WorksheetsHEMA 1 RATIO QUIZ
Total questions: 51
Worksheet time: 26mins
Anemia can be caused by:
-
BOTH
A classification of anemia wherein the MCV is greater than 96ft. MCHC is normal
Macrocytic Normochromic Anemia
Microcytic Hypochromic Anemia
Normocytic Normochromic Anemia
All of these
Impaired release of storage iron associated with increased HEPCIDIN levels is due to
Iron Deficiency
Anemia of Chronic Dse
Sideroblastic Anemia
Megaloblastic Anemia
Myelophtisic
Caused by blocks on the protoporphyrin pathway resulting in defective hemoglobin synthesis and iron overload:
Aplastic Anemia
Sideroblastic Anemia
Lead Poisoning
Porphyrias
An anemia with normocytic/normochromic anemia with characteristic course basophilic slipping:
Lead Poisoning
ACD
Thalassemia
IDA
A falsely elevated HCT is obtained. Which of the following calculated values will not be affected
MCH
MCV
MCHC
All of these
Which of these types of anemia are under the category of impaired production
All of these
IDA
ACD
Thalassemia
Megaloblastic Anemia
SITUATION: RBC indices obtained on a patient are as follows: MCV 88um3 fL; MCH 30pg; MCHC 34% (340). The RBCs on the peripheral smear would appear
Normocytic Normochromic
Macrocytic normochromic
Microcytic hypochromic
NOTA
In an uncomplicated case of severe iron deficiency anemia, which of the following sets represents the typical pattern of results
A
B
C
D
What is the first type of cell produced by the developing embryo
RBC
Erythrocyte
Granulocyte
Monocyte
As most blood cell lines mature, which of the following is characteristics?
-
B. NUCLEUS TO CYTOPLASM RATION (N:C) DECREASES
The direct antiglobulin test is often positive in
Acquired Hemolytic Anemia
IDA
Acute Posthemorrhagic Anemia
Chronic Blood loss
The anemia of chronic infection is characterized
Increased Serum Iron levels
Decreased Serum Iron levels
WBC is increased
Platelet count is decreased
A patient is admitted with a history of chronic bleeding secondary to peptic ulcer. Hematology workup reveals a sever microcytic, hypochromic anemia. Iron studies were requested. Which of the following would be expected in this case?
A
B
C
D
Which of the following sets of laboratory findings is consistent with hemolytic anemia
INCREASE ERYTHROCYTE SURVIVAL; INCREASED CATABOLISM OF HEME
DECREASE ERYTHROCYTE SURVIVAL; INCREASED CATABOLISM OF HEME
DECREASE ERYTHROCYTE SURVIVAL; DECREASE CATABOLISM OF HEME
INCREASE ERYTHROCYTE SURVIVAL; DECREASED CATABOLISM OF HEME
Chronic blood loss can lead to:
Iron Deficiency
Vitamin B12 deficiency
Anemia of Chronic Disease
Aplastic Anemia
Many micro-spherocytes, schistocytes and budding off of spherocytes can be seen on peripheral blood smear of patients with
Extensive Burns
-
Abetalipoproteinemia is characterized by mild anemia and numerous____ on the peripheral blood smear
Acanthocytes
Poikilocytosis
Stomatocytosis
Elliptocytosis
Ovalocytosis
What is the most common cause of iron deficiency
Mild Injury
Bleeding
ABO incompatibility
Extensive Burn
Ineffective erythropoiesis is/are due to the following, EXCEPT:
Iron Deficiency
Megaloblastic Anemia
Sideroblastic Anemia
Vitamin B12 Deficiency
Thalassemia
This red cell parameter is increased in iron deficiency anemia
TIBC
Ferritin
Bone Marrow Iron
Serum Iron
When there is defective G6PD in red cells, then the cause of hemolysis is:
Intrinsic
Extrinsic
Both
NOTA
In chronic post-hemorrhagic anemia, this is NOT TRUE.
Reticulocyte is VERY LOW
Platelet is VERY LOW
WBC count is slightly increased
platelet count is decreased
Isoimmune hemolytic disease of the newborn maybe due to:
ABO Incompatibility
Bleeding
Lead Poisoning
Iron Deficiency
In aplastic anemias, marrow cellularity is:
Decreased
Increased
Normal
NOTA
Rh null disease person shows morphological changes in red cells. Persons with Rh-negative condition possesses the CDE antigen.
1st statement is TRUE, 2nd statement is FALSE
1st statement is TRUE, 2nd statement is TRUE
Both are False
Both are correct
Acanthocytes and echinocytes can be differentiated based on which of the following:
-
ALL OF THESE
The opposite of aplastic anemia is:
Polycythemia
Acanthocyte
Post hemorrhagic Anemia
All of these
Extrinsic Hemolytic Anemia is caused by:
Chemical
Physical
Vegetable and animal
Infectious agents
Presence of autoantibodies, isoantibodies
Defect of red cell itself usually hereditary & grouped as membrane, metabolic or hemoglobin defects
Extrinsic Hemolytic Anemia
Intrinsic Hemolytic Anemia
Anemia most commonly present with which one of the following set of symptoms
Pallor
Shortness of Breath and Fatigue
Low blood pressure
Slight fever
Which one of the following conditions would be included in the differential diagnosis of an anemic adult patient with an MCV of 125fL and an RDW of 20% (reference interval: 11.5% to 14.5%)
Vitamin B 12 Deficiency
Aplastic Anemia
Folate Deficiency
Sickle cell anemia
Schistocytes, ovalocytes, and acanthocytes are examples of abnormal changes in RBC:
Volume
Shape
Inclusions
Hemoglobin Concentrations
Which of the following is detectable only by examination of a peripheral blood film?
