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uveitis

Total questions: 57

Worksheet time: 43mins

Name
Class
Date
1.

What systemic antiviral therapy has been reported to have hypotony and intraocular inflammation as side-effects?

a)

Intravenous cidofovir

b)

Intravenous foscarnet

c)

Intravenous ganciclovir

d)

Oral valganciclovir

2.

A patient with chronic anterior uveitis is on methotrexate. What is the preferred minimum duration that supression should be maintained before cataract surgery is performed?

a)

3 weeks

b)

3 months

c)

6 months

d)

As soon as uveitis is supressed

3.

Four months after cataract surgery, a patient presents with persistent iritis. The uveitis was present shortly after surgery despite topical corticosteroids and has gradually worsened. There is prior eye disease. On examination the eye has mutton-fat keratic precipitates, 3+ cells and flare, a capsular plaque and a mild vitritis. There are no chorioretinal inflammatory lesions or residual lens material. There is a well-centered intraocular lens implant. What is the most likely diagnosis?

a)

Sarcoidosis

b)

Toxoplasmosis

c)

P. acnes endophthalmitis

d)

Uveitis-glaucoma-hyphema syndrome

4.

A 34-year-old myopic woman has an asymmetric chronic uveitis characterized by periodic exacerbations, a mild anterior uveitis, vitritis, and 50-200 micron atrophic (punched-out) choroidal lesions. Her chest CT scan is normal and her HLA-A29 negative. On a previous visit to the referring ophthalmologist, A fluorescein angiography (FA) of the chorioretinal lesions showed early blockage and late staining. What is this woman's the most likely diagnosis?

a)

Birdshot chorioretinopathy

b)

Toxoplasmosis

c)

sarcoidosis

d)

Presumed ocular histoplasmosis syndrome (POHS)

5.

What percentage of patients who present with unilateral, nongranulomatous, acute anterior uveitis (AAU) express the HLA-B27 haplotype?

a)

10

b)

20

c)

40

d)

50

6.

When is it diagnostically useful to obtain an antinuclear antibody (ANA) test in a patient with isolated anterior uveitis and no skin, joint, or other systemic problems?

a)

Never

b)

When the unilateral anterior uveitis is chronic

c)

Always

d)

When the bilateral anterior uveitis is acute

7.

What is the most common non-ocular finding in Adamantiades-Behcet disease?

a)

Arthritis

b)

Central nervous system vasculitis

c)

Oral or genital ulcers

d)

HLA-B51 positivity

8.

An immunocompetent adult has a chronic bilateral anterior uveitis. What positive blood test would suggest a specific diagnosis and therapy?

a)

Serum antinuclear antibody (ANA) titers

b)

Microhemagglutination assay for treponema pallidum (MHA-TP)

c)

Serum angiotensin converting enzyme level

d)

Human leukocyte antigen (HLA) testing

9.

For six years, a 30-year-old woman has had poorly-controlled bilateral intermediate uveitis without any systemic symptoms. A chest x-ray and tuberculin skin-test is normal. She has not traveled internationally. What associated disorder would constitute a contraindication to adding a tumor necrosis factor inhibitor treatment?

a)

Lymphoma

b)

Tuberculosis

c)

Sarcoidosis

d)

Demyelinating disease

10.

A patient with systemic lupus erythematopsis (SLE) presents with cotton-wool spots on retinal examination. What test may be helpful in evaluating her eyes for choroidal retinopathy?

a)

Indocyanine green (ICG) angiography

b)

Ocular coherence tomorgraphy (OCT)

c)

Blood Pressure

d)

Antinuclear antibody (ANA) testing for titers

11.

For what type of uveitis would methotrexate immunosuppression be contraindicated?

a)

Infectious uveitis

b)

Pediatric uveitis

c)

Sarcoid uveitis

d)

Idiopathic uveitis

12.

The non-steroidal anti-inflammatory drug, celecoxib (Celebrex), may be useful in preventing recurrences of acute anterior uveitis. What are the FDA-mandated black-box warnings regarding this agent?

a)

Hypertension

b)

Fluid retention and congestive heart failure

c)

Potentially fatal cardiovascular thrombotic and gastrointestinal complications

d)

Renal insufficiency

13.

