating pattern

b)

amorphous solids are random

c)

amorphous solids are packed in a regular order or repeating pattern

d)

crystalline solids are random

32.

What are types of single-component crystals

a)

polymorph I

b)

polymorph II

c)

solvate

d)

salt

e)

co-crystal

33.

What are types of multicomponent crystals

a)

polymorph I

b)

polymorph II

c)

solvate

d)

salt

e)

co-crystal

34.

Polymorph I and II are chemically identical but have different arrangement of their molecules that results in different free energy

a)

true

b)

false

35.

Carbamazepine is a

a)

polymorphic drug

b)

cocrystal

c)

salt drug

d)

solvate drug

36.

What are factors that are considered when choosing a solid state form for drug development

a)

solubility, dissolution rate

b)

bioavailability

c)

manufacturing properties

d)

stability

e)

hygroscopicity

37.

About how many drugs on the market are ionizable

a)

2/3

b)

1/2

c)

9/10

d)

1/4

38.

What makes up a crystalline salt

a)

acid drug + basic counterion

b)

basic drug + acid counterion

c)

acid drug + acid counterion

d)

basic drug + basic counterion

39.

What are some reasons why we would use a salt for a drug

a)

bioavailability

b)

developability

c)

purification (optical purity)

d)

patents

e)

cost effective

40.

What are some disadvantages to using a salt based drug

a)

hygroscopic

b)

another step in synthesis

c)

cost

d)

bioavailability

41.

Cocrystals are cyrstalline molecular complexes of two or more ____ molecules, which are ____ under ambient conditions

a)

solid, neutral

b)

neutral, solid

c)

charged, solid

d)

solid, charged

42.

Amorphous drugs are ___ times more soluble at equilibrium than crystalline forms

a)

10

b)

2

c)

100

d)

50

43.

Which crystalline form has the highest free energy

a)

polymorph 1

b)

polymorph 2

c)

anhydrous

d)

hydrate

44.

Which crystalline form has the lowest equilibrium solubility

a)

polymorph 1

b)

polymorph 2

c)

anhydrous

d)

hydrate

45.

Why is drug solubility important

a)

to be absorbed in the body

b)

to be transported throughout the body

c)

to interact with active sites

d)

to be effective in aqueous and lipid systems

e)

to be excreted

46.

According to the biopharmaceutical classification system (BCS) what are characteristics of a Class I drug

a)

good solubility

b)

good permeability

c)

poor solubility

d)

poor permeability

47.

According to the biopharmaceutical classification system (BCS) what are characteristics of a Class II drug

a)

good solubility

b)

good permeability

c)

poor solubility

d)

poor permeability

48.

According to the biopharmaceutical classification system (BCS) what are characteristics of a Class III drug

a)

good solubility

b)

good permeability

c)

poor solubility

d)

poor permeability

49.

According to the biopharmaceutical classification system (BCS) what are characteristics of a Class IV drug

a)

good solubility

b)

good permeability

c)

poor solubility

d)

poor permeability

50.

What are some key factors that affect solubility

a)

molecular structure & weight

b)

crystal structure

c)

stereochemistry

d)

ionization

e)

temperature

51.

Some aqueous solubility is required for therapeutic efficacy

a)

true

b)

false

52.

What are solubility measurements

a)

equilibrium solubility

b)

solubility in different solvents

c)

pH solubility profile

d)

dissolution in cells

53.

What are some general solubility rules

a)

like dissolves like

b)

solubility in water increases with increasing capacity for hydrogen bonding

c)

solubility in water decreases with increasing number of carbons

d)

solutes with higher melting point will have lower aqueous solubility

e)

amorphous solutes are more soluble than crystalline

54.

Which solid form has the lowest physical stability

a)

amorphous solids

b)

polymorph 1

c)

polymorph 2

d)

anhydrous

e)

hydrate

55.

Which solid form has the highest physical stability

a)

amorphous solids

b)

polymorph 1

c)

polymorph 2

d)

anhydrous

e)

hydrate

56.

A solid stability can be estimated using the

a)

melting temperature

b)

heat of fusion

c)

freezing temperature

d)

condensation

57.

What is the process of an amorphous solid turning into a crystalline solid called

a)

crystallization

b)

amorphization

c)

transformation

d)

hydration

e)

drying

58.

What is the process of a crystalline solid turning into an amorphous solid called

a)

crystallization

b)

amorphization

c)

transformation

d)

hydration

e)

drying

59.

What is the process of a crystalline polymorph 1 solid turning into a crystalline polymorph 2 solid called

a)

crystallization

b)

amorphization

c)

transformation

d)

hydration

e)

drying

60.

What is the process of a anhydrous solid turning into a hydrate/solvate solid called

a)

crystallization

b)

amorphization

c)

transformation

d)

hydration

e)

drying

61.

What is the process of a hydrate/solvate solid turning into a anhydrous solid called

a)

crystallization

b)

amorphization

c)

transformation

d)

hydration

e)

drying

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