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Worksheets

Dr. Yang Ceutics III Exam 3

Total questions: 58

Worksheet time: 4hrs 42mins

Name
Class
Date
1.

Liposomes are microscopic spheres made from fatty materials, predominantly phospholipids.

a)

True

b)

False

2.

Which of the following are the ADVANTAGES of Liposomes? Select all that apply

a)

Suitable for delivery of hydrophobic, hydrophilic and amphipathic drugs and agents

b)

Chemically and physically well characterized entities

c)

Biocompatible AND Suitable to administer via various routes

d)

Suitable for controlled release

e)

Suitable to give localized action in particular tissues.

3.

One of the advantages of Liposomes is that they are suitable to administer via various routes including parenteral route.

a)

True

b)

False

4.

Liposomes CANNOT be used for controlled release.

a)

True

b)

False

5.

Liposomes ARE NOT Biocompatible.

a)

True

b)

False

6.

Liposomes are suitable to give localized action in particular tissues.

a)

True

b)

False

7.

Unilamellar vesicles are the same as Oligolamellar vesicles because sometimes Liposomes sometimes has more than one layer.

a)

True

b)

False

8.

Which of the following is the GREATEST size of the following vesicles?

a)

Giant unilamellar vesicles

b)

Unilamellar vesicles

c)

Multivesicular vesicles

d)

Oligolamellar vesicles

e)

Multilamellar large vesicles

9.

Multilamellar large vesicles are BIGGER in size than Giant unilamellar vesicles.

a)

True

b)

False

10.

Conventional Liposomes are typically bilipid layers in the structure and the drug can be incorporated into the lipid bilayers.

a)

True

b)

False

11.

Which of the following technologies is in charge of Long circulating liposomes?

a)

Stealth Technology

b)

Starlix Technology

c)

Health Technology

d)

Steel Technology

12.

Which of the following are TRUE about the two properties of Long circulating liposomes (Stealth Technology)?

a)

PEG coating

b)

Low  permeability  liquid  matrix  and  internal  aqueous  buffer  system

c)

DPG coating

d)

High  permeability  liquid  matrix  and  internal  aqueous  buffer  system

13.

Which of the following can stabilize the structure of the liposomes?

a)

Cholesterol

b)

Phiospholipids

c)

Proteins

d)

Triglycerides

e)

Proteins

14.

Cholesterol can DECREASE the permeability of the matrix and prevent unwanted drug release from the liposomes.

a)

True

b)

False

15.

 

Cholesterol can INCREASE the permeability of the matrix and prevent unwanted drug release from the liposomes.

a)

True

b)

False

16.

Which of the following represents the surface modification in the liposome?

a)

Methycellulose

b)

PEG (Polyethylene Glycol)

c)

Acacia

d)

Sodium Sulfite

e)

Ascorbic Acid

17.

Which of the following target specific ligands, such as antibodies, immunoglobulins, lectins and oligosaccharides attached to the surface?

a)

Long circulating Liposomes

b)

Targeted Liposomes

c)

Cationic Liposomes

d)

Anionic Liposomes

e)

Temperature or pH Sensitive liposomes

18.

Which of the following interact with negatively- charged DNA resulting into lipids (DNA complexes) but still under investigation or research?

a)

Long circulating Liposomes

b)

Cationic Liposomes

c)

Anionic Liposomes

d)

Targeted Liposomes

e)

Temperature or pH Sensitive liposomes

19.

Temperature or pH Sensitive liposomes are needed for CANCER targeting.

a)

True

b)

False

20.

Which of the following liposomes are needed for CANCER targeting?

a)

Cationic Liposomes

b)

Temperature or pH Sensitive liposomes

c)

Targeted Liposomes

d)

Long circulating Liposomes

21.

Which of the following are considered Physical Characterization Parameters during formulation of Liposomes? Select all that apply

a)

Mean size and size distribution

b)

Number of lamellae AND Electrical surface potential & Surface PH

c)

Osmotic behavior and entrapped volume

d)

Internal distribution of drug

e)

Structural and motional behavior of lipids

22.

OPTIMAL electrical surface will prevent small vesicles to get together.

a)

True

b)

False

23.

Which of the following should be considered in terms of stability in liposomes?

a)

Physical

b)

Chemical

c)

Biological

d)

Toxicological

24.

Which of the following are SAFETY CONCERNS when we use a formulated liposome? Select all that apply

a)

Presence of protein and lipoprotein for natural lipids

b)

Lipid toxicity (RBC lysis)

c)

Residual solvent

d)

Overload of RES

e)

Solubility

25.

Which of the following are SAFETY CONCERNS when we use a formulated liposome? Select all that apply

a)

Dose dumping (via protein binding)

b)

Stability: shelf-live and in vivo

c)

Sterility

d)

Solubility

e)

Overload of Reticuloendothelial System (RES)

26.

In particle size as safety concern, when the tail is above 1 micrometer there is a potential danger of blocking capillaries.

a)

True

b)

False

27.

All of the following are safety concerns in formulated liposomes, EXCEPT:

a)

Sterility

b)

tail below 1 blocking capillaries

c)

Overload of RES

d)

Residual solvent

e)

Lipid toxicity (RBC lysis)

28.

The size of the liposomes CAN AFFECT RES uptake and tissue targeting as a safety concern.

a)

True

b)

False

29.

