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Neuroscience PRITE Review

Total questions: 50

Worksheet time: 25mins

Name
Class
Date
1.

60 yo right‑handed man, getting lost and writing only on the right half of paper. Left‑sided hemi‑neglect—where is the lesion?

a)

Left parietal lobe

b)

Right frontal lobe

c)

Right parietal lobe

d)

Left occipital lobe

2.

66 yo with long‑standing hypertension develops vertigo, diplopia, nausea, vomiting, hiccups, left‑sided facial numbness, nystagmus, hoarseness, limb ataxia, staggering gait, and a tendency to fall to the left—diagnosis?

a)

Medial medullary stroke

b)

Lateral medullary stroke

c)

Cerebellar hemorrhage

d)

Pontine infarction

3.

26 yo with headaches and right‑hand clumsiness for weeks; exam shows dysdiadochokinesia, intention tremor, and mild dysmetria with an otherwise normal neurologic exam—where would MRI show damage?

a)

Basal ganglia

b)

Cerebellum

c)

Primary motor cortex

d)

Internal capsule

4.

78 yo post‑ischemic‑stroke patient with mild hemiplegia is unaware of weakness, neglects one side when dressing/grooming, and misattributes limb movements—brain area affected?

a)

Right parietal lobe

b)

Left frontal lobe

c)

Right temporal lobe

d)

Left parietal lobe

5.

Adult neurogenesis occurs predominantly in which brain area?

a)

Caudate nucleus

b)

Dentate gyrus of hippocampus

c)

Prefrontal cortex

d)

Amygdala

6.

Left anterior cerebral‑artery infarct most likely produces what clinical picture?

a)

Right facial droop with aphasia

b)

Weakness of contralateral foot and leg sparing face and arm with abulia

c)

Complete homonymous hemianopia

d)

Ipsilateral Horner syndrome

7.

Rapid change to profane, irresponsible behavior over six months suggests pathology in which lobe?

a)

Temporal lobe

b)

Parietal lobe

c)

Frontal lobe

d)

Occipital lobe

8.

Rapid onset of right facial weakness, left‑sided limb weakness, and diplopia indicates what process?

a)

Multiple sclerosis relapse

b)

Brain‑stem infarction

c)

Subdural hematoma

d)

Myasthenic crisis

9.

Orexin (hypocretin) is synthesized in which part of the brain?

a)

Ventromedial hypothalamus

b)

Lateral hypothalamic nuclei

c)

Nucleus basalis of Meynert

d)

Dorsal raphe nucleus

10.

Which brain area is activated by subliminal presentation of emotional faces?

a)

Primary visual cortex

b)

Amygdala

c)

Caudate head

d)

Dorsolateral prefrontal cortex

11.

Histamine is synthesized in which brain region?

a)

Hypothalamus

b)

Pons

c)

Basal forebrain

d)

Cerebellum

12.

The dopaminergic pathway that includes the nucleus accumbens and mediates reinforcement/addiction is the ______ pathway.

a)

Nigrostriatal

b)

Mesolimbic

c)

Tuberoinfundibular

d)

Mesocortical

13.

Leptin acts primarily at which brain region?

a)

Cerebellar vermis

b)

Hippocampus

c)

Hypothalamus

d)

Superior colliculus

14.

Oxytocin suppresses activity in which brain structure?

a)

Amygdala

b)

Putamen

c)

Thalamus

d)

Superior temporal gyrus

15.

Hypothalamic area most closely linked to maternal behavior?

a)

Preoptic area

b)

Supraoptic nucleus

c)

Paraventricular nucleus

d)

Suprachiasmatic nucleus

16.

Cranial nerve responsible for gag reflex and palatal elevation?

a)

Glossopharyngeal nerve (CN IX)

b)

Vagus nerve (CN X)

c)

Facial nerve (CN VII)

d)

Hypoglossal nerve (CN XII)

17.

In the first two years of life, which cortex develops before the other: motor or sensory?

a)

Sensory cortex

b)

Motor cortex

c)

Insular cortex

d)

Cingulate cortex

18.

A key cortical component of the salience network is the ______.

a)

Posterior cingulate cortex

b)

Anterior cingulate cortex

c)

Parahippocampal gyrus

d)

Precuneus

19.

Primary taste cortex in humans lies in which cortical area?

a)

Postcentral gyrus

b)

Anterior insula

c)

Orbitofrontal cortex

d)

Superior temporal gyrus

20.

Initial learning of a skilled motor sequence requires the corticostriatal system and which other system?

a)

Vestibulocerebellar

b)

Corticocerebellar

c)

Corticolimbic

d)

Corticoamygdalar

21.

Reduced hippocampal volume produces impairment of which memory domain?

a)

Procedural memory

b)

Declarative memory

c)

Working memory

d)

Priming

22.

Histaminergic neurons that regulate sleep originate in which nuclei?

a)

Suprachiasmatic nuclei

b)

Tuberomammillary nuclei

c)

Locus coeruleus

d)

Raphe nuclei

23.

Sudden dysarthria, gait ataxia, right‑body numbness, and neck pain after neck manipulation—most likely diagnosis?

a)

Cerebellar hemorrhage

b)

Vertebral artery dissection

c)

Multiple sclerosis

d)

Peripheral vestibulopathy

24.

The stria terminalis connects the amygdala with which areas?

a)

Dorsal raphe nucleus and pons

b)

Septal area and hypothalamus

c)

Ventral tegmental area and thalamus

d)

Hippocampus and cerebellum

25.

Wakefulness depends on what brain system?

a)

Ascending reticular activating system

b)

Periaqueductal gray

c)

Lateral geniculate nucleus

d)

Mammillary bodies

26.

