WorksheetsATLAS Neuro PR_Y2
Total questions: 59
Worksheet time: 30mins
What is the most common cause of primary headache?
Migraine
Tension-type headache
Psychological causes
Idiopathic
Most important element in the diagnosis of brain tumors.
Routine laboratory tests are required.
Neuroimaging is the only test necessary to diagnose brain tumors.
Additional tests such as cerebral angiogram, EEG, or LP may be helpful.
Two of the above.
All of the above.
All of the following are pain-producing structures of the brain, except for?
Scalp
Meningeal arteries
Brain parenchyma
Falx cerebri
Dural sinuses
Which of the following is an established risk factor for development of primary CNS tumors?
Exposure to ionizing radiation
Immunosuppression
Exposure to environmental risk factors
Two of the above.
All of the above.
Which of the following neurologic reflex PE is performed to check primarily S1 nerve root?
Brachioradialis Reflex
Triceps Reflex
Knee Jerk Reflex
Achilles Reflex
This motor manifestation of PD decreases the speed and coordination of facial muscles. What could it be?
Athetosis
Hypophonia
Rigidity
Hypomimia
Patient MF presents diplopia and impaired downgaze. His doctor is considering atypical parkinsonism as his diagnosis. What could that be?
Dementia with Lewy bodies
Progressive Supranuclear Palsy
Multiple System Atrophy
Corticobasal Degeneration
A Familial Tumor Syndrome presenting with hemangioblastomas in the cerebellum & retina; cysts involving the pancreas, liver & kidneys; renal carcinomas, & pheochromocytomas.
Neurofibromatoses
Schwannomatosis
Von Hippel-Lindau Disease
Tuberous Sclerosis Complex
Which is not a characteristic of febrile seizures?
Long post-ictal period
Lasts for less than 15 mins
May or may not recur within 24 hrs
Increased risk due to family history of febrile seizures
Most frequent cancer that metastasizes to the nervous system, specifically the leptomeninges.
Sarcoma
Lymphoma
Breast
Lung
Melanoma
Least common cause of secondary headache.
Systemic infection
Brain tumor
Head injury
Vascular disorders
Chemotherapeutic agent that blocks VEGF.
Atezoizumab
Bevacizumab
Carmustine
Dexamethasone
Which of the following belong/s to the most common group of primary brain tumors?
Astrocytomas
Oligodendrogliomas
Ependymomas
All of the above.
None of the above.
Most common accompanying symptom of migraine.
Photophobia
Lightheadedness
Nausea
Visual disturbance
Which of the following muscle tone disorders is described as the sudden change in tone and the inability to relax the muscles at the onset of cognitive impairment?
Paratonia
Spasticity
Flaccidity
Rigidity
Type of brain herniation with accompanying secondary hemorrhagic lesions in the midbrain & pons, termed Duret hemorrhage
Subfalcine herniation
Tonsillar herniation
Transtentorial herniation
Cingulate herniation
Type of herniation that is life-threatening, causing brainstem compression.
Subfalcine herniation
Tonsillar herniation
Transtentorial herniation
Cingulate herniation
Not true about seizures.
Common in metastatic brain tumors
All seizures arising from brain tumors have a focal onset
Presents in 90% of patients with low-grade glioma
None of the above. All are true.
The triad symptoms for acute meningitis does not include which of the ff:
Fever
Kernig sign
Headache
Nuchal rigidity
This type of secondary headache presents with stiff neck & fever.
Brain tumor
Intracranial hemorrhage
Meningitis
Temporal arteritis
Most common cause of early onset meningitis in children:
E. coli
Group B Streptococcus (GBS)
Striamonositogenesis
Pseudomonas
None of the above
Meningitis causes an increase in intracranial pressure. In response to this, a physiological response called Cushing reflex occurs. How is this physiological response manifested?
Widened pulse pressure, tachycardia, tachypnea
Widened pulse pressure, bradycardia, hypertension
Widened pulse pressure, bradycardia, irregular respirations
Widened pulse pressure, tachycardia, irregular respirations
Who among the following patients will most likely have a recurrence of febrile seizure?
2 y/o female with 12-hr fever. Current temp: 38C
2 y/o male with 24-hr fever. Current temp: 38C
8 month-old male with 12-hr fever. Current temp: 38C
8 month-old male with 24-hr fever. Current temp: 38C
The mutation of the HTT gene leads to an abnormal expansion of polyglutamine in the HTT protein. What trinucleotide repeats is the case?
CAG
CAT
CCG
CGT
CGC
Medulloblastoma, a malignant embryonal tumor, occurs exclusively in the cerebellum. The classic subtype forms what structures microscopically?
Homer Wright rosettes
Perivascular pseudorosettes
Psammoma bodies
Rosenthal fibers
Neuroimaging techniques recommended for a relatively healthy pediatric patient after his first febrile seizure:
CT Scan
MRI
EEG
Two of the options.
None of the options.
Which antibiotic should not be given to neonates due to risk of kernicterus?
Cefexime
Ceftriaxone
Rifampin
Diazepam
Probable prognosis of febrile seizure patients includes:
Low morbidity and mortality
Increased risk in learning difficulties
High chance of seizure recurrence
Outgrown by age 3
Most common cause of subarachnoid hemorrhage.
Berry aneurysm
Saccular aneurysm
Arteriovenous malformation
Head trauma
The CSF flows through all ventricles. To get to the fourth ventricle from the third ventricle, it has to flow in which of the ff. structures:
Cerebral aqueduct
Subarachnoid space
Interventricular foramina
Median aperture
Lateral aperture
Toxicity of glucocorticoids, except:
Somnolence
Weight gain
DM
Personality change
None. All are true.
