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HEMATOLOGY - RATIONALE WEEK 3

Total questions: 59

Worksheet time: 30mins

Name
Class
Date
1.

An increase LAP score is indicative of what

a)

Polycythemia vera

b)

Pregnancy of 3rd trimister

c)

Leukemoid reaction

d)

Infection

e)

AOTA

2.

Most common finding in CML patients

a)

Splenomegaly

b)

Bone marrow filtration

3.

Schilling Leukemia

a)

M5

b)

M4

c)

M6

d)

M7

4.

AML subgroup M3 is frequently associated thru the thromboplastin activity in the primary granules

a)

DIC

b)

Thrombocytopenia

c)

Polycythemia vera

5.

Also known as Hyper granular Promyelocytic Leukemia

a)

M3

b)

M1

c)

M4

d)

M6

6.

A hemolytic crisis may be precipitated in 10% of American black male suffering from G6PD deficiency by:

a)

Fava beans

b)

Primaquine

c)

Quinine

d)

Quinidine

7.

I. Acute Blood Loss can cause immediate anemia.

II. Chronic Blood Loss can cause from GIT Bleeding

a)

S1 is correct, S2 is incorrect

b)

S2 is correct, S1 is incorrect

c)

Both are correct

d)

Both are incorrect

8.

Failure or suppression of multipotent myeloid stem cell

a)

Aplastic Anemia

b)

Sideroblastic Anemia

c)

IDA

9.

The most common inherited porphyria

a)

Acute Intermittent hepatic porphyria

b)

Porphyria cutaneous tarda

10.

TIBC: INCREASE

Ferritin, % saturation, Serum Iron: DECREASE

a)

IDA

b)

SIDEROBLASTIC ANEMIA

c)

THALASSEMIA

d)

LEAD POISONING

11.

Morphological Classification of Megaloblastic Anemia

a)

Macrocytic, normochromic

b)

Microcytic, normochromic

c)

Normocytic, normochromic

d)

Macrocytic, hypochromic

12.

Most common form of anemia

a)

IDA

b)

ACD/AOI

13.

It is a rare chronic form of hemolytic anemia

a)

PNH

b)

PCH

c)

G6PD

d)

BOTH PNH AND PCH

14.

Hematopoietic cell targets in aplastic anemia are affected by

a)

Activated cytotoxic T-lymphocytes

b)

Activation of FAS receptor

c)

Direct cell to cell interaction between lymphocytes and target cells

d)

AOTA

15.

Fanconi Anemia is associated with abnormal genes located on chromosomes

a)

9,20

b)

9,22

16.

Serum Iron: Decrease

Ferritin: Decrease

TIBC: Increased

Microcytic Hypochromic: 4+

a)

Iron def with severe anemia

b)

Iron def with mild anemia

17.

Failure of gastric mucosa to secrete intrinsic factor

a)

Pernicious Anemia

b)

IDA

c)

Megaloblastic Anemia

d)

Sideroblastic Anemia

18.

Most appropriate treatment of AOI

a)

Treatment for Inflammatory Conditions

b)

Iron

19.

What is the Reticulocyte count of patient with untreated pernicious anemia

a)

0%

b)

2.3%

c)

<1.0%

d)

1.8%

20.

AML subgroups that demonstrate Auer Rods

a)

M1,M2

b)

M3,M4

c)

M6

d)

AOTA

21.

Fab M2 Chromosome

a)

t(8;21)

b)

t(9;22)

22.

A block in differentiation or maturation of immature hematopoietic progenitors are hallmarks of

a)

AML

b)

ALL

c)

CML

d)

CLL

23.

Only AML Subgroup with Negative SBB and MPO

a)

M0, M6

b)

M1,M2

c)

M3,M5

24.

Deficient chromosome in CML cases

a)

t(9;22)

b)

t(9;20)

25.

CML must be differentiated from Leukemoid Reaction by

a)

LAP score

b)

FAB score

26.

Hydrolysis of sodium alpha-naphthyl phosphate by alkaline phosphatase produces a colored precipitate with diazotized amine

a)

LAP

b)

FAB

27.

Presence of Philadelphia Chromosome in CML cases is indicative of

a)

Good prognosis

b)

Bad prognosis

28.

One way to diagnose your CML is the evidence of gene fusion known as

a)

BCR-ABL

b)

BCC-AML

29.

