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Nephrology exam 1 : Rapid Review Dr. Jones

Total questions: 55

Worksheet time: 3hrs 45mins

Name
Class
Date
1.

The main function of the kidneys is the regulation of the intracellular fluid. 

a)

True

b)

False

2.

Blood pressure is regulated through the actions of the kidneys. 

a)

True

b)

False

3.

Dilation of the afferent arteriole would increase glomerular pressure.

a)

True

b)

False

4.

A decrease in blood pressure will cause an increase in GFR through sympathetic stimulation

a)

False

b)

True

5.

  The proximal convoluted tubule reabsorbs approximately 65% of water and ions salt entering it.   

a)

True

b)

False

6.

Since water follows the reabsorption of Na+ in the proximal tubule, the filtrate is isosmotic with the blood. 

a)

True

b)

False

7.

As the tubular filtrate moves through the descending limb of the loop of Henle, the osmolality of the filtrate increases

a)

True

b)

False

8.

The collecting duct is naturally impermeable to salt but permeable to water. 

a)

True

b)

False

9.

The maximal response to antidiuretic hormone occurs in the cortical nephrons

a)

True

b)

False

10.

 Inulin clearance gives a measurement of the glomerular filtration rate. 

a)

True

b)

False

11.

The renal plasma clearance of a substance that is filtered and reabsorbed must be less than the GFR.

a)

True

b)

False

12.

Only about 20% of renal blood is filtered in one pass through the

a)

True

b)

False

13.

Increased aldosterone secretion stimulates renal potassium retention

a)

True

b)

False

14.

In response to low blood plasma Na+, reduced ADH will decrease water volume in the blood to match lower Na+ concentration while increased aldosterone will increase Na+ reabsorption to match the higher water volume of blood.

a)

True

b)

False

15.

What structures carry urine from the kidneys to the urinary bladder? 

a)

ureters

b)

urethras

c)

calyces

d)

pyramids

16.

The __________ is a capillary network that produces a blood filtrate that enters the urinary tubules. 

a)

vasa recta

b)

peritubular capillary

c)

glomerulus

d)

interlobar capillary

17.

The _______________ nephrons play an important role in producing concentrated urine. 

a)

juxtamedullary

b)

cortical

c)

pelvic

d)

calical

18.

The efferent arteriole delivers blood to the _______________ (choose all that apply)

a)

peritubular capillaries

b)

vasa recta

c)

glomerulus

d)

juxtaglomerular apparatus

19.

The renal pelvis receives urine from the 

a)

minor calyces

b)

ureters

c)

renal pyramids

d)

major calyces

20.

The __________ is the functional unit of the kidney. 

a)

calyx

b)

nephron

c)

neuron

d)

medulla

21.

The average glomerular filtration rate is equal to 

a)

180 L/day

b)

5.5 l/min

c)

180ml/day

d)

100 mmHg/hour

22.

Increased sympathetic neuron activity will cause 

a)

vasoconstriction of afferent arterioles

b)

increased GFR

c)

increased urine production

d)

decreased blood volume

23.

The ability of the kidneys to maintain a relatively constant GFR despite fluctuating blood pressures is called 

a)

renal plasma threshold

b)

renal transport maximum

c)

renal plasma clearance

d)

renal autoregulation

24.

Systemic hypotension would induce __________ of afferent arterioles. 

a)

constriction

b)

dilation

c)

no change

25.

The sensor in tubule glomerular feedback is a group of cells called the 

a)

macula densa

b)

gomerulus

c)

vasa recta

d)

macula lutea

26.

Glomerular filtration would be decreased by (choose all that apply)

a)

increased plasma protein concentration. (this does not change very often, but it does increase near the end of the glomerulus)

b)

increased glomerular filtrate protein concentration.

c)

decreased glomerular hydrostatic pressure.

d)

increased mean arterial pressure.

27.

Through renal autoregulation, an increase in blood pressure will cause the afferent arteriole to ____ and therefore the GFR will ____. A. dilate, not change.

a)

dilate, not change

b)

dilate, decrease

c)

constrict, decrease

d)

constrict, no change

28.

The return of molecules from the tubules to the blood is called 

a)

reabsorption

b)

secretion

c)

filtration

d)

autoregulation

29.

The majority of reabsorption occurs in the 

a)

collecting duct

b)

distal convoluted tubule

c)

loop of henle

d)

proximal convoluted tubule

30.

Na+ reabsorption is a(n) __________ process, while Cl- reabsorption is a(n) __________ process

a)

active, active

b)

active, passive

c)

passive, passive

d)

passive, active

31.

The ____ limb of the loop of Henle is impermeable to salt

a)

ascending

b)

descending

c)

both limbs

d)

neither limb

32.