What treatment is thought to prevent sympathetic ophthalmia? x

a)

Immunosuppressive agents at the first sign of inflammation

b)

Oral corticosteroids to treat traumatic uveitis

c)

Enucleation within 14 days of ocular injury

d)

Removal of orbital foreign bodies

14.

A 45-year-old woman has Fuch's heterochromic iridocyclitis (FHI) has bilateral 1+ cells, 1+ flare, normal intraocular pressure and minimal posterior subcapsular cataracts. Her vision is good and she has no visual complaints. What is the preferred treatment?

a)

Methotrexate

b)

Topical corticosteroids

c)

Observation, monitoring

d)

Paracentesis for rubella virus

15.

A patient with scleritis is found to have a high titer of antineutrophil cytoplasmic antibodies (ANCA) with a cytoplasmic pattern (c-ANCA). What is the most likely systemic disease associated with these findings?

a)

Polyarteritis nodosa

b)

Systemic lupus erythematosis

c)

Wegener's granulomatosis

d)

Rheumatoid arthritis

16.

A 17-year-old girl complains of blurred vision and floaters which have increased over several months. Her visual acuity last year was 20/20 OU, but now is 20/60 OD, 20/50 OS. Examination shows bilateral anterior chamber cells, a mild peripheral cortical cataract, 1-2+ vitreous cells and haze, a few snowball vitreous opacities, and small snowbanks at the ora serrata OU. What is the most likely cause of her decreased vision?

a)

Vitritis

b)

Peripheral retinal vasculitis

c)

Macular edema

d)

Cortical cataract

17.

For an otherwise healthy 30-year-old with no history of trauma, surgery, or intavenous drug use what agent most commonly causes acute retinal necrosis (ARN)?

a)

Toxoplasmosis infection

b)

Cytomegalovirus (CMV) infection

c)

Herpes zoster and herpes simplex virus infection

d)

Lymphoma

18.

For the past year, a patient with iritis (anterior uveitis) in both eyes has recurrent episodes charaterized by 2-3 + anterior chamber cells every time prednisolone actetate 1% drops are reduced fewer than 6 times per day. She has modest pain, redness, and photophobia associated with episodes. The patient does not have posterior uveitis or cystoid macular edema. What is the next step in their management?

a)

Methotrexate and intensive topical corticosteroids in the perioperative cataract surgery period

b)

Intravitreal fluocinolone implant

c)

Increase the prednisolone actetate 1% to every hour in the cataract surgery perioperative period

d)

Immunomodulatory systemic agent

19.

A male patient with uveitis and a history of unprotected sex with prostitutes is suspected of having syphilitic uveitis. His rapid plasma reagin (RPR) testing syphilis serology is negative. What is the next step in his evaluation?

a)

Obtain a fluorescent treponemal antibody absorption (FTA-ABS) test.

b)

Treat with penicillin.

c)

Do blood cultures for syphilis.

d)

Do a paracentesis for darkfield microscopy.

20.

High dose corticosteroids have controlled the necrotizing scleritis associated with Wegener's granulomatosis in your patient. What would be the preferred second intervention?

a)

Add a systemic immunosuprressive agent such as cyclophosphamide, infliximab, or mycophenolate.

b)

Continue high-dose corticosteroids (20 mg/day) for one year and then add other agents as needed.

c)

Add an oral nonsteroidal anti-inflamatory agent such as indomethacin.

d)

Add intensive topical corticosteroid and nonsteroidal anti-inflammatory agents.

21.

36-year-old African-American man presents with uveitis in his left eye. Slit lamp examination demonstrates 2+ anterior chamber cells with 1+ flare and 2 posterior synechiae in the left eye. Numerous anterior vitreous cells also are present just behind the lens. By ophthalmoscopy, no chorioretinal scarring is present. The right eye also has 2 posterior synechiae, but no anterior chamber cells or flare, and there are no anterior vitreous cells or posterior segment abnormalities. How would you classify this uveities episode?

a)

Anterior uveitis

b)

Anterior and intermediate uveitis

c)

Panuveitis

d)

Intermediate uveitis

22.

