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WorksheetsIT1 Exam 2 - Part 2
Total questions: 103
Worksheet time: 1hrs 5mins
What is the 1st sign of digoxin toxicity?
GI upset: nausea, vomiting, diarrhea
Neuro: confusion, dizziness, headache
Visual disturbances
Hyperkalemia
Who should take precaution when taking digoxin?
Acute MI
Electrolyte imbalances/renal sufficiency
Sinus node block
Hypothyroidism
Hyperthyroidism
What are some monitoring parameters for Digoxin?
Potassium
GI effect
Renal function
HR
EKG
What is Ivabradine?
New agent
reduces HR by selective inhibition of funny current
Similar to digoxin (in a sense)
Normalizes HR
Control HR
What are some adverse effects of Digoxin?
Bradycardia
Hypotension
Atrial fibrillation
Phosephene ring/spot
Dizziness
What are some contraindications of Digoxin?
Acute decompensated HF
Pacemaker dependence
Concomitant use of CYP3A4 inhibitors
Reduced CO
Inability to exercise
P
If a patient is hypoperfused and their HR is <70 what should they be put on?
Digoxin
Ivabradine
Isosorbide
IF a patient is hypoperfused and HR >70 what medication should they be put on for symptom resolution?
Digoxin
Ivabradine
Isosorbide
Hydralazine
What are some characteristics of Stage D?
Pts experience persistent and severe symptoms despite optimal therapy
Fluid retention
Severe impairment of functional exercise
History of >1 HF hospitalization in last 6 months
Memory loss
Select all that apply: Why shouldn't you put patient on BB?
Bradycardia
Fluid overload
Low BP
Reasons you shouldn't put pt on ACEi?
Hypotension
High potassium
Acute renal failure
Ejection fraction
What do you do it pt can't be put on ACEi bc high potassium and acute renal function BUT you can put them on BB?
Hydralazine Isosorbide
Digoxin
Telmisartan
Bisoprolol
Milronone
What can you tell from the info: SCr=3 (Baseline =1)
Abrupt change in SCr
Acute condition
Condronic condition
Reduced ejection fraction
CAD
What is true about Preserved Ejection Fraction?
Not fully filling
Not fully contracting
Looks like HF in ECHO
Ejection Fraction looks normal
Look like HF in EKG
What is a risk factor for HFpEF?
HTN
Age
Female
Atrial fibrillation
Male
What are the goals for HFpEF?
Increase diastolic filling time
Increase contractions
Which is kinda more recommeded for HFpEF?
ARBS
ACEi
BB
CCB
What should we use for patient with HFpEF?
ANY BB
ANY ACE/ARB
ARNI
NITRATES
DIGOXIN
Which heart condition has strict rules on which BB to use?
HFrEF
HFpEF
What to avoid in HFpEF?
Digoxin
Hydralazine
ARNI
ARBS
ACE
HF patient, all symptoms, ECHO, EF=70%, which of the following could you use: select all that apply:
Metoprolol Succinate
Metoprolol Tartrate
Bisoprolol
Atenolol
All of the above
HF patient, all symptoms, ECHO, EF=20%, which of the following could you use: select all that apply:
Bisoprolol
Carvedilol
Metoprolol Succinate
Atenolol
Metoprolol Tarrate
What are some causes for acute decompensated HF?
Medication non-adherence
Too much salt
Direct heart damage
Cardiac events
Hemodynamics
What would categorized a person to being a acute decompensated HF patient?
Stage D (ACC/AHA)
Class III-IV (NYHA)
Dry
Wet
Cold
Why is a 12 lead ECG helpful?
To look for arrhythmia
Took look for STEMI
EF
Edema
What is released when you have MI?
Troponin
Nitric Oxide
Enzymes
K
Na
What are examples of noninvasive monitoring?
ECG
automatic BP pressure
Pulse oximetry
Urine flow monitoring
Pulmonary artery catheter
Which describes central venous lines?
tells you how much fluid is in veins
DIRECTLY measures BP in the arteries
measures volume of blood by the heart
Why would you need to use a arterial line?
Measures arterial pressure DIRECTLY measures BP in the arteries
blood drains from appendages -> stay in core (where vital organs are)
Gives medications directly bc they could irritate veins
measures how much oxygen is in the veins
Which describes Subset I?
Warm
Dry
Wet
Cold
Which describes Subset II?
