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Gene + Chromosomal Mutations

Total questions: 71

Worksheet time: 51mins

Name
Class
Date
1.

What is a gene

a)

a section of DNA that codes for a trait

b)

a pair of pants that are made of denim

c)

the whole entire chromosome found in the nucleus

2.

What is a genetic mutation

a)

the making of a zombie

b)

any change in the DNA base pairs

c)

the process of duplicating the DNA in a cell

3.

A substitution mutation occurs when

a)

a base pair is missing from the DNA strand

b)

a base pair is added to the DNA strand

c)

a base pair is replaced with a different base pair

4.

An insertion/additon mutation occurs when

a)

a base pair is missing from the DNA strand

b)

a base pair is added to the DNA strand

c)

a base pair is replaced with a different base pair

5.

A deletion mutation occurs when

a)

a base pair is missing from the DNA strand

b)

a base pair is added to the DNA strand

c)

a base pair is replaced with a different base pair

6.

A mutation that helps an organism survive and reproduce

a)

harmful mutation

b)

helpful mutation

c)

neutral mutation

7.

A mutation that decreases an organism's ability to survive and reproduce

a)

harmful mutation

b)

helpful mutation

c)

neutral mutation

8.

A mutation that has NO effect on an organism's ability to survive and reproduce

a)

harmful mutation

b)

helpful mutation

c)

neutral mutation

9.

The base pair adenine always pairs with which other base pair?

a)

thymine

b)

adenine

c)

cytosine

d)

guanine

10.

The base pair thymine always pairs with which other base pair?

a)

thymine

b)

adenine

c)

cytosine

d)

guanine

11.

The base pair cytosine always pairs with which other base pair?

a)

thymine

b)

adenine

c)

cytosine

d)

guanine

12.

The base pair guanine always pairs with which other base pair?

a)

thymine

b)

adenine

c)

cytosine

d)

guanine

13.

Mutations can be...

a)

Harmful

b)

Beneficial

c)

Neutral

d)

All of the Above

14.

One nucleotide base is changed so only one amino acid

is affected

a)

Frameshift Mutation

b)

Point Mutation

c)

Translocation

d)

Insertion Mutation

15.

A point mutation where one amino acid replaces an original amino acid

a)

Silent Mutation

b)

Nonsense Mutation

c)

Frameshift Mutation

d)

Substitution/Missense Mutation

16.

A point mutation that has no effect

on the amino acid sequence

a)

Substitution/Missense Mutation

b)

Translocation

c)

Silent Mutation

d)

Nonsense Mutation

17.

A nucleotide base is inserted or deleted shifting the entire DNA sequence. Entire protein will be changed.

a)

Substitution Mutation

b)

Silent Mutation

c)

Frameshift Mutation

d)

Translocation

18.

A frameshift mutation where a nucleotide base

is removed from the DNA sequence.

a)

Deletion Mutation

b)

Substitution Mutation

c)

Translocation

d)

Silent Mutation

19.

A frameshift mutation where a nucleotide base is added

to the DNA sequence

a)

Insertion Mutation

b)

Deletion Mutation

c)

Substitution Mutation

d)

Chromosomal Mutation

20.

Mutations that involve parts of or all of

a chromosome

a)

Replication

b)

Deletion Mutation

c)

Chromosomal Mutation

d)

Transcription

21.
Are all mutations bad?
a)
Yes
b)
No
22.

Which of the following does NOT cause mutations?

a)

Mistakes in replication

b)

Exposure to chemicals

c)

Inheritance of somatic (body) cells

d)

Exposure to radiation

23.

Mutations can benefit humans because they can:

a)

Cause illness

b)

Make an organism more suited to live in its environment.

c)

Make organisms live shorter lives

d)

Cause organisms to grow extra limbs.

24.
Which change below would result in a different Amino Acid? 
3'-GCT-5'
a)
GTT
b)
TCT
c)
TCC
d)
GCA
25.
What type of gene mutation has occurred here? 
T-G-A-C-C-A
T-G-A-C-C-A-A
a)
Base Substitution
b)
Base Deletion
c)
Base Insertion
d)
Frameshift 
26.
What type of gene mutation has occurred here? Normal-
AGA-TTC-ATA-GCG
Mutant-
AGA-TTC-AAT-AGC-G
a)
deletion frameshift
b)
insertion frameshift
c)
substitution
d)
nonsense
27.
A mutation that does NOT show up through protein function is called
a)
deletion mutation
b)
inversion mutation
c)
silent mutation
d)
transverse mutation
28.

Why are insertion and deletion mutations so harmful?

a)

They change all of the codons from the mutation on down the line, which changes the amino acid sequence

b)

They insert things that an organism doesn't need.

c)

They often delete things that organisms need.

d)

Insertion and deletions are not any more harmful than substitution mutations.

29.
Why is the order of amino acids so important?
a)
The order of amino acids dictates what shape the protein will fold into.
b)
It is not important. The protein folding chamber will force the protein to fold into the correct shape.
30.

