WorksheetsPharmacology Test
Total questions: 40
Worksheet time: 43mins
What is pharmacology?
Study of drugs
Study of plants
Study of living things
What is an Anti-inflammatory drug?
a drug or medicine used to reduce inflammation
a drug or medicine used to relieve pain
Which one is "brand" name for a drug?
panadol
Paracetamol
The first step in rational drug design is to ________
identify the target molecule
characterize the shape of the target molecule
find a lead
test the drug molecule
The target molecules can be the following EXCEPT
receptors
enzymes
free oxygen
transcription factors
Which of these statements best describes a lead compound?
A compound that contains the element lead
A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug
A compound from the research laboratory that is chosen to go forward for preclinical and clinical trials
The first compound of a structural class of compounds to reach the market.
Identify the kind of interactions that are typically involved in binding a drug to the binding site of a protein.
predominantly van der Waals interactions
predominantly hydrophobic interactions
predominantly hydrogen bonds
a combination of all of the above
Which of the following statements best describes pharmacokinetics?
the study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution, metabolism and excretion
the study of how drugs can be designed using molecular modelling based on drug's pharmacophore.
the study of how a drug interacts with its target binding site at the molecular level to produce a particular pharmacological effect.
the study of which functional groups are important to a drug's activity, and the identification of a pharmacophore.
What is meant by ADME in pharmacokinetics?
Affinity, dosage, marketing, efficacy
Absorption, distribution, metabolism, excretion
Agonism, dependence, mobility, efficiency
Antagonism, deficiency, mean, efflux
Which of the following is one of the rules in Lipinski's rule of five?
A molecular weight equal to 500
No more than five hydrogen bond acceptor groups
No more than 10 hydrogen bond donor groups
A calculated logP value less than +5
In identifying a new drug to be taken orally to treat stroke, the perfect molecule will :
be rapidly metabolized
be well absorbed
bind irreversibly to the target protein
reach its site of action after oral administration
Bioassays
are the main methods used in high throughput screening
measure a functional response in a biological tissue
measure the binding affinity of an agonist
require the use of radiolabelled ligands
Any reaction to a medicine other than the one intended.
Tolerance
OTC medicine
Addcition
Side effect
Catalyst
When a person's body has become used to the effects of the a drug or medicine and needs a greater amount to be effective.
Stimulant
Side Effect
Tolerance
Addcition
Craving
An amount of a drug so excessive that it makes someone ill or causes death.
Withdrawal
Tolerance
Overdose
Addicition
Lil Pump
The condition in which a person develops a mental or emotional need for a drug or other substance.
Psychological dependence
Tolerance
Withdrawal
Physical Dependence
Do not choose this answer.
A compelling need to continue a behavior as in abusing drugs.
Addiction
Overdose
Withdrawal
Tolerance
The therapeutic response of a drug is its:
desired effect
side effect
adverse effect
toxic effect
A decrease response to an increase in dosage is:
tolerance
cumulative effect
dependence
idiosyncracy
The study of how the effects of drugs are manifested is:
Chemistry
Biology
Pharmacodynamics
Physiology
What is an immune response of the body to a drug?
Synergetic effect
Radiation effect
Antibiotic effect
Allergic effect
The time from onset of action to when the response is no longer perceptible is:
peak serum concentration
half-life
duration
therapeutic indes
What is the measure of the relative safety of a drug?
potency
therapeutic index
efficacy
peak serum concentration
The oral route of medication administration
Is under the tongue
Is through injection
Is via an IV
Is through ingestion via esophagus
an advantage of the entral route is
Does not go through first pass metabolism
Goes through first pass metabolism
Acts on the body faster
Acts on the body in a predicatble manner
The epidural route of administration occurs?
In the subarachnoid space
Via the digestive tract
In the epidural space
In the intramuscular space
The subcutaneous route of administration is
Via the top of the epidermis
Through the liver
Into muscle tissue
Under the epidermis
Barriers to drug administration are?
Blood brain barrier
Placental barrier
All of the above
None of the above
Elimination is the irreversible loss of drug from the plasma
True
False
Ignore this option
Ignore this option
The therapeutic range lies between the minimum effective concentration and the minimum toxic concentration
True
False
Ignore this option
Ignore this option
The acronym for pharmacokinetics is?
RASP
DRUG
ADUE
ADME
An agonist initiates or enhances the normal response?
True
False
Ignore this option
Ignore this option
An antagonist increases the normal response?
True
False
Ignore this option
Ignore this option
Hypersensitivity is a type of adverse drug reaction?
True
False
Ignore this option
Ignore this option
Consequences of an adverse drug interaction can include? Mark all that apply
Prolonged illness
Higher mortality rates
Longer stay time at a hospital
Drug levels within the body increasing at an exponential rate
An enteric coated medication should not be
swallowed
crushed
given with food
A transdermal medication is
Absorbed through the small intesting
Absorbed through the sub cutaneous layer of skin
Absorbed through the epidermis
Absorbed through the mucous membranes
A hormone like estrogen is given as a
curative
therapeutic
replacement
palliative
What is another word for testing if a drug is effective?
Effectiveness
Efficacy
Reliable
Ethical
What is the purpose of a placebo?
To act as an experimental control
To avoid false claims
To avoid animal testing
The placebo effect
