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WorksheetsCHAPTER 7: MUTATION
Total questions: 45
Worksheet time: 31mins
What is mutation?
Are more likely to be harmful than beneficial to human beings
Produce allelic variation and become fragile
Are permanent changes in the DNA sequence, amount or structure of chromosomes
Can be inherited from generation to the next generation if it occur in somatic cells
Gene mutation usually occurs during:
DNA repair
DNA replication
Cell division
DNA transcription
What is the term used to group X-rays, UV rays, colchicine and ethidium bromide?
Mutant
Multiply
Magical items
Mutagen
Mutation can ONLY be caused spontaneously.
True
Wrong
Tick ALL examples of physical mutagens
X-ray
Gamma-ray
UV rays
Colchicine
Gene mutation usually occurs during:
DNA repair
DNA replication
Cell division
DNA transcription
When do random, or spontaneous, mutations happen?
During cell division
When cells are exposed to hazardous chemicals
When cells are exposed to certain viruses
When cells are exposed to radiation
Identify which of the following is a genetic mutation disease..
Common head cold
Cystic fibrosis
Heart attack
Chicken pox
What mutation has occurred here?
T-G-A-C-C-A
T-G-A-G-C-A
Substitution
Deletion
Insertion
Frameshift
ATT-TGA-GCC- Original
ATT-GAG-CC - Mutated
The example above is an example of a
Insertion- Frameshift
Deletion- Substitution
Deletion -Frameshift
All of the above
What type of gene mutation has occurred here? Normal-
AGA-TTC-ATA-GCG
Mutant-
AGA-TTC-AAT-AGC-G
deletion frameshift
insertion frameshift
substitution
nonsense
Why are insertion and deletion mutations so harmful?
They change all of the codons from the mutation on down the line, which changes the amino acid sequence
They insert things that an organism doesn't need.
They often delete things that organisms need.
Insertion and deletions are not any more harmful than substitution mutations.
Identify the SUBSTITUTION mutation form the following:
normal DNA: ATG CCA AAT
ATG TCA AAT
ATG CCT AAA T
ATC CA AT
ATG CCA AAT
Which of these are the effect if base substitution mutation? Tick all correct answers
Missense
Silence
Nonsense
Frameshift
If a nucleotide is substituted yet the amino acid produce is the same, the effect of mutation is ___________
silence
missense
nonsense
frameshift
If a nucleotide is substituted, and it change one amino acid to to another. This effect is called
Missense
Nonsense
Silence
Frameshist
In sickle-cell anemia..
Glutamic acid is substituted with valine on Beta-polypeptide chain
Valine is substituted with glutamic acid on Beta-polypeptide chain
Glutamic acid is substituted with valine on alpha-polypeptide chain
Valine is substituted with glutamic acid on alpha-polypeptide chain
The polypeptide produced is truncated and short. The most likely type of point mutation that causes this is
Base substitution - nonsense mutation
Base substitution - missense mutation
Insertion mutation
Inversion mutation
The insertion of a base pair into the genetic code will cause frameshift mutation, unless the number of the base pairs inserted is
one
two
three
four
A nonsense mutation
Usually results in the formation of an abnormally short polypeptide
causes one amino acid to be changed to another
caused by insertion mutation
resulted from deletion of one or two bases
A mutation that occurs in the gametes of an
organism will most likely be transferred to which of
the following?
The siblings of the organism
The offspring of the organism
The other organisms living nearby
The mating partner of the organism
Chromosomal mutation is a change in ____________ (answer can be more than ONE)
Amount of DNA
Arrangement of gene
Number of chromosome
Structure of chromosome
Which ONE is NOT a type of chromosomal aberration?
Deletion
Insertion
Inversion
Translocation
Which of the following are types of Euploidy? (answer can be more than ONE)
Polyploidy
Aneuploidy
Allopolyploidy
Autopolyploidy
A chromosome is found to be shorter than it's homologous match. Which type of mutation involved?
insertion
deletion
translocation
inversion
Chromosomal number alterations refer to __________.
Changes in structure of chromosome
Changes in sequence of bases in DNA
Changes in numbers of chromosomes
Changes in numbers of organisms
Addition or deletion of single number of chromosome refers to ____________
Aneuploidy
Euploidy
Autopolyploidy
Allopolyploidy
Which of the following is TRUE about chromosomal aberration? (answer can be more than ONE)
Change in structure of chromosome
Change in number of chromosome
Produce abnormal gamete n-1
One segment of chromosome is removed
Which of the following are effect of aneuploidy? (answer can be more than ONE)
Monosomy 21 (2n-1)
Trisomy 21 (2n-1)
Klinefelter syndrome (44+XXY)
Turner syndrome (44+XO)
Inversion
When a segment of a chromosome breaks off.
When a segment of a chromosome breaks off, flips, and reattaches.
When a segment of a chromosome is copied or doubles.
When a segment of a chromosome breaks and attaches to a non homologous chromosome.
When entire chromosomes don't separate evenly during meiosis.
Nondisjunction in Meiosis I is more deleterious than nondisjunction in Meiosis II
True
False
Trisomy 21suggests that an individual has
Three copies of chromosome 21
Twenty one copies of chromosome 3
Three pairs of chromosome 21
Two copies of chromosome 21
Nondisjunction of sex chromosomes may occur during meiosis I of spermatogenesis. Which of the following are the possible genotypes of the zygote if the normal ovum is fertilised by these two types of the sperms?
XXY and YO
XYY and YO
XXY and XO
XYY and XO
Which of the following is caused by deletion by a large part of short arm of chromosome 5?
Cri-Du-Chat
Thalassemia
Down syndrome
Sickle cell anaemia
Polyploidy refers to
Multiple ribosomes present on a single mRNA
a chromosome which has replicated but not divided
an individual with extra sets of chromosomes
extra copies of gene adjacent to each other on a chromosome
Which of the following statement about non-disjunction is FALSE?
May produce a polyploidy
Give rise to Turner and Klinefelter syndrome
Only happens during Anaphase I of meiosis
Give rise to abnormalities in the number of both sex chromosomes and autosomes.