Tumor in Neoplastic proliferation in myeloma is located in

a)

Spleen

b)

Bone marrow

30.

Basis of FAB Classification of ALL except

a)

CD Marker

b)

Clinical Criteria

c)

Cytochemical result

d)

Cell morphology

31.

Classification of Leukemia that is considered as standard for diagnosis

a)

WHO

b)

FAB

32.

WHO Classification defines acute leukemia as ___ bone marrow blasts

a)

>20%

b)

>30%

33.

Cytochemical stain that helps differentiation in M6, L1 and L2

a)

PAS

b)

SBB

c)

Myeloperoxidase

34.

Chloroacetate Esterase stain is aka

a)

Specific stain

b)

Non specific stain

35.

All but one is a qualitative disorder of platelet

a)

Thrombocytopenia

b)

Bernard soulier syndrome

c)

vWF disease

d)

Glanzmann thrombasthenia

36.

Platelet Storage Pool Defect

a)

Chediak Higashi syndrome

b)

Bernard soulier syndrome

c)

Gray platelet syndrome

d)

Glanzmann thrombastenia

37.

Platelet Disorder with Beta Granule Deficiency

a)

Chediak Higashi syndrome

b)

Bernard soulier syndrome

c)

Gray platelet syndrome

d)

Glanzmann thrombastenia

38.

Leukocyte Alkaline Phosphatase score is known to be increase in

a)

ALL

b)

AML

c)

AML AND CLL

d)

LEUKOMOID REACTION

39.

SBB stains the lipid of these cells

a)

Granulocytes

b)

Leukocytes

c)

Thrombin

40.

FAB Classification defines acute leukemia as ___ bone marrow blasts

a)

>20%

b)

>30%

41.

Most common leukemia in adults

a)

ALL

b)

AML

c)

FABL1

d)

FABL3

42.

Most common ALL in adult population

a)

FAB L1

b)

FAB L2

c)

FAB L3

43.

Most common leukemia in CHILDREN

a)

ALL

b)

AML

c)

FABL1

d)

FABL3

44.

Which of the following is true about polychromasia?

a)

Central pallor are is greater than 1/3 the diameter of cell

b)

Measures red cell immaturity

c)

Often associated with microcytosis

d)

Also known as spherocyte

45.

Which of the following is incorrectly paired?

a)

Echinocytes- burr cells

b)

Target cells - Mexican hat

c)

Acanthocyte - spur cell

d)

Sickle cell - keratocyte

46.

Most commonly seen in LCAT deficiency?

a)

Target Cell

b)

Tear drop cell

c)

Stomatocyte

d)

Ovalocyte

47.

Deficiency in DNA due to Vit B12 or folate deficiency

a)

Megaloblastic Anemia

b)

Sideroblastic anemia

48.

Programmed Cell Death

a)

Apoptosis

b)

Endomitosis

49.

RBC Inclusion seen in Lead Poisoning

a)

Basophilic Stippling

b)

May hegglin

50.

Thinner variant of codocyte

a)

Leptocyte

b)

Ovalocyte

51.

I. Pappenheimer bodies resembles Basophilic Stippling

II. Hgb C Crystalline have a crystalline like appearance

a)

S1 is correct, S2 is incorrect

b)

S2 is correct, S1 is incorrect

c)

Both are correct

d)

Both are incorrect

52.

RBC Inclusion imparts golf ball appearance to RBC

a)

Hemoglobin C

b)

Hemoglobin H

c)

Hemoglobin SC

53.

Deficiency in Protoporphyrin Deficiency

a)

Sideroblastic Anemia

b)

Megaloblastic anemia

54.

Small round dense RBC with no central pallor

a)

Spherocyte

b)

Ovalocyte

55.

Heinz bodies are composed of

a)

Denatured hemoglobin

b)

Uncultured hemoglobin

56.

Incorrectly Paired

a)

Pappenheimer bodies-Iron

b)

Cabot Rings-Remnant of Mitotic Spindle

c)

NOTA

d)

AOTA

57.

Seen in G6PD Deficiency

a)

Blister cell

b)

Burr cell

c)

Spherocyte

d)

Keratocyte

58.

Associated with severe hemolytic anemia and painful Bone Marrow Crisis

a)

Hemoglobin C

b)

Hemoglobin H

c)

Hemoglobin SC

59.

Which of the following formed precipitation of beta chains of Hgb A?

a)

Heinz Bodies

b)

May hegglin

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