Which of the following is a known side effect of cyclosporine therapy?

a)

Renal insufficiency

b)

Cystoid macular edema

c)

Glaucoma

d)

Cataract

23.

A 32-year-old man with necrotizing scleritis and a history of recent onset sinus disease presents with necrotizing scleritis. On physical examination, there are no other systemic complaints or findings. What laboratory test is most likely to lead to a specific diagnosis?

a)

Serum angiotensin converting enzyme

b)

Serum antineutrophilic cytoplasmic antibodies (ANCA)

c)

Complete blood count

d)

rheumatoid factor and antinuclear antibodies

24.

In multifocal choroiditis and panuveitis, which clinical finding would most strongly influence you to recommendation chronic systemic immunosuppression?

a)

Progressive subretinal fibrosis

b)

Anterior chamber inflammation

c)

Cystoid macular edema

d)

Choroidal neovascularization

25.

A patient with deep ocular pain and subretinal fluid is suspected of having posterior scleritis with an exudative retinal detachment. What finding would confirm a diagnosis of posterior scleritis?

a)

Vitritis

b)

Vitreous hemorrhage

c)

Cystoid macular edema

d)

A "T" sign on B-scan ultrasound

26.

What is the most common ocular complication of rheumatoid arthritis?

a)

Episcleritis

b)

Keratoconjunctivitis sicca

c)

Scleritis

d)

Recurrent anterior uveitis

27.

Which of the following patients would have the highest likelihood of developing posterior capsular opacification following uncomplicated cataract extraction with posterior chamber lens implantation?

a)

A 35-year-old man with intermediate uveitis

b)

A 67-year-old man with recurrent toxoplasmosis

c)

A 61-year-old man with a traumatic cataract

d)

A 58-year-old woman with rheumatoid arthritis

28.

A patient has bilateral diffuse non-necrotizing anterior scleritis. His vision is 20/20 OU and he has normal intraocular pressure. He has no intraocular inflammation, and his evaluation for a systemic disorder is not revealing. Which of the following interventions is the preferred first line therapy?

a)

Flucinolone implant

b)

Intraveous cyclophosphamide

c)

Oral nonsteroidal anti-inflammatory drugs

d)

Topical steroids

29.

A-26 year-old Caucasian woman with bilateral intermediate uveitis of two years duration complains of shooting pains down her leg after a hot bath. What is the most likely diagnosis?

a)

multiple sclerosis

b)

Behcets disease

c)

B-cell lymphoma

d)

toxoplasmosis

30.

A 30-year-old woman complains of blurred central vision in the right eye for the past 3 days. Multiple chorioretinal lesions are noted in both eyes. Which of the following findings is most consistent with a diagnosis of acute posterior multifocal placoid pigment epitheliopathy (APMPPE)?

a)

Clear vitreous and subtle disc edema

b)

Subretinal hemorrhage in the macula and peripheral scotomas

c)

Vitreous cells and satellite lesions

d)

Symptoms in the other eye within 2 days

31.

A patient with Vogt-Koyanagi-Harada disease was treated with high-dose oral prednisone and had resolution of her serous retinal detachments. The dose has been gradually decreased, and 4 months into therapy, she is on prednisone 20 mg daily. She is on topical prednislolone acetate 1% QID and her visual acuity is 20/30 both eyes. There are 2+ cells in the anterior chamber of both eyes with no vitritis, cystoid macular edema, or subretinal fluid. What is the most appropriate next step?

a)

Place a flucinolone implant

b)

Posterior subtenon injections of triamcinolone acetonide

c)

Increase the oral prednisone to 40 mg/day

d)

Start a corticosteroid-sparing immunomodulatory agent

32.

A 6-year-old child presents with intermediate uveitis and a peripheral retinal granuloma in one eye. What is the most appropriate diagnostic test?

a)

Serum herpes simplex titers

b)

Serum toxocara titers

c)

A complete blood count (CBC) with differential

d)

HLA-B27 status

33.

