Font size
WorksheetsHaemoglobin and Gas Transport
Total questions: 29
Worksheet time: 18mins
the regular arrangement of amino acids in a linear sequence
primary structure
secondary structure
tertiary structure
quaternary structure
function of myoglobin
(a)
how many polypeptide chain does myoglobin have?
single
two
the number & types of polypeptide units and their spatial arrangement
primary structure
secondary structure
tertiary structure
quaternary structure
Oxidized Hb is called as
(a)
what is Q?
proximal histidine
distal histidine
how many percentage of protein in a healthy man of 65 kg?
20%
17%
30%
19%
What haemoglobin contain 2a and 2b chain?
HbF
HbA
HbA2
HbA1
what is P?
distal histidine
proximal histidine
which globular protein has higher affinity towards oxygen?
myoglobin
haemoglobin
deoxygenated haemoglobin
in cyanide posoining,met-Hb can strongly bind to this and can sequester the circulating cyanide and prevent it from inhibiting electron transpost.
H+
H2SO4
CN-
CO
what explain the steep of the haemoglobin curve in O2-Hb dissociation curve?
affinity of O2
cooperative binding
binding of CO2
which form of haemoglobin is when there is binding with oxygen?
T form
R form
What happen to 2,3-BPG in COPD patients,high altitude,and in chronic anemia?
remain unchaged
increase
decrease
the binding of an O2 molecule at one haem group increase the 02 affinity of the remaining haem groups in the same Hb molecule,this effect is reffered as
(a)
which allosteric effectors below is homotropic?
pH
pCO2
temperature
availability of 2,3-BPG
pO2
Carbon dioxide is transported as
carbaminohaemoglobin
bicarbonate ions
carbamate
dissolved
Which of the following decrease the affinity of Hb by binding to deoxy-Hb that stabilized the T form.
lactate
2,3-bisphosphoglycerate
H+
What happen when CO bind to Hb iron?
Hb shift to R form
changes sigmoid curve to hyperbola
shift the O2 saturation curve to the left
affected Hb has high affinity toward O2
What can happen in Bohr effect?
increase in pCO2
pH is reduced
decrease in O2 affinity of Hb
the curve is shift to the right
Why HbF has higher affinity to O2 compared to HbA?
bcs the foetus blood is not mix with the mother
to get the nutrients
better access to oxygen from the mother's bloodstream
what increase in B thalassemia?
HbF
HbA
HbA2
myoglobin
Which is increased in diabetes mellitus?
HbF
HbA
HbA1c
HbA2
which thalassemia only have one defective B-globin gene
a-thalassemia
B-thalassemia trait
B-thalassemia minor
thalassemia
In Hbs,glutamine is replaced with
(a)
In haemoglobin C disease,a single amino acid,lysine is substituted for
(a)
What is the lifetime of HbS
50 days
50 years
20 days
120 days
what happen in haemoglobin H disease?
1/4 a-globin gene defect
2/4 a-globin gene defect
3/4 a-globin gene defect
all four a-globin gene defect
what happen in B-globin chain in hemoglobin SC disease
all defect
some B-globin gene have sickle cell mutation
some B-globin gene carry mutation found in HbC disease
some B-globin gene have sickle cell mutation and other have HbC disease mutation
