Free Printable Apoptosis Quiz

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Apoptosis Quiz

Total questions: 20

Worksheet time: 10mins

Name

Class

Date

1.

Apoptosis is:

a)

Pathologic cell death only

b)

Programmed cell death

c)

Unregulated necrosis

d)

Cell swelling injury

2.

Key feature of apoptosis:

a)

Cell swelling

b)

Loss of membrane integrity

c)

DNA fragmentation into nucleosomes

d)

Severe inflammation

3.

Most important enzyme family in apoptosis:

a)

Kinases

b)

Caspases

c)

Phosphatases

d)

Cyclins

4.

Intrinsic apoptotic pathway is triggered by:

a)

Death receptors

b)

Mitochondrial damage only

c)

Calcium influx

d)

Bacterial toxins

5.

Anti-apoptotic member of Bcl-2 family:

a)

Bax

b)

Bak

c)

Bcl-2

d)

Bid

6.

Pro-apoptotic protein:

a)

Bcl-2

b)

Bcl-xL

c)

Bak

d)

MDM2

7.

Death receptor–mediated apoptosis involves:

a)

TNF & Fas pathways

b)

Lysosomal leakage

c)

Mitochondrial ATP rise

d)

Calcium binding

8.

Executioner caspases include:

a)

Caspase-8 and 9

b)

Caspase-3 and 6

c)

Caspase-1 and 2

d)

Caspase-11 only

9.

Apoptotic bodies are:

a)

Large swollen cells

b)

Fragments with intact membranes

c)

Necrotic debris

d)

Denatured proteins only

10.

Inflammation in apoptosis is:

a)

Severe

b)

Mild

c)

Absent

d)

Chronic

11.

Morphology of apoptosis includes:

a)

Karyorrhexis & shrinkage

b)

Cell swelling

c)

Plasma membrane rupture

d)

Lysosomal digestion

12.

Most specific marker of apoptosis:

a)

Caspase activation

b)

Lipid peroxidation

c)

Mitochondrial swelling

d)

Calcification

13.

TUNEL test detects:

a)

Protein denaturation

b)

Endonuclease-mediated DNA breaks

c)

Mitochondrial damage

d)

Cytoplasmic RNA

14.

Reversible cell injury hallmark:

a)

Nuclear fragmentation

b)

Cell swelling

c)

Membrane rupture

d)

Karyolysis

15.

Earliest reversible injury is:

a)

Fatty change

b)

Cell shrinkage

c)

Hydropic change

d)

Nuclear pyknosis

16.

Irreversible injury hallmark:

a)

Severe membrane damage

b)

Mild vacuolation

c)

Reversible swelling

d)

Fat accumulation

17.

Mitochondrial permeability transition mainly leads to:

a)

More ATP

b)

Loss of ATP

c)

More protein synthesis

d)

No effect on cell

18.

Feature of irreversible injury:

a)

Ribosome detachment only

b)

Massive calcium influx

c)

DNA condensation only

d)

Reversible blebbing

19.

Most reliable indicator of irreversible injury:

a)

Nuclear changes (karyolysis)

b)

Cell swelling

c)

Fatty change

d)

Membrane blebs

20.

Apoptosis vs necrosis difference:

a)

Necrosis = no inflammation

b)

Apoptosis = inflammation present

c)

Apoptosis = no inflammation

d)

Necrosis = shrinkage

Reset

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