Which one of the following tests is most likely to give a definitive diagnosis in a immunocompetent patient with a rapidly progressing peripheral retinal necrosis in one eye?

a)

Herpes serologies

b)

Toxoplasma serologies

c)

Vitreous for polymerase chain reaction testing for herpes viruses

d)

Complete blood cell count with differential

34.

Which of the following approaches is most appropriate for cataract surgery in a patient with Fuch's heterochromic iridocyclitis without glaucoma?

a)

Standard phacoemulsification with a posterior chamber intraocular lens implant (IOL)

b)

Start acyclovir, because Fuch's heterochromic iridocyclitis has been associated with rubella virus

c)

Start methotrexate with a goal of no more than rare cell before surgery

d)

Perform a lensectomy and vitrectomy, and leave the eye aphakic to prevent ciliary body membranes and hypotony

35.

only Retinal phlebitis is most likely to be associated with which of the following?

a)

Behcet disease

b)

Systemic lupus erythematosis

c)

Ocular sarcoidosis

d)

Polyarteritis nodosa

36.

Which one of the following is most important in diagnosing Behcet's disease?

a)

HLA-B51 status

b)

The presence of a hypopyon on slit lamp examination

c)

Findings of ischemia on indocyanine green angiography

d)

A systemic history and physical examination

37.

A patient with a bilateral anterior and intermediate uveitis is suspected of having sarcoidosis. There are no conjunctival or lid granulomata. A chest x-ray shows no abnormalities, and serum angiotensin converting enzyme is normal. Which one of the following is the most appropriate examination for pursuing the diagnosis of sarcoidosis?

a)

High-resolution CT scan of the chest

b)

HLA-B27 status

c)

Biopsy of the conjunctiva

d)

Repeat serum angiotensin converting enzyme to rule out laboratory error

38.

A 34-year-old man has a localized area of scleral thinning 5 mm nasal to the limbus. The surrounding episcleral and conjunctival tissue is not injected. The patient had eye surgery four years before presentation. He is healthy without any systemic inflammatory or infectious disease. What is the most likely surgery he had that could result in this finding?

a)

Pterygium excision with mitomycin C or Beta-irradiation

b)

Trabeculectomy

c)

Laser retinopexy

d)

LASIK

39.

What infectious agent(s) has been associated with corneal endothelial and subendothelial changes, leading to corneal edema in an eye with recurrent unilateral anterior uveitis, in a patient who is not immunosuppressed?

a)

Toxoplasmosis

b)

Herpes viruses and cytomegalovirus

c)

Rubella

d)

Bartonella

40.

What is the mechanism of action of infliximab?

a)

Corticosteroid

b)

Alkylating agent

c)

Antimetabolite

d)

Anti-tumor necrosis factor antibody

41.

A 14-year-old girl complains of a sudden onset of bilateral eye pain and photophobia. On ocular examination she has bilateral anterior uveitis. She has had a fever for two weeks, modest flank and abdominal pain, and weight loss of 10 pounds. Laboratory testing reveals an elevated erythrocyte sedimentation rate at 80 mm/hour, mild elevation of the serum creatinine, and mild proteinuria. What is the most likely diagnosis?

a)

Lyme disease

b)

Toxocara uveitis

c)

Tubulointerstitial nephritis and uveitis

d)

Toxoplasmosis

42.

A 28-year-old Hispanic woman presents with three days of headache and loss of vision in both eyes. She was admitted for suspicion of meningitis, although she has no fever. There was a mild lymphocytic response noted in her cerebrospinal fluid; stains for microbes were negative, and cultures are negative to date. On examination she has a moderate bilateral anterior uveitis and vitritis with serous retinal detachments. There is no retinal necrosis. What is the most appropriate therapy?

a)

Intravitreal acyclovir

b)

Systemic corticosteroids

c)

Cyclophospahmide

d)

Await viral cultures of the cerebrospinal fluid before starting treatment

43.

The daily dosage of cyclosporine should be adjusted based on which of the following laboratory tests?

a)

Hematocrit

b)

Glucose

c)

Creatinine

d)

Platelet count

44.