The neural tube forms from which embryonic germ layer?

a)

Endoderm

b)

Mesoderm

c)

Ectoderm

d)

Neural crest

27.

High‑frequency rTMS for major depression targets which cortical region?

a)

Ventromedial prefrontal cortex

b)

Dorsolateral prefrontal cortex

c)

Primary motor cortex

d)

Inferior parietal lobule

28.

Adult neurogenesis is restricted primarily to what region?

a)

Olfactory bulb

b)

Subventricular zone of lateral ventricle

c)

Dentate gyrus of hippocampus

d)

Caudate tail

29.

Of the listed structures, which is part of the hippocampal formation?

a)

Amygdala

b)

Dentate gyrus

c)

Caudate head

d)

Thalamus

30.

Bipolar disorder is associated with decreased connectivity between which regions?

a)

Amygdala and prefrontal cortex

b)

Thalamus and cerebellum

c)

Basal ganglia and parietal cortex

d)

Somatosensory cortex and insula

31.

CNS fear responses are mediated chiefly by what structure?

a)

Central nucleus of the amygdala

b)

Bed nucleus of stria terminalis

c)

Hippocampal CA3

d)

Orbitofrontal cortex

32.

Fear‑related projections to brain‑stem and hypothalamus arise from which amygdalar nuclei?

a)

Basolateral nuclei of the amygdala

b)

Corticomedial nuclei of the amygdala

c)

Centromedial nuclei of the amygdala

d)

Paralaminar nuclei of the amygdala

33.

Remembering a phone number briefly before dialing relies on which brain area?

a)

Posterior parietal cortex

b)

Dorsolateral prefrontal cortex

c)

Entorhinal cortex

d)

Superior temporal gyrus

34.

The circuit enabling resistance to hostile impulses centers on which frontal region?

a)

Orbitofrontal cortex

b)

Supplementary motor cortex

c)

Dorsomedial prefrontal cortex

d)

Inferior parietal lobule

35.

The loop producing worry/obsessive symptoms includes DLPFC, striatum, and which other structure?

a)

Cerebellar dentate nucleus

b)

Thalamus

c)

Amygdala

d)

Hippocampus

36.

Hyperactivity of orbitofrontal cortex, basal ganglia, and thalamus characterizes which disorder?

a)

Panic disorder

b)

Obsessive‑compulsive disorder

c)

Schizophrenia

d)

PTSD

37.

Dopamine neurons mediating cognitive processing belong to which pathway?

a)

Mesolimbic

b)

Mesocortical

c)

Nigrostriatal

d)

Tuberoinfundibular

38.

Stem cells in the adult hippocampus reside in which zone?

a)

Subgranular zone

b)

Hilus

c)

Molecular layer

d)

Alveus

39.

Stroke causing predominant right‑leg weakness, passivity, and abulia likely involves which artery?

a)

Right middle cerebral artery

b)

Left anterior cerebral artery

c)

Right posterior cerebral artery

d)

Left vertebral artery

40.

Hemisensory loss followed by pain/hyperpathia to midline suggests ischemia of which artery?

a)

Middle cerebral artery

b)

Posterior cerebral artery

c)

Anterior choroidal artery

d)

Anterior cerebral artery

41.

Combined third‑nerve palsy and equal face/arm/leg weakness on the right indicates occlusion of a branch of which artery?

a)

Anterior cerebral artery

b)

Posterior cerebral artery

c)

Superior cerebellar artery

d)

Basilar artery

42.

Bilateral leg weakness, abulia/mutism, and incontinence result from occlusion of which artery?

a)

Middle cerebral artery

b)

Basilar artery

c)

Anterior cerebral artery

d)

Anterior choroidal artery

43.

Pure sensory lacunar stroke extending to midline (face, arm, trunk, leg) localizes to what site?

a)

Posterior limb internal capsule

b)

Lateral thalamus

c)

Parietal cortex

d)

Midbrain tegmentum

44.

Right PCA occlusion causes what visual field defect?

a)

Right homonymous hemianopsia

b)

Left homonymous hemianopsia

c)

Bitemporal hemianopsia

d)

Superior quadrantanopia

45.

Bilateral leg/foot anesthetic‑motor deficits with bladder dysfunction in a cocaine user indicate what spinal event?

a)

Posterior spinal artery infarction

b)

Anterior spinal artery infarction

c)

Transverse myelitis

d)

Central cord syndrome

46.

Intact primary somatosensation but inability to recognize objects by touch (astereognosis) suggests lesion where?

a)

Primary somatosensory cortex

b)

Posterior parietal lobe

c)

Dorsolateral prefrontal cortex

d)

Inferior temporal gyrus

47.

Apraxia (loss of learned motor acts) without weakness or ataxia localizes to which cortex?

a)

Left parietal cortex

b)

Right frontal cortex

c)

Left occipital cortex

d)

Cerebellar hemispheres

48.

Romberg negative with eyes open but falls when eyes closed—abnormality in which cerebellar region?

a)

Cerebellar hemispheres

b)

Cerebellar vermis

c)

Vestibular nuclei

d)

Dentate nucleus

49.

Right‑temporal hyperactivity on motor‑speech fMRI indicates damage where?

a)

Calcarine fissure

b)

Broca area

c)

Right insula

d)

Cerebellar vermis

50.

Non‑fluent, effortful “telegraphic” speech (Broca aphasia) localizes to which lobe?

a)

Posterior frontal lobe

b)

Anterior temporal lobe

c)

Inferior parietal lobe

d)

Occipital lobe