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WorksheetsDr. Yang Ceutics III Exam 3
Total questions: 58
Worksheet time: 4hrs 42mins
Liposomes are microscopic spheres made from fatty materials, predominantly phospholipids.
True
False
Which of the following are the ADVANTAGES of Liposomes? Select all that apply
Suitable for delivery of hydrophobic, hydrophilic and amphipathic drugs and agents
Chemically and physically well characterized entities
Biocompatible AND Suitable to administer via various routes
Suitable for controlled release
Suitable to give localized action in particular tissues.
One of the advantages of Liposomes is that they are suitable to administer via various routes including parenteral route.
True
False
Liposomes CANNOT be used for controlled release.
True
False
Liposomes ARE NOT Biocompatible.
True
False
Liposomes are suitable to give localized action in particular tissues.
True
False
Unilamellar vesicles are the same as Oligolamellar vesicles because sometimes Liposomes sometimes has more than one layer.
True
False
Which of the following is the GREATEST size of the following vesicles?
Giant unilamellar vesicles
Unilamellar vesicles
Multivesicular vesicles
Oligolamellar vesicles
Multilamellar large vesicles
Multilamellar large vesicles are BIGGER in size than Giant unilamellar vesicles.
True
False
Conventional Liposomes are typically bilipid layers in the structure and the drug can be incorporated into the lipid bilayers.
True
False
Which of the following technologies is in charge of Long circulating liposomes?
Stealth Technology
Starlix Technology
Health Technology
Steel Technology
Which of the following are TRUE about the two properties of Long circulating liposomes (Stealth Technology)?
PEG coating
Low permeability liquid matrix and internal aqueous buffer system
DPG coating
High permeability liquid matrix and internal aqueous buffer system
Which of the following can stabilize the structure of the liposomes?
Cholesterol
Phiospholipids
Proteins
Triglycerides
Proteins
Cholesterol can DECREASE the permeability of the matrix and prevent unwanted drug release from the liposomes.
True
False
Cholesterol can INCREASE the permeability of the matrix and prevent unwanted drug release from the liposomes.
True
False
Which of the following represents the surface modification in the liposome?
Methycellulose
PEG (Polyethylene Glycol)
Acacia
Sodium Sulfite
Ascorbic Acid
Which of the following target specific ligands, such as antibodies, immunoglobulins, lectins and oligosaccharides attached to the surface?
Long circulating Liposomes
Targeted Liposomes
Cationic Liposomes
Anionic Liposomes
Temperature or pH Sensitive liposomes
Which of the following interact with negatively- charged DNA resulting into lipids (DNA complexes) but still under investigation or research?
Long circulating Liposomes
Cationic Liposomes
Anionic Liposomes
Targeted Liposomes
Temperature or pH Sensitive liposomes
Temperature or pH Sensitive liposomes are needed for CANCER targeting.
True
False
Which of the following liposomes are needed for CANCER targeting?
Cationic Liposomes
Temperature or pH Sensitive liposomes
Targeted Liposomes
Long circulating Liposomes
Which of the following are considered Physical Characterization Parameters during formulation of Liposomes? Select all that apply
Mean size and size distribution
Number of lamellae AND Electrical surface potential & Surface PH
Osmotic behavior and entrapped volume
Internal distribution of drug
Structural and motional behavior of lipids
OPTIMAL electrical surface will prevent small vesicles to get together.
True
False
Which of the following should be considered in terms of stability in liposomes?
Physical
Chemical
Biological
Toxicological
Which of the following are SAFETY CONCERNS when we use a formulated liposome? Select all that apply
Presence of protein and lipoprotein for natural lipids
Lipid toxicity (RBC lysis)
Residual solvent
Overload of RES
Solubility
Which of the following are SAFETY CONCERNS when we use a formulated liposome? Select all that apply
Dose dumping (via protein binding)
Stability: shelf-live and in vivo
Sterility
Solubility
Overload of Reticuloendothelial System (RES)
In particle size as safety concern, when the tail is above 1 micrometer there is a potential danger of blocking capillaries.
True
False
All of the following are safety concerns in formulated liposomes, EXCEPT:
Sterility
tail below 1 blocking capillaries
Overload of RES
Residual solvent
Lipid toxicity (RBC lysis)
The size of the liposomes CAN AFFECT RES uptake and tissue targeting as a safety concern.
