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WorksheetsPatho Exam 1 Quiz
Total questions: 78
Worksheet time: 40mins
When a patient asks the nurse what hypersensitivity is, how should the nurse respond? Hypersensitivity is best defined as:
a. a reduced immune response found in most pathologic states.
b. a normal immune response to an infectious agent.
c. an excessive or inappropriate response of the immune system to a sensitizing antigen.
d. antigenic desensitization
A 75-year-old male presents with chest pain on exertion. The chest pain is most likely due to hypoxic injury caused (secondary to) by:
a. Ischemia
b. Chemical injury
c. Diabetes
d. Alcohol toxicity
Sodium and water accumulation in an injured cell are a direct result of: (select all that apply)
a. Failure of Na/K active transport pump
b. Inflammatory response
c. Insufficient nutrients
d. Hypoxic injury
A syndrome refers to signs and symptoms that emerge from a diseased state (T or F)
True
False
The brain is the most common site for what type of necrosis?
1. Caseous
2. Liquefactive
3. Fat
4. Coagulative
When a patient presents at the emergency department for an allergic reaction, the nurse recognizes the most severe consequence of a type I hypersensitivity reaction is:
a. urticaria.
b. hives.
Anaphylaxis
antibody-dependent cell-mediated cytotoxicity
A 30-year-old female complains of fatigue, arthritis, rash, and changes in urine color. Laboratory testing reveals anemia, lymphopenia, and kidney inflammation. Assuming a diagnosis of SLE, which of the following is also likely to be present?
Anti-LE antibodies
Autoantibodies
Anti Herpes antibodies
Anti-CMV antibodies
A 22-year-old was recently diagnosed with acquired immunodeficiency syndrome (AIDS). Which decreased lab findings would be expected to accompany this virus?
CD4+ T-helper
CD8 T-helper
CDC cells
CDC10 cells
Which statement describes an individual who is sensitized and is predisposed to a type I hypersensitivity reaction?
mast cells are degranulated
urticaria has developed on the skin
antigens have bound to IgE receptors on mast cells
Attachment of large amounts of IgE to mast cell membranes has occurred
True or false: Serotonin is the major vasoactive amine released by mast cells. It causes dilation of the capillaries which increases vascular permeability.
True
False
What does healing by secondary intention mean? Select all that apply (SATA).
Requires more time to treat
Healing occurs from the bottom up
Dermal edges are close together
Results in a complete return to function
What causes the redness, heat, swelling, and pain in inflammation? Select all that apply (SATA).
Increased blood flow allows more immune cells to be carried to the injured tissue
Increased Capillary permeability
Bacteria is bursting in the blood causing macrophages to eat the cell
Plasma proteins are not being synthesized in the kidneys
Bradykinins
Asthma is considered an acute airway inflammatory disease resulting in dysfunction of the airways and tissue remodeling. True or False?
True
False
A disease has spread across the United States border. This is considered a...
Epidemic
Endemic
Pandemic
Disease
Parathyroid hormone decreases the calcium levels in your blood. True or False?
True
False
Less Calcium blocks more sodium channels. How does this affect the body? Select all that apply (SATA).
Chvostek and trousseau sign
Increases neuromuscular activity
Convulsions
Dehydration
Hypoactive reflexes
Manifestations of hyponatremia include... SATA
Decreased extracellular fluid osmotic pressure
Causes are diuretics
Confusion
Renal dysfunction
Hyperkalemia stresses the cardiovascular system leading to lethal arrhythmias and other pathologies T or F
True
False
What are the characteristics of a Type III hypersensitivity response?
Immediate reactions, Ag- AB complex deposited in tissues
IgE mediated- allergic reactions
T cell-mediated reaction- delayed reaction
None of the above
The two main factors that cause autoimmune diseases are age and level of development T or F
F
T
Characteristics of Rheumatoid Arthritis are: SATA
Inflammatory destruction of the synovial membrane
It's a autoimmune disease
Acute disease
Causes inflammation of the joint
Manifestations of somatic death include: (select all that apply)
rigor mortis
an increase in body temperature
putrefaction and pallor mortis
pupil dilation and bloating
slippage or loosening of skin from underlying tissue
Dry gangrene is more likely to occur with disruption of:
oxygen delivery
arterial obstruction
venous obstruction
infection of injured tissue
A 65-year-old female is diagnosed with metastatic breast cancer. She has developed muscle wasting. Which of the following substances would be produced in large quantities to eliminate the tumor cells and cause muscle wasting?
Cytokines
Interleukins
Tumor Necrosis Factor
Macrophages
The nurse is assessing a patient with a diagnosis of inflammation. The nurse would expect to find which of the following signs and symptoms consistent with acute inflammation. (select all that apply)
Rubor
Loss of function
Heat
Pain
Edema
A 12-year-old male is fighting with another child when he receives a puncture wound from a pencil. The school nurse cleans and bandages the wound. After about 1 week, the wound would be in which phase of healing?