A 25-year-old, Brazilian man presents with a history of decreased vision in his left eye for 1 week. Visual acuity is 20/70, and moderate vitreitis is present. On dilated examination, a pigmented scar in the posterior pole with adjacent yellow white chorioretinitis is present. What is the most appropriate treatment?

a)

Pyrimethamine, sulfadiazine, and folinic acid

b)

Amphotericin B

c)

IV acyclovir

d)

Oral corticosteroids

45.

Which of the following is a recommended treatment for serpiginous choroiditis involving the macula?

a)

Oral corticosteroids

b)

Topical corticosteroids

c)

Acyclovir

d)

Alkylating agents

46.

A 30-year-old man with sinus inflammation, bilateral scleritis, mild anterior uveitis, and a positive anti-neutrophilic cytoplasmic antibodies (c-ANCA) test. What is the diagnosis?

a)

Wegeners granulomatosis,

b)

sarcoidosis

c)

Herpes zoster

d)

ankylosing spondylitis

47.

A 39-year-old man with AIDS and cytomegalovirus (CMV) retinitis in 1 eye is treated with valganciclovir, but declines highly active antiretroviral therapy. After 2 months, the retinitis is inactive. Nine months after beginning therapy, the retinitis is active, and the patient's CD4+ count is 15 cells/μL. He undergoes placement of a ganciclovir implant. Two months later, the retinitis remains active. What would the most appropriate approach at this time be?

a)

Begin weekly intravitreous ganciclovir injections

b)

Allow more time for the ganciclovir implant to take effect

c)

Place another ganciclovir implant

d)

Begin intravenous foscarnet

48.

Which of the following statements best describes the typical fundus findings of serpiginous choroiditis?

a)

Old, scarred lesions may be present in the newly-diagnosed eye.

b)

Intense vitritis is common.

c)

Multiple, new, isolated lesions occur with recurrences.

d)

Vasculitis is a prominent feature.

49.

Which one of the following tests is most important for patients with either intermediate or posterior uveitis, but without keratitis or scleritis?

a)

Treponema-specific syphilis serologies

b)

Serum rheumatoid factor

c)

Serum antinuclear antibodies

d)

HLA-B27

50.

The fluocinolone acetonide implant releases therapeutic levels of corticosteroids to the vitreous cavity for approximately how many days?

a)

100

b)

500

c)

1000

d)

10000

51.

What are Dalen-Fuchs nodules associated with?

a)

Eales disease

b)

Sympathetic ophthalmia

c)

Ocular sarcoidosis

d)

Behcet disease

52.

Which of the following uveitic conditions is most likely to present with a white and asymptomatic eye?

a)

Herpetic anterior uveitis

b)

Acute retinal necrosis syndrome

c)

Wegener's granulomatosis

d)

Juvenile idiopathic arthritis-associated uveitis

53.

Which form of juvenile idiopathic arthritis is most likely to be associated with anterior uveitis?

a)

Pauciarticular

b)

Polyarticular

c)

Still's disease

d)

ANA-; RF+

54.

Sterility is a side effect associated with which of the following immunomodulatory drugs?

a)

Mycophenolate mofetil

b)

Azathioprine

c)

Chlorambucil

d)

Cyclosporine A

55.

What does the differential diagnosis of idiopathic pars planitis include?

a)

Ankylosing spondylitis

b)

Rheumatoid arthritis

c)

Lymphoma

d)

Vogt-Koyanagi-Harada syndrome

56.

Which form of juvenile idiopathic arthritis is most likely to be associated with anterior uveitis?

a)

Pauciarticular

b)

Polyarticular

c)

Still's disease

d)

ANA-; RF+

57.

An immunocompetent adult has a chronic bilateral anterior uveitis. What positive blood test would suggest a specific diagnosis and therapy?

a)

Serum antinuclear antibody (ANA) titers

b)

Microhemagglutination assay for treponema pallidum (MHA-TP)

c)

Serum angiotensin converting enzyme level

d)

Human leukocyte antigen (HLA) testing