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WorksheetsPODA IV Exam 1 Cancer: Breast, Prostate, Cervical, Skin
Total questions: 51
Worksheet time: 34mins
SATA: WOTF does Alpelidib (Piqray) inhibit
PI3K
Pik3
Phosphoinositide 3 kinsae
Microtubule assembly
WOTF best describes the MOA of Eribulin (Halaven)
Antimitotic agent: inhibits the assembly of microtubules
Phosphoinositide 3 kinase inhibitor
HER2 Inhibitor that binds to NK cells
Represents autologous immunity
Provide strand breakage; Inhibit Topo2; Generate free radicals; Alter cell membrans
WOTF medications should be administered with food?
Ibrance
Palbococlib
Olaparib
Lynparza
WOTF medication's metabolism may be described as a 3A4 and 2B6 inducer; undergoes glucuronide and sulfa conjugation; and to a lesser extent 3A4 inhibition
Olaparib (Lynparza)
Palbociclib (Ibrance)
Bicalutamide (Casodex)
Goserelin (Zoladex)
SATA: WOTF are adverse effects of taxanes?
Mucositis (mouth sores)
Neuritis
VTAC and Bradycardia
CHF
Bone Marrow Depression
WOTF medications are used to manage taxane induced Mucositis?
Polyfermin (Kapivance)
Flutamide (Eulexin)
Epoetin (Procritt)
Sodium thiosulfate
SATA: WOTF are possible adverse effects of HER-2 Inhibitors
Pulmonary effects
GI Effects
Bone marrow depression
CHF
SATA: WOTF is a gonadotropin releasing hormone analog that is used in the treatment of cancer and has adverse effects such as reduced libido, edema, potential for MIs, and hot flashes
Nafarelin (Synarel)
Leuprolide (Lupron)
Goserelin (Zoladex)
Eribulin (Halaven)
SATA: WOTF are agents that can be used in the management of chemotherapy induced anemia
Epoetin (Procritt)
Darbepoetin (Aranesp)
Filgrastim (Neupogen)
Conivaptin (Vaprisol)
Management of chemotherapy induced extravasation includes SATA
Sodium thiosulfate
Cold compress
Limb elevation
Acetylcholine (Mucomyst)
Allopurinol (Zyloprim) can be used to treat hyperuricemia caused by what class of chemotherapy agents?
Vinblastine (Velban)
Oxaliplatin (Eloxatin)
Pembrolizumab (Keytruda)
Finasteride (Proscar)
Which of the following combos that you use for breast cancer employs (contains) Novantrone?
FEC regimen
Coopers regimen
CMF regimen
CFM regimen
VATH regimen
WOTF would produce it’s therapeutic effect by inhibiting PI3K
Abarelix (Plenaxis)
Ketoconazole (Nizoral)
Doxorubicin (Adriamycin)
Eribulin (Halaven)
Alpelisib (Piqray)
WOTF is used to manage cancer chemotherapy induced Nausea and vomiting because it inhibits serotonin 3 receptors
Reglan (Metoclopramide)
Emend (aprepitant)
Valium (Diazepam)
Tropisetron (Novaban)
Allopurinol (Zyloprim)
Which of those listed above will produce its effect by inhibiting substance P (always associated with neurokinin 1 receptors)
Reglan (Metoclopramide)
Emend (aprepitant)
Valium (Diazepam)
Tropisetron (Novaban)
Allopurinol (Zyloprim)
Considering it’s adverse effects, which of the following would result from cisplatin administration
Hypomagnesemia
Hypocalcemia
Hypokalemia
Hyperuricemia
Hypernatremia
How does cisplatin produce an electrolyte imbalance - what does it inhibit?
(a)
What would you use to manage cisplatin induced nephrotoxicity and how does it work
Amifostine (Ethyol)
It’s a scavenger of free radicals
Capivance (palifermin)
It help protect cells
What would you use to manage mucositis caused by your taxanes?
Capivance (palifermin)
Amifostine (Ethyol)
Febuxostat (Uloric)
Sodium thiosulfate
WOTF would you use to manage extravasation (leaving blood vessels when you try to inject and get out in the tissues) caused by a vesicant?
Elevate the limbs of the patient
Apply some cold compresses
Administer paliformin
Give some sodium thiosulfate
Hydrate the patient
SATA: Examples of vesicants include
Antracycles
Vinca Alkaloids
Mitomycin
Nitrous urea
Nitrogen mustards except for cyclophosphamide
How would you manage chemotherapy induced hemorrhagic cystitis?
Give mesna
Hydrate the patient
Give mucomyst
Administer capivance
Give zyloprim
For cancer chemotherapy induced anemia, which of the following would be appropriate for the pharmacist to recommend?
Procrit
Epoetin
Darbepoetin
Aranesp
Epogen
WOTF would you use to manage cancer chemotherapy induced leukopenia or neutropenia What if it’s white blood cells? neutropenia/?leukopenia
Intron
Neupogen
Neulasta
Pegintron
Leukine
Which of the following would be effective in managing cancer chemotherapy induced hyperuricemia
Zyloprim (allopurinol)
Uloric (Febuxostat)
Elitek (rasburicase)
Krystexxa (pegloticase)
Zurampic (lesinurad)
WOTF is an adverse effect of vinca alkaloid?
SIADH
Loss of hair - alopecia
Hyperuricemia
Extravasation
Diarrhea
SATA: WOTF are used to manage SIADH caused by chemotherapy
demeclocycline
loop diuretics
lithium carbonate
Vaptans
WOTF is least likely to be an adverse effect of lupron (leuprolide)
Hot flashes
MI - myocardial infarction
Thromboembolism
Increase libido
Arrhythmias
WOTF combination regimens that you use to treat prostate cancer represents a complete androgen blockade?
