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WorksheetsCardio remediation exam 2 drug quiz
Total questions: 66
Worksheet time: 38mins
Which of the following is a contraindication for Warfarin?
Pregnancy
Alopecia
Autoimmune diseases
Stopping the medication suddenly
Which Apolipoprotein is found on LDL only?
C2
B100
E
B48
Which drug is an NPC1L1 inhibiter that can be paired with certain statins to reduce LDL?
Juxtapid
Lomitapide
Zetia
Mipomersan
Which of the following are PSCK9 inhibitors?
Alirocumab
Repatha
Inclisiran
Lomitapide
What do statin drugs target?
HMG-COA
De novo
Acety-COA
Malonyl-COA
The maximum effect of statins are not seen until...
3 weeks
4 weeks
12 weeks
6 weeks
Which statin drugs can be taken any time of day?
Atorva-
Rosuva-
Pitava-
Prava-
Which statin drug is the most hydrophilic?
Atorva-
Fluva-
Lova-
Rosuva-
Which statin drug is the most lipophilic?
Atorva-
Simva-
Lova-
Rosvua-
Which statin drugs have CYP3A4 interactions?
Lova-
Simva-
Prava-
Atorva-
Which statins have CYP2C9 interactions?
Atorva-
Pita-
Rosuva-
Fluva-
Which statins can be used with cyclosporin?
Fluva-
Simva-
Rosuva-
Lova-
Which statin can be used with Gemfibrozil at 5 mg maximum?
Fluva-
Atorva-
Rosuva-
Lova-
Which statins are considered to be high intensity and at what dose?
Atorva (60 mg)
Atorva (80 mg)
Rosuva (10 mg)
Rosuva (20 mg)
Which statins are considered to be low intensity and what is their correct dosing?
Lova (10 mg)
Lova (20 mg)
Prava (15 mg)
Prava (10 to 20 mg)
Which of the following people would you calculate an ASCVD score for?
A 20 year old with familial hypercholesterolemia.
A 40 year old with a history of a CV event.
A 55 year old with LDL greater than 160 and has diabetes.
A 40 year old with an LDL of 150 that does not have diabetes.
For someone who has an ASCVD score considered to be of high risk, what should their LDL treatment goal be?
Under 190
Under 100
Under 90
Under 50
Which of the following are bile acid sequestrants?
Bempedoic acid
Colestipol
Welchol
Anatara
Who would be a good candidate for a bile acid sequestrant?
Someone with high triglyceride levels.
Someone who cannot be on a statin due to myopathy concerns.
Someone with hyperuricemia who needs to reduce circulating LDL.
Someone with a ruptured tendon and cannot be on a fibrate.
Who would be a good candidate for a fibrate drug?
Someone with gallbladder disease can cannot tolerate a statin.
Someone with LDL levels over 160.
Someone with severe renal dysfunction.
Someone on Rosuvastatin the needs to lower LDL levels more.
Which of the following classes of drugs can show a decrease in triglycerides?
Fibrates
Niacin
PSCK9
Fish oil
Which factors are activated in the intrinsic pathway?
12
11
9
8
Which of the following are direct thrombin inhibitors?
Idarucizumab
Apixaban
Dabigatran
Argatroban
Which of the following is NOT an anticoagulant class?
Direct thrombin inhibitor
Direct Xa inhibitor
Glycoprotein 2b&3a inhibitor
Vitamin K epoxide reductase
Which of the following drugs are PDE inhibitors?
Dipyridamole
Clopidogrel
Prasugrel
Cilostazol
Which ADP receptor inhibitor binds irreversibly?
Clopidogrel
Prasugrel
Ticagrelor
Aspirin
A patient has intermittent claudication, which drug will they be placed on?
Aspirin
Clopidogrel
Cilostazol
Vytorin
Which of the following drug classes bind to fibrinogen and prevent cross-linking?