Microcytosis
Anisocytosis
Hypochromia
Poikilocytosis
Which of the following patients would be considered anemic with a hemoglobin value of 14.5g/dL?
Adult man
Adult woman
A newborn boy
10-year old girl
What are the initial laboratory tests that are performed for the diagnosis of anemia
CBC, iron studies, and reticulocyte count
CBC, reticulocyte count, and peripheral blood film examination
Reticulocyte count and serum iron, vitamin B12 and folate assays
Bone marrow study, iron studies, and peripheral blood film examination
An increased in which one of the following suggests a shorted life span of RBCs and hemolytic anemia?
Reticulocyte count
Red cell count
Hematocrit count
WBC count
An autoimmune reaction destroys the hematopoietic stem cells in the bone marrow of a young adult patient, and the amount of active bone marrow, including erythroid precursors, is diminished. Erythroid precursor that are present are normal in appearance, but there are too few to meet the demand for circulating red blood cells, and anemia develops. The reticulocyte count is low. The mechanism of the anemia would be described as
Effective erythropoiesis
Ineffective erythropoiesis
Insufficient erythropoiesis
Which of the following are important to consider in the patient’s history when investigating the cause of an anemia?
Diet and medications
Occupation, hobbies, and travel
Bleeding episodes in the patient
All of the above
To determine which of the following condition would be included in the differential diagnosis of an anemic adult patient with an absolute reticulocyte count of 20 3 109 /L and an MVC of 65fL
Aplastic Anemia
Sickle cell anemia
Iron deficiency
Vitamin B12 deficiency
Which one of the ff is reduced as an adaptation to long-standing anemia
Heart rate
Respiratory Rate
Oxygen affinity of hemoglobin
Volume of blood ejected from the heart w each contraction
Which of the following findings is consistent with a
diagnosis of megaloblastic anemia?
Hyposegmentation of neutrophils
Decreased serum lactate dehydrogenase level
Absolute increase in reticulocytes
Increased MCV
A patient has a clinical picture of megaloblastic anemia.
The serum folate level is decreased, and the serum vitamin
B12 level is 600 pg/mL (reference interval is 200 to 900
pg/mL). What is the expected value for the methylmalonic
acid assay?
Increased
Decreased
Within the reference interval
Which one of the following statements characterizes the
relationships among macrocytic anemia, megaloblastic
anemia, and pernicious anemia?
Macrocytic anemias are megaloblastic.
Macrocytic anemia is pernicious anemia.
Megaloblastic anemia is macrocytic.
Megaloblastic anemia is pernicious anemia.
Which of the following CBC findings is most suggestive
of a megaloblastic anemia?
MCV of 103 fL
Hypersegmentation of neutrophils
RDW of 16% d. Hemoglobin concentration of 9.1 g/dL
In the following description of a bone marrow smear, find
the statement that is inconsistent with the expected picture
in megaloblastic anemia. “The marrow appears
hypercellular with a myeloid-to-erythroid ratio of 1:1 due to
prominent erythroid hyperplasia. Megakaryocytes appear
normal in number and appearance. WBC elements appear
larger than normal, with especially large metamyelocytes,
although they otherwise appear morphologically normal.
Erythroid precursors also appear large. There is
nuclear-cytoplasmic asynchrony, with the nucleus appearing more mature than expected for the color of the cytoplasm.”
Erythroid nuclei that are more mature than cytoplasm
Larger than normal WBC elements
Larger than normal erythroid precursors
Normal appearance of megakaryocytes
Which one of the following findings would be inconsistent
with elevated titers of intrinsic factor blocking antibodies?
a. Hypersegmentation of neutrophils
b. Low levels of methylmalonic acid
c. Macrocytic RBCs
d. Low levels of vitamin B12
Which of the following is the most metabolically active
form of absorbed vitamin B12?
Transcobalamin
Intrinsic factor-vitamin B12 complex
Holotranscobalamin
d. Haptocorrin-vitamin B12 complex
8. Folate and vitamin B12 work together in the production of:
Amino acids
RNA
Phospholipids
DNA
The macrocytosis associated with megaloblastic anemia
results from:
Reduced numbers of cell divisions with normal
cytoplasmic development
Activation of a gene that is typically active only in
megakaryocytes
Reduced concentration of hemoglobin in the cells so that
larger cells are needed to provide the same oxygen-carrying
capacity
Increased production of reticulocytes in an attempt to
compensate for the anemia
Which one of the following groups has the highest risk
for pernicious anemia?
Malnourished infants
Children during growth periods
Persons older than 60 years of ageChildren during growth periods
Pregnant women