A point mutation where one base replaces an original base. What would happen because of this mutation (circled)?

a)

the same amino acid would be made

b)

a different amino acid would be made

c)

no amino acid would be made

31.
ATTTGAGCC- Original
ATTGAGCC - Mutated
The example above is an example of a 
a)
Insertion- Frameshift
b)
Deletion- Substitution
c)
Deletion -Frameshift
d)
All of the above
32.

A single base pair change (point mutation) can result in all of the following except __________.

a)
Missense mutation
b)
Frameshift Mutation
c)
Silent Mutation
d)
Nonsense mutation
33.
What kind of mutation is the result of an insertion?
a)
Silent Mutation
b)
Missense mutation
c)
Nonsense mutation
d)
Frameshift mutation
34.

A nonsense mutation produces _________.

a)

A shortened polypeptide chain

b)

A slightly altered polypeptide chain

c)

A shift in the reading frame

d)

A lengthened polypeptide chain

35.

Deletion

a)

A

b)

B

c)

C

36.

Substitution

a)

A

b)

B

c)

C

37.

Insertion

a)

A

b)

B

c)

C

38.

What type of mutation is this?

a)

Nonsense mutation

b)

Missense mutation

c)

Silent mutation

d)

Frameshift mutation

39.
Which of the following would result in a frameshift mutation?
a)
Insertions only
b)
Substitution only
c)
Deletion only
d)
Insertions and Deletions
40.

True or false, mutations create genetic diversity?

a)

True

b)

False

41.

A piece of a chromosome is lost

a)

deletion

b)

duplication

c)

inversion

d)

translocation

42.

A piece of a chromosome is copied and remains within the chromosome

a)

deletion

b)

duplication

c)

inversion

d)

translocation

43.

A piece of the chromosome detches, turns 180 degrees, and reattaches

a)

deletion

b)

duplication

c)

inversion

d)

translocation

44.

A piece of one chromosome detaches and reattaches to a different chromosome

a)

deletion

b)

duplication

c)

inversion

d)

translocation

45.

The chromosomal mutation shown in the image is a

a)

deletion

b)

duplication

c)

inversion

d)

translocation

46.

The chromosomal mutation shown in the image is a

a)

deletion

b)

duplication

c)

inversion

d)

translocation

47.

The chromosomal mutation shown in the image is a

a)

deletion

b)

duplication

c)

inversion

d)

translocation

48.

The chromosomal mutation shown in the image is a

a)

deletion

b)

duplication

c)

inversion

d)

translocation

49.
Identify the mutation in the picture.
a)
Inversion
b)
Deletion
c)
Duplication
d)
Translocation
50.
Identify the mutation in the picture.
a)
Inversion
b)
Duplication
c)
Deletion
d)
Translocation
51.
Identify the mutation in the picture.
a)
Deletion
b)
Inversion
c)
Duplication
d)
Translocation
52.
What type of chromosomal mutation has occurred?
a)
substitution
b)
insertion
c)
deletion
d)
nondisjunction
53.
A chromosome is found to be shorter than it's homologous match.  Which type of mutation would this most likely be?
a)
insertion
b)
deletion
c)
translocation
d)
inversion
54.
An example of a mutation where a piece of chromosome breaks off and attaches to another chromosome is called ___.
a)
trisomy
b)
translocation
c)
inversion
d)
deletion
55.

Notice the abnormal 23rd chromosome. This individual has an extra X chromosome. What type of mutation is this?

a)

Translocation

b)

Nondisjunction

c)

Dublication

d)

Inversion

e)

Deletion

56.

Deletion

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

57.

Inversion

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

58.

Duplication

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

59.

Translocation

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

60.

Nondisjunction

a)

When a segment of a chromosome breaks off.

b)

When a segment of a chromosome breaks off, flips, and reattaches.

c)

When a segment of a chromosome is copied or doubles.

d)

When a segment of a chromosome breaks and attaches to a non homologous chromosome.

e)

When entire chromosomes don't separate evenly during meiosis.

61.

Deletion

a)

A

b)

B

c)

C

d)

D

62.

Translocation

a)

A

b)

B

c)

C

d)

D

63.

Duplication

a)

A

b)

B

c)

C

d)

D

64.

Inversion

a)

A

b)

B

c)

C

d)

D

65.

Duplication

a)

A

b)

B

c)

C

d)

D

e)

E

66.

Inversion

a)

A

b)

B

c)

C

d)

D

e)

E

67.

Translocation

a)

A

b)

B

c)

C

d)

D

e)

E

68.

Deletion

a)

A

b)

B

c)

C

d)

D

69.

Duplication

a)

A

b)

B

c)

C

d)

D

70.

Inversion

a)

A

b)

B

c)

C

d)

D

71.

Translocation

a)

A

b)

B

c)

C

d)

D

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