PDE inhibitors
GP 2b&3a antagonists
COX inhibitors
direct thrombin inhibitors
A patient is being considered for a statin drug but genetic testing shows that the patient has a SLCO1B1*1b/*5 diplotype, what is the fphenotype function level?
High function
intermediate function
Low function
No function
A patient enters a hospital with a ischemic stroke, they should begin therapy within...
30 minutes
45 minutes
90 minutes
60 minutes
Which factors are involved the extrinisic pathway?
3
7
tissue factor
12
What is the correct dosing for Alteplase? Select all that apply.
Max dose is 90 mg
10% of the treatment should be administered as a bolus for the first minute of treatment.
it should be infused intravenously over the course of an hour
Decrease the dose by half if it is the patient's second occurence of a stroke occurs within 24 hours of the 1st stroke.
Which of the following MUST be done before a tPA is administered?
Blood glucose test
Genetic testing
Blood pressure check
Non-contrast CT scan
A patient just had a stroke. It is discovered that the patient had a stroke a month ago, which of the following is true?
They can be given Alteplase.
They can be given Tenecteplase.
Wait it out.
They can undergo a mechanical thrombectomy.
A triple therapy unit involving a steroid, an antihistamine, and a H2RA is used for which kind of patient?
A patient who is hemorrhaging.
A patient with horner's syndrome.
A patient who broke out in hives after treatment.
A patient who have tPA associated orolingual angioedema.
Which of the following can be use to stop intracranial bleeding after a tPA has been administered?
Cyroprecipitate
Trenexamic acid
Aminocaproic acid
Warfarin
A patient enters the hospital. It is discovered that they have a hemorrhagic stroke, which of the following can be given to help prevent expansion?
Nimodipine
Vitamin K injection
Fresh frozen plasma
Mannitol
A patient enters the hospital with a hemorrhagic stroke, what can be given to them to prevent cerebral edema?
Mannitol
Hypertonic Saline
Furosemide
Nimodipine
What is carnitine used for?
Beta oxidation of fatty acids in the mitochondria
Beta oxidation of fatty acids in the cytoplasm
Reducing fatty acids in the mitochondria
Reducing fatty acids in the cytoplasm
Which of the following statements is/are true?
Bile acids emulsify fat since they are not water soluble.
Triglycerides are transported via chylomicrons.
APO-C2 activates lipoprotein lipase
Fatty acids travel from adipose to other tissues by adhering to albumin.
How does insulin affect the synthesis of cholesterol?
By decreasing cholesterol synthesis
By increasing cholesterol synthesis
By shifting cholesterol from the adipose to the liver
By shifting cholesterol from the liver to adipose.
Which of the following help form chylomicrons?
CETP
ACAT
NPC1L1
MTTP
Which of the following is NOT a side effect of a statin drug?
Teratogenicity
Hyperuricemia
Myopathy
Hepatotoxicity
A patient has just been placed on Gemfibrozil, which of the following drugs should NOT be given to her in conjunction to her new therapy?
Niacin
Atorvastatin
Mipomersan
Fish oil supplement
Patient on simvastatin with the SLCO1B1 521C genetic variant are at increased risk for which of the following adverse event?
Myopathy
Neuropathy
Retinopathy
Telepathy
What would be the expected effect of the c.521T.C genetic polymorphism on OATP1B1 activity and statin plasma concentration?
Increase OATP1B1 activity, decrease statin plasma concentration
Increase OATP1B1 activity, increase statin plasma concentration
Decrease OATP1B1 activity, increase statin plasma concentration
Decrease OATP1B1 activity, decrease statin plasma concentration
JL is a 54 year old female being considered for treatment with simvastatin 20 mg PO daily. She has a history of hypertension for which she takes amlodipine 5 mg PO daily. Genetic testing is done and reveal SLCO1B1 5/15 diplotype. Which of the following recommendations is the most appropriate for this patient?
Stop simvastatin
Decrease simvastatin to 10 mg daily
Decrease simvastatin to 10 mg twice a day
Increase simvastatin to 40 mg a day
How do the three types of bile acid sequestrants differ chemically?