Wet
Warm
Cold
Dry
Patient: perfusion OK, BP OK, No blue lips but congested and fluid overloaded what subset are they?
Subset I
Subset II
Subset III
Subset IIII
What should be prescribed to someone in subset II?
IV loop diuretics
Beta blocker
ARB
ACEi
What if patient in Subset II does not get improvement from IV loop diuretics? What can we do?
Continuous IV diuretics
Dialysis
Combination therapy of thiazide, thiazide like and K sparing
ACEi/ARB
Which describes subset III?
Cold
Dry
Wet
Warm
What are Inotropes used for?
Patients that have low output status
Patients that can't pump
Patients that have problems with filling
What are some things that come along with using Inotropes?
Causes heart to work harder
Makes heart attacks worse
Increase mortality with use
Increase risk of arrhythmia
Lowers BP
True or false: Inotropes help manage HF symptoms
False
True
What is the true about Inotropes?
Opposite of beta blocker
Milrinone increases contractility and works on same receptor as Dobutamine
Digoxin is strong and comparable to Dobutamine
Dobutamine is what we use for positive inotropes
Digoxon can be used to manage HF symptoms long term
Which describes subset IIII?
Cold
Wet
Dry
Warm
What is the first thing that needs to be addressed in a Subset IIII pt?
Cold
Wet
Dry
Warm
Which problem is a 1st priority problem?
Perfusion
Congestion
Edema
BP
HR
What is a first line vasopressin?
Norepinephrine
Epinephrine
Dopamine
Dobutamine
______ may help to calm them down when they are on a ventilator?
Morphine
Fentanyl
Oxycodone
Nicotine
What does COLD met in subset terms?
Hypoperfused
Hyperperfused
Congested
Normal
High BP
Select the two that mean a person is a normal subset?
Warm
Dry
Wet
Cold
What is a good indicator of well perfusion?
>2.2 L/min/m2
Warm
<2.2 L/min/m2
Cold
Which indicates fluid overload?
>18 mmHg
<12 mmhG
12-17 mmHg
>16 mmHg
1 mg
What level of pulmonary artery occlusion pressure do you want to be at?
12-18 mmHg
>18 mmHg
<12 mmHg
What is considered COLD subset symptoms?
Signs of hypoperfusion
Blue lips
BP low
High HR
Select all that apply: What would be considered in the WARM subset?
Normal BP
OK perfusion
Organs OK
Edema
SOB
What would be considered in the DRY subset?
SOB
No SOB
JVD
No JVD
Edema
What would be considered in the WET subset?
SOB
JVD
Edema
Dehydration
Blue lips
What are the GOALS for subset IIII?
Restore perfusion
Relieve congestive symptoms
Optimize volume status
Be able to discharge a pt that is stable
What are important EFFICACY endpoints for acute HF?
Weight
Fluid intake/output
Heart failure S/SX
Hemodynamics
Renal function
What are safety endpoints for HF?
Weight
Hemodynamics (BP, MAP)
Electrolytes
Renal function
Weight
What needs to be addressed before discharging a pt for HF?
Exacerbated factors addressed
Optimal volume status
Stable on all oral meds
Education
Stable with no meds
Which subset's main problem is FLUID?
Subset I
Subset II
Subset III
Subset III
What should you give to patient that have fluid overload?
Diuretic
ACEi
ARB
CCB
Which subset's problem is hypoperfusion?
Subset I
Subset II
Subset III
Subset IIII
What kills first?
Congestion
Perfusion
Which drugs are shown to DECREASE mortality?
ACEi/ARB
ARNI (Entresto)
BB
Aldosterone Receptor Antagonists
Hydralazine/Nitrates
What are non-pharm treatments for those wiith acute decompensated HF?
Monitor weight
Sodium restriction
Fluid restriction
Add fluid
Decrease BMI
What are the MAIN pharm treatments for HF
ACEi/ARB/ARNI
BB
Aldosterone
Loops
Digoxin
What is used for symptoms relief for HF?
Diuretics
Digoxin
Ivabradine (Corlanor)
ACEi
Hydralazine/Isosorbide
Which is affected by volume of venous return or fluid status
Preload
Afterload
Affected by aortic pressure and SVR
Preload
Afterload
“load” the heart must overcome to eject blood
Afterload
Preload
Which are peripheral hemodynamics?