Debridement
Primary intention
Resolution
Maturation
A 25-year-old female experiences a headache and takes aspirin for relief. A nurse recalls aspirin relieves the headache by:
Decreasing leukotriene production
Increasing histamine release
Decreasing prostaglandin production
Increasing platelet-activating factor
A 54-year-old male with a long history of smoking complains of excessive tiredness, shortness of breath, and overall ill feelings. Lab results reveal decreased pH, increased CO2, and normal bicarbonate ion. These findings help to confirm the diagnosis of:
Respiratory acidosis
Metabolic acidosis
Respiratory alkalosis
Metabolic alkalosis
A 60-year-old male with a 30-year history of smoking is diagnosed with a hormone-secreting lung tumor. Further testing indicates that the tumor secretes ADH. Which of the following assessment findings should the nurse expect? (Select all that apply.)
Weakness
Confusion
Nausea
Muscle twitching
Increased ICP
Which of the following patients is the most at risk for developing hypernatremia? A patient with:
Dehydration
Vomiting
Diuretic use
Hypoaldosteronism
A nurse is reviewing lab reports. The nurse recalls blood plasma is located in which of the following fluid compartments?
ICF
ECF
Interstitial fluid
Intravascular fluid
ADH is made in the hypothalamus and is released by the anterior pituitary gland when blood osmolarity goes up.
True
False
Edema is caused by an increase in forces favoring fluid filtration from the capillaries.
True
False
What type of exudate is a blister?
Fibrinous
Serous
Purulent
Ulceration
If someone is experiencing hypotonic hyponatremia what would be the best way to replace fluids?
Give them a gallon of water to replace excessive dehydration
Give them a gatorade to replace the electrolytes
Give them a hypotonic solution
Have them rest and eat plenty of protein
The primary actions of the complement cascade include all EXCEPT..
Increased vascular permeability
Vasodilation
Vasoconstriction
Chemotaxis
What is a manifestation of a patient having a systemic response to an infection?
Redness
Warm arm
Pain
Fever
A patient was admitted to the hospital after contracting HPV. Upon biopsy of the cervical tissue the doctor notices misshapen cells on the culture. What type of cellular adaptation is this?
Hypertrophy
Atrophy
Metaplasia
Dysplasia
Joe comes into the ED after having an allergic reaction to peanuts. What type of hypersensitivity reaction is this?
Type I
Type II
Type III
Type IV
This type of immunoglobulin is found in saliva, tears, colostrum and mucus. It prevents antigens from entering the body.
IgM
IgA
IgD
IgE
T cells are responsible for cell-mediated immunity (T or F)
True
False
Joe had a heart attack two years ago and he experienced additional damage to his heart once blood flow had been restored. What is this phenomenon called?
Ischemia
Myocardial Infarction
Reperfusion Injury
Hypertension
What is the name of the process the mast cell initiates for the inflammatory response to happen?
Leukocytosis
Chemotaxis
Degranulation
Apoptosis
What type of cell is the first responder to an injury and you would see primarily during acute inflammation?
Eosinophils
Neutrophils
Leukotrienes
Histamine
The slower response results in vessel remodeling and includes profound changes in the cellular architecture. (T or F)
True
False
Factor XII (Hageman’s factor) promotes formation of what?
antigens/antibodies
classic complements
bradykinin
extrinsic pathway
__________ cells tolerate hypoxia for only a few minutes
Skin
Renal
Neuron and glial
Hepatic
Hydrostatic pressure can be described as...
Water moving across the capillary membrane by filtration
Proteins such as albumin
Pulling factors
Assisting electrons to flow down a gradient
Secretion of ADH is stimulated by:
Increased plasma osmolarity
Increased serum potassium
Decreased renal blood flow
Intracellular dehydration
Which statement indicates a correct understanding of antibodies? The most abundant class of antibodies in the serum is:
IgG
IgM
IgA
IgE
Blood vessel walls divide intracellular fluid from blood plasma (True or False)
True
False
Which of the following electrolytes are found in high concentrations in the extracellular fluid? (Select all that apply)
Sodium (Na⁺)
Magnesium (Mg²⁺)
Potassium (K⁺)
Calcium (Ca²⁺)
Chloride (Cl⁻)
B cells are responsible for cell-mediated immunity that is mediated by circulating antibodies (True or False)
True
False
Which of the following statements best describes the actions of vasoactive amines during the early stages of inflammation?
Histamine and serotonin are released later in the inflammatory response and primarily decrease blood flow
Histamine, released from mast cells, increases capillary permeability by causing endothelial cell retraction and can also cause vasodilation
Serotonin and histamine both inhibit vascular permeability to limit swelling
Platelets, released from mast cells, cause temporary vasoconstriction and venule dilation
Primary cell types that produce mediators during acute inflammation are all except...
