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Worksheets

Dr. Keshvara Allergic Rhinitis

Total questions: 42

Worksheet time: 2hrs 3mins

Name
Class
Date
1.

Histamine is considered to be a primary mediator released by mast cells because:

a)

histamine is the first mediator synthesized upon mast cell activation

b)

it is stored in granules ready to be released upon activation

c)

other mediators are produced from histamine

d)

only mast cells produce histamine

2.

Symptoms of allergic rhinitis are mediated by the action of histamine on which of the following receptors?

a)

H1

b)

H2

c)

H3

d)

H4

3.

With respect to their effects on H1 receptor, histamines are considered to be:

a)

competitive antagonists

b)

non-competitive antagonists

c)

inverse agonists

d)

partial agonists

4.

Compared to the first generation, as a group, the second generation of antihistamines: [select all that apply]

a)

Are less sedating

b)

Are more sedating

c)

Are more likely to enter the brain

d)

Are more selective for H1 receptors

e)

Have fewer anticholinergic effects

5.

Which of the following are first generation antihistamines? [select all that apply]

a)

doxylamine

b)

promethazine

c)

hydroxyzine

d)

clemastine

e)

cetirizine

6.

Which of the following are second generation antihistamines? [select all that apply]

a)

levocetirizine

b)

loratadine

c)

desloratadine

d)

fexofenadine

e)

cetirizine

7.

Which of the following are the most sedating antihistamine used for allergy & sleep aid? Select all that apply

a)

Pheniramine

b)

Chlorpheniramine

c)

Clemastine

d)

Doxylamine (Unisom)

e)

Diphenhydramine (Benadryl)

8.

Which of the following is least sedating antihistamine?

a)

hydrozyzine

b)

levocetirizine

c)

cetirizine

d)

clemastine

9.

Which of the following is useful for treating nausea/vomiting induced by chemotherapy?

a)

meclizine

b)

dimenhydrate

c)

promethazine

d)

hydroxyzine

10.

Which of the following is TRUE regarding loratadine?

a)

it is a prodrug

b)

it has a shorter half-life than desloratadine

c)

it is more sedating than desloratadine

d)

it is a metabolite of desloratadine

11.

Cetirizine is a metabolite by oxidation of?

a)

Levocetirizine

b)

Hydroxyzine

c)

Doxylamine

d)

Terfenadine

12.

Which of the following is a primary mediator (released by degranulation)?

a)

Histamine

b)

Leukotriene

13.

Itchiness and edema are Histamine major symptoms.

a)

True

b)

False

14.

Histidine is converted to Histamine by which enzyme?

a)

Carbonic Anhydrase

b)

Histidine decarboxylase

c)

Histidine Anhydrase

15.

Which functional groups compose Histamine? Select all that apply

a)

Imidazole

b)

Ethanolamine

c)

Mebendazole

16.

Which of the following can store Histamine in large amounts within the tissues?

a)

mast cells & eosinophils

b)

mast cells & basophils

17.

Histamine (H1) Receptors will have a response to which of the following? Select all that apply

a)

Bronchoconstriction

b)

Vasodilation

c)

Rhinitis

d)

Brain

e)

mood and sleep wake cycle

18.

H1 Receptor Mediated Effects include which of the following? Select all that apply

a)

Cardiovascular

b)

Neuronal

c)

Pulmonary

d)

edema and decrease in BP

19.

Anaphylaxis the most dangerous aspect of allergy.

a)

True

b)

False

20.

Which of the following effects will 1st Generation Histamine cause? Select all that apply

a)

significant entry in brain

b)

sedative effect

c)

anti emetic, anti motion sickness effects

d)

more selective for H1 receptors

21.

Which of the following effects will 2ndt Generation Histamine cause? Select all that apply

a)

Limited entry into brain

b)

Fewer adverse effects

c)

More selective (for H1R)

d)

sedative effect

e)

anti emetic, anti motion sickness effects

22.

Many H1 Antihistamines (mostly 1st Gen) antagonize which of the following receptors?

a)

muscarinic

b)

beta

c)

alpha

23.