Which of the following correctly describes seizures:
Can happen even without convulsions
Frequently happens in children during school time
Occurs in resting period
Two of the options
All of the options.
Which shows a correct relationship of protein to neurodegenerative disease?
α-synuclein: Amyotrophic lateral sclerosis
tau: Corticobasal degeneration
FUS: Progressive supranuclear palsy
TPD-43: Multiple system atrophy
tau: Spinal bulbar muscle atrophy
What poses risk/s for Alzheimer’s Disease?
increased homocysteine levels
presence of APOE e4 allele
Trisomy 21
Only two of the options
All of the above
A patient who is having difficulty speaking, eyes does not respond to speech and pain, and limbs remain flaccid has a Glasgow score of 5 is categorized as:
Best response
Mild Head Injury
Comatosed
Unresponsive
A patient reported experiencing brief shock-like muscular contractions. He also informed you that he was awake and conscious during the seizure. What type of generalized seizure was experienced by the patient?
Tonic
Clonic
Myoclonic
Atonic
Which of the following may describe grand mal seizures:
Sustained muscle contraction
Repetitive muscle contractions
May occur even without loss of postural control
Two of the options.
All of the options.
What innervates the triceps reflex?
C5-C6
C7-C8
C5-C7
C4-C6
Seizure may be caused by a variety of factors and these causes may also differ per age group. Which of the ff. causes of seizure is observed at any age group?
Cerebrovascular disease
Brain tumor
Metabolic disturbances
CNS infection
What is the core feature of Parkinson’s Disease?
Tremor
Bradykinesia
Rigidity
Micrographia
Which of the following factors poses the highest risk of occurrence of a subsequent epilepsy after a febrile seizure?
Family history of epilepsy
Neurodevelopmental abnormalities
Fever less than an hour before febrile seizure
Simple febrile seizure
The primary feature of Huntington’s disease is the degeneration of neurons in the:
Putamen
Caudate
Cerebral Cortex
Only two of the options
All of the above
Visual field deficit is a symptom of?
High-grade glioma
Low-grade glioma
Meningioma
Metastatic brain tumor
The accumulation of α-synuclein protein in the substantia nigra is secondary to the following genetic predisposition except:
APOE4 mutation
LRRK2 mutation
SNCA mutation
PINK1 mutation
Of the following causes of Dementia, which is considered to be a reversible cause?
Leukoencephalitis
Normal-pressure hydrocephalus
Frontotemporal Dementia
Dementia with Lewy Bodies
Which cholinesterase inhibitor used in AD is a competitive inhibitor?
Donepezil
Rivastigmine
Galantamine
Tacrine
The following are features of AD, EXCEPT:
Neuritic plaques
Neurofibrillary tangles
Granulovacuolar degeneration of hippocampal pyramidal cells
Neuronal loss in Nucleus Basalis of Myenert
None of the above.
Chemotherapy that blocks a protein, decreasing blood supply to the tumor and slowing tumor growth.
Antiangiogenic agent
Targeted therapy
Nitrosoureas
Immunomodulator
The autosomal dominant form of the disease is linked to which gene that lead/s to the increased generation of beta-amyloid by interfering with the processing of gamma-secretase?
APP
PSEN1
PSEN2
Only two of the options
All of the above
All of the following is true about Alzheimer’s Disease except:
Loss of episodic memory comes first before progressive dementia
Low educational attainment is a risk factor
It is an autosomal recessive inheritance
Aluminum, mercury, and viruses are some of the environmental factors.
None of the above.
An 80-year-old patient presents concerns with his memory. The patient reports having difficulty remembering to do various daily tasks. He has been going to the same church for over 50 years and is troubled by the fact he got lost driving back home after church twice now. Which of the following is true regarding the most likely cause of this patient's symptoms?
Most patients develop symptoms by age 50
Neuritic plaques are specific for this disease
Patients with Down syndrome are at higher risk for this disease
Neuritic plaques are most commonly seen in the occipital lobe
Which of the following drugs are given together with Levodopa to prevent the action of aromatic L amino acid decarboxylase?
Bromocriptine
Entacapone
Carbidopa
Selegiline
What is considered to be the prodrome of Alzheimer's Disease?
Mild cognitive impairment interfering daily activities
Increased tau and reduced amyloidꞵ42
Memory loss
Presence of Apoε4 gene
Tyrosine is the precursor of what neurotransmitter/s?
Epinephrine
Dopamine
Serotonin
Only two of the options
All of the above
This centrally acting cholinergic drug is given to PD patients with severe tremor. What is it?
Amantadine
Benztropine
Stalevo
Sinemet
What drug should be used to inhibit the central decarboxylase?
Bromocriptine
Entacapone
Carbidopa
Selegiline
None of the above
All of the following is true about Parkinson’s Disease except:
Aging dopamine cells switch from sodium to calcium pacing.
The major input region is the striatum which is GABAergic to the thalamus and brainstem.
Dopamine denervation reduces the activation of cortical systems.
Non-dopaminergic degeneration precedes the onset of its motor features.
None of the above
What blocks the central metabolism of dopamine?
Selegiline
Rasagiline
LabanLeni
Only two of the options
All of the above
Which neurodegenerative disease forms pick bodies due to tau protein aggregation in neurons?
Prion Disease
Progressive Supranuclear Palsy
Frontotemporal lobe degeneration
Huntington Disease