Which of the following is the correct order of the nephron tubule structures? 

a)

distal convoluted tubule, loop of Henle, proximal convoluted tubule, Bowman's capsule

b)

proximal convoluted tubule, Bowman's capsule, distal convoluted tubule, loop of Henle

c)

Bowman's capsule, proximal convoluted tubule, loop of Henle, distal convoluted tubule

d)

loop of Henle, Bowman's capsule, proximal convoluted tubule, distal convoluted tubule

33.

Which of the following is NOT a potential filtration barrier in the glomerular capsule? 

a)

glomerular basement membrane

b)

capillary fenestrae

c)

parietal layer of the capsule

d)

slit diaphragm

34.

The primary filter to exclude proteins from the filtrate is the 

a)

glomerular basement membrane

b)

capillary fenestrae

c)

parietal layer of the capsule

d)

slit diaphragm

35.

What is the order that filtrate must pass through to the glomerular capsule? 

a)

podocytes of glomerular epithelium, glomerular basement membrane, capillary fenestrae

b)

capillary fenestrae, glomerular basement membrane, podocytes of visceral glomerular epithelium

c)

glomerular basement membrane, capillary fenestrae, podocytes of visceral glomerular epithelium

d)

capillary fenestrae, podocytes of visceral glomerular epithelium, glomerular basement membrane

36.

The tubular filtrate osmolarity __________ as it flows through the ascending limb of the loop of Henle. 

a)

increases

b)

decreases

c)

remains unchanged

37.

The concentration of renal filtrate is highest in the 

a)

proximal convoluted tubule

b)

base of the loop of Henle

c)

distal convoluted tubule

d)

cortical portion of the collecting duct

38.

Countercurrent multiplication occurs by the actions of the 

a)

vasa recta

b)

peritubular capillaries

c)

loop of Henle

39.

_________ is a non salt molecule that contributes to the hypertonicity of the interstitial fluid of the renal tubules. 

a)

Urea

b)

Protein

c)

Creatinine

d)

Xenobiotic molecule

40.

Antidiuretic hormone:

a)

stimulates water reabsorption by the kidney.

b)

induces fusion of aquaporin containing vesicles with the plasma membrane.

c)

is secreted in response to dehydration.

41.

The movement of molecules and ions from the peritubular capillaries into interstitial fluid and then into the nephron tubule is called 

a)

secretion

b)

reabsorption

c)

excretion

d)

filtration

42.

If the rate of urine formation is 2 ml/min, the urine inulin concentration is 25 mg/ml, and the plasma inulin concentration 0.5 mg/ml, then the GFR is 

a)

0.04 ml/min

b)

100 ml/min

c)

6.25 ml/min

43.

Decreased glomerular filtration rate would 

a)

increase plasma protein clearance rate

b)

increase plasma urea clearance rate

c)

decrease plasma creatinine clearance rate

d)

decrease plasma glucose clearance rate

44.

The renal plasma clearance of a substance that is filtered but not reabsorbed or secreted is ___ the GFR. 

a)

greater than

b)

less than

c)

equal to

45.

The _________________ is the saturation point of renal carrier molecules. 

a)

transport maximum

b)

GFR

c)

renal plasma clearance

d)

renal plasma treshold

46.

Excessive aldosterone secretion would induce 

a)

decrease plasma potassium

b)

decrease plasma sodium

c)

decrease plasma chloride

d)

no change un plasma ion balance

47.

Diuretics

a)

decrease urine production

b)

induce hypertension

c)

often act on the proximal convoluted tubule

d)

often act on the distal convoluted tubule

48.

The main region of aldosterone action is the 

a)

distal convoluted tubule

b)

proximal convoluted tubule

c)

medullary collecting duct

d)

cortical collecting duct

49.

Granular cells of the juxtaglomerular apparatus respond to decreased blood volume and increased sympathetic nerve activity by secreting 

a)

renin

b)

inulin

c)

angiotensinogen

d)

natriuretic hormone

50.

Angiotensin-converting enzyme is mostly present in the capillaries of the 

a)

liver

b)

kidneys

c)

lungs

d)

adrenal medulla

51.

The presence of renin secreting tumors may cause 

a)

hypertension

b)

increase aldosterone secretion

c)

increased renal sodium reabsorption

52.

Hemorrhage would induce 

a)

increased renin secretion

b)

increased atrial natriuretic peptide secretion

c)

decreased ADH secretion

53.

Aldosterone secretion from the adrenal cortex is stimulated by a(n) ____ in blood Na+ or a(n) ___ in blood K+

a)

increase, decrease

b)

increase, increase

c)

decrease, increase

d)

decrease, decrease

54.

Spironolactone 

a)

inhibits the actions of aldosterone

b)

blocks bicarbonate reabsorption

c)

stimulates hypertension

d)

activates NA+/K+ pumps

55.

Loop diuretics such as Lasix 

a)

inhibit the action of ADH

b)

add extra solutes to the filtrate

c)

inhibit active transport of salt out of the ascending loop of Henle limb

d)

inhibit salt transport in the first section of the distal tubule.