Protein binding as safety concern CAN produce some toxicity and also can affect the effectiveness of the drug.

a)

True

b)

False

30.

Which of the following is TRUE about how drugs are released from liposomes?

a)

The lipid bilayer of the liposome CANNOT fuse with other bilayers (e.g. cell membrane) delivering the liposome contents

b)

The lipid bilayer of the liposome can fuse with other bilayers (e.g. cell membrane) delivering the liposome contents

31.

Which of the following factors affecting Release of Drug from the liposomes? Select all that apply

a)

Solvents

b)

pH

c)

Temperature

d)

Agitation

e)

Enzymes

32.

Which of the following factors affecting Release of Drug from the liposomes? Select all that apply

a)

Cell culture

b)

Sink conditions

c)

Volume

d)

Sampling interval

33.

How should we use liposomes as drug delivery with vehicle? Select all that apply

a)

Sustained or Controlled Delivery

b)

Liposomes as Protein Carriers

c)

Oral Drug Delivery

d)

Site Specific  Delivery

e)

Gene Therapeutics

34.

Liposomes can be used for protein delivery.

a)

True

b)

False

35.

Liposomes can be used for Sustained or Controlled Delivery.

a)

True

b)

False

36.

Liposomes can be used for oral drug delivery, site specific delivery and gene therapeutics.

a)

True

b)

False

37.

Which of the following approved liposome products target the kopasi sarcoma disease? Select all that apply

a)

Doxil

b)

Daunorubicin

c)

Daunoxome

d)

Ambisome

e)

Amphotericin B

38.

 

Which of the following approved liposome products target serious fungal infections? Select all that apply

a)

Amphotericin B

b)

Ambisome

c)

Daunoxome

d)

Doxil

e)

Daunorubicin

39.

Lipopolyplexes is a combination of DNA, RNA, polymers and liposomes resulting in better gene transfer and lower toxicity as compare to cationic liposomes.

a)

True

b)

False

40.

Cationic liposomes has better gene transfer and lower toxicity than Lipopolyplexes.

a)

True

b)

False

41.

A Nanoparticle is a microscopic particle with at least one dimension less than 100 nanonemeters.

a)

True

b)

False

42.

 

A Nanoparticle is a microscopic particle with at least one dimension less than 100 micrometers.

a)

True

b)

False

43.

Which of the following particles sizes represent a Nanoparticle?

a)

150 nanometers

b)

100 nanometers

c)

100 micrometers

d)

150 micrometers

e)

200 nanometers

44.

Which of the following particles sizes represent a Nanoparticle example?

a)

150 nanometers

b)

200 nanometers

c)

101 nanometers

d)

95 nanometers

e)

105 nanometers

45.

Which of the following particles sizes represent a Nanoparticle example?

a)

101 nanometers

b)

1 nanometer

c)

105 nanometers

d)

200 nanometers

e)

100 micrometers

46.

A difference between liposomes and nanoparticles is that liposomes CAN BE larger.

a)

True

b)

False

47.

Nanoparticles are more solid structure rather than liposomes that are more liquid.

a)

True

b)

False

48.

Which of the following are types of Nanoparticles? Select all that apply

a)

Targeted

b)

Monolithic

c)

Capsule type

d)

Cationic

e)

pH sensitive

49.

Drugs are always evenly distributed in nanoparticles.

a)

True

b)

False

50.

Drugs are not always evenly distributed in nanoparticles.

a)

True

b)

False

51.

One strike similarity in the application of liposomes and nanoparticles is the drug in both can be oral and targeted delivered.

a)

True

b)

False

52.

Which of the following physiochemical phenomena/parameters MUST be accountable in Nanoparticles? Select all that apply

a)

Particle size

b)

Molecular weight density

c)

Cristallinity

d)

Surface charge

e)

Hydrophobicity

53.

Which of the following physiochemical phenomena/parameters MUST be accountable in Nanoparticles? Select all that apply

a)

Surface element analysis

b)

Surface properties

c)

Osmotic behavior and entrapped volume

d)

Number of lamellae

e)

Motional behavior of lipids

54.

Which of the following are TRUE about the applications of Nanoparticles? Select all that apply

a)

Parenteral drug delivery

b)

Oral drug delivery and targeted drug delivery similar as liposomes

c)

Ocular drug delivery

d)

Pulmonary drug delivery

e)

Liposomes as protein carriers

55.

Which of the following are Colloidal  dispersions  of  nanosized  drug  particle produced  by  suitable  method  and  stabilized  by  suitable  stabilizer?

a)

Nanosuspensions

b)

Nanotherapies

c)

Cationic liposomes

d)

pH sensitive liposomes

56.

Which of the following is TRUE about Nanodispersions?

a)

colloidal dispersions of megasized

b)

colloidal dispersions of nanosized

c)

colloidal dispersions of small vesicle size

d)

colloidal dispersions of multivesicular vesicles

e)

colloidal dispersions of unilamellar vesicles

57.

Which of the following are NANOSUSPENSIONS formulations? Select all that apply

a)

Doxil

b)

Rapamune

c)

Emend

d)

Daunorubicin

e)

Ambisome

58.

All of the following are examples of approved Liposome Products, EXCEPT:

(Select all that apply)

a)

Doxil

b)

Daunoxome

c)

Amphotericin B

d)

Rapamune

e)

Emend