Macrophages
Dendritic cells
Natural killer cells
Mast cells
The principal systemic effects of inflammation are fever and increases in levels of circulating... (SATA)
leukocytes
mast cells
plasma proteins
serotonin
Bradykinin
Alloimmunity is the immune system’s reaction against antigens on the tissues of other members of the same species (T and F)
True
False
Cytotoxic B cells mistakenly attack the body’s own cells.
True
False
Cellular tolerance to hypoxia may involve all except
reduction in the metabolic rate
increased extraction of oxygen from the blood and surrounding tissues
adaptations of enzymes to allow metabolism at low partial pressures of oxygen
autodigestion of intracellular structures
The most common types of blunt-force injuries include (SATA)
motor vehicle accidents
assaults
falls
sports injuries
strangulation
What hormone provides a means of controlling water output independently of sodium?
Aldosterone
Parathyroid hormone
Antidiuretic hormone
Calcitonin
Changes in urine volume are usually linked to adjustments in potassium reabsorption (Tor F)
True
False
When planning care for a cardiac patient, the nurse knows that in response to an increased workload, cardiac myocardial cells will _______.
Hypertrophy
Atrophy
Undergo apoptosis
Remain unchanged
What Pathophysiological concept should the health professional consider when developing a plan of care for a patient with myocardial ischemia?
There is a lack of oxygen reaching the myocardium, but the supply of glucose is adequate.
There is a lack of glucose reaching the myocardium, but the supply of oxygen is adequate.
There is a decrease in the amount of oxygen and glucose reaching the myocardium
There us a complete lack of both oxygen and glucose reaching the myocardium
Potassium imbalances are the most dangerous of all electrolyte imbalances. (T or F)
True
False
The increased intracellular concentration of _______ may inappropriately activate a number of enzymes with potentially damaging effects.
Calcium
Sodium
Potassium
Magnesium
Which of the following statements accurately describes Type I hypersensitivity reactions? (Select all that apply)
They are mediated by IgE antibodies that trigger mast cell degranulation
They typically occur hours to days after antigen exposure
Common allergens include pollens, molds, foods, and animal dander
Tissues rich in mast cells, such as the skin, GI tract, and respiratory tract, are often affected
The route of allergen entry can influence whether the reaction is local or systemic
Signs and symptoms of Hypercalcemia (SATA)
Nerves fire more easily
Lethargy
Tetanus
Stupor
Muscle weakness
The important chemical buffer systems include all the following except…
The protein system
The carbonic acid-bicarbonate system
The phosphate system
The calcium system
When an patient asks the nurse about the purpose of the inflammatory process, how should the nurse respond?
To provide specific responses toward antigens
To lyse cell membranes of microorganisms
To prevent infection of the injured tissue
To create immunity against subsequent tissue injury
(T or F) Type II hypersensitivity reactions are mediated by IgG or IgM antibodies that bind to antigens on cell surfaces, leading to tissue-specific cytotoxic effects.
true
false
A patient experiences a rapid rise in extracellular potassium levels due to a crush injury. Which of the following statements correctly describes the effects on nerve and muscle cells?
The sudden increase in potassium hyperpolarizes the cells, making them less excitable.
Rapid extracellular potassium rise initially depolarizes cells, increasing excitability, but then slows repolarization and reduces excitability.
Slow potassium infusion produces immediate cardiac arrest.
Hyperkalemia has no effect on the resting membrane potential of cells.
All are signs and symptoms of Lupus except…
Butterfly rash
Pericarditis
Nonerosive arthritis
Photosensitivity
If the immune system cannot perform functions properly, a variety of illnesses may result—including hypersensitivity reactions and autoimmune disorders (T or F)
True
False
John, a 60-year-old man with severe chronic obstructive pulmonary disease (COPD), presented to the emergency department with worsening shortness of breath. Arterial blood gas analysis revealed significant hypoxemia, highlighting the chronic hypoxic state experienced by his cells due to impaired gas exchange in the lungs, resulting in hypoxic cell injury and contributing to the progression of his COPD. Which of the following would be seen in hypoxic cell injury? Select all that apply:
Decreased ATP production
Decreased membrane permeability
Mitochondrial dysfunction and increased reactive oxygen species (ROS)
Decreased intracellular sodium
Increased intracellular sodium
What is the main difference between B cells and T cells?
B cells produce antibodies, while T cells kill infected cells directly.
B cells are part of the innate immune system, while T cells are part of the adaptive immune system.
B cells are found only in the spleen, while T cells are found throughout the body.
B cells can live for many years, while T cells live for a few days.
The cells/signaling molecules involved in the initiation of the inflammatory response are ___, while cells/signaling molecules that initiate dilation of blood vessels are ___.
phagocytes and lysozymes
macrophages/chemokines; mast cells/histamines
dendritic cells/interferons; mast cells/lysozymes
mast cells/ histamines; phagocytes
Which cellular response mechanism results in an increase in the number of cells?
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
