WorksheetsDr. Keshvara Allergic Rhinitis
Total questions: 42
Worksheet time: 2hrs 3mins
Histamine is considered to be a primary mediator released by mast cells because:
histamine is the first mediator synthesized upon mast cell activation
it is stored in granules ready to be released upon activation
other mediators are produced from histamine
only mast cells produce histamine
Symptoms of allergic rhinitis are mediated by the action of histamine on which of the following receptors?
H1
H2
H3
H4
With respect to their effects on H1 receptor, histamines are considered to be:
competitive antagonists
non-competitive antagonists
inverse agonists
partial agonists
Compared to the first generation, as a group, the second generation of antihistamines: [select all that apply]
Are less sedating
Are more sedating
Are more likely to enter the brain
Are more selective for H1 receptors
Have fewer anticholinergic effects
Which of the following are first generation antihistamines? [select all that apply]
doxylamine
promethazine
hydroxyzine
clemastine
cetirizine
Which of the following are second generation antihistamines? [select all that apply]
levocetirizine
loratadine
desloratadine
fexofenadine
cetirizine
Which of the following are the most sedating antihistamine used for allergy & sleep aid? Select all that apply
Pheniramine
Chlorpheniramine
Clemastine
Doxylamine (Unisom)
Diphenhydramine (Benadryl)
Which of the following is least sedating antihistamine?
hydrozyzine
levocetirizine
cetirizine
clemastine
Which of the following is useful for treating nausea/vomiting induced by chemotherapy?
meclizine
dimenhydrate
promethazine
hydroxyzine
Which of the following is TRUE regarding loratadine?
it is a prodrug
it has a shorter half-life than desloratadine
it is more sedating than desloratadine
it is a metabolite of desloratadine
Cetirizine is a metabolite by oxidation of?
Levocetirizine
Hydroxyzine
Doxylamine
Terfenadine
Which of the following is a primary mediator (released by degranulation)?
Histamine
Leukotriene
Itchiness and edema are Histamine major symptoms.
True
False
Histidine is converted to Histamine by which enzyme?
Carbonic Anhydrase
Histidine decarboxylase
Histidine Anhydrase
Which functional groups compose Histamine? Select all that apply
Imidazole
Ethanolamine
Mebendazole
Which of the following can store Histamine in large amounts within the tissues?
mast cells & eosinophils
mast cells & basophils
Histamine (H1) Receptors will have a response to which of the following? Select all that apply
Bronchoconstriction
Vasodilation
Rhinitis
Brain
mood and sleep wake cycle
H1 Receptor Mediated Effects include which of the following? Select all that apply
Cardiovascular
Neuronal
Pulmonary
edema and decrease in BP
Anaphylaxis the most dangerous aspect of allergy.
True
False
Which of the following effects will 1st Generation Histamine cause? Select all that apply
significant entry in brain
sedative effect
anti emetic, anti motion sickness effects
more selective for H1 receptors
Which of the following effects will 2ndt Generation Histamine cause? Select all that apply
Limited entry into brain
Fewer adverse effects
More selective (for H1R)
sedative effect
anti emetic, anti motion sickness effects
Many H1 Antihistamines (mostly 1st Gen) antagonize which of the following receptors?
muscarinic
beta
alpha
Which of the following can treat PD symptoms? Select all that apply
Procyclidine (Kemadrin)
Diphenhydramine
Clemastine
Doxylamine
Cetirizine
Which of the following drugs can treat PD symptoms BUT will cause SEDATION?
Procyclidine (Kemadrin)
Diphenydramine
Which of the following drugs is for the treatment of Motion sickness? Select all that apply
Dimenhydrinate
Doxylamine (Unisom)
Diphenydramine
Antivert (Meclizine)
Promethazine
Which of the following antihistamines have Ethanolamine Ethers in their structure? Select all that apply
Benadryl (Diphenydramine)
Unisom (Doxylamine)
Clemastine (Tavist)
Dimenhydrinate (Dramamine)
Pheniramine
Which of the following antihistamines have Alkyl amines in their structure? Select all that apply
Pheniramine
Chlorpheniramine
Brompheniramine
Dimenhydrinate
Which of the following drugs Alkyl amines have the longer half life (greater than 20 hrs.)? Select all that apply
Pheniramine
Chlorpheniramine
Brompheniramine
Which of the following drugs is for the treatment of VERTIGO and motion sickness?
Meclizine
Hydroxyzine
Cetirizine
Diphenhydramine
Which of the following drugs is for the treatment of Urticaria and itchiness, very potent sedative and anxiolytic, antipsychotic.
Hydrozyzine
Meclizine
Cetirizine
Promethazine
Which of the following drugs are considered Piperazines? Select all that apply
Meclizine
Hydroxyzine
Cetirizine
Promethazine
Which of the following classifications is Promethazine in?
Piperazine
Alkyl amines
Tricyclic Antihistamines
Ethanolamine Ethers
Which of the following drugs is a phenothiazine that binds to H1R and other receptors (e.g. D2) and Inhibits dopamine neurons in vomiting center (brain)?
Promethazine
Diphenydramine
Cetirizine
Meclizine
Levocetirizine, desloratadine, fexofenadine sometimes considered to be 3rd Gen.
True
False
Fexofenadine is a metabolite of which of the following?
terfenadine
cetirizine
hydroxyzine
loratadine
Which of the following drugs is the more sedative, but still a weakly sedative, from the 2ng generation drugs?
Loratadine
Cetirizine
Levocetirizine
Desloratadine
Fexofenadine
Which of the following drugs have a shorter onset, show some anti-inflammatory activity and very effective in children? Select all that apply
promethazine
cetirizine
levocetirizine
diphenydramine
Which of the following non-sedating drugs is a stronger inhibitor of histamine release with a half life of 28 hrs.
Desloratadine
Loratadine
Which of the following drugs may cause insomnia and ↓ absorption with metal cations (so decrease absorption of Maalox and Mylanta)
cetirizine
fexofenadine
loratadine
desloratadine
levocetirizine
Which of the following drugs is to treat allergic rhinitis only in children greater than 12 years old?
Olopatadine (Patanase)
Azelastin (Astelin)
Which of the following drugs is to treat allergic & nonallergic rhinitis in children greater than 5 years old?
Azelastin (Astelin)
Olopatadine (Patanase)
Which of the following statements are TRUE about Nasal Antihistamines? Select all that apply
Bitter taste
Used once or twice daily
Relief of nasal congestion/discharge only
Short lasting
