WorksheetsTumor Classification Quiz
Total questions: 17
Worksheet time: 14mins
A biopsy from the colon shows malignant epithelial cells forming glandular structures. The correct nomenclature is:
Squamous cell carcinoma
Adenocarcinoma
Papilloma
Sarcoma
Which of the following best describes the growth pattern of benign tumors?
Infiltrative and poorly circumscribed
Rapid growth with necrosis
Expansile, may be encapsulated
Always progress to malignancy
A tumor showing loss of differentiation, nuclear pleomorphism, prominent nucleoli, and atypical mitotic figures is most likely:
Well-differentiated carcinoma
Dysplasia
Anaplastic carcinoma
Benign adenoma
Which of the following features is NOT characteristic of malignant tumors?
High nuclear-cytoplasmic ratio
Frequent abnormal mitoses
Encapsulation with compressive growth
Invasion beyond basement membrane
A middle-aged patient has a mixed tumor of the salivary gland containing both epithelial and mesenchymal elements (cartilage-like). The correct name is:
Carcinosarcoma
Pleomorphic adenoma
Adenosarcoma
Adenocarcinoma
According to the WHO 2022 classification, bladder cancers are now organized based on:
Histological grade (low vs high)
Tumor lineage (urothelial, squamous, glandular)
Molecular profile only
Tumor stage (invasive vs non-invasive)
Which of the following WHO updates emphasizes the importance of molecular classification in central nervous system tumors?
Oligodendroglioma grading
Astrocytoma, IDH-mutant and IDH-wildtype
Medulloblastoma staging
Meningioma histological typing
Anaplastic tumor cells showing tripolar spindle mitosis represent:
Normal cell division
Benign glandular hyperplasia
Malignant change with abnormal mitosis
Reactive hyperplasia
Which of the following best defines a neoplasm?
A collection of inflammatory cells responding to injury
A clonal proliferation of cells with loss of normal growth control
A localized swelling due to fluid accumulation
Hyperplasia secondary to chronic irritation
Which of the following “-oma” lesions is not a true neoplasm?
Lipoma
Hematoma
Chondroma
Fibroma
Which of the following tumour type is paired correctly with its tissue of origin?
Carcinoma – epithelial origin
Sarcoma – germ cell origin
Lymphoma – mesenchymal origin
Seminoma – lymphoid origin
Which of the following tumours is malignant despite ending with “-oma”?
Hamartoma
Chordoma
Lipoma
Choristoma
A 16-year-old boy presents with a small round cell tumour of bone. Histology suggests Ewing sarcoma, but FISH is negative for EWSR1 rearrangement. Molecular studies reveal CIC rearrangement. According to WHO, this tumour is best classified as:
Classical Ewing sarcoma
CIC-rearranged sarcoma (Ewing-like)
Undifferentiated pleomorphic sarcoma
Alveolar rhabdomyosarcoma
Which molecular alteration is most predictive of response to imatinib therapy in gastrointestinal stromal tumors (GISTs)?
TP53 mutation
KIT or PDGFRA mutation
KRAS mutation
BRAF mutation
Which of the following historical terms has been reclassified in modern WHO classification?
Carcinoid → Neuroendocrine tumor
Osteogenic sarcoma → Osteosarcoma
Malignant fibrous histiocytoma → Undifferentiated pleomorphic sarcoma
All of the above
State two microscopic features that distinguish malignant from benign tumours.
A soft tissue biopsy shows highly pleomorphic spindle cells with storiform arrangement, bizarre multinucleated giant cells, and absence of specific differentiation. Historically this was called “Malignant Fibrous Histiocytoma (MFH)”. What is the current WHO terminology for this tumour?