FL regimen
PE regimen
VE regimen
EMCYT
FZ regimen
WOTF agents used to treat prostate cancer is a representation of autologous inhibition of the cancer cells? (produce autologous immunity)
PIQRAY (Alpelisib)
Perjeta (Pertuzumab)
Proscar (Finasteride)
Prevagen
Provenge (Sipuleucel-T)
WOTF would be suggestive of a fast growing and aggressive prostate cancer?
A diploid tumor
A tumor with a gleason number of 8
A well differentiated tumor
A poorly differentiated tumor
An aneuploid tumor
WOTF has been associated with the development of prostate cancer. Mutations in which of the following genes
P53
BRCA1
BRCA2
PRCA 1
HPC 1
WOTF will result in breast cancer development
Loss of P53 gene
Mutations of BRCA2 gene
Amplification of CERB 2 gene
A decrease in the expression of cyclin D gene
A decrease in the expression of BRCA1 gene
WOTF will decrease the risk of prostate cancer development
Lycopene
Selenium
Vitamin E
Vasectomy
Orchiectomy
WOTF produces its effect by inhibiting 5 alpha reductase
Jalyn (Dutasteride/tamsulosin)
Proscar (finasteride)
Dutasteride (Avodart)
Tamsulosin (Flomax)
Saw palmetto
WOTF describe the MOA of anthracyclines?
Alter the membrane
Inhibition of topoisomerase 2 to prevent the resealing of the DNA strands which will prevent DNA division
Generate free radicals which can attack breast cancer cells to alter their membrane
Intercalate DNA and cause strand breakage
WOTF will produce its pharmacological effect by inhibiting 17 hydroxylase enzyme
Zytiga (abiraterone)
Megace
Androcur (cyproterone)
Orilissa (elagolix)
Goserelin (zoladex)
WOTF is effective in the management of basal cell carcinoma because it inhibits the SMO receptor and thereby inhibits the hedgehog signaling pathway
Libtayo (Cemiplimab-rwlc)
Keytruda (Pembrolizumab)
Erivedge (Vismodegib
Zyclara (imiquimod)
Efudex (Topical 5-FU)
WOTF produces its anticancer effect by inhibiting CTLA 4. Very effective in NSCLC
Trastuzumab (Herceptin)
Bevacizumab (Avastin)
Sacituzumab (Trodelvy)
Ipilimumab (Yervoy)
Rituximab (MabThera, Rixathon and Truxima)
WOTF would you recommend for treating HER-2+ metastatic breast cancer?
Rucaparib (Rubraca)
Kisqali (Ribociclib)
Piqray (Alpelisib)
Pertuzumab (Perjeta)
Ibrance (Palbociclib)
What is the dosage of arimidex used in combination with ibrance?
Arimidex (Anastrozole) is given 1 mg po daily
Aromasin is given 25 mg
Femara (Letrozole) is given 2.5 mg
Ibrance is given 125 mg
Faslodex is given 500 mg IM injection into the buttox
WOTF statements will be correct about Ibrance when it is administered with Fluvestrant it is dosed in treating metastatic breast cancer
With fulvestrant via slow im injection into the buttox
When it is administered with fulvestrant it is used to treat a HER2(-) HR+ breast cancer
Ibrance is administered with Fulvestrant with Ibrance orally on days 1-21 on an empty stomach
Ibrance can be given with fulvestrant to treat breast cancer after a prior hormonal treat of the breast cancer
WOTF statements about Ibrance is true
PPB of 85%
Half life is 2-3 hours
Metabolized by 3A4
Administered parenterally
Its kinetics will not be significantly affected by renal dysfunction
WOTF about olaparib would be false?
It has a plasma protein capability of 82%
It is an inhibitor of 2B6
It is effective in treating HER 2 - G (germline) BRCA Mutated breast cancer
It is effective in treating HER2 - S (somatic) BRCA mutated breast cancer
It is a PARP1 inhibitor
WOTF statements about olaparib are true?
Usual dose of 300 mg BID
Has the half-life of about 15 hours
It is a stimulator of 3A4
It is mostly excreted through the urine
It is an inhibitor of 3A4
How would you classify margetuximab?
HER2- Inhibitor
PARP Inhibitor
CDK Inhibitor
RTK Inhibitor
A patient who has malignant melanoma who is being treated with Dartmouth regime is receiving all of the following except
Cisplatin (Platinol)
Sorafenib (Mexavar)
Dacarbazine (DTIC)
Tamoxifen (Novaldex, Soltamox)
Carmustine (BiCNU)
WOTF is a Braf inhibitor that is useful in the management of malignant melanoma?
Dactinomycin (Cosmegen)
Dacarbazine (DTIC)
Dabrafenib (Tafinlar)
Vemurafenib
Sorafenib
WOTF is a PDL1 inhibitor that is used in the treatment of merkel cell carcinoma
Keytruda (Pembrolizumab)
Libtlyo (Cemiplimab)
Bavencio (Avelumab)
Odomzo (Soniedegib)
Erivedge (Vismodegib)
WOTF is a PD1 inhibitor that is used in the treatment of merkel cell carcinoma
Keytruda (Pembrolizumab)
Libtlyo (Cemiplimab)
Bavencio (Avelumab)
Odomzo (Soniedegib)
Erivedge (Vismodegib)
WOTF would be true about the actions of Tivdak (Tivostumab) when it is used to manage cervical cancer?
It inhibits the incorporation of thymidine into DNA
It stops the progression of cell cycle
It is/contains a monoclonal antibody
It induces DNA strand breakage
It is an antibody drug conjugate