Which of the following can treat PD symptoms? Select all that apply

a)

Procyclidine (Kemadrin)

b)

Diphenhydramine

c)

Clemastine

d)

Doxylamine

e)

Cetirizine

24.

Which of the following drugs can treat PD symptoms BUT will cause SEDATION?

a)

Procyclidine (Kemadrin)

b)

Diphenydramine

25.

Which of the following drugs is for the treatment of Motion sickness? Select all that apply

a)

Dimenhydrinate

b)

Doxylamine (Unisom)

c)

Diphenydramine

d)

Antivert (Meclizine)

e)

Promethazine

26.

Which of the following antihistamines have Ethanolamine Ethers in their structure? Select all that apply

a)

Benadryl (Diphenydramine)

b)

Unisom (Doxylamine)

c)

Clemastine (Tavist)

d)

Dimenhydrinate (Dramamine)

e)

Pheniramine

27.

Which of the following antihistamines have Alkyl amines in their structure? Select all that apply

a)

Pheniramine

b)

Chlorpheniramine

c)

Brompheniramine

d)

Dimenhydrinate

28.

Which of the following drugs Alkyl amines have the longer half life (greater than 20 hrs.)? Select all that apply

a)

Pheniramine

b)

Chlorpheniramine

c)

Brompheniramine

29.

Which of the following drugs is for the treatment of VERTIGO and motion sickness?

a)

Meclizine

b)

Hydroxyzine

c)

Cetirizine

d)

Diphenhydramine

30.

Which of the following drugs is for the treatment of Urticaria and itchiness, very potent sedative and anxiolytic, antipsychotic.

a)

Hydrozyzine

b)

Meclizine

c)

Cetirizine

d)

Promethazine

31.

Which of the following drugs are considered Piperazines? Select all that apply

a)

Meclizine

b)

Hydroxyzine

c)

Cetirizine

d)

Promethazine

32.

Which of the following classifications is Promethazine in?

a)

Piperazine

b)

Alkyl amines

c)

Tricyclic Antihistamines

d)

Ethanolamine Ethers

33.

Which of the following drugs is a phenothiazine that binds to H1R and other receptors (e.g. D2) and Inhibits dopamine neurons in vomiting center (brain)?

a)

Promethazine

b)

Diphenydramine

c)

Cetirizine

d)

Meclizine

34.

Levocetirizine, desloratadine, fexofenadine sometimes considered to be 3rd Gen.

a)

True

b)

False

35.

Fexofenadine is a metabolite of which of the following?

a)

terfenadine

b)

cetirizine

c)

hydroxyzine

d)

loratadine

36.

Which of the following drugs is the more sedative, but still a weakly sedative, from the 2ng generation drugs?

a)

Loratadine

b)

Cetirizine

c)

Levocetirizine

d)

Desloratadine

e)

Fexofenadine

37.

Which of the following drugs have a shorter onset, show some anti-inflammatory activity and very effective in children? Select all that apply

a)

promethazine

b)

cetirizine

c)

levocetirizine

d)

diphenydramine

38.

Which of the following non-sedating drugs is a stronger inhibitor of histamine release with a half life of 28 hrs.

a)

Desloratadine

b)

Loratadine

39.

Which of the following drugs may cause insomnia and ↓ absorption with metal cations (so decrease absorption of Maalox and Mylanta)

a)

cetirizine

b)

fexofenadine

c)

loratadine

d)

desloratadine

e)

levocetirizine

40.

Which of the following drugs is to treat allergic rhinitis only in children greater than 12 years old?

a)

Olopatadine (Patanase)

b)

Azelastin (Astelin)

41.

Which of the following drugs is to treat allergic & nonallergic rhinitis in children greater than 5 years old?

a)

Azelastin (Astelin)

b)

Olopatadine (Patanase)

42.

Which of the following statements are TRUE about Nasal Antihistamines? Select all that apply

a)

Bitter taste

b)

Used once or twice daily

c)

Relief of nasal congestion/discharge only

d)

Short lasting