BP
MAP
HR
CVP
PAP
What is the GOAL map we are shooting for?
<65 mmHG
>65 mmHG
>45 mmHG
10-15 mmHG
Which describes assesses fluid status during resuscitation, it is the DIRECT measurement of BP in the right atrium
CVP
CO
CI
SVR
What is the goal CVP we want to reach?
8-12 mmHG
12-15 mmHG
1-15 mmG
>65 mmHG
What is the GOAL CVP if the pt is mechanically ventilated?
12-15 mmHG
8-12 mmHG
12-15 mmHG
>65 mmHG
What is the Cardiac Index (L/min/m2) level that means you are WELL PERFUSED?
>2.2
<2.2
>18
<18
What level means you have pulmonary edema (L/min/m2)?
>18
<18
>2.2
<2.2
What is Mixed-venous oxygen saturation (Svo2) a reflection of?
Oxygen delivery
Tissue perfusion
Surrogate markers for CO
Tachycardic
Determinant of which BB to use
HF
What is the svo2 goal?
>65%
>60%
>55%
>70%
What is the goal for scvo2?
>65%
>70%
<70%
>35%
What is the definition of shock?
Acute state of inadequate perfusion of critical organs
Blood pressure extremely low
Dizziness and extreme vomiting
State of confusion
Which of these can shock do to your body?
SBP <90 mmHg
MAP <70 mmHg
MAP >70 mmHg
Bradycardia
End organ damage
Which type of shock is consists of trauma and hemorrage?
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
Which type of shock is consists of acute myocardial infarc and HF?
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
Which type of shock is consists of trauma and hemorrhage?
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
Which type of shock is consists of cardiac tamponade, pneumothorax and pulmonary emboli?
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
Which type of shock is consists of sepsis, anaphylaxis and neurogenic?
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
When talking about vasodilator or distributive shock which condition are we addressing?
Pre-resuscitation
Post-resusitation
Choose the two shocks that are very similar in presentation
Hypovolemic
Cardiogenic
Obstructive
Vasodilatory
Pre-resuscitation
What would a SBP <90 mmHg likely cause?
Hypotension
Tachycardia
Hyperventilation
Cutaneous vasoconstriction
Liguria
What would a HR > 90 bpm likely cause?
Hypotension
Tachycardia
Hyperventilation
Cutaneous vasoconstriction
Liguria
What would a RR > 20 bpm likely cause?
Hypotension
Tachycardia
Hyperventilation
Cutaneous vasoconstriction
Liguria
What would a UOP <20 mL/hr likely cause?
Hypotension
Tachycardia
Hyperventilation
Cutaneous vasoconstriction
Liguria
What is a sign of cutaneous vasoconstriction?
Cold
Clammy extremities
Edema
Confusion
Altered mental state
What is a indictor of sepsis?
Hyperthermia
Hypothermia
Leukocytes WBC > 12 x 103/mm3
Thrombocytopenia
Leukopenia WBC <4 x 103/mm3
Select the evidence of organ hypoperfusion
Neuro: altered mental status
CV: altered hemodynamics, elevated troponin, EKG changes
Respiratory: decrease oxygen saturdation
GI: decrease bowel sounds, ileus, incrased LFTs, PT/INR and PTT
Renal: Decrease UOP
What are the 4 stages of treatment:
Salvage
Optimization
De-escalation
Stabilization
Replenish
For the Salvage phase what is our target?
Lactate clearance
MAP > 65 mm Hg
MAP <65 mmHg
Fluid replenish
What is our main goal for Optimization stage?
Target MAP >65 mmHg
Target MAP < 65 mmHG
Target lactate clearance
Target euvolemia
What are the fluids of choice for fluid resuscitation?
Normal saline
Lactated ringers
H2O
PDE 5%
How do you evaluate a stopping point for fluids?
Passive leg raise
Hemodynamics parameters
Pitting check
BP measurement
Cognitive tests
How do you administer vasopressins and inotropes for shock?
Central line
Peripheral line
Orally
Which induce vasoconstriction -> Increase SVR and MAP
Inotrope
Vasopressor
ACEi
ARB
Digoxin
Which increase rate and contractility -> increase CO and MAP?
Vasopressin
Inotrope
ARB
ACEi
CCB
You should avoid doses >0.125 of Digoxin if:
Age >60
Age >70
Impaired renal function
Low BMI
High BMI