True
False
Protein binding as safety concern CAN produce some toxicity and also can affect the effectiveness of the drug.
True
False
Which of the following is TRUE about how drugs are released from liposomes?
The lipid bilayer of the liposome CANNOT fuse with other bilayers (e.g. cell membrane) delivering the liposome contents
The lipid bilayer of the liposome can fuse with other bilayers (e.g. cell membrane) delivering the liposome contents
Which of the following factors affecting Release of Drug from the liposomes? Select all that apply
Solvents
pH
Temperature
Agitation
Enzymes
Which of the following factors affecting Release of Drug from the liposomes? Select all that apply
Cell culture
Sink conditions
Volume
Sampling interval
How should we use liposomes as drug delivery with vehicle? Select all that apply
Sustained or Controlled Delivery
Liposomes as Protein Carriers
Oral Drug Delivery
Site Specific Delivery
Gene Therapeutics
Liposomes can be used for protein delivery.
True
False
Liposomes can be used for Sustained or Controlled Delivery.
True
False
Liposomes can be used for oral drug delivery, site specific delivery and gene therapeutics.
True
False
Which of the following approved liposome products target the kopasi sarcoma disease? Select all that apply
Doxil
Daunorubicin
Daunoxome
Ambisome
Amphotericin B
Which of the following approved liposome products target serious fungal infections? Select all that apply
Amphotericin B
Ambisome
Daunoxome
Doxil
Daunorubicin
Lipopolyplexes is a combination of DNA, RNA, polymers and liposomes resulting in better gene transfer and lower toxicity as compare to cationic liposomes.
True
False
Cationic liposomes has better gene transfer and lower toxicity than Lipopolyplexes.
True
False
A Nanoparticle is a microscopic particle with at least one dimension less than 100 nanonemeters.
True
False
A Nanoparticle is a microscopic particle with at least one dimension less than 100 micrometers.
True
False
Which of the following particles sizes represent a Nanoparticle?
150 nanometers
100 nanometers
100 micrometers
150 micrometers
200 nanometers
Which of the following particles sizes represent a Nanoparticle example?
150 nanometers
200 nanometers
101 nanometers
95 nanometers
105 nanometers
Which of the following particles sizes represent a Nanoparticle example?
101 nanometers
1 nanometer
105 nanometers
200 nanometers
100 micrometers
A difference between liposomes and nanoparticles is that liposomes CAN BE larger.
True
False
Nanoparticles are more solid structure rather than liposomes that are more liquid.
True
False
Which of the following are types of Nanoparticles? Select all that apply
Targeted
Monolithic
Capsule type
Cationic
pH sensitive
Drugs are always evenly distributed in nanoparticles.
True
False
Drugs are not always evenly distributed in nanoparticles.
True
False
One strike similarity in the application of liposomes and nanoparticles is the drug in both can be oral and targeted delivered.
True
False
Which of the following physiochemical phenomena/parameters MUST be accountable in Nanoparticles? Select all that apply
Particle size
Molecular weight density
Cristallinity
Surface charge
Hydrophobicity
Which of the following physiochemical phenomena/parameters MUST be accountable in Nanoparticles? Select all that apply
Surface element analysis
Surface properties
Osmotic behavior and entrapped volume
Number of lamellae
Motional behavior of lipids
Which of the following are TRUE about the applications of Nanoparticles? Select all that apply
Parenteral drug delivery
Oral drug delivery and targeted drug delivery similar as liposomes
Ocular drug delivery
Pulmonary drug delivery
Liposomes as protein carriers
Which of the following are Colloidal dispersions of nanosized drug particle produced by suitable method and stabilized by suitable stabilizer?
Nanosuspensions
Nanotherapies
Cationic liposomes
pH sensitive liposomes
Which of the following is TRUE about Nanodispersions?
colloidal dispersions of megasized
colloidal dispersions of nanosized
colloidal dispersions of small vesicle size
colloidal dispersions of multivesicular vesicles
colloidal dispersions of unilamellar vesicles
Which of the following are NANOSUSPENSIONS formulations? Select all that apply
Doxil
Rapamune
Emend
Daunorubicin
Ambisome
All of the following are examples of approved Liposome Products, EXCEPT:
(Select all that apply)
Doxil
Daunoxome
Amphotericin B
Rapamune
Emend