One of them has Ring A
One of them has Ring B
They vary in carbon degrees.
They vary in amine degrees.
A patient has both diabetes and gout, what medication should they avoid?
Vascepa
Lovaza
Trilipix
Niaspan
A 64 year old female has a history of a stroke, LDL is 115, and her blood pressure is 132/82. Which of the following medications should she be put on?
Atorvastatin 80 mg
Pravastatin 10 mg
Fluvastatin 2 mg
Rosuvastatin 10 mg
A 64 year old female has a history of a stroke, LDL is 115, and her blood pressure is 132/82. What should her LDL goal?
Reduce by 30%
Reduce by 50%
Reduce by 50% or more
Reduce by 30% or more
A 52 year old man has a history of type 2 DM and hypertension. His LDL levels are 166 and he is currently taking metformin, lisinopril, and diltiazem. Which cholesterol reducing medication should he be put on?
Atorvastatin 80 mg
Atorvastatin 40 mg
Rosuvastatin 20 mg
Rosuvastatin 10 mg
Mutation in the exon region of the VKORC1 enzyme will likely cause...
A slowed down rate of blood clotting.
An increase in warfarin metabolism.
A decrease in warfarin metabolism.
An increase in blood clotting rate.
Mutations in the upstream region of the VKORC1 enzyme is most likely to cause...
An increase in VKORC1 concentration.
A decrease in VKORC1 concentration.
A increase in rate in metabolizing warfarin.
A decrease in rate of metabolizing warfarin.
Mutations of the exon region of the CYP2C9 enzyme will likely cause...
A slowed down rate of metabolizing warfarin.
An increase rate of metabolizing warfarin.
The likelihood of clot formation increases.
The likelihood of clot formation decreases.
How should warfarin be adjusted for someone who has the homozygous *2 allele?
Double the dose
Decrease the dose
Give them the standard dose
Increase the dose
What is the correct order from first to last of coagulation factors in the cascade?
X, II, I, VII
X, I, II, VII
VII, X, I, II
VII, X, II, I
Which of the following would be the most appropriate indication for pursuing CYP2C19 genetic testing prior to initiation of clopidogrel?
NSTEMI undergoing PCI
Fibrinolysis for STEMI
A.Fib
Secondary stroke prevention
Which of the following diplotypes is associated with a normal or increased level of platelet inhibition with clopidogrel?
1/3
1/2
3/3
1/17
A patient is scheduled for an elective PCI(Percutaneous Coronary Intervention) and has the CYP2C19 1/2 diplotype. Based on CPIC guidelines, which of the following is the most appropriate recommendation for this patient?
Standard dose of clopidogrel
High dose clopidogrel
Consider an alternative treatment
This patient cannot be on any antiplatelet therapy
A 78-yo Asian male is scheduled for an elective PCI (percutaneous coronary intervention). CYP2C19 genetic testing is performed and he is found to have the CYP2C19 2/17 genotype. What is the phenotype of this patient in terms of clopidogrel metabolism?
Extensive
Ultrarapid
Intermediate
Poor
Dipyridamole can be used with which drug to prevent ischemic thrombotic stroke in those with previous stroke history?
Warfarin
Prasugrel
Clopidogrel
Aspirin
Dipyridamole can be used with which drug for post-op primary prophylaxis of thromboemboli in those with a prosthetic heart valve?
Aspirin
Warfarin
Prasugrel
Bempedoic acid
A 76 year old man has been diagnosed with a.fib, which of the following drugs would be given to him for primary stroke prevention? He is currently taking lisinopril, metformin, hydrochlorothiazide, and insulin.
Aspirin 81 mg
Endoxaparin 40 mg sc
Heparin 5000 units
Warfarin 2.5 mg
What is the CHADS2VASC score for 77 year old patient with a prior history of stroke?
1
2
3
4
If someone score higher than a 2 on the CHA2DSCASC score what should be given?
Nothing
Oral anticoagulant
Aspirin
Oral antiplatelet
